Gene expression signature of the gross morphology in hepatocellular carcinoma.

Abstract:

OBJECTIVE:To evaluate the gene expression signature of hepatocellular carcinoma (HCC) in relation to the gross morphology. BACKGROUND:Eggel's nodular type of HCC is morphologically subclassified into the single nodular (SN) type, the single nodular type with extranodular growth (SNEG), and the confluent multinodular (CM) type, but their biomolecular differences remain unclear. METHODS:The clinicopathological characteristics and genome-wide gene expressions were analyzed in 275 patients with nodular-type HCC (124 SN-type, 91 SNEG-type, and 60 CM-type) who received curative hepatectomy. RESULTS:Significantly poor prognosis was recognized in CM types in overall survival (P = 0.0020) and recurrence-free survival (P = 0.0066). Analysis of the genome-wide expression patterns revealed significant difference of CM-type HCC from either SN- or SNEG-type HCC. In particular, a stem cell marker EpCAM was dominantly expressed in CM-type HCC. Immunohistochemical studies confirmed the specific expression of EpCAM in HCC cancer cells of CM type. In multivariate analysis, the gross morphology of CM type was significantly associated with EpCAM expression (P = 0.0092), α-fetoprotein (P = 0.0424), "lens culinaris agglutinin-reactive fraction of α-fetoprotein" level (P = 0.0288), and the portal vein invasion (P = 0.0150). Furthermore, EpCAM was predictive for poor prognosis in overall and recurrence-free survivals of patients with CM-type HCC (P = 0.0082 and P = 0.0043, respectively). CONCLUSION:Our studies suggest that the distinct signature of gene expression is closely related to morphological progression in HCC. Especially, EpCAM might play a critical role in the aggressiveness of CM-type HCC.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Murakata A,Tanaka S,Mogushi K,Yasen M,Noguchi N,Irie T,Kudo A,Nakamura N,Tanaka H,Arii S

doi

10.1097/SLA.0b013e3181f9bc00

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

94-100

issue

1

eissn

0003-4932

issn

1528-1140

pii

00000658-201101000-00016

journal_volume

253

pub_type

杂志文章
  • Laparoscopic Lavage Versus Primary Resection for Acute Perforated Diverticulitis: Review and Meta-analysis.

    abstract:OBJECTIVE:To compare clinical outcomes after laparoscopic lavage (LL) or colonic resection (CR) for purulent diverticulitis. BACKGROUND:Laparoscopic lavage has been suggested as an alternative treatment for traditional CR. Comparative studies to date have shown conflicting results. METHODS:Electronic searches of Emba...

    journal_title:Annals of surgery

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/SLA.0000000000002236

    authors: Penna M,Markar SR,Mackenzie H,Hompes R,Cunningham C

    更新日期:2018-02-01 00:00:00

  • Colon cancer cells that are not growth inhibited by TGF-beta lack functional type I and type II TGF-beta receptors.

    abstract:OBJECTIVE:The authors determined the molecular mechanisms for the failure of transforming growth factor-beta (TGF-beta) to inhibit the growth of SW1116 and SW48 colon cancer cell lines. BACKGROUND:Transforming growth factor-beta is a bifunctional regulator of cell growth that typically stimulates proliferation of mese...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199506000-00015

    authors: MacKay SL,Yaswen LR,Tarnuzzer RW,Moldawer LL,Bland KI,Copeland EM 3rd,Schultz GS

    更新日期:1995-06-01 00:00:00

  • Defining the "Tipping Point" to Success as a Surgeon-Scientist: An Analysis of Applicants and Awardees of the American College of Surgeons Jacobson Promising Investigator Award.

    abstract:BACKGROUND:Since 2005, the American College of Surgeons has administered the Jacobson Promising Investigator Award (JPIA), which recognizes surgeon-scientists at the "tipping point" of their research careers. OBJECTIVE:We retrospectively reviewed JPIA applicants to identify factors associated with selection for the aw...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004142

    authors: Emamaullee J,Lian T,Moroz S,Zuckerbraun B,Matthews J,Gosain A

    更新日期:2020-07-07 00:00:00

  • Remission of type 2 diabetes after Roux-en-Y gastric bypass or sleeve gastrectomy is associated with a distinct glycemic profile.

