The role of calcium ions and calcium channel entry blockers in experimental ischemia-reperfusion-induced liver injury.

Abstract:

:Verapamil administered before treatment, but not after treatment, had a beneficial effect on a 90-minute warm ischemia-reperfusion rat liver injury model. The possible activation of proteases converting the xanthine dehydrogenase to xanthine oxidase, the significant mitochondrial calcium loading during the ischemic period, and the potentiation of calcium and oxygen-derived free radicals to promote injury to mitochondria are mechanisms supported by this study, based on both histologic observations and on the pattern of enzyme leak after the acute ischemic event.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Nauta RJ,Tsimoyiannis E,Uribe M,Walsh DB,Miller D,Butterfield A

doi

10.1097/00000658-199102000-00008

subject

Has Abstract

pub_date

1991-02-01 00:00:00

pages

137-42

issue

2

eissn

0003-4932

issn

1528-1140

journal_volume

213

pub_type

杂志文章
  • Prognostic Implications of Pathological Response to Neoadjuvant Chemoradiation in Pathologic Stage III Rectal Cancer.

    abstract:OBJECTIVE:To evaluate the independent prognostic ability of the American Joint Committee on Cancer (AJCC) tumor regression scores within pathologic stage II and III rectal cancers. BACKGROUND:Response to neoadjuvant chemoradiation (nCRT) has been debated as a biologic surrogate for tumor biology and prognosis in recta...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002719

    authors: Karagkounis G,Thai L,Mace AG,Wiland H,Pai RK,Steele SR,Church JM,Kalady MF

    更新日期:2019-06-01 00:00:00

  • Ethics of Codes and Codes of Ethics: When Is It Ethical to Provide Cardiopulmonary Resuscitation During the COVID-19 Pandemic?

    abstract:OBJECTIVE:Our study aims to provide a paradigm when it is ethical to perform cardiopulmonary resuscitation (CPR) on patients during the COVID-19 pandemic. SUMMARY BACKGROUND DATA:Hospitals around the nation are enacting systems to limit CPR in caring for COVID+ patients for a variety of legitimate reasons and based on...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004318

    authors: Kopar PK,Brown DE,Turnbull IR

    更新日期:2020-12-01 00:00:00

  • The Use of Caffeinated Substances by Surgeons for Cognitive Enhancement.

    abstract:OBJECTIVE:To investigate the use of coffee, caffeinated drinks, and caffeine tablets for pharmacological cognitive enhancement (CE) among surgeons. BACKGROUND:Surgeons have demanding workloads, and the resulting fatigue and concentration deficits can lead to medical errors. Some surgeons use substances that promote wa...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000000830

    authors: Franke AG,Bagusat C,McFarlane C,Tassone-Steiger T,Kneist W,Lieb K

    更新日期:2015-06-01 00:00:00

  • The 30-day versus in-hospital and 90-day mortality after esophagectomy as indicators for quality of care.

    abstract:OBJECTIVE:To describe causes of death in the first year after esophagectomy and determine the time frame that should be used for measurement of quality of surgery. A case-mix adjustment model was developed for the comparison between hospitals. BACKGROUND:The time period in which postoperative mortality should be measu...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000000482

    authors: Talsma AK,Lingsma HF,Steyerberg EW,Wijnhoven BP,Van Lanschot JJ

    更新日期:2014-08-01 00:00:00

  • Acute hand burns in children: management and long-term outcome based on a 10-year experience with 698 injured hands.

    abstract:OBJECTIVE:To document long-term results associated with an coordinated plan of care for acutely burned hands in children. SUMMARY AND BACKGROUND DATA:Optimal hand function is a crucial component of a high-quality survival after burn injury. This can be achieved only with a coordinated approach to the injuries. Long-te...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199904000-00016

    authors: Sheridan RL,Baryza MJ,Pessina MA,O'Neill KM,Cipullo HM,Donelan MB,Ryan CM,Schulz JT,Schnitzer JJ,Tompkins RG

