A randomized, controlled, double-blind crossover study on the effects of 1-L infusions of 6% hydroxyethyl starch suspended in 0.9% saline (voluven) and a balanced solution (Plasma Volume Redibag) on blood volume, renal blood flow velocity, and renal corti

Abstract:

OBJECTIVE:We compared the effects of intravenous administration of 6% hydroxyethyl starch (maize-derived) in 0.9% saline (Voluven; Fresenius Kabi, Runcorn, United Kingdom) and a "balanced" preparation of 6% hydroxyethyl starch (potato-derived) [Plasma Volume Redibag (PVR); Baxter Healthcare, Thetford, United Kingdom] on renal blood flow velocity and renal cortical tissue perfusion in humans using magnetic resonance imaging. BACKGROUND:Hyperchloremia resulting from 0.9% saline infusion may adversely affect renal hemodynamics when compared with balanced crystalloids. This phenomenon has not been studied with colloids. METHODS:Twelve healthy adult male subjects received 1-L intravenous infusions of Voluven or PVR over 30 minutes in a randomized, double-blind manner, with crossover studies 7 to 10 days later. Magnetic resonance imaging proceeded for 60 minutes after commencement of infusion to measure renal artery blood flow velocity and renal cortical perfusion. Blood was sampled, and weight was recorded at 0, 30, 60, 120, 180, and 240 minutes. RESULTS:Mean peak serum chloride concentrations were 108 and 106 mmol/L, respectively, after Voluven and PVR infusion (P = 0.032). Changes in blood volume (P = 0.867), strong ion difference (P = 0.219), and mean renal artery flow velocity (P = 0.319) were similar. However, there was a significant increase in mean renal cortical tissue perfusion after PVR when compared with Voluven (P = 0.033). There was no difference in urinary neutrophil gelatinase-associated liopcalin to creatinine ratios after the infusion (P = 0.164). CONCLUSIONS:There was no difference in the blood volume-expanding properties of the 2 preparations of 6% hydroxyethyl starch. The balanced starch produced an increase in renal cortical tissue perfusion, a phenomenon not seen with starch in 0.9% saline.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Chowdhury AH,Cox EF,Francis ST,Lobo DN

doi

10.1097/SLA.0000000000000324

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

881-7

issue

5

eissn

0003-4932

issn

1528-1140

journal_volume

259

pub_type

杂志文章,随机对照试验
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    authors: Heitmiller RF,Redmond M,Hamilton SR

    更新日期:1996-07-01 00:00:00

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    authors: Aminian A,Zajichek A,Tu C,Wolski KE,Brethauer SA,Schauer PR,Kattan MW,Nissen SE

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    doi:10.1097/SLA.0000000000004433

    authors: Balentine CJ,Morris M,Knight SJ,Turan JM,Flood KL,Gutierrez-Meza D,Macdonald CL,Bhatia S,Brown CJ

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    abstract::Descriptions of the fasciae of the lower half of the face and of the adjacent cervical fasciae have long been puzzling and descriptively much too complex. For this reason, medical students, young medical and dental practitioners, and at times even senior surgeons frequently do not understand the anatomy of the cervico...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198612000-00015

    authors: Lindner HH

    更新日期:1986-12-01 00:00:00

  • Effect of moderate hypothermia in the treatment of canine hemorrhagic shock.

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    authors: Meyer DM,Horton JW

    更新日期:1988-04-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/01.sla.0000186440.02977.de

    authors: Lau H

    更新日期:2005-11-01 00:00:00

  • Desmoid-type fibromatosis and pregnancy: a multi-institutional analysis of recurrence and obstetric risk.

    abstract:BACKGROUND:Many women who present with desmoid-type fibromatosis (DF) have had a recent pregnancy. Long-term data about disease behavior during and after pregnancy are lacking. OBJECTIVE:To investigate the possible relationship between DF and pregnancy. PATIENTS AND METHODS:A cohort of women with DF and pregnancy was...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

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    authors: Fiore M,Coppola S,Cannell AJ,Colombo C,Bertagnolli MM,George S,Le Cesne A,Gladdy RA,Casali PG,Swallow CJ,Gronchi A,Bonvalot S,Raut CP

    更新日期:2014-05-01 00:00:00

  • Primary hepatocytes outperform Hep G2 cells as the source of biotransformation functions in a bioartificial liver.

    abstract:OBJECTIVE:Metabolic activity of transformed human liver (Hep G2) cells and primary rat hepatocytes were compared during in vitro application of a gel entrapment bioartificial liver. BACKGROUND:Clinical trials of bioartificial liver devices containing either transformed liver cells or primary hepatocytes have been init...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:

    authors: Nyberg SL,Remmel RP,Mann HJ,Peshwa MV,Hu WS,Cerra FB

    更新日期:1994-07-01 00:00:00

  • Surgical management of acute cholecystitis in patients 65 years of age and older.