    abstract:BACKGROUND:Roux-en-Y gastric bypass (RYGBP) and sleeve gastrectomy (SG) have been associated with a high remission rate of type 2 diabetes mellitus (T2DM). However, whether such remission is associated with full restoration of postprandial glucose profile and/or the potentially nonrestored glycemic profile is associate...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000000586

    authors: Jiménez A,Ceriello A,Casamitjana R,Flores L,Viaplana-Masclans J,Vidal J

    更新日期:2015-02-01 00:00:00

  • Pathologic Response to Pretransplant Locoregional Therapy is Predictive of Patient Outcome After Liver Transplantation for Hepatocellular Carcinoma: Analysis From the US Multicenter HCC Transplant Consortium.

    abstract:OBJECTIVE:The aim of the study was to determine the rate, predictors, and impact of complete pathologic response (cPR) to pretransplant locoregional therapy (LRT) in a large, multicenter cohort of hepatocellular carcinoma (HCC) patients undergoing liver transplantation (LT). BACKGROUND:LRT is used to mitigate waitlist...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000003253

    authors: DiNorcia J,Florman SS,Haydel B,Tabrizian P,Ruiz RM,Klintmalm GB,Senguttuvan S,Lee DD,Taner CB,Verna EC,Halazun KJ,Hoteit M,Levine MH,Chapman WC,Vachharajani N,Aucejo F,Nguyen MH,Melcher ML,Tevar AD,Humar A,Mobley

    更新日期:2020-04-01 00:00:00

  • Transfusion Requirement in Burn Care Evaluation (TRIBE): A Multicenter Randomized Prospective Trial of Blood Transfusion in Major Burn Injury.

    abstract:OBJECTIVE:Our objective was to compare outcomes of a restrictive to a liberal red cell transfusion strategy in 20% or more total body surface area (TBSA) burn patients. We hypothesized that the restrictive group would have less blood stream infection (BSI), organ dysfunction, and mortality. BACKGROUND:Patients with ma...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/SLA.0000000000002408

    authors: Palmieri TL,Holmes JH 4th,Arnoldo B,Peck M,Potenza B,Cochran A,King BT,Dominic W,Cartotto R,Bhavsar D,Kemalyan N,Tredget E,Stapelberg F,Mozingo D,Friedman B,Greenhalgh DG,Taylor SL,Pollock BH

    更新日期:2017-10-01 00:00:00

  • Chronic idiopathic intestinal pseudo-obstruction. A surgical approach.

    abstract::Chronic idiopathic intestinal pseudo-obstruction is an increasingly recognized syndrome in which patients usually present with an acute or chronic history suggestive of intestinal obstruction, although no obstructing lesion is found at surgery. The diagnosis can be suspected in most cases from the clinical presentatio...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198012000-00011

    authors: Schuffler MD,Deitch EA

    更新日期:1980-12-01 00:00:00

  • Variation in Bariatric Surgery Episode Costs in the Commercially Insured: Implications for Bundled Payments in the Private Sector.

    abstract:OBJECTIVE:To describe hospital-level variation in roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) in Michigan. BACKGROUND:Bariatric surgery is an increasingly prevalent elective surgical procedure that will likely be considered for future bundled payment programs, both public and private. Past research in ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002462

    authors: Kelsall AC,Cassidy R,Ghaferi AA

    更新日期:2018-12-01 00:00:00

  • Effect of moderate hypothermia in the treatment of canine hemorrhagic shock.

    abstract::This study evaluated a possible protective and therapeutic effect of moderate hypothermia in the treatment of severe hemorrhagic shock. A modified Wiggers shock preparation was used. Normothermic dogs (Group I, N = 6) were maintained at normal body temperature throughout hemorrhagic shock and resuscitation. In Group I...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198804000-00015

    authors: Meyer DM,Horton JW

    更新日期:1988-04-01 00:00:00

  • Advanced leg salvage of the critically ischemic leg with major tissue loss by vascular and plastic surgeon teamwork: Long-term outcome.