    更新日期:1999-04-01 00:00:00

  • Peroral endoscopic drainage/debridement of walled-off pancreatic necrosis.

    abstract:BACKGROUND:Experience with minimal access, transoral/transmural endoscopic drainage/debridement of walled-off pancreatic necrosis (WOPN) after necrotizing pancreatitis is limited. We sought to determine outcome using this technique. METHODS:Retrospective analysis. RESULTS:From 1998 to 2006, 53 patients underwent tran...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000254366.19366.69

    authors: Papachristou GI,Takahashi N,Chahal P,Sarr MG,Baron TH

    更新日期:2007-06-01 00:00:00

  • Metabolic changes in patients severely affected by tetanus.

    abstract::Metabolic changes in six severely affected tetanus patients suffering from characteristic labile hypertension (maximum systolic blood pressure greater than 200 mmHG, maximum diurnal change in systolic pressure greater than 100 mmHg) were investigated. Daily urinary excretion of urea nitrogen increased gradually from t...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199101000-00011

    authors: Hiraide A,Katayama M,Sugimoto H,Yoshioka T,Sugimoto T

    更新日期:1991-01-01 00:00:00

  • Aneurysm of the aorta treated by wiring: case report of a 38-year survival.

    abstract::A patient with a syphilitic aneurysm of the aorta treated by the insertion of wire is presented. The patient remained well for almost 40 years, but finally succumbed after rupture. The autopsy findings are discussed. To our knowledge, this represents the longest reported survival after treatment of an aortic aneurysm ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197612000-00014

    authors: Altman P,Voorhees AB Jr

    更新日期:1976-12-01 00:00:00

  • Does the incorporation of motion metrics into the existing FLS metrics lead to improved skill acquisition on simulators? A single blinded, randomized controlled trial.

    abstract:OBJECTIVE:We hypothesized that training to expert-derived levels of speed and motion will lead to improved learning and will translate to better operating room (OR) performance of novices than training to goals of speed or motion alone. BACKGROUND:Motion tracking has been suggested to be a more sensitive performance m...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0b013e318285f531

    authors: Stefanidis D,Yonce TC,Korndorffer JR Jr,Phillips R,Coker A

    更新日期:2013-07-01 00:00:00

  • Experimental subcapsular hematoma of the spleen: natural history and radioisotope scan correlation.

    abstract::An experimental model was developed in dogs to correlate radioisotope scan findings of iatrogenic, in vivo, splenic injury with the natural history of the injury as determined by the clinical course and both gross and microscopic observations. It was found that small subcapsular injuries do not appear as discrete foca...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197804000-00011

    authors: Washburn ME,Balk MW,Mazat BA,Zurlo JA

    更新日期:1978-04-01 00:00:00

  • End-to-end versus end-to-side esophagogastrostomy after esophageal cancer resection: a prospective randomized study.

    abstract:OBJECTIVE:To compare single-layered hand-sewn cervical end-to-side (ETS) anastomosis with end-to-end (ETE) anastomosis in a prospective randomized fashion. BACKGROUND:The preferred organ used for reconstruction after esophagectomy for cancer is the stomach. Previous studies attempted to define the optimal site of anas...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0b013e31822676a9

    authors: Nederlof N,Tilanus HW,Tran TC,Hop WC,Wijnhoven BP,de Jonge J

    更新日期:2011-08-01 00:00:00

  • A statewide, population-based time-series analysis of the outcome of ruptured abdominal aortic aneurysm.

    abstract:OBJECTIVES:The purpose of this study was to perform the first statewide, population-based, time-series analysis of the frequency of ruptured abdominal aortic aneurysm (RAAA), to determine the outcomes of RAAA, and to assess the association of patient, physician, and hospital factors with survival after RAAA. The hypoth...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199605000-00005

    authors: Rutledge R,Oller DW,Meyer AA,Johnson GJ Jr

    更新日期:1996-05-01 00:00:00

  • Long-term complications of laparotomy in Hodgkin's disease.

