APC and PIK3CA Mutational Cooperativity Predicts Pathologic Response and Survival in Patients Undergoing Resection for Colorectal Liver Metastases.

Abstract:

OBJECTIVE:The aim of the study was to determine the prognostic impact of co-existence of APC and PIK3CA mutations in patients undergoing preoperative chemotherapy and resection for colorectal liver metastases (CLM). BACKGROUND:Co-occurring genetic events have been shown to drive carcinogenesis in multiple malignancies. METHODS:We identified 396 patients with primary colorectal cancer and known somatic mutation status by next-generation sequencing who underwent hepatectomy for CLM (2005-2015). Survival after hepatectomy in patients with double mutation of APC and PIK3CA and others was analyzed. Predictors of pathologic response and survival were determined. The prognostic value of double mutation was evaluated with a separate cohort of 157 patients with CLM undergoing chemotherapy alone. RESULTS:Forty-five patients had double mutation of APC and PIK3CA; 351 did not. Recurrence-free survival (RFS) and overall survival (OS) after hepatectomy were worse in patients with double mutation (3-year RFS, 3.1% vs 20% [P < 0.001]; 3-year OS, 44% vs 84% [P < 0.001]). Independent predictors of major pathologic response were bevacizumab use (odds ratio [OR] 2.22; P = 0.001), tumor size <3 cm (OR 1.97; P = 0.004), wild-type RAS (OR 2.00; P = 0.003), and absence of double mutation (OR 2.91; P = 0.002). Independent predictors of worse OS were primary advanced T category (hazard ratio [HR] 2.12; P = 0.021), RAS mutation (HR 1.74; P = 0.015), and double mutation (HR 3.09; P < 0.001). In the different medical cohort, patients with double mutation had worse 3-year OS of 18%, compared with 35% without double mutation (P = 0.023). CONCLUSIONS:Double mutation of APC and PIK3CA predicts inferior response to preoperative chemotherapy and poor survival in patients with CLM.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Yamashita S,Chun YS,Kopetz SE,Maru D,Conrad C,Aloia TA,Vauthey JN

doi

10.1097/SLA.0000000000002245

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

1080-1085

issue

6

eissn

0003-4932

issn

1528-1140

pii

00000658-202012000-00032

journal_volume

272

pub_type

杂志文章
  • Postoperative Morbidity After Radical Resection of Primary Retroperitoneal Sarcoma: A Report From the Transatlantic RPS Working Group.

    abstract:OBJECTIVE:To investigate the safety of radical resection for retroperitoneal sarcoma (RPS). BACKGROUND:The surgical management of RPS frequently involves complex multivisceral resection. Improved oncologic outcomes have been demonstrated with this approach compared to marginal excision, but the safety of radical resec...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000002250

    authors: MacNeill AJ,Gronchi A,Miceli R,Bonvalot S,Swallow CJ,Hohenberger P,Van Coevorden F,Rutkowski P,Callegaro D,Hayes AJ,Honoré C,Fairweather M,Cannell A,Jakob J,Haas RL,Szacht M,Fiore M,Casali PG,Pollock RE,Barretta F,

    更新日期:2018-05-01 00:00:00

  • Subclassification of Microscopic Vascular Invasion in Hepatocellular Carcinoma.

    abstract:OBJECTIVE:To investigate whether subclassification of microscopic vascular invasion (MiVI) affects the long-term outcome after curative surgical resection or liver transplantation (LT) in patients with hepatocellular carcinoma (HCC). SUMMARY OF BACKGROUND DATA:The most important factor for TNM staging in HCC is MiVI, ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003781

    authors: Kang I,Jang M,Lee JG,Han DH,Joo DJ,Kim KS,Kim MS,Choi JS,Kim SI,Park YN,Choi GH

    更新日期:2020-01-14 00:00:00

  • Reductive surgery plus percutaneous isolated hepatic perfusion for multiple advanced hepatocellular carcinoma.

