Stimulation of wound healing by epidermal growth factor. A dose-dependent effect.

Abstract:

:This work was undertaken to study the effects of various doses of locally applied epidermal growth factor (EGF) on developing granulation tissue in rats. Cylindrical hollow sponge implants were used as an inductive matrix for the growth of granulation tissue. In the test groups, the implants were injected daily with a solution containing 0.2, 1, or 5 micrograms of EGF in 0.1% albumin while the implants of the control group were treated correspondingly with the carrier solution only. Analyses of granulation tissue in the sponge cylinders were carried out 7 days after implantation. A stimulatory, dose-dependent effect of EGF on granulation tissue formation was observed: cellularity increased, as evidenced by the elevated amounts of nucleic acids, and accumulation of collagen and glycosaminoglycans was enhanced.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Laato M,Niinikoski J,Lebel L,Gerdin B

doi

10.1097/00000658-198604000-00007

subject

Has Abstract

pub_date

1986-04-01 00:00:00

pages

379-81

issue

4

eissn

0003-4932

issn

1528-1140

journal_volume

203

pub_type

杂志文章
  • Gastroesophageal reflux: prevalence in adults older than 28 years after correction of esophageal atresia.

    abstract:OBJECTIVE:To study the incidence of gastroesophageal reflux (GER)related complications after correction of esophageal atresia (EA). SUMMARY BACKGROUND DATA:The association of EA and GER in children is well known. However, little is known about the prevalence of GER and its potential complications in adults who have un...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000094303.07910.05

    authors: Deurloo JA,Ekkelkamp S,Bartelsman JF,Ten Kate FJ,Schoorl M,Heij HA,Aronson DC

    更新日期:2003-11-01 00:00:00

  • Use of abdominal ultrasonography to assess pediatric splenic trauma. Potential pitfalls in the diagnosis.

    abstract:OBJECTIVE:The purpose of this study was to evaluate the accuracy of abdominal ultrasonography (US) for screening and grading pediatric splenic injury. SUMMARY BACKGROUND DATA:The use of abdominal US has increased rapidly as a method of evaluating organ damage after blunt abdominal trauma. Despite US's increasing use, ...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000658-199704000-00010

    authors: Krupnick AS,Teitelbaum DH,Geiger JD,Strouse PJ,Cox CS,Blane CE,Polley TZ

    更新日期:1997-04-01 00:00:00

  • Gallstone pancreatitis: biliary tract pathology in relation to time of operation.

    abstract::During a 29-month trial, 65 patients with acute gallstone pancreatitis were randomly selected for biliary tract explorations either within 73 hours of admission (36 patients) or at three months following remission with nonoperative measures (29 patients, with five others awaiting elective operation). The details of su...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198109000-00008

    authors: Stone HH,Fabian TC,Dunlop WE

    更新日期:1981-09-01 00:00:00

  • Predictive value of MicroRNAs in the progression of barrett esophagus to adenocarcinoma in a long-term follow-up study.

    abstract:OBJECTIVE:The aim of this study is to identify a set of microRNAs (miRNAs) as prognostic molecular biomarkers for the progression of Barrett esophagus (BE) to esophageal adenocarcinoma (EAC) to rationalize the surveillance programs in patients with BE. BACKGROUND:Histological dysplasia is currently used as the main bi...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31826ddba6

    authors: Revilla-Nuin B,Parrilla P,Lozano JJ,de Haro LF,Ortiz A,Martínez C,Munitiz V,de Angulo DR,Bermejo J,Molina J,Cayuela ML,Yélamos J

    更新日期:2013-05-01 00:00:00

  • Pathologic Response to Pretransplant Locoregional Therapy is Predictive of Patient Outcome After Liver Transplantation for Hepatocellular Carcinoma: Analysis From the US Multicenter HCC Transplant Consortium.

