Impaired nonspecific cellular immunity in experimental cholestasis.

Abstract:

:The abilities of polymorphonuclear leukocytes (PMN) and pulmonary alveolar macrophages (PAM), to demonstrate chemotaxis, phagocytosis, and superoxide release after bile duct ligation in the rat were investigated to determine the effect of cholestasis on nonspecific cellular immune mechanisms. Chemotactic response to C5a and FMLP, phagocytosis of 14C labeled Staphylococcus aureus, and zymosan-induced superoxide release were evaluated 21 days after bile duct ligation (BDL), sham operation, or in normal controls. Serum total bilirubin level was elevated after BDL (p less than 0.01). Chemotactic ability was similar to each group. PMN phagocytic uptake of 14C labeled Staphylococcus aureus was depressed in BDL (p less than 0.05). BDL rats exhibited impaired PAM phagocytic indices and improved PMN superoxide release (p less than 0.03). PAM superoxide release was similar in each study group. Alterations in phagocytic function with cholestasis are important deficits in nonspecific cellular immunity that may contribute to the high incidence of infective complications associated with obstructive jaundice.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Roughneen PT,Drath DB,Kulkarni AD,Rowlands BJ

doi

10.1097/00000658-198711000-00004

subject

Has Abstract

pub_date

1987-11-01 00:00:00

pages

578-82

issue

5

eissn

0003-4932

issn

1528-1140

journal_volume

206

pub_type

杂志文章
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    authors: Detmer DE,Tyson TJ

    更新日期:1978-02-01 00:00:00

  • Plasma cholecystokinin and pancreatic polypeptide response after radical pancreatoduodenectomy with Billroth I and Billroth II type of reconstruction.

    abstract::This study was conducted to elucidate plasma cholecystokinin (CCK) and pancreatic polypeptide (PP) response after pancreatoduodenectomy and to compare response of CCK and PP in patients who had pancreatoduodenectomy with Billroth I and Billroth II type of reconstruction. Basal levels of plasma CCK were significantly l...

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    authors: Inoue K,Tobe T,Suzuki T,Hosotani R,Kogire M,Fuchigami A,Miyashita T,Tsuda K,Seino Y

    更新日期:1987-08-01 00:00:00

  • Gastrointestinal hemorrhage from adhesion-related mesenteric varices.

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    journal_title:Annals of surgery

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    doi:10.1097/00000658-197601000-00005

    authors: Moncure AC,Waltman AC,Vandersalm TJ,Linton RR,Levine FH,Abbott WM

    更新日期:1976-01-01 00:00:00

  • Perfect Registration Leads to Imperfect Performance: A Randomized Trial of Multimodal Intraoperative Image Guidance.

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    journal_title:Annals of surgery

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    authors: Dilley JWR,Hughes-Hallett A,Pratt PJ,Pucher PH,Camara M,Darzi AW,Mayer EK

    更新日期:2019-02-01 00:00:00

  • Metabolic changes in patients severely affected by tetanus.

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    doi:10.1097/00000658-199101000-00011

    authors: Hiraide A,Katayama M,Sugimoto H,Yoshioka T,Sugimoto T

    更新日期:1991-01-01 00:00:00

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    journal_title:Annals of surgery

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    更新日期:2012-06-01 00:00:00

  • Influence of Depression on Recovery After Major Noncardiac Surgery: A Prospective Cohort Study.

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    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000001448

    authors: Orri M,Boleslawski E,Regimbeau JM,Barry C,Hassler C,Gregoire E,Bachellier P,Scatton O,Mabrut JY,Adham M,Vibert E,Revah-Levy A,Farges O

    更新日期:2015-11-01 00:00:00

  • Operative management of renovascular hypertension.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197512000-00019

    authors: McCombs PR,Berkowitz HD,Roberts B

    更新日期:1975-12-01 00:00:00

  • Estrogen receptor and natural course of breast cancer.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197601000-00017

    authors: Singhakowinta A,Potter HG,Buroker TR,Samal B,Brooks SC,Vaitkevicius VK

    更新日期:1976-01-01 00:00:00

  • Comparison of amputation with limb-sparing operations for adult soft tissue sarcoma of the extremity.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199203000-00012

    authors: Williard WC,Hajdu SI,Casper ES,Brennan MF

    更新日期:1992-03-01 00:00:00

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    pub_type: 杂志文章,评审

    doi:10.1097/SLA.0000000000000206

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    更新日期:2013-12-01 00:00:00

  • Enhancement of gene therapy specificity for diffuse colon carcinoma liver metastases with recombinant herpes simplex virus.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199609000-00008

    authors: Carroll NM,Chiocca EA,Takahashi K,Tanabe KK

    更新日期:1996-09-01 00:00:00

  • Surgical management of acute cholecystitis in patients 65 years of age and older.