    abstract:OBJECTIVE:The authors determined the incidence of complications in 133 patients who had undergone staging laparotomy with splenectomy before treatment for Hodgkin's disease (stages I-IV). METHODS AND MATERIALS:Medical records were reviewed, and the patients or their relatives were interviewed. Median follow-up after l...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/00000658-199406000-00004

    authors: Jockovich M,Mendenhall NP,Sombeck MD,Talbert JL,Copeland EM 3rd,Bland KI

    更新日期:1994-06-01 00:00:00

  • Paradigm shift in the management of gastroesophageal reflux disease.

    abstract:OBJECTIVE:To compare the short-term results of the radiofrequency treatment of the gastroesophageal junction known as the Stretta procedure versus laparoscopic fundoplication (LF) in patients with gastroesophageal reflux disease (GERD). SUMMARY BACKGROUND DATA:The Stretta procedure has been shown to be safe, well tole...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/01.SLA.0000064358.25509.36

    authors: Richards WO,Houston HL,Torquati A,Khaitan L,Holzman MD,Sharp KW

    更新日期:2003-05-01 00:00:00

  • Liver transplantation for nonresectable liver metastases from colorectal cancer.

    abstract:OBJECTIVE:The objective of this pilot study was to investigate the potential for long-term overall survival (OS) after liver transplantation for colorectal liver metastases (CLMs). BACKGROUND:Patients with nonresectable CLMs have poor prognosis, and few survive beyond 5 years. CLMs are currently considered an absolute...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/SLA.0b013e3182823957

    authors: Hagness M,Foss A,Line PD,Scholz T,Jørgensen PF,Fosby B,Boberg KM,Mathisen O,Gladhaug IP,Egge TS,Solberg S,Hausken J,Dueland S

    更新日期:2013-05-01 00:00:00

  • The spectrum and natural history of common bile duct stenosis in chronic alcohol-induced pancreatitis.

    abstract::Sixty patients with chronic alcohol-induced pancreatitis with endoscopic retrograde cholangiopancreatography evidence of common bile duct stenosis were studied to determine the clinical spectrum and natural history of this complication, as well as the indications for biliary bypass. In 17% of patients, common bile duc...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198911000-00007

    authors: Kalvaria I,Bornman PC,Marks IN,Girdwood AH,Bank L,Kottler RE

    更新日期:1989-11-01 00:00:00

  • Alpha Fetoprotein: An index of progression or regression of hepatoma, and a target for immunotherapy.

    abstract::CLINICAL AND LABORATORY STUDIES OF AFP PRODUCING HEPATOMAS DEMONSTRATED THAT: 1) serum AFP levels correlated directly with tumor growth; 2) circulating AFP could be cleared by passive administration of an. excess of anti-AFP; and 3) highly specific anti-AFP functioned as a carrier to localize diagnostic and possibly t...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197410000-00025

    authors: Parks LC,Baer AN,Pollack M,Williams GM

    更新日期:1974-10-01 00:00:00

  • HuR status is a powerful marker for prognosis and response to gemcitabine-based chemotherapy for resected pancreatic ductal adenocarcinoma patients.

    abstract:BACKGROUND:Pancreatic ductal adenocarcinoma (PDA) is a devastating disease that killed nearly 38,000 people in the United States this past year. OBJECTIVE:Treatment of PDA typically includes surgery and/or chemotherapy with gemcitabine. No reliable biomarker exists for prognosis or response to chemotherapy. Two previo...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181f1fd44

    authors: Richards NG,Rittenhouse DW,Freydin B,Cozzitorto JA,Grenda D,Rui H,Gonye G,Kennedy EP,Yeo CJ,Brody JR,Witkiewicz AK

    更新日期:2010-09-01 00:00:00

  • Disease-free Survival and Local Recurrence for Laparoscopic Resection Compared With Open Resection of Stage II to III Rectal Cancer: Follow-up Results of the ACOSOG Z6051 Randomized Controlled Trial.