    abstract:OBJECTIVE:The aim of the study was to determine the rate, predictors, and impact of complete pathologic response (cPR) to pretransplant locoregional therapy (LRT) in a large, multicenter cohort of hepatocellular carcinoma (HCC) patients undergoing liver transplantation (LT). BACKGROUND:LRT is used to mitigate waitlist...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000003253

    authors: DiNorcia J,Florman SS,Haydel B,Tabrizian P,Ruiz RM,Klintmalm GB,Senguttuvan S,Lee DD,Taner CB,Verna EC,Halazun KJ,Hoteit M,Levine MH,Chapman WC,Vachharajani N,Aucejo F,Nguyen MH,Melcher ML,Tevar AD,Humar A,Mobley

    更新日期:2020-04-01 00:00:00

  • Reframing Surgical Care: Understanding Complexity and Promoting Teaming.

    abstract::Reframing healthcare delivery in terms of the principles of complex adaptive systems has practical implications for addressing the challenges in improving surgical care. In an Integrated Practice Unit (IPU) - such as a surgical service line, a surgical in-patient floor, or an acute care unit - a diverse group of careg...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001251

    authors: Dillon PW

    更新日期:2015-12-01 00:00:00

  • The role of splenectomy in multimodality treatment of thrombotic thrombocytopenic purpura.

    abstract::Current treatment modalities for thrombotic thrombocytopenic purpura (TTP) include plasmapheresis (PP), splenectomy, steroids, dextran, other antiplatelet agents, and vinca alkaloids. Prior to the development of PP and use of multimodality treatment for TTP, mortality rates exceeded 50%. This report reviews 11 patient...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198509000-00007

    authors: Schneider PA,Rayner AA,Linker CA,Schuman MA,Liu ET,Hohn DC

    更新日期:1985-09-01 00:00:00

  • The Effect of Postoperative Complications After Minimally Invasive Esophagectomy on Long-term Survival: An International Multicenter Cohort Study.

    abstract:BACKGROUND:Esophagectomy is a technically challenging procedure, associated with significant morbidity. The introduction of minimally invasive esophagectomy (MIE) has reduced postoperative morbidity. OBJECTIVE:Although the short-term effect on complications is increasingly being recognized, the impact on long-term sur...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003772

    authors: Fransen LFC,Berkelmans GHK,Asti E,van Berge Henegouwen MI,Berlth F,Bonavina L,Brown A,Bruns C,van Daele E,Gisbertz SS,Grimminger PP,Gutschow CA,Hannink G,Hölscher AH,Kauppi J,Lagarde SM,Mercer S,Moons J,Nafteux P,Ni

    更新日期:2020-01-14 00:00:00

  • Surgical correction of posttransplant renovascular hypertension.

    abstract::The incidence of renovascular hypertension in the transplanted kidney is reported to range between 5 and 15%. A review of 391 consecutive renal transplant patients revealed 16 patients (5.4%) with hypertension secondary to partial obstruction of renal arterial blood flow. The clinical course of this group of patients ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198011000-00010

    authors: Dickerman RM,Peters PC,Hull AR,Curry TS,Atkins C,Fry WJ

    更新日期:1980-11-01 00:00:00

  • Surgical aspects of sclerosing cholangitis. Results in 178 patients.

    abstract::Of 178 patients with sclerosing cholangitis treated since 1950, 88 patients had associated inflammatory bowel disease, 72 had no such history, and 18 had iatrogenic injury or stone disease. A total of 233 biliary operations were performed, with a 75% rate of temporary improvement after initial operation. Subsequent op...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199010000-00017

    authors: Martin FM,Rossi RL,Nugent FW,Scholz FJ,Jenkins RL,Lewis WD,Gagner M,Foley E,Braasch JW

    更新日期:1990-10-01 00:00:00

  • Effects of a perioperative smoking cessation intervention on postoperative complications: a randomized trial.

    abstract:OBJECTIVE:To determine whether an intervention with smoking cessation starting 4 weeks before general and orthopedic surgery would reduce the frequency of postoperative complications. SUMMARY BACKGROUND DATA:Complications are a major concern after elective surgery and smokers have an increased risk. There is insuffici...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/SLA.0b013e3181889d0d

    authors: Lindström D,Sadr Azodi O,Wladis A,Tønnesen H,Linder S,Nåsell H,Ponzer S,Adami J

