Usefulness of selective arterial secretin injection test for localization of gastrinoma in the Zollinger-Ellison syndrome.

Abstract:

:Secretin was injected into a feeding or nonfeeding artery of a gastrinoma and blood samples were taken from the hepatic vein (HV) or a peripheral artery (PA) to measure the changes of serum immunoreactive gastrin concentration (IRG). The IRG in the HV rose within 40 seconds and in the PA rose within 60 seconds after the injection of secretin into a feeding artery, but not after secretin was injected into a nonfeeder. These results indicated that secretin directly stimulates a gastrinoma to release gastrin in vivo. The selective arterial secretin injection test (SASI test) was applied in three patients in whom gastrinomas could not be located by computed tomography, ultrasonography, or arteriography, and functioning gastrinomas were located in all three patients. In one patient, malignant gastrinomas in the head of the pancreas and in the duodenum could be resected radically with the help of this test.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Imamura M,Takahashi K,Adachi H,Minematsu S,Shimada Y,Naito M,Suzuki T,Tobe T,Azuma T

doi

10.1097/00000658-198703000-00003

subject

Has Abstract

pub_date

1987-03-01 00:00:00

pages

230-9

issue

3

eissn

0003-4932

issn

1528-1140

journal_volume

205

pub_type

杂志文章
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    pub_type: 临床试验,杂志文章,随机对照试验

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