Casting A Wide Net On Surgery: The Central Role of Neutrophil Extracellular Traps.

Abstract:

:: Since their discovery, neutrophil extracellular traps (NETs) have been implicated in a broad array of functions, both beneficial and detrimental to the host. Indeed, NETs have roles in infection, sepsis, wound healing, thrombotic disease, and cancer propagation, all of which are directly implicated in the care of surgical patients. Here we provide an updated review on the role of NETs in the perioperative period with specific emphasis on perioperative infections, wound healing, vascular complications, cancer propagation, as well as discussing ongoing, and future therapeutic targets. Surgeons will benefit from understanding the latest discoveries in neutrophil biology and how these novel functions affect the care of surgical patients. Furthermore, novel anti-NET therapies are being developed which may have profound effects on the care of surgical patients.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Eustache JH,Tohme S,Milette S,Rayes RF,Tsung A,Spicer JD

doi

10.1097/SLA.0000000000003586

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

277-283

issue

2

eissn

0003-4932

issn

1528-1140

pii

00000658-202008000-00060

journal_volume

272

pub_type

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