    更新日期:2008-11-01 00:00:00

  • Axillary lymph node status, but not tumor size, predicts locoregional recurrence and overall survival after mastectomy for breast cancer.

    abstract:OBJECTIVE:To assess the significance of axillary lymph node status and tumor size for predicting locoregional recurrence (LRR) and overall survival after mastectomy for breast cancer and to discuss the utility of postmastectomy radiation therapy. SUMMARY BACKGROUND DATA:Patients with locally advanced breast cancer req...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.SLA.0000065289.06765.71

    authors: Beenken SW,Urist MM,Zhang Y,Desmond R,Krontiras H,Medina H,Bland KI

    更新日期:2003-05-01 00:00:00

  • Surgical management of abdominal aortic aneurysms: factors influencing mortality and morbidity--a 20-year experience.

    abstract::Abdominal aortic aneurysmectomy is being performed with progressively lower operative mortality and morbidity. Three hundred thirty seven patients have had elective aneurysm repair since 1954. Factors affecting mortality and morbidity in the last 108 cases are analyzed. Seventy-four per cent of patients had pre-existi...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197505000-00020

    authors: Thompson JE,Hollier LH,Patman RD,Persson AV

    更新日期:1975-05-01 00:00:00

  • Hospital Length of Stay Reduction Over Time and Patient Readmission for Severe Adverse Events Following Surgery.

    abstract:OBJECTIVE:The aim of the study was to investigate whether patients who undergo surgery in hospitals experiencing significant length of stay (LOS) reductions over time are exposed to a higher risk of severe adverse events in the postoperative period. SUMMARY BACKGROUND DATA:Surgical care innovation has encouraged hospi...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003206

    authors: Pascal L,Polazzi S,Piriou V,Cotte E,Wegrzyn J,Carty MJ,Chollet F,Sanchez S,Lifante JC,Duclos A

    更新日期:2020-07-01 00:00:00

  • The use of closed suction drainage after lumpectomy and axillary node dissection for breast cancer. A prospective randomized trial.

    abstract::Closed suction drainage has been used to prevent seroma formation after lumpectomy and axillary node dissection for breast cancer. To study the efficacy of closed suction drains, the authors conducted a prospective randomized study from 1987 to 1990 of 227 axillary dissections. One hundred eight were randomized to a d...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-199202000-00009

    authors: Somers RG,Jablon LK,Kaplan MJ,Sandler GL,Rosenblatt NK

    更新日期:1992-02-01 00:00:00

  • Small bowel obstruction after nephrectomy for Wilms' tumor. A report of the National Wilms' Tumor Study-3.

    abstract:OBJECTIVE:This study was undertaken to define the incidence and etiology of small bowel obstruction (SBO) after nephrectomy for Wilms' tumor. SUMMARY BACKGROUND DATA:Intestinal obstruction is one of the most common postoperative complications after nephrectomy for nephroblastoma. However, few reports have evaluated ri...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199321850-00011

    authors: Ritchey ML,Kelalis PP,Etzioni R,Breslow N,Shochat S,Haase GM

    更新日期:1993-11-01 00:00:00

  • Surgical management of pheochromocytoma with the use of metyrosine.

    abstract::Despite recommended preoperative preparation with alpha-adrenergic blockers, severe hemodynamic instability may occur during operations to resect pheochromocytoma. We combined the alpha-blocker phenoxybenzamine with the tyrosine hydroxylase inhibitor metyrosine in an attempt to better manage the hypertension of patien...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000658-199011000-00010

    authors: Perry RR,Keiser HR,Norton JA,Wall RT,Robertson CN,Travis W,Pass HI,Walther MM,Linehan WM

    更新日期:1990-11-01 00:00:00

  • Management of Pneumoperitoneum: Role and Limits of Nonoperative Treatment.