    abstract:OBJECTIVE:To assess long-term outcome and prognostic factors for extreme surgery by vascular and plastic surgical teamwork for leg salvage in patients with critically ischemic large tissue defects. SUMMARY BACKGROUND DATA:Combined vascular reconstruction and microvascular free-flap transfer has been used to improve di...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000247985.45541.e8

    authors: Tukiainen E,Kallio M,Lepäntalo M

    更新日期:2006-12-01 00:00:00

  • Long-term results of brachial thrombectomy following cardiac catheterization.

    abstract::The late results of brachial thrombectomy following cardiac catheterization were evaluated in 20 patients. All patients had a radial pulse present and no symptoms or signs of ischemia of the hand at the time of discharge from the hospital. Late evaluation of these 20 patients revealed 8 in whom the long-term results w...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197604000-00019

    authors: Nicholas GG,DeMuth WE Jr

    更新日期:1976-04-01 00:00:00

  • Transcutaneous quantitation of arterial flow with ultrasound.

    abstract::Arterial blood flow was measured in dogs simultaneously with electromagnetic flow probes and with ultrasonic "flow probes." The ultrasonic probes were used to determine transcutaneously the mean velocity of arterial flow and the cross-sectional area of the blood vessel. A 10 MHz probe was used for blood vessels 1 cm d...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198204000-00013

    authors: Kasulke RJ,Lichti EA,Kapsch DN,Silver D

    更新日期:1982-04-01 00:00:00

  • Intestinal radioprotection by vitamin E (alpha-tocopherol).

    abstract:OBJECTIVES:The major objective of this study was to test vitamin E as a potential radioprotectant for the small bowel of the rat. SUMMARY BACKGROUND DATA:Vitamin E has previously been shown to provide radioprotection in animal models: increased survival after whole-body irradiation, diminished absorptive malfunction, ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199522240-00008

    authors: Felemovicius I,Bonsack ME,Baptista ML,Delaney JP

    更新日期:1995-10-01 00:00:00

  • Significance of Examined Lymph Node Number in Accurate Staging and Long-term Survival in Resected Stage I-II Pancreatic Cancer-More is Better? A Large International Population-based Cohort Study.

    abstract:OBJECTIVE:This large international cohort study aimed to investigate the associations of examined lymph node (ELN) number with accurate staging and long-term survival in pancreatic adenocarcinoma (PaC) and to robustly determine the minimal and optimal ELN thresholds. SUMMARY BACKGROUND DATA:ELN number is an important ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003558

    authors: Huang L,Jansen L,Balavarca Y,van der Geest L,Lemmens V,Groot Koerkamp B,van Santvoort HC,Grützmann R,Besselink MG,Schrotz-King P,Brenner H

    更新日期:2019-08-13 00:00:00

  • Bariatric Surgery and the Risk of Cancer in a Large Multisite Cohort.

    abstract:OBJECTIVE:To determine whether bariatric surgery is associated with a lower risk of cancer. BACKGROUND:Obesity is strongly associated with many types of cancer. Few studies have examined the relationship between bariatric surgery and cancer risk. METHODS:We conducted a retrospective cohort study of patients undergoin...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000002525

    authors: Schauer DP,Feigelson HS,Koebnick C,Caan B,Weinmann S,Leonard AC,Powers JD,Yenumula PR,Arterburn DE

    更新日期:2019-01-01 00:00:00

  • Gastrointestinal adaptation following small bowel bypass for obesity.

    abstract::Small intestinal morphologic and biochemical changes were studied following jejuno-ileal bypass for obesity after body weight stabilization had occurred. Four patients underwent biopsy of in-continuity and bypassed jejunal and ileal segments of the small intestine 11 to 22 months after the bypass operation. Microscopi...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197706000-00005

    authors: Dudrick SJ,Daly JM,Castro G,Akhtar M

    更新日期:1977-06-01 00:00:00

  • Minimal access retroperitoneal pancreatic necrosectomy: improvement in morbidity and mortality with a less invasive approach.

    abstract:OBJECTIVE:Comparison of minimal access retroperitoneal pancreatic necrosectomy (MARPN) versus open necrosectomy in the treatment of infected or nonresolving pancreatic necrosis. SUMMARY OF BACKGROUND DATA:Infected pancreatic necrosis may lead to progressive organ failure and death. Minimal access techniques have been ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181d96c53

    authors: Raraty MG,Halloran CM,Dodd S,Ghaneh P,Connor S,Evans J,Sutton R,Neoptolemos JP

