Lymph node ratio as a quality and prognostic indicator in stage III colon cancer.

Abstract:

BACKGROUND:The presence and number of nodal metastasis significantly impact colon cancer prognosis. Similarly, the number of resected/evaluated nodes impacts staging accuracy. This ratio of metastatic to examined nodes or lymph node ratio (LNR) may have independent prognostic value in colon carcinoma. PURPOSE:: To evaluate the impact of LNR on overall survival in colon cancer patients with fewer than 12 or 12 examined nodes or more. METHODS:Patients (n = 36,712) with node-positive nonmetastatic colon cancer diagnosed between 1992 and 2004 were identified from the Surveillance, Epidemiology, and End Results database and stratified according to LNR and number of nodes examined. Survival was estimated by Kaplan-Meier method, and differences analyzed by log-rank test. A Cox proportional hazards model was used for multivariate analysis. RESULTS:Patients with fewer than 12 nodes were older and male and had lower primary tumor stage, grade, and N stage (P < 0.01). Survival appeared greater with 12 total nodes examined or more (median 53 vs. 66 months, P < 0.001). Within each LNR stratum, survival with 12 nodes or more was improved for those with less than 10% of nodes positive for cancer, but was worse with higher LNRs (P < 0.01). Lymph node ratio was significantly associated with survival independent of total nodes (HR 1.24-5.12, P < 0.001). Other significant factors included age, race, tumor grade, stage, location, and N stage. CONCLUSION:Metastatic LNR independently estimates survival in Stage III colon cancer, irrespective of number of nodes examined. However, statistically significant differences in each LNR stratum between those with resection of fewer than 12 or 12 nodes or more would indicate that a 12-node minimum may still be necessary for accurate staging.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Chen SL,Steele SR,Eberhardt J,Zhu K,Bilchik A,Stojadinovic A

doi

10.1097/SLA.0b013e3181ffa780

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

82-7

issue

1

eissn

0003-4932

issn

1528-1140

journal_volume

253

pub_type

杂志文章
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    abstract::The pattern of failure was studied in 1012 patients with resected Stage I or II non-small-cell carcinoma of the lung. Initial intrathoracic failure (41%) was more common than initial extrathoracic failure (34%) even though a complete resection was the intent in all patients. The most frequent sites of initial failure ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198701000-00012

    authors:

    更新日期:1987-01-01 00:00:00

  • Endovascular stent graft repair of abdominal and thoracic aortic aneurysms: a ten-year experience with 817 patients.

    abstract:OBJECTIVE:On November 23, 1992, the first endovascular stent graft (ESG) repair of an aortic aneurysm was performed in North America. Following the treatment of this patient, we have continued to evaluate ESG over the past 10 years in the treatment of 817 patients. SUMMARY AND BACKGROUND DATA:Abdominal (AAA) or thorac...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/01.sla.0000090473.63393.e9

    authors: Marin ML,Hollier LH,Ellozy SH,Spielvogel D,Mitty H,Griepp R,Lookstein RA,Carroccio A,Morrissey NJ,Teodorescu VJ,Jacobs TS,Minor ME,Sheahan CM,Chae K,Oak J,Cha A

    更新日期:2003-10-01 00:00:00

  • Clinical experience with the use of a valve-bearing conduit to construct a second left ventricular outflow tract in cases of unresectable intra-ventricular obstruction.

    abstract::Two patients, ages 7 and 17, with unresectable obstructions within the left ventricular cavity, have been managed by interposing a conduit bearing a porcine aortic valve between the apex of the left ventricle and the infra-renal abdominal aorta. The younger child had idiopathic hypertrophic subaortic stenosis (IHSS) r...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197609000-00009

    authors: Dembitsky WP,Weldon CS

    更新日期:1976-09-01 00:00:00

  • Is surgical resection superior to transplantation in the treatment of hepatocellular carcinoma?

    abstract:OBJECTIVE:To compare outcomes for patients with hepatocellular carcinoma (HCC) treated with either liver resection or transplantation. METHODS:A retrospective, single-institution analysis of 413 HCC patients from 1999 to 2009. RESULTS:A total of 413 patients with HCC underwent surgical resection (n = 106) and transpl...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31822ca66f

    authors: Koniaris LG,Levi DM,Pedroso FE,Franceschi D,Tzakis AG,Santamaria-Barria JA,Tang J,Anderson M,Misra S,Solomon NL,Jin X,DiPasco PJ,Byrne MM,Zimmers TA

    更新日期:2011-09-01 00:00:00

  • The advantages of 131I-orthoiodohippurate scintiphotography in the management of patients after renal transplantation.

