A prospective study of thymectomy and serum acetylcholine receptor antibodies in myasthenia gravis.

Abstract:

:Forty-seven consecutively presenting myasthenia gravis (MG) patients with generalized weakness were treated according to a standardized prospective protocol. All patients underwent a sternal splitting "total" thymectomy. Medical status before surgery was optimized by plasmapheresis without immunosuppression. Medications were avoided or discontinued whenever possible. All patients were improved. At the time of latest follow-up 83% were free of generalized weakness and 61% were on no medications. There was no significant change in Acetylcholine Receptor Antibody (AChR-AB) titer. The following conclusions were made: (1) thymectomy is an effective therapy for MG, (2) additional medications are not necessary in the majority of patients, and (3) a reduction in the AChR-AB titer is not essential for clinical benefit.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Olanow CW,Wechsler AS,Roses AD

doi

10.1097/00000658-198208000-00001

subject

Has Abstract

pub_date

1982-08-01 00:00:00

pages

113-21

issue

2

eissn

0003-4932

issn

1528-1140

journal_volume

196

pub_type

杂志文章
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