    abstract::The proportion of the population of the U.S. 65 years of age and over is increasing. Biliary tract disease is estimated to involve 15% of the adult population. A review of 12,200 patients treated surgically at one medical center reveals that 2401 (20%) had acute cholecystitis. There were 93 deaths, for a mortality rat...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198101000-00009

    authors: Glenn F

    更新日期:1981-01-01 00:00:00

  • Medullary thyroid carcinoma: relationship of method of diagnosis to pathologic staging.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197809000-00013

    authors: Wells SA Jr,Baylin SB,Gann DS,Farrell RE,Dilley WG,Preissig SH,Linehan WM,Cooper CW

    更新日期:1978-09-01 00:00:00

  • The Influence of Hospital Volume on Circumferential Resection Margin Involvement: Results of the Dutch Surgical Colorectal Audit.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001009

    authors: Gietelink L,Henneman D,van Leersum NJ,de Noo M,Manusama E,Tanis PJ,Tollenaar RA,Wouters MW,Dutch Surgical Colorectal Cancer Audit Group.

    更新日期:2016-04-01 00:00:00

  • Tacrolimus monotherapy in liver transplantation: one-year results of a prospective, randomized, double-blind, placebo-controlled study.

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    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0b013e31819009c9

    authors: Lerut J,Mathys J,Verbaandert C,Talpe S,Ciccarelli O,Lemaire J,Bonaccorsi-Riani E,Vanthuyne V,Hetsch N,Roggen F,Reyck CD,Goffette P,Latinne D,Orlando G,Rahier J,Sempoux C,Wallemacq P,Laterre PF,Gianello P

    更新日期:2008-12-01 00:00:00

  • The 100 Most Cited Papers in the History of the American Surgical Association.

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    pub_type: 历史文章,杂志文章

    doi:10.1097/SLA.0000000000003633

    authors: Landreneau JP,Weaver M,Delaney CP,Aminian A,Dimick JB,Lillemoe KD,Schauer PR

    更新日期:2020-04-01 00:00:00

  • Effectiveness of steroid/antibiotic treatment in primates administered LD100 Escherichia coli.

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    pub_type: 杂志文章

    doi:10.1097/00000658-198107000-00009

    authors: Hinshaw LB,Beller-Todd BK,Archer LT,Benjamin B,Flournoy DJ,Passey R,Wilson MF

    更新日期:1981-07-01 00:00:00

  • Biliary atresia-polysplenia syndrome: surgical and clinical relevance in liver transplantation.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199804000-00022

    authors: Varela-Fascinetto G,Castaldo P,Fox IJ,Sudan D,Heffron TG,Shaw BW,Langnas AN

    更新日期:1998-04-01 00:00:00

  • Activities of daily living and quality of life of elderly patients after elective surgery for gastric and colorectal cancers.

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    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0b013e3180caa3fb

    authors: Amemiya T,Oda K,Ando M,Kawamura T,Kitagawa Y,Okawa Y,Yasui A,Ike H,Shimada H,Kuroiwa K,Nimura Y,Fukata S

    更新日期:2007-08-01 00:00:00

  • Wnt pathway activation predicts increased risk of tumor recurrence in patients with stage I nonsmall cell lung cancer.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31826d81fd

    authors: Shapiro M,Akiri G,Chin C,Wisnivesky JP,Beasley MB,Weiser TS,Swanson SJ,Aaronson SA

    更新日期:2013-03-01 00:00:00

  • Neurokinin-2 receptor levels correlate with intensity, frequency, and duration of pain in chronic pancreatitis.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e318070d56e

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    更新日期:2007-11-01 00:00:00

  • Caloric restriction increases the expression of heat shock protein in the gut.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199605000-00015

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    更新日期:1996-05-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-200103000-00016

    authors: Cohn SM,Giannotti G,Ong AW,Varela JE,Shatz DV,McKenney MG,Sleeman D,Ginzburg E,Augenstein JS,Byers PM,Sands LR,Hellinger MD,Namias N

    更新日期:2001-03-01 00:00:00

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:10.1097/00000658-198112000-00003

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    doi:10.1097/SLA.0000000000001765

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    pub_type: 杂志文章,随机对照试验

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    journal_title:Annals of surgery

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    pub_type: 杂志文章

    doi:10.1097/00000658-198006000-00006

    authors: Flint LM Jr,McCoy M,Richardson JD,Polk HC Jr

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:

    authors: Murayama Y

    更新日期:1990-03-01 00:00:00

  • Is Annual Volume Enough? The Role of Experience and Specialization on Inpatient Mortality After Hepatectomy.

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    更新日期:2017-10-01 00:00:00