    abstract:OBJECTIVE:To evaluate the efficacy of a novel 2-stage treatment with reductive surgery plus percutaneous isolated hepatic perfusion (PIHP) for multiple hepatocellular carcinoma (HCC), which was previously unresectable. SUMMARY BACKGROUND DATA:Surgical resection is the treatment of choice for HCC, but the majority of p...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/01.sla.0000103133.03688.3d

    authors: Ku Y,Iwasaki T,Tominaga M,Fukumoto T,Takahashi T,Kido M,Ogata S,Takahashi M,Kuroda Y,Matsumoto S,Obara H

    更新日期:2004-01-01 00:00:00

  • Total laparoscopic pancreaticoduodenectomy for pancreatic ductal adenocarcinoma: oncologic advantages over open approaches?

    abstract:OBJECTIVE:To directly compare the oncologic outcomes of TLPD and OPD in the setting of pancreatic ductal adenocarcinoma. BACKGROUND:Total laparoscopic pancreaticoduodenectomy (TLPD) has been demonstrated to be feasible and may have several potential advantages over open pancreaticoduodenectomy (OPD), including lower b...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000000937

    authors: Croome KP,Farnell MB,Que FG,Reid-Lombardo KM,Truty MJ,Nagorney DM,Kendrick ML

    更新日期:2014-10-01 00:00:00

  • What Promotes Surgeon Practice Change? A Scoping Review of Innovation Adoption in Surgical Practice.

    abstract:OBJECTIVE:The goal of this scoping review was to summarize the literature on facilitators and barriers to surgical practice change. This information can inform research to implement best practices and evaluate new surgical innovations. BACKGROUND:In an era of accelerated innovations, surgeons face the difficult decisi...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004355

    authors: Arroyo NA,Gessert T,Hitchcock M,Tao M,Smith CD,Greenberg C,Fernandes-Taylor S,Francis DO

    更新日期:2020-08-26 00:00:00

  • A rational approach to surgery of the chronic venous statis syndrome.

    abstract::Ambulatory venous pressure (AVP) and ascending and retro-grade phlebography have been used to elucidate the precise pathogenetic factors in cases of venous stasis. On the bases of this information, procedures aimed at the correction of the particular pathophysiological alterations were carried out. Fifty-two lower ext...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198201001-00004

    authors: Schanzer H,Peirce EC 2nd

    更新日期:1982-01-01 00:00:00

  • Prehospital intravenous fluid administration is associated with higher mortality in trauma patients: a National Trauma Data Bank analysis.

    abstract:OBJECTIVE:Prehospital intravenous (IV) fluid administration is common in trauma patients, although little evidence supports this practice. We hypothesized that trauma patients who received prehospital IV fluids have higher mortality than trauma patients who did not receive IV fluids in the prehospital setting. METHODS...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e318207c24f

    authors: Haut ER,Kalish BT,Cotton BA,Efron DT,Haider AH,Stevens KA,Kieninger AN,Cornwell EE 3rd,Chang DC

    更新日期:2011-02-01 00:00:00

  • Axillary-contralateral brachial artery bypass for arm ischemia.

    abstract::A right axillary to left brachial arterial bypass (saphenous vein) was used in the treatment of a left subclavian artery obstruction secondary to radical mastectomy and irradiation 28 years previously. The axillary bypass was chosen over other surgical approaches because of its simplicity and efficacy. ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197406000-00001

    authors: Jacobson JH 2nd,Baron MG

    更新日期:1974-06-01 00:00:00

  • Brush border transport of glutamine and other substrates during sepsis and endotoxemia.

    abstract::The effects of severe infection on luminal transport of amino acids and glucose by the small intestine were investigated. Studies were done in endotoxin-treated rats and in septic patients who underwent resection of otherwise normal small bowel. In rats the kinetics of the brush border glutamine transporter and the gl...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199105000-00004

    authors: Salloum RM,Copeland EM,Souba WW

    更新日期:1991-05-01 00:00:00

  • Carcinoid tumors of the rectum: a multi-institutional international collaboration.

    abstract:OBJECTIVE:This study aims to describe recent experience with rectal carcinoids in European and North American centers. BACKGROUND:While considered indolent, the propensity of carcinoids to metastasize can be significant. METHODS:Rectal carcinoid patients were identified from prospective databases maintained at 9 inst...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0b013e3181fb8df6

    authors: Shields CJ,Tiret E,Winter DC,International Rectal Carcinoid Study Group.