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    pub_type: 杂志文章

    doi:10.1097/00000658-198101000-00009

    authors: Glenn F

    更新日期:1981-01-01 00:00:00

  • Brush border transport of glutamine and other substrates during sepsis and endotoxemia.

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    doi:10.1097/00000658-199105000-00004

    authors: Salloum RM,Copeland EM,Souba WW

    更新日期:1991-05-01 00:00:00

  • Efficacy and Safety of Glutamine-supplemented Parenteral Nutrition in Surgical ICU Patients: An American Multicenter Randomized Controlled Trial.

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    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/SLA.0000000000001487

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    更新日期:2016-04-01 00:00:00

  • Surgical aspects in the treatment of patients with unilateral wilms tumor: a report from the SIOP 93-01/German Society of Pediatric Oncology and Hematology.

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    journal_title:Annals of surgery

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    doi:10.1097/SLA.0b013e31819ed92b

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    更新日期:2009-04-01 00:00:00

  • Post-traumatic changes in, and effect of colloid osmotic pressure on the distribution of body water.

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    doi:10.1097/00000658-198909000-00015

    authors: Böck JC,Barker BC,Clinton AG,Wilson MB,Lewis FR

    更新日期:1989-09-01 00:00:00

  • Improving the Quality of Ward-based Surgical Care With a Human Factors Intervention Bundle.

    abstract:OBJECTIVE:This study aimed to explore the impact of a human factors intervention bundle on the quality of ward-based surgical care in a UK hospital. SUMMARY OF BACKGROUND DATA:Improving the culture of a surgical team is a difficult task. Engagement with stakeholders before intervention is key. Studies have shown that ...

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    更新日期:2018-01-01 00:00:00

  • The effect of jejunoileal bypass on bile composition and the formation of billiary calculi.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197801000-00011

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    更新日期:1978-01-01 00:00:00

  • Main pancreatic ductal anatomy can direct choice of modality for treating pancreatic pseudocysts (surgery versus percutaneous drainage).

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    更新日期:2002-06-01 00:00:00

  • Disparities in surgical 30-day readmission rates for Medicare beneficiaries by race and site of care.

    abstract:OBJECTIVE:To determine whether black patients have higher odds of readmission than white patients after major surgery, and to ascertain whether these disparities are related to where black patients receive care. BACKGROUND:Racial disparities are known to exist for many aspects of surgical care. However, it is unknown ...

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    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000000326

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    更新日期:2014-06-01 00:00:00

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    journal_title:Annals of surgery

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    更新日期:1976-07-01 00:00:00

  • Response of protein and urea kinetics in burn patients to different levels of protein intake.

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    更新日期:1983-02-01 00:00:00

  • The Use of Caffeinated Substances by Surgeons for Cognitive Enhancement.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000000830

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    更新日期:2015-06-01 00:00:00

  • Multiple cutaneous malignant melanomas with features of primary melanoma.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198102000-00021

    authors: Unger SW,Wanebo HJ,Cooper PH

    更新日期:1981-02-01 00:00:00

  • Fetus-in-fetu: An ususual cause for abdominal mass in infancy.

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    pub_type: 杂志文章

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    authors: Grosfeld JL,Stepita DS,Nance WE,Palmer CG

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  • Preventing Parastomal Hernia Using a Modified Sugarbaker Technique With Composite Mesh During Laparoscopic Abdominoperineal Resection: A Randomized Controlled Trial.

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    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/SLA.0000000000001684

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    doi:10.1097/SLA.0000000000003430

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  • The Effect of Postoperative Complications After Minimally Invasive Esophagectomy on Long-term Survival: An International Multicenter Cohort Study.

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    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003772

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    doi:10.1097/00000658-199505000-00006

    authors: Spotnitz WD,Sanders RP,Hanks JB,Nolan SP,Tribble CG,Bergin JD,Zacour RK,Abbott RD,Kron IL

    更新日期:1995-05-01 00:00:00