Liver transplantation for nonresectable liver metastases from colorectal cancer.

Abstract:

OBJECTIVE:The objective of this pilot study was to investigate the potential for long-term overall survival (OS) after liver transplantation for colorectal liver metastases (CLMs). BACKGROUND:Patients with nonresectable CLMs have poor prognosis, and few survive beyond 5 years. CLMs are currently considered an absolute contraindication for liver transplantation, although liver transplantation for primary and some secondary liver malignancies shows excellent outcome in selected patients. Before 1995, several liver transplantations for CLMs were performed, but outcome was poor (5-year survival rate: 18%) and liver transplantation for CLMs was abandoned. Since then, the survival rate after liver transplantation in general has improved by almost 30%. On the basis of this, a 5-year survival rate of about 50% after liver transplantation for CLMs could be anticipated. METHODS:In a prospective pilot study, liver transplantation for nonresectable CLMs was performed (n = 21). Main inclusion criteria were liver-only CLMs, excised primary tumors, and at least 6 weeks of chemotherapy. RESULTS:Kaplan-Meier estimates of the OS rate at 1, 3, and 5 years were 95%, 68%, and 60%, respectively. Metastatic recurrence of disease was common (mainly pulmonary). However, a significant proportion of the recurrences were accessible for surgery, and at follow-up (after median of 27 months; range, 8-60), 33% had no evidence of disease. Hepatic tumor load before liver transplantation, time from primary surgery to liver transplantation, and progressive disease on chemotherapy were identified as significant prognostic factors. CONCLUSIONS:OS exceeds by far reported outcome for chemotherapy, which is the only treatment option available for this patient group. Furthermore, OS is comparable with liver resection for resectable CLMs and survival after repeat liver transplantation for nonmalignant diseases. Selection strategies based on prognostic factors may further improve the outcome (ClinicalTrials.gov: NCT01311453).

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Hagness M,Foss A,Line PD,Scholz T,Jørgensen PF,Fosby B,Boberg KM,Mathisen O,Gladhaug IP,Egge TS,Solberg S,Hausken J,Dueland S

doi

10.1097/SLA.0b013e3182823957

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

800-6

issue

5

eissn

0003-4932

issn

1528-1140

journal_volume

257

pub_type

临床试验,杂志文章
  • Laparoscopic adrenalectomy: lessons learned from 100 consecutive procedures.

    abstract:UNLABELLED:One hundred consecutive laparoscopic adrenal procedures for a variety of endocrine disorders were reviewed. There was no mortality, morbidity was 12%, and conversions was 3%. During follow-up, none had recurrence of hormonal excess. Laparoscopic adrenalectomy is the procedure of choice for adrenal removal ex...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000658-199709000-00003

    authors: Gagner M,Pomp A,Heniford BT,Pharand D,Lacroix A

    更新日期:1997-09-01 00:00:00

  • Impact of neoadjuvant chemoradiation on lymph node status in esophageal cancer: post hoc analysis of a randomized controlled trial.

    abstract:OBJECTIVE:The study objectives were to analyze the impact of the number of lymph nodes (LNs) reported as resected (NLNr) and the number of LNs invaded (NLNi) on the prognosis of esophageal cancer (EC) after neoadjuvant chemoradiotherapy. BACKGROUND:Pathological LN status is a major disease prognostic factor and marker...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/SLA.0000000000000991

    authors: Robb WB,Dahan L,Mornex F,Maillard E,Thomas PA,Meunier B,Boige V,Pezet D,Le Brun-Ly V,Bosset JF,Mabrut JY,Triboulet JP,Bedenne L,Seitz JF,Mariette C,Fédération Française de Cancérologie Digestive, Société Française de Radiot

    更新日期:2015-05-01 00:00:00

  • Local and Visiting Physician Perspectives on Short Term Surgical Missions in Guatemala: A Qualitative Study.

    abstract:OBJECTIVE:To explore the impact of short-term surgical missions (STMs) on medical practice in Guatemala as perceived by Guatemalan and foreign physicians. SUMMARY BACKGROUND DATA:STMs send physicians from high-income countries to low and middle-income countries to address unmet surgical needs. Although participation a...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003292

    authors: Coughran AJ,Merrell SB,Pineda C,Sceats LA,Yang GP,Morris AM

    更新日期:2019-04-18 00:00:00

  • Subareolar versus peritumoral injection for location of the sentinel lymph node.