    更新日期:2010-11-01 00:00:00

  • Use of radionuclide imaging in the early diagnosis and treatment of renal allograft rejection.

    abstract::Data are presented on the clinical application of radionuclide imaging to evaluate changes in cadaver transplant function in the immediate postoperative period. The method uses orthoiodohippuric acid (hippuran) administered IV, with scintillation imaging, and curve analysis by a digital computer. An initial study is a...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197505000-00013

    authors: Mandel SR,Mattern WD,Staab E,Johnson G Jr

    更新日期:1975-05-01 00:00:00

  • Laser surgery in exsanguinating liver injury.

    abstract::Thirty-two conditioned 15-18 kg dogs underwent laparotomy, heparinization, left lateral hepatic lobe injury and subsequent partial left lateral hepatic lobectomy. The hemostatic capabilities of the surgical scalpel combined with suture ligatures and stay sutures, the Bovie, and the CO2 laser were compared. The CO2 las...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197501000-00016

    authors: Fidler JP,Hoefer RW,Polanyi TG,Bredemeier HC,Siler VE,Altemeier WA

    更新日期:1975-01-01 00:00:00

  • Pulmonary microembolism associated with massive transfusion: I. Physiologic effects and comparison in vivo of standard and dacron wool (swank) blood transfusion filters in its prevention.

    abstract::Pulmonary microembolism of microaggregates associated with massive blood transfusion may be a cause of post-traumatic pulmonary embolism. The purpose of this study was to investigate in the dog the influence on certain physiologic parameters of transfusion of blood containing platelet: white blood cell: fibrin (PWF) a...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197501000-00012

    authors: Dawidson I,Barrett JA,Miller E,Litwin MS

    更新日期:1975-01-01 00:00:00

  • Barium granuloma of the rectum: an uncommon complication of barium enema.

    abstract::Barium sulfate granuloma of the rectum may develop when this contrast material is forced through a discontinuity in the rectal mucosa. The ensuing mass may be confused with carcinoma. Preoperative biopsy and attention to plain films will prevent unnecessary inappropriate surgery. ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197504000-00009

    authors: Lewis JW Jr,Kerstein MD,Koss N

    更新日期:1975-04-01 00:00:00

  • Long-term follow-up of brachial artery ligation in children.

    abstract::Ligation of the brachial artery in the antecubital fossa in children can be performed without limb loss, but the effect on subsequent limb growth is unknown. From 1969 to 1974, brachial artery ligation for insertion of a Scribner shunt was performed in 27 patients with a mean age of 8.4 years (range, 3 to 15 years). W...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199008000-00013

    authors: Lally KP,Foster CE 3rd,Chwals WJ,Brennan LP,Atkinson JB

    更新日期:1990-08-01 00:00:00

  • Microwave ablation for hepatic malignancies: a multiinstitutional analysis.

    abstract:OBJECTIVE:This study hypothesized that tumor size, number of tumors, surgical approach, and tumor histology significantly affected microwave ablation (MWA) success and recurrence-free survival. BACKGROUND:Although many hepatobiliary centers have adopted MWA, the factors that influence local control are not well descri...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000000234

    authors: Groeschl RT,Pilgrim CH,Hanna EM,Simo KA,Swan RZ,Sindram D,Martinie JB,Iannitti DA,Bloomston M,Schmidt C,Khabiri H,Shirley LA,Martin RC,Tsai S,Turaga KK,Christians KK,Rilling WS,Gamblin TC

