The prevalence and prognostic value of BRAF mutation in thyroid cancer.

Abstract:

OBJECTIVE:To examine the prevalence of BRAF mutation among thyroid cancer histologic subtypes and determine the association of BRAF mutation with indicators of poor prognosis for papillary thyroid cancer and patient outcome. SUMMARY BACKGROUND DATA:The appropriate extent of surgical treatment, adjuvant therapy and follow-up monitoring for thyroid cancer remains controversial. Advances in the molecular biology of thyroid cancer have helped to identify candidate markers of disease aggressiveness. A commonly found genetic alternation is a point mutation in the BRAF oncogene (BRAF V600E), which is primarily found in papillary thyroid cancer and is associated with more aggressive disease. METHODS:BRAF V600E mutation status was determined in 347 tumor samples from 314 patients with thyroid cancer (245 with conventional papillary thyroid cancer, 73 with follicular thyroid cancer, and 29 with the follicular variant of papillary thyroid cancer). Univariate and multivariate analyses were performed to determine the association of BRAF V600E with clinicopathologic factors and patient outcome. RESULTS:: The prevalence of BRAF V600E mutation was higher in conventional papillary thyroid cancer (51.0%) than in follicular variant of papillary thyroid cancer (24.1%) and follicular thyroid cancer (1.4%) (P < 0.0001). In patients with conventional papillary thyroid cancer, BRAF V600E mutation was associated with older age (P = 0.0381), lymph node metastasis (P = 0.0323), distant metastasis (P = 0.045), higher TNM stage (I and II vs. III and IV, P = 0.0389), and recurrent and persistent disease (P = 0.009) with a median follow-up time of 6.0 years. Multivariate analysis showed that BRAF V600E mutation [OR (95% CI) = 4.2 (1.2-14.6)] and lymph node metastasis [OR (95% CI) = 7.75 (2.1-28.5)] were independently associated with recurrent and persistent disease in patients with conventional papillary thyroid cancer. CONCLUSIONS:BRAF V600E mutation is primarily present in conventional papillary thyroid cancer. It is associated with an aggressive tumor phenotype and higher risk of recurrent and persistent disease in patients with conventional papillary thyroid cancer. Testing for this mutation may be useful for selecting initial therapy and for follow-up monitoring.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Kebebew E,Weng J,Bauer J,Ranvier G,Clark OH,Duh QY,Shibru D,Bastian B,Griffin A

doi

10.1097/SLA.0b013e318148563d

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

466-70; discussion 470-1

issue

3

eissn

0003-4932

issn

1528-1140

pii

00000658-200709000-00013

journal_volume

246

pub_type

杂志文章
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    abstract:OBJECTIVE:Marked variations in sentinel lymph node dissection (SLND) technique have been identified, and definitive qualifications for SLND performance remain controversial. Based on previous reports and expert opinion, we predicted that 20 to 30 cases of SLND with axillary lymph node dissection (ALND) would enable sur...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1097/01.sla.0000184210.68646.77

    authors: Posther KE,McCall LM,Blumencranz PW,Burak WE Jr,Beitsch PD,Hansen NM,Morrow M,Wilke LG,Herndon JE 2nd,Hunt KK,Giuliano AE

    更新日期:2005-10-01 00:00:00

  • Multivisceral transplantation for diffuse portomesenteric thrombosis.

    abstract:OBJECTIVE:To evaluate the clinical outcomes of multivisceral transplantation (MVT) in the setting of diffuse thrombosis of the portomesenteric venous system. BACKGROUND:Liver transplantation (LT) in the face of cirrhosis and diffuse portomesenteric thrombosis (PMT) is controversial and contraindicated in many transpla...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31825429c0

    authors: Vianna RM,Mangus RS,Kubal C,Fridell JA,Beduschi T,Tector AJ

    更新日期:2012-06-01 00:00:00

  • Response of protein and urea kinetics in burn patients to different levels of protein intake.