    abstract:BACKGROUND:Sentinel lymph node (SLN) biopsy is fast becoming the standard for testing lymph node involvement in many institutions. However, questions remain as to the best method of injection. The authors hypothesized that a subareolar injection of material would drain to the same lymph node as a peritumoral injection,...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000658-199906000-00013

    authors: Klimberg VS,Rubio IT,Henry R,Cowan C,Colvert M,Korourian S

    更新日期:1999-06-01 00:00:00

  • Incidence and Risk Factors of Postoperative Mortality and Morbidity After Elective Versus Emergent Abdominal Surgery in a National Sample of 8193 Patients With Cirrhosis.

    abstract:OBJECTIVE:To describe the incidence and risk factors for mortality and morbidity in patients with cirrhosis undergoing elective or emergent abdominal surgeries. BACKGROUND:Postoperative morbidity and mortality are higher in patients with cirrhosis; variation by surgical procedure type and cirrhosis severity remain unc...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003674

    authors: Johnson KM,Newman KL,Green PK,Berry K,Cornia PB,Wu P,Beste LA,Itani K,Harris AHS,Kamath PS,Ioannou GN

    更新日期:2019-10-23 00:00:00

  • Narcotic Free Cervical Endocrine Surgery: A Shift in Paradigm.

    abstract:BACKGROUND AND OBJECTIVE:The opioid epidemic has stimulated initiatives to reduce the number of unnecessary narcotic prescriptions. We adopted an opt-in prescription system for patients undergoing ambulatory cervical endocrine surgery (CES). We hypothesized that empowering patients to decide whether or not to receive n...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003443

    authors: Ruffolo LI,Jackson KM,Juviler P,Kaur R,Chennell T,Glover DM,Linehan DC,Moalem J

    更新日期:2019-07-06 00:00:00

  • Choledochal cyst in the adult.

    abstract:OBJECTIVE:The authors examined the natural history of choledochal cysts in adults treated surgically. BACKGROUND:An initial diagnosis of choledochal cyst is uncommon in adults. The recommended treatment is excision, rather than bypass, to achieve effective biliary drainage and because of the risk of cancer. METHODS:A...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199508000-00004

    authors: Stain SC,Guthrie CR,Yellin AE,Donovan AJ

    更新日期:1995-08-01 00:00:00

  • The 30-day versus in-hospital and 90-day mortality after esophagectomy as indicators for quality of care.

    abstract:OBJECTIVE:To describe causes of death in the first year after esophagectomy and determine the time frame that should be used for measurement of quality of surgery. A case-mix adjustment model was developed for the comparison between hospitals. BACKGROUND:The time period in which postoperative mortality should be measu...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000000482

    authors: Talsma AK,Lingsma HF,Steyerberg EW,Wijnhoven BP,Van Lanschot JJ

    更新日期:2014-08-01 00:00:00

  • Current Surgical Management of Pediatric Idiopathic Constipation: A Systematic Review of Published Studies.

    abstract:OBJECTIVE:Surgery for pediatric idiopathic constipation (IC) is undertaken after failure of bowel management programs. Decisions are influenced by rectal biopsy, transit studies, megacolon/megarectum, degree of soiling/incontinence, and anorectal manometry profile(s). A systematic review of ALL published studies critic...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/SLA.0000000000001191

    authors: Siminas S,Losty PD

    更新日期:2015-12-01 00:00:00

  • Low degree of formal education and musical experience predict degree of music-induced stress reduction in relatives and friends of patients: a single-center, randomized controlled trial.

    abstract:OBJECTIVE:To determine the factors that may predict music-induced relaxation in friends and family of patients in the emergency department. BACKGROUND:It remains unclear to date which demographic and experiential factors predict the effectiveness of music-induced relaxation. Furthermore, in-hospital stressors for frie...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0b013e31828ee1da

    authors: Tilt AC,Werner PD,Brown DF,Alam HB,Warshaw AL,Parry BA,Jazbar B,Booker A,Stangenberg L,Fricchione GL,Benson H,Lillemoe KD,Conrad C