    abstract:OBJECTIVE:To determine the disease-free survival (DFS) and recurrence after the treatment of patients with rectal cancer with open (OPEN) or laparoscopic (LAP) resection. BACKGROUND:This randomized clinical trial (ACOSOG [Alliance] Z6051), performed between 2008 and 2013, compared LAP and OPEN resection of stage II/II...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/SLA.0000000000003002

    authors: Fleshman J,Branda ME,Sargent DJ,Boller AM,George VV,Abbas MA,Peters WR Jr,Maun DC,Chang GJ,Herline A,Fichera A,Mutch MG,Wexner SD,Whiteford MH,Marks J,Birnbaum E,Margolin DA,Larson DW,Marcello PW,Posner MC,Read TE

    更新日期:2019-04-01 00:00:00

  • Remission of type 2 diabetes after Roux-en-Y gastric bypass or sleeve gastrectomy is associated with a distinct glycemic profile.

    abstract:BACKGROUND:Roux-en-Y gastric bypass (RYGBP) and sleeve gastrectomy (SG) have been associated with a high remission rate of type 2 diabetes mellitus (T2DM). However, whether such remission is associated with full restoration of postprandial glucose profile and/or the potentially nonrestored glycemic profile is associate...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000000586

    authors: Jiménez A,Ceriello A,Casamitjana R,Flores L,Viaplana-Masclans J,Vidal J

    更新日期:2015-02-01 00:00:00

  • Variability in Patterns of Recurrence After Resection of Primary Retroperitoneal Sarcoma (RPS): A Report on 1007 Patients From the Multi-institutional Collaborative RPS Working Group.

    abstract:BACKGROUND:Retroperitoneal sarcomas (RPS) are rare tumors composed of several well defined histologic subtypes. The aim of this study was to analyze patterns of recurrence and treatment variations in a large population of patients, treated at reference centers. METHODS:All consecutive patients with primary RPS treated...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000001447

    authors: Gronchi A,Strauss DC,Miceli R,Bonvalot S,Swallow CJ,Hohenberger P,Van Coevorden F,Rutkowski P,Callegaro D,Hayes AJ,Honoré C,Fairweather M,Cannell A,Jakob J,Haas RL,Szacht M,Fiore M,Casali PG,Pollock RE,Raut CP

    更新日期:2016-05-01 00:00:00

  • Extended Molecular Profiling Improves Stratification and Prediction of Survival After Resection of Colorectal Liver Metastases.

    abstract:OBJECTIVE:The aim of this study was to assess the effect of cancer-related genes and their mutations analyzed by next-generation sequencing (NGS) on the oncological outcome after resection of colorectal liver metastases (CRLM). BACKGROUND:Traditional prognostic scores include clinical and pathological parameters of pr...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003527

    authors: Lang H,Baumgart J,Heinrich S,Tripke V,Passalaqua M,Maderer A,Galle PR,Roth W,Kloth M,Moehler M

    更新日期:2019-11-01 00:00:00

  • Stat 6-dependent induction of myeloid derived suppressor cells after physical injury regulates nitric oxide response to endotoxin.

    abstract:OBJECTIVE:To delineate the role of T-helper 2 (Th2) cytokines in the induction of trauma induced myeloid suppressor cells (TIMSC) and the regulation of nitric oxide production. BACKGROUND:Trauma induces myeloid cells that express CD11b+/Gr1+ and arginase 1 and exhibit an immune suppressing activity. This article explo...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181bfda1c

    authors: Munera V,Popovic PJ,Bryk J,Pribis J,Caba D,Matta BM,Zenati M,Ochoa JB

    更新日期:2010-01-01 00:00:00

  • Laparoscopic skills suffer on the first shift of sequential night shifts: program directors beware and residents prepare.

    abstract:OBJECTIVE:Research evaluating fatigue-induced skills decline has focused on acute sleep deprivation rather than the effects of circadian desynchronization associated with multiple shifts. As a result, the number of consecutive night shifts that residents can safely be on duty without detrimental effects to their techni...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181661a99

    authors: Leff DR,Aggarwal R,Rana M,Nakhjavani B,Purkayastha S,Khullar V,Darzi AW

    更新日期:2008-03-01 00:00:00

  • A prospective pathologic analysis using whole-mount sections of rectal cancer following preoperative combined modality therapy: implications for sphincter preservation.