    abstract:OBJECTIVES:The aim of this study was to compare morbidity and mortality between nonoperative and operative treatment of pneumoperitoneum. BACKGROUND:Pneumoperitoneum is a potentially life-threatening condition that has been traditionally treated with surgical intervention. Adequately powered studies comparing treatmen...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003492

    authors: Udelsman B,Lee K,Qadan M,Lillemoe KD,Chang D,Lindvall C,Cooper Z

    更新日期:2019-07-23 00:00:00

  • Incidence and Risk Factors for Anastomotic Failure in 1594 Patients Treated by Transanal Total Mesorectal Excision: Results From the International TaTME Registry.

    abstract:OBJECTIVE:To determine the incidence of anastomotic-related morbidity following Transanal Total Mesorectal Excision (TaTME) and identify independent risk factors for failure. BACKGROUND:Anastomotic leak and its sequelae are dreaded complications following gastrointestinal surgery. TaTME is a recent technique for recta...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000002653

    authors: Penna M,Hompes R,Arnold S,Wynn G,Austin R,Warusavitarne J,Moran B,Hanna GB,Mortensen NJ,Tekkis PP,International TaTME Registry Collaborative.

    更新日期:2019-04-01 00:00:00

  • Regional differences in surgical care based upon uniform physician and hospital discharge abstract data.

    abstract::Population based surgical rates for various common surgical procedures were analyzed on a regional basis by examining select uniform hospital discharge abstract data from Wisconsin hospitals. The surgical asbracts of nearly 64,000 procedures were compared to the supply of physicians and showed a significant variation ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197802000-00012

    authors: Detmer DE,Tyson TJ

    更新日期:1978-02-01 00:00:00

  • Gastric carcinoma following operation for peptic ulcer disease.

    abstract::Gastric carcinoma following operation for benign peptic ulcer disease has been considered rare but nine patients have been seen during the past five years. All were male patients, the average time interval from prior ulcer operation to development of cancer was 17 years, but was a short as ten years. The symptoms of c...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197803000-00007

    authors: Eberlein TJ,Lorenzo FV,Webster MW

    更新日期:1978-03-01 00:00:00

  • Total thyroidectomy plus neck dissection in differentiated papillary thyroid carcinoma patients: pattern of nodal metastasis, morbidity, recurrence, and postoperative levels of serum parathyroid hormone.

    abstract:OBJECTIVE:To investigate the pattern of nodal metastasis, morbidity, recurrence rates of papillary thyroid carcinoma (PTC), and parathyroid hormone (PTH) responses following neck dissection (ND) plus total thyroidectomy (TT). SUMMARY BACKGROUND DATA:While hypoparathyroidism develops after TT plus ND, little is known o...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000250451.59685.67

    authors: Roh JL,Park JY,Park CI

    更新日期:2007-04-01 00:00:00

  • Two thousand transhiatal esophagectomies: changing trends, lessons learned.

    abstract:OBJECTIVE:"Rediscovered" in 1976, transhiatal esophagectomy (THE) has been applicable in most situations requiring esophageal resection and reconstruction. The objective of this study was to review the authors' 30-year experience with THE and changing trends in its use. METHODS:Using the authors' prospective Esophagec...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31814697f2

    authors: Orringer MB,Marshall B,Chang AC,Lee J,Pickens A,Lau CL

    更新日期:2007-09-01 00:00:00

  • Therapeutic delay and survival after surgery for cancer of the pancreatic head with or without preoperative biliary drainage.

    abstract:OBJECTIVE:To evaluate the relation between delay in surgery because of preoperative biliary drainage (PBD) and survival in patients scheduled for surgery for pancreatic head cancer. BACKGROUND:Patients with obstructive jaundice due to pancreatic head cancer can undergo PBD. The associated delay of surgery can lead to ...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/SLA.0b013e3181fd36a2

    authors: Eshuis WJ,van der Gaag NA,Rauws EA,van Eijck CH,Bruno MJ,Kuipers EJ,Coene PP,Kubben FJ,Gerritsen JJ,Greve JW,Gerhards MF,de Hingh IH,Klinkenbijl JH,Nio CY,de Castro SM,Busch OR,van Gulik TM,Bossuyt PM,Gouma DJ