    更新日期:2013-05-01 00:00:00

  • Complications of gastroesophageal reflux disease. Role of the lower esophageal sphincter, esophageal acid and acid/alkaline exposure, and duodenogastric reflux.

    abstract::The factors contributing to the development of esophageal mucosal injury in gastroesophageal reflux disease (GERD) are unclear. The lower esophageal sphincter, esophageal acid and acid/alkaline exposure, and the presence of excessive duodenogastric reflux (DGR) was evaluated in 205 consecutive patients with GERD and v...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199207000-00006

    authors: Stein HJ,Barlow AP,DeMeester TR,Hinder RA

    更新日期:1992-07-01 00:00:00

  • The American Association of Endocrine Surgeons Guidelines for the Definitive Surgical Management of Thyroid Disease in Adults.

    abstract:OBJECTIVE:To develop evidence-based recommendations for safe, effective, and appropriate thyroidectomy. BACKGROUND:Surgical management of thyroid disease has evolved considerably over several decades leading to variability in rendered care. Over 100,000 thyroid operations are performed annually in the US. METHODS:The...

    journal_title:Annals of surgery

    pub_type: 杂志文章,实务指引

    doi:10.1097/SLA.0000000000003580

    authors: Patel KN,Yip L,Lubitz CC,Grubbs EG,Miller BS,Shen W,Angelos P,Chen H,Doherty GM,Fahey TJ 3rd,Kebebew E,Livolsi VA,Perrier ND,Sipos JA,Sosa JA,Steward D,Tufano RP,McHenry CR,Carty SE

    更新日期:2020-03-01 00:00:00

  • Barium granuloma of the rectum: an uncommon complication of barium enema.

    abstract::Barium sulfate granuloma of the rectum may develop when this contrast material is forced through a discontinuity in the rectal mucosa. The ensuing mass may be confused with carcinoma. Preoperative biopsy and attention to plain films will prevent unnecessary inappropriate surgery. ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197504000-00009

    authors: Lewis JW Jr,Kerstein MD,Koss N

    更新日期:1975-04-01 00:00:00

  • Intratumoral Genetic Heterogeneity in Rectal Cancer: Are Single Biopsies representative of the entirety of the tumor?

    abstract:OBJECTIVE:Demonstrate intratumoral genetic heterogeneity in rectal cancer. BACKGROUND:Several clinical management decisions in rectal cancer may be influenced by pretreatment biopsy information. However, in the setting of significant intratumoral heterogeneity, biopsies may not be representative of the entirety of the...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001937

    authors: Bettoni F,Masotti C,Habr-Gama A,Correa BR,Gama-Rodrigues J,Vianna MR,Vailati BB,São Julião GP,Fernandez LM,Galante PA,Camargo AA,Perez RO

    更新日期:2017-01-01 00:00:00

  • Overcoming obstacles to resident-patient continuity of care.

    abstract:OBJECTIVE:Because continuity of care (CC) is a necessary component of resident education, this analysis was done to understand what keeps CC between residents and patients low and how it can be most effectively improved. BACKGROUND:Many authors lament low CC between residents and patients, especially in the era of dut...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3182468dcf

    authors: Turner JP,Rodriguez HE,Daskin MS,Mehrotra S,Speicher P,DaRosa DA

    更新日期:2012-04-01 00:00:00

  • Computerized nuclear morphometry: a new morphologic assessment for advanced gastric adenocarcinoma.

    abstract:OBJECTIVE:To evaluate the correlation between the morphologic nuclear features and clinicopathologic parameters in patients with advanced gastric cancer. SUMMARY BACKGROUND DATA:Nuclear profiles have been reported as useful prognostic predictors in various cancers. Data from computerized morphometries are objective an...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199901000-00007

    authors: Ikeguchi M,Oka S,Saito H,Kondo A,Tsujitani S,Maeta M,Kaibara N

    更新日期:1999-01-01 00:00:00

  • Neutrophils dysfunction during the course of intra-abdominal infection.