    abstract::The effects of two levels of protein intake on protein metabolism in six severely burned adult patients were studied (means of 70% BSA burned). A crossover experimental design enabled the authors to study each patient at the end of two three-day dietary regimens. All diets were isocaloric and provided approximately 25...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198302000-00007

    authors: Wolfe RR,Goodenough RD,Burke JF,Wolfe MH

    更新日期:1983-02-01 00:00:00

  • Management of nonpalpable breast abnormalities.

    abstract::From January 1982 to June 1986, 444 patients had localization of 500 nonpalpable mammographically suspicious lesions using the Kopans hook wire technique. Four hundred ninety-nine biopsies were performed in 443 patients. Cancer was identified in 12% of the biopsies performed for a suspicious mass or density and in 20%...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198705000-00010

    authors: Symmonds RE Jr,Roberts JW

    更新日期:1987-05-01 00:00:00

  • Esophagogastrectomy for adenocarcinoma of the cardia. Ten years' experience and current approach.

    abstract::During a 10-year period, 94 surgical resections for adenocarcinoma of the cardia (75 "curative" and 19 palliative) were performed using three primary approaches: Group I (46 curative, 14 palliative), esophagogastrectomy performed through a left thoracotomy or left thoraco-abdominal incision; Group II (17 curative, 4 p...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198202000-00004

    authors: Molina JE,Lawton BR,Myers WO,Humphrey EW

    更新日期:1982-02-01 00:00:00

  • Biliary atresia-polysplenia syndrome: surgical and clinical relevance in liver transplantation.

    abstract:OBJECTIVE:To review a single center's 10-year experience with liver transplantation (LTx) for the biliary atresia-polysplenia syndrome (BA-PS) and to define surgical and clinical guidelines for its management. SUMMARY BACKGROUND DATA:BA is the most common indication for pediatric liver transplantation (LTx) and is ass...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199804000-00022

    authors: Varela-Fascinetto G,Castaldo P,Fox IJ,Sudan D,Heffron TG,Shaw BW,Langnas AN

    更新日期:1998-04-01 00:00:00

  • Prospective Creation and Validation of the PREVENTT (Prediction and Enaction of Prevention Treatments Trigger) Scale for Surgical Site Infections (SSIs) in Patients With Diverticulitis.

    abstract:OBJECTIVE:Create and validate diverticulitis surgical site infection prediction scale. BACKGROUND:Surgical site infections cause significant morbidity after colorectal surgery. An infection prediction scale could target infection prevention bundles to high-risk patients. METHODS:Prospectively collected National Surgi...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002859

    authors: Bordeianou L,Cauley CE,Patel R,Bleday R,Mahmood S,Kennedy K,Ahmed KF,Yokoe D,Hooper D,Rubin M,Partners Colorectal Collaborative.

    更新日期:2019-12-01 00:00:00

  • Minimally invasive cardiac valve surgery improves patient satisfaction while reducing costs of cardiac valve replacement and repair.

    abstract:OBJECTIVE:This study compares the quality of valve replacement and repair performed through minimally invasive incisions as compared to the standard operation for aortic and mitral valve replacement. SUMMARY BACKGROUND DATA:With the advent of minimally invasive laparoscopic approaches to orthopedic surgery, urology, g...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199710000-00003

    authors: Cohn LH,Adams DH,Couper GS,Bichell DP,Rosborough DM,Sears SP,Aranki SF

    更新日期:1997-10-01 00:00:00

  • 250 robotic pancreatic resections: safety and feasibility.

    abstract:BACKGROUND AND OBJECTIVES:Computer-assisted robotic surgery allows complex resections and anastomotic reconstructions to be performed with nearly identical standards to open surgery. We applied this technology to a variety of pancreatic resections to assess the safety, feasibility, versatility, and reliability of this ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3182a4e87c

    authors: Zureikat AH,Moser AJ,Boone BA,Bartlett DL,Zenati M,Zeh HJ 3rd

    更新日期:2013-10-01 00:00:00

  • Metabolic changes in patients severely affected by tetanus.

