Pathogenesis of paralytic ileus: intestinal manipulation opens a transient pathway between the intestinal lumen and the leukocytic infiltrate of the jejunal muscularis.

Abstract:

OBJECTIVE:To investigate the existence of a pathway between intraluminal products and the muscularis leukocytic infiltrate. SUMMARY BACKGROUND DATA:Mild intestinal manipulation or lipopolysaccharide initiates an intense inflammatory response within the intestinal muscularis, resulting in paralytic ileus. A major potential morbidity factor in ileus is luminal bacterial overgrowth. METHODS:ACI rats were subjected to small bowel manipulation, after which fluorescent carboxylated or paramagnetic microspheres were administered into the gut lumen. Animals were killed between 0 and 24 hours; unoperated rats served as controls. RESULTS:Intestinal manipulation led to an early transient transference of microspheres from the intestinal lumen into mesenteric lymph that was not observed in unmanipulated controls. A time- dependent, significant increase in microsphere-laden phagocytes was observed within the intestinal muscularis. Immunohistochemistry and electron microscopy of the intestinal muscularis identified the phagocytes as extravasating ED1+ monocytes. Interruption of the lymphatics abolished the accumulation of microsphere-laden monocytes within the muscularis, although a significant monocytic recruitment could still be observed within the intestinal muscularis. CONCLUSIONS:These data show that intestinal manipulation leads to a transient increase in mucosal permeability and that the extraintestinal endocytotic uptake of transferred particles by circulating monocytes precedes their infiltration into the gut wall. The transference of luminal bacterial products may follow a similar route and time course as the microspheres. The authors hypothesize that endogenous bacterial products act synergistically with the inflammatory response within the postsurgical intestinal muscularis, leading to an exacerbation of postoperative ileus.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Schwarz NT,Beer-Stolz D,Simmons RL,Bauer AJ

doi

10.1097/00000658-200201000-00005

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

31-40

issue

1

eissn

0003-4932

issn

1528-1140

journal_volume

235

pub_type

杂志文章
  • Host defense against opportunist microorganisms following trauma. II. Changes in complement and immunoglobulins in patients with abdominal trauma and in septic patients without trauma.

    abstract::Total hemolytic complement (CH50), conversion of C3 by inulin and cobra venom factor (CoVF), and immunochemical levels of Clq, C4, C2, C3, C5, factor B, properdin, C3b inactivator (KAF), and immunoglobulins (Igs) G, A, and M were measured in the sera of ten patients with abdominal trauma and ten medical patients with ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197807000-00017

    authors: Bjornson AB,Altemeier WA,Bjornson HS

    更新日期:1978-07-01 00:00:00

  • Anti-TNF Therapy Is Associated With an Increased Risk of Postoperative Morbidity After Surgery for Ileocolonic Crohn Disease: Results of a Prospective Nationwide Cohort.

    abstract:OBJECTIVE:To determine the risk factors of morbidity after surgery for ileocolonic Crohn disease (CD). SUMMARY BACKGROUND DATA:The risk factors of morbidity after surgery for CD, particularly the role of anti-TNF therapy, remain controversial and have not been evaluated in a large prospective cohort study. METHODS:Fr...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000002017

    authors: Brouquet A,Maggiori L,Zerbib P,Lefevre JH,Denost Q,Germain A,Cotte E,Beyer-Berjot L,Munoz-Bongrand N,Desfourneaux V,Rahili A,Duffas JP,Pautrat K,Denet C,Bridoux V,Meurette G,Faucheron JL,Loriau J,Guillon F,Vicaut E

    更新日期:2018-02-01 00:00:00

  • Insulin treatment improves hepatic morphology and function through modulation of hepatic signals after severe trauma.

    abstract:OBJECTIVE:The purpose of the present study was to determine the effect of insulin therapy on hepatic function, structure, and hepatic mRNA and protein cytokine expression during the hypermetabolic cascade post burn. SUMMARY BACKGROUND DATA:Liver function and morphology are crucial for survival of patients suffering fr...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000133353.57674.cd

    authors: Klein D,Schubert T,Horch RE,Jauch KW,Jeschke MG

    更新日期:2004-08-01 00:00:00

  • Enhanced Recovery After Surgery (ERAS) Pathway in Esophagectomy: Is a Reasonable Prediction of Hospital Stay Possible?