    abstract::Twenty-four patients with intra-peritoneal infections were studied sequentially to evaluate neutrophil chemotaxis, spontaneous migration, and chemiluminescence. In six patients, infection was due to spontaneous disease processes and 18 others, infection was a sequel of intra-abdominal operation. In the patients studie...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198107000-00003

    authors: Solomkin JS,Bauman MP,Nelson RD,Simmons RL

    更新日期:1981-07-01 00:00:00

  • The impact of perioperative risk, tumor pathology and surgical complications on disease recurrence following potentially curative resection of colorectal cancer.

    abstract:OBJECTIVE:The objective of the study was to identify determinants of disease recurrence after potentially curative resection of colorectal cancer. SUMMARY BACKGROUND DATA:The identification of patients at increased risk of disease recurrence is currently based on pathological factors. Recently, there has been consider...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31821fd469

    authors: Richards CH,Platt JJ,Anderson JH,McKee RF,Horgan PG,McMillan DC

    更新日期:2011-07-01 00:00:00

  • Comparison of surgical outcomes between teaching and nonteaching hospitals in the Department of Veterans Affairs.

    abstract:OBJECTIVE:To determine whether the investment in postgraduate education and training places patients at risk for worse outcomes and higher costs than if medical and surgical care was delivered in nonteaching settings. SUMMARY BACKGROUND DATA:The Veterans Health Administration (VA) plays a major role in the training of...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200109000-00011

    authors: Khuri SF,Najjar SF,Daley J,Krasnicka B,Hossain M,Henderson WG,Aust JB,Bass B,Bishop MJ,Demakis J,DePalma R,Fabri PJ,Fink A,Gibbs J,Grover F,Hammermeister K,McDonald G,Neumayer L,Roswell RH,Spencer J,Turnage RH,V

    更新日期:2001-09-01 00:00:00

  • Effect of ethanol on pancreatic interstitial pH and blood flow in cats with chronic pancreatitis.

    abstract:OBJECTIVE:The objective of this study was to investigate the effects of ethanol on pancreatic blood flow and interstitial pH in chronic pancreatitis. BACKGROUND:Ethanol is known to contribute to the development of both acute and chronic pancreatitis. However, it is unclear how ethanol precipitates episodes of acute pa...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199702000-00011

    authors: Toyama MT,Patel AG,Nguyen T,Ashley SW,Reber HA

    更新日期:1997-02-01 00:00:00

  • Aneurysm of the aorta treated by wiring: case report of a 38-year survival.

    abstract::A patient with a syphilitic aneurysm of the aorta treated by the insertion of wire is presented. The patient remained well for almost 40 years, but finally succumbed after rupture. The autopsy findings are discussed. To our knowledge, this represents the longest reported survival after treatment of an aortic aneurysm ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197612000-00014

    authors: Altman P,Voorhees AB Jr

    更新日期:1976-12-01 00:00:00

  • Lessons learned from more than 1,000 pancreas transplants at a single institution.

    abstract:OBJECTIVE:To determine outcome in diabetic pancreas transplant recipients according to risk factors and the surgical techniques and immunosuppressive protocols that evolved during a 33-year period at a single institution. SUMMARY BACKGROUND DATA:Insulin-dependent diabetes mellitus is associated with a high incidence o...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/00000658-200104000-00003

    authors: Sutherland DE,Gruessner RW,Dunn DL,Matas AJ,Humar A,Kandaswamy R,Mauer SM,Kennedy WR,Goetz FC,Robertson RP,Gruessner AC,Najarian JS

    更新日期:2001-04-01 00:00:00

  • Changing paradigm in the management of hepatocellular carcinoma improves the survival benefit of early detection by screening.

    abstract:OBJECTIVE:To evaluate the impact of improved surgical management of hepatocellular carcinoma (HCC) on the survival of patients with screened HCC. SUMMARY BACKGROUND DATA:It is unclear whether the advent of new treatment modalities such as liver transplantation and radiofrequency ablation (RFA) in recent years have imp...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31816a747a

    authors: Chan AC,Poon RT,Ng KK,Lo CM,Fan ST,Wong J

    更新日期:2008-04-01 00:00:00

  • A prospective study of thymectomy and serum acetylcholine receptor antibodies in myasthenia gravis.