    abstract::Metabolic changes in six severely affected tetanus patients suffering from characteristic labile hypertension (maximum systolic blood pressure greater than 200 mmHG, maximum diurnal change in systolic pressure greater than 100 mmHg) were investigated. Daily urinary excretion of urea nitrogen increased gradually from t...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199101000-00011

    authors: Hiraide A,Katayama M,Sugimoto H,Yoshioka T,Sugimoto T

    更新日期:1991-01-01 00:00:00

  • An Implementation Assessment of the Virtual Acute Care for Elders Program From the Perspective of Key Stakeholders.

    abstract:OBJECTIVE:The aim of this study was to obtain feedback from key stakeholders and end users to identify program strengths and weaknesses to plan for wider dissemination and implementation of the Virtual Acute Care for Elders (Virtual ACE) program, a novel intervention that improves outcomes for older surgical patients. ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004433

    authors: Balentine CJ,Morris M,Knight SJ,Turan JM,Flood KL,Gutierrez-Meza D,Macdonald CL,Bhatia S,Brown CJ

    更新日期:2020-11-16 00:00:00

  • Host defense against opportunist microorganisms following trauma. II. Changes in complement and immunoglobulins in patients with abdominal trauma and in septic patients without trauma.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197807000-00017

    authors: Bjornson AB,Altemeier WA,Bjornson HS

    更新日期:1978-07-01 00:00:00

  • Prospective study of eukaryotic initiation factor 4E protein elevation and breast cancer outcome.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200205000-00016

    authors: Li BD,Gruner JS,Abreo F,Johnson LW,Yu H,Nawas S,McDonald JC,DeBenedetti A

    更新日期:2002-05-01 00:00:00

  • Lymph node ratio as a quality and prognostic indicator in stage III colon cancer.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181ffa780

    authors: Chen SL,Steele SR,Eberhardt J,Zhu K,Bilchik A,Stojadinovic A

    更新日期:2011-01-01 00:00:00

  • Bacillus anthracis as an agent of bioterrorism: a review emphasizing surgical treatment.

    abstract:OBJECTIVE:To familiarize surgeons with the specific complications of cutaneous, gastrointestinal, inhalation, and systemic infection with Bacillus Anthracis, which may require surgical treatment. SUMMARY BACKGROUND DATA:The recent cases of intentional exposure to Bacillus Anthracis in the United States make familiarit...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/00000658-200207000-00004

    authors: Binkley CE,Cinti S,Simeone DM,Colletti LM

    更新日期:2002-07-01 00:00:00

  • Gene expression signature of the gross morphology in hepatocellular carcinoma.

    abstract:OBJECTIVE:To evaluate the gene expression signature of hepatocellular carcinoma (HCC) in relation to the gross morphology. BACKGROUND:Eggel's nodular type of HCC is morphologically subclassified into the single nodular (SN) type, the single nodular type with extranodular growth (SNEG), and the confluent multinodular (...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181f9bc00

    authors: Murakata A,Tanaka S,Mogushi K,Yasen M,Noguchi N,Irie T,Kudo A,Nakamura N,Tanaka H,Arii S

    更新日期:2011-01-01 00:00:00

  • "Contemplating the Next Maneuver": Functional Neuroimaging Reveals Intraoperative Decision-making Strategies.

    abstract:OBJECTIVE:To investigate differences in the quality, confidence, and consistency of intraoperative surgical decision making (DM) and using functional neuroimaging expose decision systems that operators use. SUMMARY BACKGROUND DATA:Novices are hypothesized to use conscious analysis (effortful DM) leading to activation ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001651

    authors: Leff DR,Yongue G,Vlaev I,Orihuela-Espina F,James D,Taylor MJ,Athanasiou T,Dolan R,Yang GZ,Darzi A

    更新日期:2017-02-01 00:00:00

  • Use of fibrin sealant for prosthetic mesh fixation in laparoscopic extraperitoneal inguinal hernia repair.