    更新日期:2014-06-01 00:00:00

  • Prophylactic and preventive antibiotic therapy: timing, duration and economics.

    abstract::Previous studies have demonstrated that administered antibiotics must be active against major anticipated pathogens and must have reached sufficient concentrations in the tissue or body fluid at risk by the time of bacterial challenge if prophylactic therapy is to be maximally effective in reducing the infection rate ...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-197906000-00004

    authors: Stone HH,Haney BB,Kolb LD,Geheber CE,Hooper CA

    更新日期:1979-06-01 00:00:00

  • Metabolic and hormonal studies comparing three parenteral nutrition regimens in infants.

    abstract::Metabolic and hormonal studies were performed in 6 infants during the first 3 months of life while receiving 3 different types of parenteral nutrition: 1) 20% glucose and a nitrogen source (Dudrick's method) 2) 12% glucose, a nitrogen source and soybean fat emulsion (Intralipid method) and 3) 12% glucose, a nitrogen s...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-197507000-00012

    authors: Asch MJ,Sperling M,Fiser R,Leake R,Moore TC,Oh W

    更新日期:1975-07-01 00:00:00

  • General surgery in patients on maintenance hemodialysis.

    abstract::A review of the experience with 66 patients on chronic hemodialysis who underwent 67 major surgical procedures is presented. There were 58 general surgical procedures, and nine major cardiovascular procedures including four emergency cardiac valve replacements. The preoperative, intraoperative and postoperative manage...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197406000-00008

    authors: Haimov M,Glabman S,Schupak E,Neff M,Burrows L

    更新日期:1974-06-01 00:00:00

  • Bacillus anthracis as an agent of bioterrorism: a review emphasizing surgical treatment.

    abstract:OBJECTIVE:To familiarize surgeons with the specific complications of cutaneous, gastrointestinal, inhalation, and systemic infection with Bacillus Anthracis, which may require surgical treatment. SUMMARY BACKGROUND DATA:The recent cases of intentional exposure to Bacillus Anthracis in the United States make familiarit...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/00000658-200207000-00004

    authors: Binkley CE,Cinti S,Simeone DM,Colletti LM

    更新日期:2002-07-01 00:00:00

  • Phospholipase A2 isoforms are altered in chronic pancreatitis.

    abstract:OBJECTIVE:To determine if phospholipase A2 (PLA2) type II and type IV mRNA expression and protein are altered in chronic pancreatitis. SUMMARY BACKGROUND DATA:PLA2s have an important regulatory function in several signaling pathways, especially in inflammation. In this study, we examined the expression of three PLA2 i...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199802000-00011

    authors: Kashiwagi M,Friess H,Uhl W,Graber H,Duarte R,Zimmermann A,Büchler MW

    更新日期:1998-02-01 00:00:00

  • Prognosis in acute organ-system failure.

    abstract::This prospective study describes the current prognosis of patients in acute Organ System Failure (OSF). Objective definitions were developed for five OSFs, and then 5677 ICU admissions from 13 hospitals were monitored. The number and duration of OSF were linked to outcome at hospital discharge for each of the 2719 ICU...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198512000-00004

    authors: Knaus WA,Draper EA,Wagner DP,Zimmerman JE

    更新日期:1985-12-01 00:00:00

  • Is Physician Work in Procedure and Test Codes More Highly Valued Than That in Evaluation and Management Codes?

    abstract:OBJECTIVES:To determine whether the Centers for Medicare & Medicaid Services (CMS) Physician Fee Schedule confers higher value for physician work in procedure and test codes than in Evaluation and Management (E/M) codes. BACKGROUND:Medicare Payment Advisory Commission previously demonstrated that time for medical serv...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000000990

    authors: Kerber KA,Raphaelson M,Barkley GL,Burke JF

    更新日期:2015-08-01 00:00:00

  • Pigment gallstones form as a composite of bacterial microcolonies and pigment solids.