    更新日期:2010-05-01 00:00:00

  • Resident operative experience in general surgery, plastic surgery, and urology 5 years after implementation of the ACGME duty hour policy.

    abstract:OBJECTIVE:Resident duty hour restrictions were implemented in 2002-2003. This study examines changes in resident surgical experience since these restrictions were put into place. METHOD:Operative log data for 3 specialties were examined: general surgery, urology, and plastic surgery. The academic year immediately prec...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181e62299

    authors: Simien C,Holt KD,Richter TH,Whalen TV,Coburn M,Havlik RJ,Miller RS

    更新日期:2010-08-01 00:00:00

  • Endothelial-directed hepatic regeneration after partial hepatectomy.

    abstract:OBJECTIVE:To determine the role of the microvascular endothelium in the regulation of regenerating liver mass after partial hepatectomy. SUMMARY BACKGROUND DATA:Angiogenesis is critical for both pathologic and physiologic processes. The ability of certain tissues, such as the liver, kidney, and spleen, to regenerate a...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.SLA.0000059986.96051.EA

    authors: Greene AK,Wiener S,Puder M,Yoshida A,Shi B,Perez-Atayde AR,Efstathiou JA,Holmgren L,Adamis AP,Rupnick M,Folkman J,O'Reilly MS

    更新日期:2003-04-01 00:00:00

  • Leiomyoma of the esophagus.

    abstract::Esophageal leiomyoma, while rare, is the most common benign tumor of the esophagus. Nine cases from a large teaching hospital are reviewed with long-term follow-up. Steps in the diagnosis and management of this lesion are discussed. ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198402000-00020

    authors: Solomon MP,Rosenblum H,Rosato FE

    更新日期:1984-02-01 00:00:00

  • Permanent Pancreatic Duct Occlusion With Neoprene-based Glue Injection After Pancreatoduodenectomy at High Risk of Pancreatic Fistula: A Prospective Clinical Study.

    abstract:OBJECTIVE:The aim of this study was to assess safety and efficacy of pancreatic duct occlusion (PDO) with neoprene-based glue in selected patients undergoing pancreatoduodenectomy (PD) at high risk of postoperative pancreatic fistula (POPF). BACKGROUND DATA:PD is the reference standard approach for tumors of the pancr...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/SLA.0000000000003514

    authors: Mazzaferro V,Virdis M,Sposito C,Cotsoglou C,Droz Dit Busset M,Bongini M,Flores M,Prinzi N,Coppa J

    更新日期:2019-11-01 00:00:00

  • Causes of short-term mortality after appendectomy: a population-based case-controlled study.

    abstract:OBJECTIVE:This case control study is a detailed analysis of the causes of death and the risk factors of short-term mortality after appendectomy. SUMMARY BACKGROUND DATA:Although death is a rare event after appendectomy, we found a 7-fold excess mortality after appendectomy overall and a 9-fold excess mortality after n...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31821ad9c4

    authors: Andersson MN,Andersson RE

    更新日期:2011-07-01 00:00:00

  • Incorporation of Procedure-specific Risk Into the ACS-NSQIP Surgical Risk Calculator Improves the Prediction of Morbidity and Mortality After Pancreatoduodenectomy.

    abstract:OBJECTIVE:This multicenter study sought to evaluate the accuracy of the American College of Surgeons National Surgical Quality Improvement Program's (ACS-NSQIP) surgical risk calculator for predicting outcomes after pancreatoduodenectomy (PD) and to determine whether incorporating other factors improves its predictive ...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000001796

    authors: McMillan MT,Allegrini V,Asbun HJ,Ball CG,Bassi C,Beane JD,Behrman SW,Berger AC,Bloomston M,Callery MP,Christein JD,Dickson E,Dixon E,Drebin JA,Fernandez-Del Castillo C,Fisher WE,Fong ZV,Haverick E,Hollis RH,House MG

    更新日期:2017-05-01 00:00:00

  • Treatment of anal incontinence by an implantable prosthetic anal sphincter.