    abstract:OBJECTIVE:To assess whether perioperative variables or deviation from enhanced recovery after surgery (ERAS) items could be associated with delayed discharge after esophagectomy, and to convert them into a scoring system to predict it. SUMMARY BACKGROUND DATA:ERAS perioperative pathways have been recently applied to e...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002775

    authors: Parise P,Ferrari C,Cossu A,Puccetti F,Elmore U,De Pascale S,Garutti L,Fumagalli UR,Di Serio MS,Rosati R

    更新日期:2019-07-01 00:00:00

  • Clinicopathological characteristics and molecular analyses of multifocal intraductal papillary mucinous neoplasms of the pancreas.

    abstract:OBJECTIVE:To examine the clinicopathologic features and clonal relationship of multifocal intraductal papillary mucinous neoplasms (IPMNs) of the pancreas. BACKGROUND:Intraductal papillary mucinous neoplasms are increasingly diagnosed cystic precursor lesions of pancreatic cancer. Intraductal papillary mucinous neopla...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3182378a18

    authors: Matthaei H,Norris AL,Tsiatis AC,Olino K,Hong SM,dal Molin M,Goggins MG,Canto M,Horton KM,Jackson KD,Capelli P,Zamboni G,Bortesi L,Furukawa T,Egawa S,Ishida M,Ottomo S,Unno M,Motoi F,Wolfgang CL,Edil BH,Cameron J

    更新日期:2012-02-01 00:00:00

  • Carotid sinus syndrome: treatment by carotid sinus denervation.

    abstract::Hypersensitive carotid sinus is a rare cause of spontaneous syncopal attacks. It must be differentiated from the other more common causes, such as intrinsic cardiac disease, vasovagal responses, postural hypotension and cerebrovascular insufficiency, although it may accompany these conditions. The definition of caroti...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197905000-00006

    authors: Trout HH 3rd,Brown LL,Thompson JE

    更新日期:1979-05-01 00:00:00

  • Congenital mixed vascular deformities of the lower limb: the relevance of lymphatic abnormalities to their diagnosis and treatment.

    abstract::Nineteen patients with vascular deformities of the lower extremity were studied and were classified into three groups based on their clinical and angiographic findings. 1) The Klippel or Venous Dysplasia Group (n = 8) demonstrated: cutaneous nevi of metameric distribution, congenital varices (many of which were anomal...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197702000-00005

    authors: O'Donnell TF Jr

    更新日期:1977-02-01 00:00:00

  • The comparative survivals of alcoholics versus nonalcoholics after distal splenorenal shunt.

    abstract::Survival after distal splenorenal shunt in appreciably better in nonalcoholic patients than in alcoholics. This increase in survival does not appear to be dependent upon the state of biochemical liver function or the severity of changes in liver histology since these latter were similar for both groups. We suggest tha...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197805000-00008

    authors: Zeppa R,Hensley GT,Levi JU,Bergstresser PR,Hutson DG Sr,Livingstone AS,Schiff ER,Fink P

    更新日期:1978-05-01 00:00:00

  • In-hospital Surgical Delay Does Not Increase the Risk for Perforated Appendicitis in Children: A Single-center Retrospective Cohort Study.

    abstract:OBJECTIVE:To investigate the correlation between in-hospital surgical delay before appendectomy for suspected appendicitis and the finding of perforated appendicitis in children. METHODS:All children undergoing acute appendectomy for suspected acute appendicitis at Karolinska University Hospital, Stockholm, Sweden fro...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001694

    authors: Almström M,Svensson JF,Patkova B,Svenningsson A,Wester T

    更新日期:2017-03-01 00:00:00

  • Remission of type 2 diabetes after Roux-en-Y gastric bypass or sleeve gastrectomy is associated with a distinct glycemic profile.