    更新日期:2010-11-01 00:00:00

  • Tumor Size, Histology, and Survival after Stereotactic Ablative Radiotherapy and Sublobar Resection in Node-negative Non-small Cell Lung Cancer.

    abstract:BACKGROUND:While stereotactic ablative radiotherapy (SABR) is increasingly emerging as an alternative to surgery for node-negative non-small cell lung cancer (NSCLC), there is poor understanding of patients who may most benefit SABR compared to surgery. OBJECTIVE:This study examined the relationship between tumor size...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004730

    authors: Raman V,Jawitz OK,Cerullo M,Voigt SL,Rhodin KE,Yang CJ,D'Amico TA,Harpole DH,Kelsey CR,Tong BC

    更新日期:2021-01-07 00:00:00

  • Enteral contrast in the computed tomography diagnosis of appendicitis: comparative effectiveness in a prospective surgical cohort.

    abstract:OBJECTIVE:Our goal was to perform a comparative effectiveness study of intravenous (IV)-only versus IV + enteral contrast in computed tomographic (CT) scans performed for patients undergoing appendectomy across a diverse group of hospitals. BACKGROUND:Small randomized trials from tertiary centers suggest that enteral ...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000000272

    authors: Drake FT,Alfonso R,Bhargava P,Cuevas C,Dighe MK,Florence MG,Johnson MG,Jurkovich GJ,Steele SR,Symons RG,Thirlby RC,Flum DR,Writing Group for SCOAP-CERTAIN.

    更新日期:2014-08-01 00:00:00

  • Casting A Wide Net On Surgery: The Central Role of Neutrophil Extracellular Traps.

    abstract::: Since their discovery, neutrophil extracellular traps (NETs) have been implicated in a broad array of functions, both beneficial and detrimental to the host. Indeed, NETs have roles in infection, sepsis, wound healing, thrombotic disease, and cancer propagation, all of which are directly implicated in the care of su...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/SLA.0000000000003586

    authors: Eustache JH,Tohme S,Milette S,Rayes RF,Tsung A,Spicer JD

    更新日期:2020-08-01 00:00:00

  • A randomized, controlled, double-blind crossover study on the effects of 1-L infusions of 6% hydroxyethyl starch suspended in 0.9% saline (voluven) and a balanced solution (Plasma Volume Redibag) on blood volume, renal blood flow velocity, and renal corti

    abstract:OBJECTIVE:We compared the effects of intravenous administration of 6% hydroxyethyl starch (maize-derived) in 0.9% saline (Voluven; Fresenius Kabi, Runcorn, United Kingdom) and a "balanced" preparation of 6% hydroxyethyl starch (potato-derived) [Plasma Volume Redibag (PVR); Baxter Healthcare, Thetford, United Kingdom] o...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0000000000000324

    authors: Chowdhury AH,Cox EF,Francis ST,Lobo DN

    更新日期:2014-05-01 00:00:00

  • Emergency portacaval shunt for variceal hemorrhage. A prospective study.

    abstract::Emergency portacaval shunt for variceal bleeding is associated with a high operative mortality, particularly if used as a last resort. Because of this, a strong case has been made against emergency shunt. This report describes an experience with emergency portacaval shunt for the treatment of variceal bleeding when us...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198707000-00007

    authors: Villeneuve JP,Pomier-Layrargues G,Duguay L,Lapointe R,Tanguay S,Marleau D,Willems B,Huet PM,Infante-Rivard C,Lavoie P

    更新日期:1987-07-01 00:00:00

  • Ethics of Codes and Codes of Ethics: When Is It Ethical to Provide Cardiopulmonary Resuscitation During the COVID-19 Pandemic?

    abstract:OBJECTIVE:Our study aims to provide a paradigm when it is ethical to perform cardiopulmonary resuscitation (CPR) on patients during the COVID-19 pandemic. SUMMARY BACKGROUND DATA:Hospitals around the nation are enacting systems to limit CPR in caring for COVID+ patients for a variety of legitimate reasons and based on...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004318

    authors: Kopar PK,Brown DE,Turnbull IR

    更新日期:2020-12-01 00:00:00