Neutrophils dysfunction during the course of intra-abdominal infection.

Abstract:

:Twenty-four patients with intra-peritoneal infections were studied sequentially to evaluate neutrophil chemotaxis, spontaneous migration, and chemiluminescence. In six patients, infection was due to spontaneous disease processes and 18 others, infection was a sequel of intra-abdominal operation. In the patients studied prior to drainage, operation chemotaxis, spontaneous migration and chemiluminescence were all significantly depressed. Operation resulted in a further depression of these functions, and recovery of neutrophil migratory responses was delayed for two weeks. During the period of functional depression, 16 patients developed recurrent infections (nine episodes of intra-abdominal abscess, and 12 episodes of extra-abdominal infection). These infection were associated with a fall-off in neutrophil migratory and chemiluminescence responses prior to clinical evidence of infection. This study suggests that the delayed recovery of neutrophil function may be related to the recurrent infection seen in this patient population. Further, monitoring of neutrophil function in patients recovering from intra-abdominal infection may provide early evidence of recurrent infection.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Solomkin JS,Bauman MP,Nelson RD,Simmons RL

doi

10.1097/00000658-198107000-00003

subject

Has Abstract

pub_date

1981-07-01 00:00:00

pages

9-17

issue

1

eissn

0003-4932

issn

1528-1140

journal_volume

194

pub_type

杂志文章
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    更新日期:2017-03-01 00:00:00

  • Repeat hepatic surgery for colorectal cancer metastasis to the liver.

    abstract:OBJECTIVE:The authors addressed whether a repeat hepatic operation is warranted in patients with recurrent isolated hepatic metastases. Are the results as good after second operation as after first hepatic operation? SUMMARY BACKGROUND DATA:Five-year survival after initial hepatic operation for colorectal metastases i...

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    authors: Pinson CW,Wright JK,Chapman WC,Garrard CL,Blair TK,Sawyers JL

    更新日期:1996-06-01 00:00:00

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    更新日期:2012-11-01 00:00:00

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    更新日期:1996-05-01 00:00:00

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    更新日期:2010-11-01 00:00:00

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    更新日期:2017-07-01 00:00:00

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    更新日期:1996-01-01 00:00:00

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    更新日期:2008-03-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198812000-00018

    authors: Jönsson K,Hunt TK,Mathes SJ

    更新日期:1988-12-01 00:00:00

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  • Long-term follow-up of brachial artery ligation in children.

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    pub_type: 杂志文章

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    authors: Lally KP,Foster CE 3rd,Chwals WJ,Brennan LP,Atkinson JB

    更新日期:1990-08-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1097/00000658-198101000-00018

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    更新日期:1981-01-01 00:00:00

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    pub_type: 杂志文章

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    authors: Loop FD,Cosgrove DM,Lytle BW,Thurer RL,Simpfendorfer C,Taylor PC,Proudfit WL

    更新日期:1979-10-01 00:00:00

  • An in vitro evaluation of the stability of mechanical properties of surgical suture materials in various pH conditions.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198308000-00019

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    更新日期:1983-08-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198310000-00009

    authors: Crawford ES

    更新日期:1983-10-01 00:00:00

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    pub_type: 临床试验,杂志文章

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    更新日期:2009-07-01 00:00:00

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    authors: Klein D,Schubert T,Horch RE,Jauch KW,Jeschke MG

    更新日期:2004-08-01 00:00:00

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    authors: Leung CH,Caldarone CA,Wang F,Venkateswaran S,Ailenberg M,Vadasz B,Wen XY,Rotstein OD

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