A novel therapeutic strategy for attenuating neutrophil-mediated lung injury in vivo.

Abstract:

OBJECTIVE:To evaluate the effect of inhalation of aerosolized opsonized dead Escherichia coli on inflammatory pulmonary neutrophil (PMN) apoptosis, lung injury, and survival in a PMN-mediated lung injury model in vivo. SUMMARY BACKGROUND DATA:Neutrophils that have transmigrated into an inflammatory focus display increased functional capacity and delayed apoptosis, resulting in an increased capacity to injure normal host tissue. The authors have previously shown that E. coli induces PMN apoptosis in vitro. METHODS:Lung injury mediated by PMNs was established by aortic occlusion and reperfusion. Adult male Sprague-Dawley rats were randomized into four groups: sham ischemia-reperfusion (I/R) treated with intratracheal inhalation of aerosolized normal saline, I/R treated with aerosolized normal saline intratracheally, I/R treated with aerosolized opsonized dead E. coli intratracheally, and I/R treated with aerosolized opsonized dead E. coli and the caspase inhibitor zVAD-FMK intratracheally 5 minutes before reperfusion. Both systemic and bronchoalveolar lavage PMNs were isolated and apoptosis was quantified at 0, 6, 12, 18, and 24 hours. Lung injury parameters including wet/dry lung weight ratio, histology, myeloperoxidase activity, and protein content were also assessed. In addition, a survival study was performed, both in a prophylactic and in a therapeutic setting. RESULTS:Administration of aerosolized dead E. coli before the reperfusion injury induced pulmonary PMN apoptosis and reversed the delayed apoptosis evident in the I/R plus normal saline group. There was also a significant improvement in lung injury parameters as well as in survival, both prophylactically as well as therapeutically. CONCLUSIONS:Directly modulating PMN cell death represents a novel mechanism for attenuating PMN-mediated lung injury and may ultimately benefit the outcome in patients with adult respiratory distress syndrome.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Sookhai S,Wang JJ,McCourt M,Kirwan W,Bouchier-Hayes D,Redmond P

doi

10.1097/00000658-200202000-00018

subject

Has Abstract

pub_date

2002-02-01 00:00:00

pages

285-91

issue

2

eissn

0003-4932

issn

1528-1140

journal_volume

235

pub_type

杂志文章
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    abstract::Human lymphocyte antigen (HLA) class I and class II antigens and beta 2 microglobulin (B2M) were identified in peritoneal dialysate (PD) and serum from patients with end-stage renal disease (ESRD) using monoclonal antibodies in an enzyme-linked immunoassay. The HLA class I and class II antigens each exhibited approxim...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199106000-00009

    authors: Gelder FB,McDonald JC,Landreneau MD,McMillan RM,Aultman DF

    更新日期:1991-06-01 00:00:00

  • Pathogenesis of paralytic ileus: intestinal manipulation opens a transient pathway between the intestinal lumen and the leukocytic infiltrate of the jejunal muscularis.

    abstract:OBJECTIVE:To investigate the existence of a pathway between intraluminal products and the muscularis leukocytic infiltrate. SUMMARY BACKGROUND DATA:Mild intestinal manipulation or lipopolysaccharide initiates an intense inflammatory response within the intestinal muscularis, resulting in paralytic ileus. A major poten...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200201000-00005

    authors: Schwarz NT,Beer-Stolz D,Simmons RL,Bauer AJ

    更新日期:2002-01-01 00:00:00

  • Assessing functional mobility after lower limb reconstruction: a psychometric evaluation of a sensor-based mobility score.

    abstract:OBJECTIVE:To develop and validate a robust, objective mobility assessment tool, Hamlyn Mobility Score (HMS), using a wearable motion sensor. BACKGROUND:Advances in reconstructive techniques allow more limbs to be salvaged. However, evidence demonstrating superior long-term outcomes compared with amputation is unavaila...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000000711

    authors: Kwasnicki RM,Hettiaratchy S,Jarchi D,Nightingale C,Wordsworth M,Simmons J,Yang GZ,Darzi A

    更新日期:2015-04-01 00:00:00

  • Autologous blood in the treatment of intraoperative hemorrhage.

    abstract::Severe hemorrhage associated with major trauma and vascular procedures is seen frequently in our operating rooms. Immediate autotransfusion has enabled us to safely and adquately correct blood losses without placing overwhelming demands on our blood bank. Since October 1973, a device capable of retrieving, filtering a...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197703000-00013

    authors: Bonfils-Roberts EA,Stutman L,Nealon TF Jr

    更新日期:1977-03-01 00:00:00

  • The anatomy of the fasciae of the face and neck with particular reference to the spread and treatment of intraoral infections (Ludwig's) that have progressed into adjacent fascial spaces.