    abstract::Forty-seven consecutively presenting myasthenia gravis (MG) patients with generalized weakness were treated according to a standardized prospective protocol. All patients underwent a sternal splitting "total" thymectomy. Medical status before surgery was optimized by plasmapheresis without immunosuppression. Medicatio...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198208000-00001

    authors: Olanow CW,Wechsler AS,Roses AD

    更新日期:1982-08-01 00:00:00

  • Usefulness of selective arterial secretin injection test for localization of gastrinoma in the Zollinger-Ellison syndrome.

    abstract::Secretin was injected into a feeding or nonfeeding artery of a gastrinoma and blood samples were taken from the hepatic vein (HV) or a peripheral artery (PA) to measure the changes of serum immunoreactive gastrin concentration (IRG). The IRG in the HV rose within 40 seconds and in the PA rose within 60 seconds after t...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198703000-00003

    authors: Imamura M,Takahashi K,Adachi H,Minematsu S,Shimada Y,Naito M,Suzuki T,Tobe T,Azuma T

    更新日期:1987-03-01 00:00:00

  • Is Physician Work in Procedure and Test Codes More Highly Valued Than That in Evaluation and Management Codes?

    abstract:OBJECTIVES:To determine whether the Centers for Medicare & Medicaid Services (CMS) Physician Fee Schedule confers higher value for physician work in procedure and test codes than in Evaluation and Management (E/M) codes. BACKGROUND:Medicare Payment Advisory Commission previously demonstrated that time for medical serv...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000000990

    authors: Kerber KA,Raphaelson M,Barkley GL,Burke JF

    更新日期:2015-08-01 00:00:00

  • Do safety checklists improve teamwork and communication in the operating room? A systematic review.

    abstract:OBJECTIVES:The aim of this systematic review was to assess the impact of surgical safety checklists on the quality of teamwork and communication in the operating room (OR). BACKGROUND:Safety checklists have been shown to impact positively on patient morbidity and mortality following surgery, but it is unclear whether ...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/SLA.0000000000000206

    authors: Russ S,Rout S,Sevdalis N,Moorthy K,Darzi A,Vincent C

    更新日期:2013-12-01 00:00:00

  • Microbial colonization of tumors in relation to the upper gastrointestinal tract in patients with gastric carcinoma.

    abstract::The microbial colonization of the oropharynx, the esophagus, the stomach, and the duodenum was studied in relation to the microbial flora found on tumor and gastric mucosal biopsies in 23 patients with gastric carcinoma. The tumor was colonized in all patients, and the stomach, the esophagus, the duodenum, and the gas...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198803000-00020

    authors: Sjöstedt S,Kager L,Heimdahl A,Nord CE

    更新日期:1988-03-01 00:00:00

  • The ILAILL study: iloprost as adjuvant to surgery for acute ischemia of lower limbs: a randomized, placebo-controlled, double-blind study by the italian society for vascular and endovascular surgery.

    abstract:SUMMARY BACKGROUND DATA:High rate of complications has been reported following revascularization for acute limb ischemia (ALI). No adjuvant pharmacologic treatment, apart from anticoagulation and standard perioperative care, has been shown clinically effective. OBJECTIVE:Aim of this study was to evaluate the effects o...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/01.sla.0000217555.49001.ca

    authors: de Donato G,Gussoni G,de Donato G,Andreozzi GM,Bonizzoni E,Mazzone A,Odero A,Paroni G,Setacci C,Settembrini P,Veglia F,Martini R,Setacci F,Palombo D

    更新日期:2006-08-01 00:00:00

  • Long-term results of brachial thrombectomy following cardiac catheterization.

    abstract::The late results of brachial thrombectomy following cardiac catheterization were evaluated in 20 patients. All patients had a radial pulse present and no symptoms or signs of ischemia of the hand at the time of discharge from the hospital. Late evaluation of these 20 patients revealed 8 in whom the long-term results w...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197604000-00019

    authors: Nicholas GG,DeMuth WE Jr

    更新日期:1976-04-01 00:00:00