    abstract::Renal scintiphotography with (131)I-hippurate was the primary diagnostic procedure in evaluating renal failure and complications in over 500 transplant patients. This diagnostic test has become our principal method of evaluation and followup of renal transplants, especially in the early post-transplant period. It has ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197409000-00014

    authors: Salvatierra O Jr,Powell MR,Price DC,Kountz SL,Belzer FO

    更新日期:1974-09-01 00:00:00

  • Morbidity and mortality after pelvic exenteration for colorectal adenocarcinoma.

    abstract::A retrospective analysis was made of the complications from pelvic exenterations performed over the past 30 years for colorectal adenocarcinoma at the Roswell Park Cancer Institute. Seventy-five patients underwent exenteration, 51 for primary disease (PD) and 24 for recurrent disease (RD). Both total and posterior exe...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199201000-00009

    authors: Hafner GH,Herrera L,Petrelli NJ

    更新日期:1992-01-01 00:00:00

  • Comparison of mammographically guided breast biopsy techniques.

    abstract:OBJECTIVE:To determine which mammographically guided breast biopsy technique is the most efficient in making a diagnosis in women with suspicious mammograms. SUMMARY BACKGROUND DATA:Mammographically guided biopsy techniques include stereotactic 14-gauge core-needle biopsy (SC bx), stereotactic 11-gauge suction-assiste...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000658-199905000-00004

    authors: Velanovich V,Lewis FR Jr,Nathanson SD,Strand VF,Talpos GB,Bhandarkar S,Elkus R,Szymanski W,Ferrara JJ

    更新日期:1999-05-01 00:00:00

  • Comparison of surgical outcomes between teaching and nonteaching hospitals in the Department of Veterans Affairs.

    abstract:OBJECTIVE:To determine whether the investment in postgraduate education and training places patients at risk for worse outcomes and higher costs than if medical and surgical care was delivered in nonteaching settings. SUMMARY BACKGROUND DATA:The Veterans Health Administration (VA) plays a major role in the training of...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200109000-00011

    authors: Khuri SF,Najjar SF,Daley J,Krasnicka B,Hossain M,Henderson WG,Aust JB,Bass B,Bishop MJ,Demakis J,DePalma R,Fabri PJ,Fink A,Gibbs J,Grover F,Hammermeister K,McDonald G,Neumayer L,Roswell RH,Spencer J,Turnage RH,V

    更新日期:2001-09-01 00:00:00

  • Hemodynamic dysfunction in obesity hypoventilation syndrome and the effects of treatment with surgically induced weight loss.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198805000-00015

    authors: Sugerman HJ,Baron PL,Fairman RP,Evans CR,Vetrovec GW

    更新日期:1988-05-01 00:00:00

  • An evaluation of information transfer through the continuum of surgical care: a feasibility study.

    abstract:OBJECTIVE:To evaluate information transfer and communication (ITC) across the surgical care pathway with the use of Information Transfer and Communication Assessment Tool for Surgery (ITCAS). BACKGROUND:Communication failures are the leading cause of surgical errors and adverse events. It is vital to assess the ITC ac...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181e986df

    authors: Nagpal K,Vats A,Ahmed K,Vincent C,Moorthy K

    更新日期:2010-08-01 00:00:00

  • Popliteal artery trauma. Systemic anticoagulation and intraoperative thrombolysis improves limb salvage.

    abstract:OBJECTIVE:This study was conducted to evaluate those factors associated with popliteal artery injury that influence amputation, with emphasis placed on those that the surgeon can control. SUMMARY BACKGROUND DATA:Generally accepted factors impacting amputation after popliteal artery injury include blunt trauma, prolong...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199705000-00009

    authors: Melton SM,Croce MA,Patton JH Jr,Pritchard FE,Minard G,Kudsk KA,Fabian TC

    更新日期:1997-05-01 00:00:00

  • Visceral blood flow following thermal injury.

    abstract::To determine if visceral blood flow was altered by thermal injury, effective renal blood flow (ERBF) was measured by para-aminohippurate clearance in five control subjects and 13 nonbacteremic burn patients (mean burn size: 50% total body surface, range: 24.5-83.5) 6-25 days after burn injury. Splanchnic blood flow (S...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198101000-00018

    authors: Aulick LH,Goodwin CW Jr,Becker RA,Wilmore DW

    更新日期:1981-01-01 00:00:00

  • Can We Predict Incisional Hernia?: Development of a Surgery-specific Decision-Support Interface.

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    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003472

    authors: Basta MN,Kozak GM,Broach RB,Messa CA 4th,Rhemtulla I,DeMatteo RP,Serletti JM,Fischer JP

    更新日期:2019-09-01 00:00:00

  • The physiologic effects of pneumoperitoneum in the morbidly obese.