    abstract::Descriptions of the fasciae of the lower half of the face and of the adjacent cervical fasciae have long been puzzling and descriptively much too complex. For this reason, medical students, young medical and dental practitioners, and at times even senior surgeons frequently do not understand the anatomy of the cervico...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198612000-00015

    authors: Lindner HH

    更新日期:1986-12-01 00:00:00

  • Diabetes and hypertension in severe obesity and effects of gastric bypass-induced weight loss.

    abstract:OBJECTIVE:To evaluate the preoperative relationships of hypertension and diabetes mellitus in severe obesity and the effects of gastric bypass (GBP)-induced weight loss. SUMMARY BACKGROUND DATA:Severe obesity is associated with multiple comorbidities, particularly hypertension and type 2 diabetes mellitus, that may af...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.SLA.0000071560.76194.11

    authors: Sugerman HJ,Wolfe LG,Sica DA,Clore JN

    更新日期:2003-06-01 00:00:00

  • Acute hemorrhagic pancreatitis and pseudocyst due to mumps.

    abstract::This is the first reported case of mumps hemorrhagic pancreatitis in a child, documented at operation, and by rising mumps titers and complicated by a pseudocyst. In severe cases when surgery is indicated, drainage of the lesser sac usually prevents pseudocyst formation. If a pseudocyst occurs, drainage is required to...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197407000-00012

    authors: Feldstein JD,Johnson FR,Kallick CA,Doolas A

    更新日期:1974-07-01 00:00:00

  • APC and PIK3CA Mutational Cooperativity Predicts Pathologic Response and Survival in Patients Undergoing Resection for Colorectal Liver Metastases.

    abstract:OBJECTIVE:The aim of the study was to determine the prognostic impact of co-existence of APC and PIK3CA mutations in patients undergoing preoperative chemotherapy and resection for colorectal liver metastases (CLM). BACKGROUND:Co-occurring genetic events have been shown to drive carcinogenesis in multiple malignancies...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002245

    authors: Yamashita S,Chun YS,Kopetz SE,Maru D,Conrad C,Aloia TA,Vauthey JN

    更新日期:2020-12-01 00:00:00

  • The impact of the 80-hour resident workweek on surgical residents and attending surgeons.

    abstract:OBJECTIVE:To assess the impact of the 80-hour resident workweek restrictions on surgical residents and attending surgeons. SUMMARY BACKGROUND DATA:The ACGME mandated resident duty hour restrictions have required a major workforce restructuring. The impact of these changes needs to be critically evaluated for both the ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000220042.48310.66

    authors: Hutter MM,Kellogg KC,Ferguson CM,Abbott WM,Warshaw AL

    更新日期:2006-06-01 00:00:00

  • The walk-in anergic patient. How best to assess the risk of sepsis following elective surgery.

    abstract::This prospective study evaluated host resistance in a surgical population who walked into the hospital for elective surgery. Patients were stratified into Hospital Reactive (HR, n = 19) if they reacted to two or more of five recall skin test antigens and Walk-in Anergic (WA, n = 26) if they did not react to the antige...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198404000-00011

    authors: Christou NV,Rode H,Larsen D,Loose L,Broadhead M,Meakins JL

    更新日期:1984-04-01 00:00:00

  • Reductive surgery plus percutaneous isolated hepatic perfusion for multiple advanced hepatocellular carcinoma.

    abstract:OBJECTIVE:To evaluate the efficacy of a novel 2-stage treatment with reductive surgery plus percutaneous isolated hepatic perfusion (PIHP) for multiple hepatocellular carcinoma (HCC), which was previously unresectable. SUMMARY BACKGROUND DATA:Surgical resection is the treatment of choice for HCC, but the majority of p...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/01.sla.0000103133.03688.3d

    authors: Ku Y,Iwasaki T,Tominaga M,Fukumoto T,Takahashi T,Kido M,Ogata S,Takahashi M,Kuroda Y,Matsumoto S,Obara H

    更新日期:2004-01-01 00:00:00

  • Risk and location of cancer in patients with preoperative colitis-associated dysplasia undergoing proctocolectomy.

    abstract:OBJECTIVE:To evaluate the influence of preoperative dysplasia grade, appearance, and site on risk and location of cancer in patients with colitis. BACKGROUND:The ability to predict the presence and location of cancer in colitis patients with dysplasia is essential to facilitate recommendations regarding the necessity ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31828e7417

    authors: Kiran RP,Ahmed Ali U,Nisar PJ,Khoury W,Gu J,Shen B,Remzi FH,Hammel JP,Lavery IC,Fazio VW,Goldblum JR