    abstract:OBJECTIVE:The aims of this study were to use a comprehensive whole-mount pathologic analysis to characterize microscopic patterns of residual disease, as well as circumferential and distal resection margins, in rectal cancer treated with preoperative CMT; and to identify clinicopathologic factors associated with residu...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000232540.82364.43

    authors: Guillem JG,Chessin DB,Shia J,Suriawinata A,Riedel E,Moore HG,Minsky BD,Wong WD

    更新日期:2007-01-01 00:00:00

  • The Safer Delivery of Surgical Services Program (S3): Explaining Its Differential Effectiveness and Exploring Implications for Improving Quality in Complex Systems.

    abstract:OBJECTIVE:To analyze the challenges encountered during surgical quality improvement interventions, and explain the relative success of different intervention strategies. SUMMARY BACKGROUND DATA:Understanding why and how interventions work is vital for developing improvement science. The S3 Program of studies tested wh...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001583

    authors: Flynn LC,McCulloch PG,Morgan LJ,Robertson ER,New SJ,Stedman FE,Martin GP

    更新日期:2016-12-01 00:00:00

  • Prevention of surgical malpractice claims by use of a surgical safety checklist.

    abstract:OBJECTIVE:To assess what proportion of surgical malpractice claims might be prevented by the use of a surgical safety checklist. BACKGROUND:Surgical disciplines are overrepresented in the distribution of adverse events. The recently described multidisciplinary SURgical PAtient Safety System (SURPASS) checklist covers ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3182068880

    authors: de Vries EN,Eikens-Jansen MP,Hamersma AM,Smorenburg SM,Gouma DJ,Boermeester MA

    更新日期:2011-03-01 00:00:00

  • Factors Predicting Response, Perioperative Outcomes, and Survival Following Total Neoadjuvant Therapy for Borderline/Locally Advanced Pancreatic Cancer.

    abstract:OBJECTIVE:To identify predictive factors associated with operative morbidity, mortality, and survival outcomes in patients with borderline resectable (BR) or locally advanced (LA) pancreatic ductal adenocarcinoma (PDAC) undergoing total neoadjuvant therapy (TNT). BACKGROUND:The optimal preoperative treatment sequencin...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003284

    authors: Truty MJ,Kendrick ML,Nagorney DM,Smoot RL,Cleary SP,Graham RP,Goenka AH,Hallemeier CL,Haddock MG,Harmsen WS,Mahipal A,McWilliams RR,Halfdanarson TR,Grothey AF

    更新日期:2021-02-01 00:00:00

  • Subtotal versus total gastrectomy for gastric cancer: five-year survival rates in a multicenter randomized Italian trial. Italian Gastrointestinal Tumor Study Group.

    abstract:OBJECTIVE:To evaluate the impact of subtotal (SG) versus total (TG) gastrectomy on the oncologic outcome of patients with cancer of the distal stomach from 28 Italian institutions. SUMMARY BACKGROUND DATA:There is controversy over whether SG and TG have a different impact on the 5-year survival probability of patients...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/00000658-199908000-00006

    authors: Bozzetti F,Marubini E,Bonfanti G,Miceli R,Piano C,Gennari L

    更新日期:1999-08-01 00:00:00

  • Colorectal carcinoma in patients under age 40.

    abstract::Patients under the age of 40 with colorectal cancer (29 females, 18 males) were compared with similar patients in our general hospital population and analyzed for patterns of presentation, stage at diagnosis, degree of tumor differentiation, and survival. There was a higher incidence of poorly differentiated tumors in...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198511000-00013

    authors: Behbehani A,Sakwa M,Ehrlichman R,Maguire P,Friedman S,Steele GD Jr,Wilson RE

    更新日期:1985-11-01 00:00:00