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    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/01.sla.0000151791.93571.70

    authors: Nguyen NT,Wolfe BM

    更新日期:2005-02-01 00:00:00

  • Surgical management of papillary and follicular carcinoma of the thyroid.

    abstract::The clinical outcome in 155 patients with papillary or follicular carcinoma of the thyroid gland operated on over a 25-year period demonstrated no difference in survival rates or incidence of recurrent tumor between those treated by total thyroidectomy and those undergoing less than total thyroidectomy. However, the c...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198012000-00001

    authors: Farrar WB,Cooperman M,James AG

    更新日期:1980-12-01 00:00:00

  • Pancreatic necrosis: results of necrosectomy, packing, and ultimate closure over drains.

    abstract:OBJECTIVE:The treatment of pancreatic necrosis at a tertiary referral center was reviewed to effect better patient outcome. SUMMARY BACKGROUND DATA:Pancreatic necrosis is a devastating disease that leads to death in 10% to 50% of cases. Infected necrosis is particularly deadly because 80% of deaths from necrosis are d...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199806000-00010

    authors: Branum G,Galloway J,Hirchowitz W,Fendley M,Hunter J

    更新日期:1998-06-01 00:00:00

  • Circulating Tumor Cell Phenotype Predicts Recurrence and Survival in Pancreatic Adenocarcinoma.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001600

    authors: Poruk KE,Valero V 3rd,Saunders T,Blackford AL,Griffin JF,Poling J,Hruban RH,Anders RA,Herman J,Zheng L,Rasheed ZA,Laheru DA,Ahuja N,Weiss MJ,Cameron JL,Goggins M,Iacobuzio-Donahue CA,Wood LD,Wolfgang CL

    更新日期:2016-12-01 00:00:00

  • Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma.

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    pub_type: 杂志文章,评审

    doi:10.1097/00000658-200007000-00003

    authors: Tung-Ping Poon R,Fan ST,Wong J

    更新日期:2000-07-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000118751.95179.c6

    authors: Abdel-Latif MM,O'Riordan J,Windle HJ,Carton E,Ravi N,Kelleher D,Reynolds JV

    更新日期:2004-04-01 00:00:00

  • Thrombotic thrombocytopenic purpura (TTP) and splenectomy: a current appraisal.

    abstract::Thrombotic thrombocytopenic purpura (TTP) is a disease process characterized by microangiopathic anemia, fever, neurologic manifestations, renal abnormalities, and thrombocytopenia. These clinical findings are caused by vascular occlusions of the microcirculation. At present the utilization of splenectomy, in the trea...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197811000-00021

    authors: Rutkow IM

    更新日期:1978-11-01 00:00:00

  • Perfect Registration Leads to Imperfect Performance: A Randomized Trial of Multimodal Intraoperative Image Guidance.

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    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

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    authors: Dilley JWR,Hughes-Hallett A,Pratt PJ,Pucher PH,Camara M,Darzi AW,Mayer EK

    更新日期:2019-02-01 00:00:00

  • Villous tumors of the duodenum.

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    pub_type: 杂志文章

    doi:10.1097/00000658-198803000-00002

    authors: Galandiuk S,Hermann RE,Jagelman DG,Fazio VW,Sivak MV

    更新日期:1988-03-01 00:00:00

  • Prognosis in acute organ-system failure.

    abstract::This prospective study describes the current prognosis of patients in acute Organ System Failure (OSF). Objective definitions were developed for five OSFs, and then 5677 ICU admissions from 13 hospitals were monitored. The number and duration of OSF were linked to outcome at hospital discharge for each of the 2719 ICU...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198512000-00004

    authors: Knaus WA,Draper EA,Wagner DP,Zimmerman JE

    更新日期:1985-12-01 00:00:00

  • Career decisions and the structure of training: an American Board Of Colon and Rectal Surgery survey of colorectal residents.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181ad64f1

    authors: Schmitz CC,Rothenberger DA,Trudel JL,Wolff BG

    更新日期:2009-07-01 00:00:00

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    pub_type: 杂志文章

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    authors: Tahara K,Murakami T,Fujishiro J,Takahashi M,Inoue S,Hashizume K,Matsuno K,Kobayashi E

    更新日期:2005-07-01 00:00:00

  • Virtual reality applied to hepatic surgery simulation: the next revolution.

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    pub_type: 临床试验,杂志文章,随机对照试验

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    authors: Fong Y,Hesse DG,Tracey KJ,Albert JD,Legaspi A,Brennan MF,Lowry SF

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    doi:10.1097/00000658-198011000-00010

    authors: Dickerman RM,Peters PC,Hull AR,Curry TS,Atkins C,Fry WJ

    更新日期:1980-11-01 00:00:00

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    doi:10.1097/SLA.0000000000000990

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    pub_type: 杂志文章

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    更新日期:1988-10-01 00:00:00