    更新日期:2014-02-01 00:00:00

  • A Propensity-matched Analysis Comparing Survival After Esophagectomy Followed by Adjuvant Chemoradiation to Surgery Alone for Esophageal Squamous Cell Carcinoma.

    abstract:BACKGROUND:The role of adjuvant chemoradiation in esophageal cancer has been underestimated in the literature. This study was undertaken to determine whether adjuvant chemoradiation improves survival compared with surgery alone. METHODS:Data of 1095 esophageal squamous cell carcinoma (ESCC) patients, including 679 in ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001410

    authors: Hwang JY,Chen HS,Hsu PK,Chao YK,Wang BY,Huang CS,Liu CC,Wu SC

    更新日期:2016-07-01 00:00:00

  • HER-3 overexpression is prognostic of reduced breast cancer survival: a study of 4046 patients.

    abstract:INTRODUCTION:Advances in molecular biology have led to the identification of potential markers of prognostic and therapeutic importance in human cancers. HER-2 testing and targeted therapy now represents a critical cornerstone in the management of breast cancer. The objectives of the current study were to determine the...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181dbb77e

    authors: Chiu CG,Masoudi H,Leung S,Voduc DK,Gilks B,Huntsman DG,Wiseman SM

    更新日期:2010-06-01 00:00:00

  • Hemodynamic consequences of femoral arteriovenous bovine shunts.

    abstract::Seventeen patients with femoral arteriovenous bovine shunts (FAVBS) were evaluated to delineate the cardiovascular consequences of the procedure. The resting cardiac index (CI), as estimated by echocardiography, was increased in 8 patients (47%). Twelve of the 17 patients (71%) had more than a 20% reduction in CI afte...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197607000-00017

    authors: Fee HJ Jr,Levisman JA,Dickmeyer JP,Golding AL

    更新日期:1976-07-01 00:00:00

  • Total thyroidectomy for benign thyroid disease: is it really worthwhile?

    abstract:OBJECTIVE:To compare the outcomes of bilateral subtotal (BST) versus total thyroidectomy (TT) for benign bilateral thyroid disease (BBTD). BACKGROUND:The extent of thyroid resection in benign goiter is controversial. Potential advantages of TT over BST may include: one-stage removal of incidental thyroid cancer, and a...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3182360118

    authors: Barczyński M,Konturek A,Stopa M,Cichoń S,Richter P,Nowak W

    更新日期:2011-11-01 00:00:00

  • Demography of penetrating cardiac trauma.

    abstract::All cases of penetrating cardiac trauma in 1985 and 1986 in Jefferson County, Alabama, where patients dying of penetrating trauma received autopsies, were retrospectively reviewed. All hospitals in the county plus the single coroner's office provided the records of the 72 patients comprising this study. Incidents occu...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198906000-00004

    authors: Naughton MJ,Brissie RM,Bessey PQ,McEachern MM,Donald JM Jr,Laws HL

    更新日期:1989-06-01 00:00:00

  • Hepatocellular carcinoma: current management and perspectives for the future.

    abstract:OBJECTIVE:To review the literature on current management of hepatocellular carcinoma (HCC). BACKGROUND:Hepatocellular carcinoma represents one of the most common malignancies worldwide with a rising incidence in western countries. There have been substantial advances in the surgical and medical treatment of HCC within...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/SLA.0b013e31820d944f

    authors: Rahbari NN,Mehrabi A,Mollberg NM,Müller SA,Koch M,Büchler MW,Weitz J

    更新日期:2011-03-01 00:00:00

  • The pregnant motor vehicle accident casualty: adherence to basic workup and admission guidelines.

    abstract:OBJECTIVE:To investigate the workup/treatment provided to pregnant motor vehicle accident (MVA) casualties in a mature trauma system. Adherence to recommendations was used to measure quality of care. BACKGROUND:MVAs affect approximately 3% of pregnant women. Trauma casualty outcome improves after implementation of gui...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31822638d4

    authors: Sela HY,Weiniger CF,Hersch M,Smueloff A,Laufer N,Einav S

    更新日期:2011-08-01 00:00:00

  • Insulinlike growth factor-I-mediated migration and invasion of human colon carcinoma cells requires activation of c-Met and urokinase plasminogen activator receptor.