    abstract::Twelve patients with anal incontinence due to neurologic disease or failure of previous incontinence surgery underwent implantation of an artificial anal sphincter. The system used was a modification of the AMS 800 artificial urinary sphincter. In two patients, infection necessitated removal of the system, and in four...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199204000-00013

    authors: Christiansen J,Sparsø B

    更新日期:1992-04-01 00:00:00

  • Motor function in the excluded esophagus and its implications in the management of patients with unresectable carcinoma of the esophagus.

    abstract::Palliative exclusion of the esophagus by use of transposed stomach was performed in a 63-year-old woman with unresectable cervical esophageal cancer. Twelve weeks after this operation, motor function of the excluded esophagus was assessed. All voluntary swallows produced a motor response in the esophageal body. Eighty...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198712000-00017

    authors: Duranceau AC,Lafontaine ER,Archambault SC,Jamieson GG

    更新日期:1987-12-01 00:00:00

  • Sentinel node staging of resectable colon cancer: results of a multicenter study.

    abstract:OBJECTIVE AND SUMMARY BACKGROUND DATA:Sentinel lymph node (LN) sampling, a technique widely used to manage breast cancer and melanoma, seeks to select LNs that accurately predict regional node status and can be extensively examined to identify nodal metastatic disease not detected by standard histopathological staging....

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1097/01.sla.0000140753.41357.20

    authors: Bertagnolli M,Miedema B,Redston M,Dowell J,Niedzwiecki D,Fleshman J,Bem J,Mayer R,Zinner M,Compton C

    更新日期:2004-10-01 00:00:00

  • Long-term maturation of congenital diaphragmatic hernia treatment results: toward development of a severity-specific treatment algorithm.

    abstract:OBJECTIVES:To assess the impact of varying approaches to congenital diaphragmatic hernia (CDH) repair timing on survival and need for ECMO when controlled for anatomic and physiologic disease severity in a large consecutive series of patients with CDH. BACKGROUND:Our publication of 60 consecutive patients with CDH in ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3182a53c49

    authors: Kays DW,Islam S,Larson SD,Perkins J,Talbert JL

    更新日期:2013-10-01 00:00:00

  • The evolution of the concept of the use of surgical castration in the palliation of breast cancer in pre-menopausal females.

    abstract::The understanding of the association of mammalian ovarian function with lactation was common knowledge to dairy-men early in the 19th century or earlier. This thesis reviews the application of these empiric observations to lactation in humans by Beatson of Glasgow, supported by his preliminary laboratory investigation...

    journal_title:Annals of surgery

    pub_type: 传,历史文章,杂志文章

    doi:10.1097/00000658-197612000-00009

    authors: Macmahon CE,Cahill JL

    更新日期:1976-12-01 00:00:00

  • The HYSLAR trial: a prospective randomized controlled trial of the use of a restrictive fluid regimen with 3% hypertonic saline versus lactated Ringers in patients undergoing pancreaticoduodenectomy.

    abstract:OBJECTIVE:This study was designed to determine whether the volume and type of fluid administered for pancreaticoduodenectomy impacts postoperative outcomes. BACKGROUND:Three percent hypertonic saline (HYS) has been suggested as a means of reducing the volume of fluid required to sustain tissue perfusion in the periope...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0000000000000872

    authors: Lavu H,Sell NM,Carter TI,Winter JM,Maguire DP,Gratch DM,Berman RA,Feil MG,Grunwald Z,Leiby BE,Pequignot EC,Rosato EL,Yeo CJ

    更新日期:2014-09-01 00:00:00

  • Technical refinements and results in full-right full-left splitting of the deceased donor liver.

    abstract:OBJECTIVE:Splitting of the liver at the line of Cantlie of otherwise healthy people is accepted worldwide as a reasonable procedure for the donors in adult living donor liver transplantation. A similar operation is still considered as experimental if performed in the deceased donor liver. The aim of this study is to ev...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000189120.62975.0d

    authors: Broering DC,Wilms C,Lenk C,Schulte am Esch J 2nd,Schönherr S,Mueller L,Kim JS,Helmke K,Burdelski M,Rogiers X

    更新日期:2005-12-01 00:00:00