    abstract:BACKGROUND:Roux-en-Y gastric bypass (RYGBP) and sleeve gastrectomy (SG) have been associated with a high remission rate of type 2 diabetes mellitus (T2DM). However, whether such remission is associated with full restoration of postprandial glucose profile and/or the potentially nonrestored glycemic profile is associate...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000000586

    authors: Jiménez A,Ceriello A,Casamitjana R,Flores L,Viaplana-Masclans J,Vidal J

    更新日期:2015-02-01 00:00:00

  • The effect of mesh removal and selective neurectomy on persistent postherniotomy pain.

    abstract:UNLABELLED:SUMMARY BACKGROUND DATA AND OBJECTIVE: Persistent pain affects everyday activities in 5% to 8% of patients after groin hernia repair. Because previous reports on the effect of neurectomy and/or mesh removal suffer from methodological problems we performed a detailed prospective trial of the effect of neurect...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/SLA.0b013e31818eec49

    authors: Aasvang EK,Kehlet H

    更新日期:2009-02-01 00:00:00

  • Michelassi II Strictureplasty for Crohn's Disease: A New Side-to-Side Isoperistaltic Strictureplasty With Discontinuous Bowel Loops.

    abstract:OBJECTIVE:We report on a new side-to-side isoperistaltic strictureplasty (SSIS), the Michelassi II or end-to-side-to-side-to-end strictureplasty, performed with discontinuous bowel loops. SUMMARY BACKGROUND DATA:The SSIS Michelassi strictureplasty was described a quarter of a century ago to avoid massive bowel resecti...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003430

    authors: Mege D,Michelassi F

    更新日期:2020-01-01 00:00:00

  • Should perioperative supplemental oxygen be routinely recommended for surgery patients? A Bayesian meta-analysis.

    abstract:OBJECTIVE:The purpose of this study is to use updated data and Bayesian methods to evaluate the effectiveness of hyperoxia to reduce surgical site infections (SSIs) and/or mortality in both colorectal and all surgery patients. Because few trials assessed potential harms of hyperoxia, hazards were not included. BACKGRO...

    journal_title:Annals of surgery

    pub_type: 杂志文章,meta分析

    doi:10.1097/SLA.0b013e31826cc8da

    authors: Kao LS,Millas SG,Pedroza C,Tyson JE,Lally KP

    更新日期:2012-12-01 00:00:00

  • Morbidity and mortality after pelvic exenteration for colorectal adenocarcinoma.

    abstract::A retrospective analysis was made of the complications from pelvic exenterations performed over the past 30 years for colorectal adenocarcinoma at the Roswell Park Cancer Institute. Seventy-five patients underwent exenteration, 51 for primary disease (PD) and 24 for recurrent disease (RD). Both total and posterior exe...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199201000-00009

    authors: Hafner GH,Herrera L,Petrelli NJ

    更新日期:1992-01-01 00:00:00

  • Reperfusion inhibits elevated splanchnic prostanoid production after hemorrhagic shock.

    abstract::The effect of reperfusion following hemorrhagic shock on splanchnic prostanoid release was studied. Anesthetized male rats were bled to a mean arterial blood pressure of 30 mmHg for 30 minutes and either killed or treated with shed blood for 60 minutes and then killed. The superior mesenteric arterial bed was cannulat...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199012000-00006

    authors: Myers SI,Taylor BJ,Stanislawska M

    更新日期:1990-12-01 00:00:00

  • Impact of pancreatic head resection on direct medical costs in patients with chronic pancreatitis.

    abstract:OBJECTIVE:To quantitate disease-specific hospital-based medical costs in 34 patients with chronic pancreatitis before and after treatment by either duodenal-preserving pancreatic head resection (DPPHR) or pylorus-preserving pancreaticoduodenectomy (PPPD). SUMMARY BACKGROUND DATA:Pancreatic head resection in selected p...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200111000-00012

    authors: Howard TJ,Jones JW,Sherman S,Fogel E,Lehman GA

    更新日期:2001-11-01 00:00:00

  • Gallstone pancreatitis: biliary tract pathology in relation to time of operation.