    abstract:OBJECTIVE:To determine whether insulinlike growth factor-I (IGF-I) and hepatocyte growth factor (HGF) cooperate to induce migration and invasion of human colorectal carcinoma (CRC) cells and whether the effects of IGF-I and/or HGF are mediated through activation of the urokinase plasminogen activator (uPA)/uPA receptor...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000160699.59061.92

    authors: Bauer TW,Fan F,Liu W,Johnson M,Parikh NU,Parry GC,Callahan J,Mazar AP,Gallick GE,Ellis LM

    更新日期:2005-05-01 00:00:00

  • Risk factors for surgery and postoperative recurrence in Crohn's disease.

    abstract:OBJECTIVE:To assess the impact of possible risk factors on intestinal resection and postoperative recurrence in Crohn's disease (CD) and to evaluate the disease course. SUMMARY BACKGROUND DATA:The results of previous studies on possible risk factors for surgery and recurrence in Crohn's disease have been inconsistent....

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200001000-00006

    authors: Bernell O,Lapidus A,Hellers G

    更新日期:2000-01-01 00:00:00

  • Gastrocolic fistulae in benign peptic ulcer disease.

    abstract::Occurence of gastroenteric fistulae in non-surgically treated peptic ulcer disease is rare as suggested by only 26 cases published in the literature so far. We had the opportunity to care for 3 patients with this problem in a period of one year. At our institution, a search of the medical records dating back to 1955 y...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197608000-00017

    authors: Kumar GK,Razzaque MA,Naidu VG,Barbour EM

    更新日期:1976-08-01 00:00:00

  • Restoration of normal distensive characteristics of the esophagogastric junction after fundoplication.

    abstract:OBJECTIVE:To study the mechanical characteristics of the esophagogastric junction (EGJ) of postfundoplication patients and compare them with previously reported data on normal subjects and GERD patients. METHODS:Eight normal subjects, 9 GERD patients, and 8 fundoplication patients were studied with concurrent manometr...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000167868.44211.f0

    authors: Pandolfino JE,Curry J,Shi G,Joehl RJ,Brasseur JG,Kahrilas PJ

    更新日期:2005-07-01 00:00:00

  • Postconditioning, a series of brief interruptions of early reperfusion, prevents neurologic injury after spinal cord ischemia.

    abstract:OBJECTIVE:We sought to test whether postconditioning, a series of brief mechanical interruptions of reperfusion applied during the onset of reperfusion, can prevent neurologic injury of the spinal cord after transient ischemia. SUMMARY BACKGROUND DATA:Ischemia-reperfusion injury of the spinal cord is the principal mec...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000217608.08582.35

    authors: Jiang X,Shi E,Nakajima Y,Sato S

    更新日期:2006-07-01 00:00:00

  • Recurrent carotid artery stenosis following endarterectomy.

    abstract::Spectral analysis was used to examine 257 carotid arteries in 227 patients who had undergone carotid endarterectomy at 1, 3, 6, and 12 months after surgery and annually thereafter. Routine intraoperative completion angiography ensured that the operations were technically satisfactory. Postoperative restenoses were ide...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198407000-00013

    authors: Thomas M,Otis SM,Rush M,Zyroff J,Dilley RB,Bernstein EF

    更新日期:1984-07-01 00:00:00

  • Women Surgeons' Perspectives on System-level Strategies to Address Interpersonal Workplace Conflict.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004074

    authors: Lindquist KM,Vitous CA,Dossett LA,Jagsi R,Telem DA

    更新日期:2020-07-07 00:00:00

  • Prevention of Postsurgical Lymphedema by 9-cis Retinoic Acid.

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    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001525

    authors: Bramos A,Perrault D,Yang S,Jung E,Hong YK,Wong AK

    更新日期:2016-08-01 00:00:00

  • Fifty years' experience with esophageal atresia and tracheoesophageal fistula. Beginning with Cameron Haight's first operation in 1935.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198610000-00013

    authors: Manning PB,Morgan RA,Coran AG,Wesley JR,Polley TZ Jr,Behrendt DM,Kirsh MM,Sloan HE

    更新日期:1986-10-01 00:00:00

  • Congenital mixed vascular deformities of the lower limb: the relevance of lymphatic abnormalities to their diagnosis and treatment.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197702000-00005

    authors: O'Donnell TF Jr

    更新日期:1977-02-01 00:00:00

  • Pancreatic Cancer Surgery: The New R-status Counts.

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    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001731

    authors: Strobel O,Hank T,Hinz U,Bergmann F,Schneider L,Springfeld C,Jäger D,Schirmacher P,Hackert T,Büchler MW

    更新日期:2017-03-01 00:00:00