    abstract::Although previous studies have suggested that bacteria may contribute to pigment gallstone formation, the current experiments provide evidence that bacteria have a central role in this process. The studies included scanning electron microscopy (SEM) of gallstones, measurements of bacterial adherence to gallstones in v...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198709000-00002

    authors: Stewart L,Smith AL,Pellegrini CA,Motson RW,Way LW

    更新日期:1987-09-01 00:00:00

  • Longitudinal pancreaticojejunostomy in chronic relapsing pancreatitis with onset in childhood.

    abstract::Despite the rarity of chronic relapsing pancreatitis in children, in the last 15 years at Vanderbilt University Medical Center and its Children's Hospital we have used longitudinal pancreaticojejunostomy in treatment of eight patients whose symptoms began in childhood. Duration of symptoms ranged from 2 to 36 years. S...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198405000-00017

    authors: Scott HW Jr,Neblett WW,O'Neill JA Jr,Sawyers JL,Avant GS,Starnes VA

    更新日期:1984-05-01 00:00:00

  • The Unconventional Role for Gastric Volume in the Response to Bariatric Surgery for Both Weight Loss and Glucose Lowering.

    abstract:OBJECTIVE:To study the relationship between the amount of surgery-induced gastric volume reduction and long-term weight loss and glucose tolerance. BACKGROUND DATA:Vertical sleeve gastrectomy (VSG) has recently surpassed gastric bypass to become the most popular surgical intervention to induce sustained weight loss. B...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003240

    authors: Evers SS,Lewis AG,Tong C,Shao Y,Alvarez R,Ridelman E,Grant B,Seeley RJ

    更新日期:2020-06-01 00:00:00

  • Effects of superoxide dismutase and allopurinol on the survival of acute island skin flaps.

    abstract::We have demonstrated previously that oxygen-derived free radicals are important mediators of tissue injury following ischemia (total venous occlusion) and reperfusion in small (3 cm X 6 cm) island skin flaps in rats. In this study, we evaluated extension of this concept to regional ischemia in large (8 cm X 8 cm) acut...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198503000-00018

    authors: Im MJ,Manson PN,Bulkley GB,Hoopes JE

    更新日期:1985-03-01 00:00:00

  • Multiple cutaneous malignant melanomas with features of primary melanoma.

    abstract::A case report and review of the literature regarding multiple primary melanomas, and a discussion of the histologic differentiation between cutaneous primary melanomas and dermal metastases are presented. This report concerns a patient who, following wide surgical resection of a 1.3 mm thick primary melanoma with sate...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198102000-00021

    authors: Unger SW,Wanebo HJ,Cooper PH

    更新日期:1981-02-01 00:00:00

  • Survival outcome of local excision versus radical resection of colon or rectal carcinoma: a Surveillance, Epidemiology, and End Results (SEER) population-based study.

    abstract:OBJECTIVE:To compare cancer-specific results of local excision with major resection. BACKGROUND:Technological advances have enabled endoscopic and local excision techniques to be applied in the treatment of early colorectal cancer in preference to radical surgery. METHOD:Patients with stage 0 (carcinoma in situ) or s...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3182a4e85a

    authors: Bhangu A,Brown G,Nicholls RJ,Wong J,Darzi A,Tekkis P

    更新日期:2013-10-01 00:00:00

  • Technical refinements and results in full-right full-left splitting of the deceased donor liver.

    abstract:OBJECTIVE:Splitting of the liver at the line of Cantlie of otherwise healthy people is accepted worldwide as a reasonable procedure for the donors in adult living donor liver transplantation. A similar operation is still considered as experimental if performed in the deceased donor liver. The aim of this study is to ev...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000189120.62975.0d

    authors: Broering DC,Wilms C,Lenk C,Schulte am Esch J 2nd,Schönherr S,Mueller L,Kim JS,Helmke K,Burdelski M,Rogiers X

    更新日期:2005-12-01 00:00:00