    abstract::During a 29-month trial, 65 patients with acute gallstone pancreatitis were randomly selected for biliary tract explorations either within 73 hours of admission (36 patients) or at three months following remission with nonoperative measures (29 patients, with five others awaiting elective operation). The details of su...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198109000-00008

    authors: Stone HH,Fabian TC,Dunlop WE

    更新日期:1981-09-01 00:00:00

  • Activating KRAS mutations and overexpression of epidermal growth factor receptor as independent predictors in metastatic colorectal cancer patients treated with cetuximab.

    abstract:OBJECTIVE:Cetuximab, a monoclonal antibody targeting epidermal growth factor receptor (EGFR), has been proven to be efficient in metastatic colorectal cancer (mCRC); however, the therapeutic response is variable and markers predictive of response are urgently required. This study was conducted to determinate the predic...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181bc9d96

    authors: Yen LC,Uen YH,Wu DC,Lu CY,Yu FJ,Wu IC,Lin SR,Wang JY

    更新日期:2010-02-01 00:00:00

  • Comparison of amputation with limb-sparing operations for adult soft tissue sarcoma of the extremity.

    abstract::The use of amputation in extremity soft tissue sarcoma has been decreasing at Memorial Sloan-Kettering Cancer Center (MSKCC) over the last 15 years. In an attempt to define the efficacy and future role of amputation in extremity soft tissue sarcoma, a prospective sarcoma database compiled at MSKCC from July 1982 to Ja...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199203000-00012

    authors: Williard WC,Hajdu SI,Casper ES,Brennan MF

    更新日期:1992-03-01 00:00:00

  • Carcinoid tumors of the rectum: a multi-institutional international collaboration.

    abstract:OBJECTIVE:This study aims to describe recent experience with rectal carcinoids in European and North American centers. BACKGROUND:While considered indolent, the propensity of carcinoids to metastasize can be significant. METHODS:Rectal carcinoid patients were identified from prospective databases maintained at 9 inst...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0b013e3181fb8df6

    authors: Shields CJ,Tiret E,Winter DC,International Rectal Carcinoid Study Group.

    更新日期:2010-11-01 00:00:00

  • Endocrine tumors of the duodenum. Clinical characteristics and hormone content.

    abstract::Nineteen patients with primary duodenal carcinoid were analysed retrospectively, and eight of the tumors were immunocytochemically examined. One tumor contained somatostatin, two tumors gastrin, two tumors both these peptides, and one tumor contained serotonin. In two tumors no peptide or amine could be demonstrated. ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198304000-00003

    authors: Lasson A,Alwmark A,Nobin A,Sundler F

    更新日期:1983-04-01 00:00:00

  • Recurrent carotid stenosis. A five-year series of 65 reoperations.

    abstract::From 1979 to 1983, 1726 carotid endarterectomies were performed at the Cleveland Clinic. During this period, 39 men (mean age, 60 years) and 22 women (mean age, 63 years) required 65 reoperations (3.8%) for correction of recurrent carotid stenosis occurring 3 to 194 months (mean, 42 months) after previous endarterecto...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198507000-00004

    authors: Das MB,Hertzer NR,Ratliff NB,O'Hara PJ,Beven EG

    更新日期:1985-07-01 00:00:00

  • Hospital length of stay after admission for traumatic injury in Canada: a multicenter cohort study.

    abstract:OBJECTIVE:To describe acute care length of stay (LOS) over all consecutive hospitalizations for the injury and according to level of care [intensive care unit (ICU), intermediate care, general ward], compare observed and expected LOS, and identify predictors of LOS. BACKGROUND:Prolonged LOS has important consequences ...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000000624

    authors: Moore L,Stelfox HT,Turgeon AF,Nathens A,Bourgeois G,Lapointe J,Gagné M,Lavoie A

    更新日期:2014-07-01 00:00:00

  • Should adenocarcinoma of the esophagogastric junction be classified as esophageal cancer? A comparative analysis according to the seventh AJCC TNM classification.