    abstract:OBJECTIVE:To evaluate the efficacy of mesh fixation with fibrin sealant (FS) in laparoscopic preperitoneal inguinal hernia repair and to compare it with stapled fixation. SUMMARY BACKGROUND DATA:Laparoscopic hernia repair involves the fixation of the prosthetic mesh in the preperitoneal space with staples to avoid dis...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200101000-00004

    authors: Katkhouda N,Mavor E,Friedlander MH,Mason RJ,Kiyabu M,Grant SW,Achanta K,Kirkman EL,Narayanan K,Essani R

    更新日期:2001-01-01 00:00:00

  • Gastric carcinoma following operation for peptic ulcer disease.

    abstract::Gastric carcinoma following operation for benign peptic ulcer disease has been considered rare but nine patients have been seen during the past five years. All were male patients, the average time interval from prior ulcer operation to development of cancer was 17 years, but was a short as ten years. The symptoms of c...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197803000-00007

    authors: Eberlein TJ,Lorenzo FV,Webster MW

    更新日期:1978-03-01 00:00:00

  • Indications for different modes of surgical therapy in medically refractory ventricular arrhythmias.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198606000-00013

    authors: Hammon JW Jr,Echt DS,Merrill WH,Primm KR,Woosley RL,Smith RF,Roden DM,Bender HW Jr

    更新日期:1986-06-01 00:00:00

  • Quantification of asymmetric lung pathophysiology as a guide to the use of simultaneous independent lung ventilation in posttraumatic and septic adult respiratory distress syndrome.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198510000-00004

    authors: Siegel JH,Stoklosa JC,Borg U,Wiles CE 3rd,Sganga G,Geisler FH,Belzberg H,Wedel S,Blevins S,Goh KC

    更新日期:1985-10-01 00:00:00

  • Logistics and technique for procurement of intestinal, pancreatic, and hepatic grafts from the same donor.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200011000-00010

    authors: Abu-Elmagd K,Fung J,Bueno J,Martin D,Madariaga JR,Mazariegos G,Bond G,Molmenti E,Corry RJ,Starzl TE,Reyes J

    更新日期:2000-11-01 00:00:00

  • Intra-aortic balloon counterpulsation: potential for therapy in hemorrhagic shock with associated myocardial failure.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197501000-00025

    authors: Proctor HJ,Hsiao H,Fry J,Ebert C

    更新日期:1975-01-01 00:00:00

  • Effect of Esophageal Cancer Surgeon Volume on Management and Mortality From Emergency Upper Gastrointestinal Conditions: Population-based Cohort Study.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002387

    authors: Markar SR,Mackenzie H,Askari A,Faiz O,Hanna GB

    更新日期:2017-11-01 00:00:00

  • Adjuvant radiotherapy is associated with increased sexual dysfunction in male patients undergoing resection for rectal cancer: a predictive model.

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    pub_type: 杂志文章

    doi:10.1097/01.sla.0000183608.24549.68

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    更新日期:2005-10-01 00:00:00

  • Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation.

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    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001664

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    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e318211cc0f

    authors: Bilimoria KY,Ko CY,Tomlinson JS,Stewart AK,Talamonti MS,Hynes DL,Winchester DP,Bentrem DJ

    更新日期:2011-04-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198510000-00010

    authors: Martin DJ,Lucas CE,Ledgerwood AM,Hoschner J,McGonigal MD,Grabow D

    更新日期:1985-10-01 00:00:00

  • The influence of injury severity on complication rates after primary closure or colostomy for penetrating colon trauma.

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    pub_type: 杂志文章

    doi:10.1097/00000658-198904000-00009

    authors: Nelken N,Lewis F

    更新日期:1989-04-01 00:00:00

  • Management and In-hospital Mortality of 2235 Patients With a Traumatic Intimal Tear of the Thoracic Aorta.

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    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004415

    authors: Jacob-Brassard J,Al-Omran M,Nathens AB,Forbes TL,de Mestral C

    更新日期:2020-09-01 00:00:00