    abstract:OBJECTIVE:The aim of this study was to evaluate the adequacy of esophageal classification for adenocarcinoma of the esophagogastric junction (AEJ) of the seventh American Joint Committee on Cancer (AJCC) TNM classification. BACKGROUND:The seventh AJCC TNM classification proposed the new classification for AEJ as a par...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31824beb95

    authors: Suh YS,Han DS,Kong SH,Lee HJ,Kim YT,Kim WH,Lee KU,Yang HK

    更新日期:2012-05-01 00:00:00

  • Subareolar versus peritumoral injection for location of the sentinel lymph node.

    abstract:BACKGROUND:Sentinel lymph node (SLN) biopsy is fast becoming the standard for testing lymph node involvement in many institutions. However, questions remain as to the best method of injection. The authors hypothesized that a subareolar injection of material would drain to the same lymph node as a peritumoral injection,...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000658-199906000-00013

    authors: Klimberg VS,Rubio IT,Henry R,Cowan C,Colvert M,Korourian S

    更新日期:1999-06-01 00:00:00

  • Femoroperoneal bypass: evaluation of potential for revascularization of the severely ischemic lower extremity.

    abstract::In 79 patients in whom distal small vessel bypass with autogenous vein was used for revascularization because of gangrene, gangrenous ulceration or rest pain, 14 had femoroperoneal bypasses. Femorotibial or femoroperoneal bypasses were performed in those patients in whom no popliteal runoff was present on pre-operativ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197502000-00010

    authors: Reichle FA,Tyson RR

    更新日期:1975-02-01 00:00:00

  • Variation in practice and resource utilization associated with the diagnosis and management of appendicitis at freestanding children's hospitals: implications for value-based comparative analysis.

    abstract:OBJECTIVE:To characterize the scope and magnitude of practice variation associated with the diagnosis and treatment of appendicitis at freestanding children's hospitals. BACKGROUND:Variation in care has been associated with poor outcomes and is believed to be a key driver of excess health care spending. METHODS:Retro...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000000246

    authors: Rice-Townsend S,Barnes JN,Hall M,Baxter JL,Rangel SJ

    更新日期:2014-06-01 00:00:00

  • Additional resection of an intraoperative margin-positive proximal bile duct improves survival in patients with hilar cholangiocarcinoma.

    abstract:OBJECTIVE:To assess the survival benefit of additional resection of an intraoperative positive proximal bile duct margin (BD(Marg)) in patients undergoing hepatectomy for hilar cholangiocarcinoma (HCCA). SUMMARY BACKGROUND DATA:Intraoperative evidence of invasive cancer at the proximal (BD(Marg)) is associated with a ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3182368f85

    authors: Ribero D,Amisano M,Lo Tesoriere R,Rosso S,Ferrero A,Capussotti L

    更新日期:2011-11-01 00:00:00

  • Intramuscular pressure in the lower leg in deep vein thrombosis and phlegmasia cerulae dolens.

    abstract::The influence of deep vein thrombosis on intramuscular pressure was evaluated in 22 patients by means of the wick technique. Intramuscular pressure was measured in the anterior tibial and the deep posterior compartments in both legs before and during treatment. The intramuscular pressure was significantly (p less than...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198304000-00013

    authors: Qvarfordt P,Eklöf B,Ohlin P

    更新日期:1983-04-01 00:00:00

  • Regional therapy in the management of intrahepatic recurrence after surgery for hepatoma.

    abstract::The significance of regional therapy against the intrahepatic recurrence for hepatocellular carcinoma (HCC) was evaluated. During the past 6 years, 101 patients who had radical operations for HCC (liver cirrhosis, 75%; chronic hepatitis, 22%) were followed. Forty-seven patients (47%) had recurrences; the liver was the...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198707000-00006

    authors: Sasaki Y,Imaoka S,Fujita M,Miyoshi Y,Ohigashi H,Ishikawa O,Furukawa H,Koyama H,Iwanaga T,Kasugai H

    更新日期:1987-07-01 00:00:00