Outcomes of endoscopy and novel pH-impedance parameters in children: is there a correlation?

Abstract:

OBJECTIVES:Discordance exists between outcomes of endoscopy, multichannel intraluminal impedance monitoring (pH-MII), MII baselines, and gastroesophageal reflux symptoms. The aim of the present study was to determine the association between endoscopy, pH-MII and MII baselines, in children with gastroesophageal reflux symptoms. METHODS:Endoscopies were graded for reflux esophagitis (RE). Biopsies of the distal esophagus were assessed for signs suggestive of esophagitis. Reflux index (RI), symptom association probability (SAP), number of reflux episodes, and mean baseline values were calculated. pH-MII was considered positive in children when RI was ≥ 3% and/or SAP was ≥ 95% and for infants when RI was ≥ 10% and/or SAP was ≥ 95%. Baselines were manually calculated and compared with an automated analysis. For MII baselines, patients were divided in 3 groups: normal endoscopy and negative overall pH-MII; normal endoscopy and an overall positive pH-MII; and RE. RESULTS:A total of 26 children and 14 infants were included, median age: 26.5 months (2 months-16.2 years). Thirteen (32.5%) had RE. A significant negative association was found for RI and MII baselines (P = 0.009) and between SAP and RE (P = 0.039, odds ratio 1.018). MII baseline values were predictive for neither conventional pH-MII parameters nor RE. Manual analysis and automated calculation of MII baselines showed a perfect correlation. Distal MII baselines were significantly lower in children with a positive overall pH-MII outcome compared with the proximal esophagus (P = 0.049). No significant changes were found in baselines among the different groups 1 to 3. CONCLUSIONS:Acid-related parameters are significantly related to MII baselines. A perfect correlation between manual- and automated analysis of MII baselines was found. Large prospective studies are needed to confirm the exact role of endoscopy and MII baselines.

authors

van der Pol RJ,Loots CM,Peeters L,Vandenplas Y,Hauser B,Devreker T,Omari TI,Benninga MA,van Wijk MP

doi

10.1097/MPG.0b013e31827167e2

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

196-200

issue

2

eissn

0277-2116

issn

1536-4801

pii

00005176-201302000-00018

journal_volume

56

pub_type

杂志文章
  • Impact of Breast Milk, Respiratory Insufficiency, and Gastroesophageal Reflux Disease on Enteral Feeding in Infants With Omphalocele.

    abstract:OBJECTIVES:The aim of this study was to document the process of achieving full enteral feeding in infants with omphalocele and to identify factors that affect feeding success. METHODS:After institutional review board approval (study no. 5100169), 123 infants with omphalocele, born between 1993 and 2011 were reviewed. ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001463

    authors: Haug S,St Peter S,Ramlogan S,Goff D,Thorpe D,Hopper A,Baerg J

    更新日期:2019-06-01 00:00:00

  • Reporting outcome measures in trials of infant colic.

    abstract:OBJECTIVES:Infant colic (IC), with an estimated prevalence of 5% to 25%, has a high impact on health care costs. Furthermore, reported negative sequelae are disturbed parent-infant interaction, increased susceptibility to abdominal pain, and even child abuse. Its etiology remains unknown, leading to a wide variety in i...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:10.1097/MPG.0000000000000412

    authors: Steutel NF,Benninga MA,Langendam MW,de Kruijff I,Tabbers MM

    更新日期:2014-09-01 00:00:00

  • Clinical Presentation of Acute Gastroenteritis in Children With Functional Abdominal Pain Disorders.

    abstract::Visceral hypersensitivity and abnormal coping are common in children with functional abdominal pain disorders (FAPDs). Thus, it would be expected that children with visceral hypersensitivity would report more pain if their gut is acutely inflamed. The aim of the study was to compare clinical symptoms and somatization ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章

    doi:10.1097/MPG.0000000000001466

    authors: Saps M,Mintjens S,Pusatcioglu CK,Cohen DM,Sternberg P

    更新日期:2017-08-01 00:00:00

  • Future horizons in the treatment of enteric neuropathies.

    abstract::Enteric neuropathies comprise a vast and disparate array of congenital and acquired disorders of the enteric nervous system (ENS), reflecting both the complexity of its neuronal composition and the many interactions that modulate its function. Although present therapeutic strategies, largely limited to surgery and the...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:10.1097/MPG.0b013e31812e667c

    authors: Thapar N

    更新日期:2007-12-01 00:00:00

  • Parenteral nutrition for infants: effect of high versus low calcium and phosphorus content.

    abstract::Calcium (Ca) and phosphorus (P) homeostasis were determined in 18 infants (birth weight, 2,810 +/- 135 g; gestational age, 37.4 +/- 0.5 weeks; mean +/- SEM) who received high or low Ca and P content (Ca, P) parenteral nutrition (PN) with a fixed, low dose of vitamin D (25 IU/dl). Nine infants were randomized into low ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Koo WW,Tsang RC,Steichen JJ,Succop P,Babcock D,Oestreich AE,Noseworthy J,Horn J,Farrell MK

    更新日期:1987-01-01 00:00:00

  • Severity scores in children with acute pancreatitis.

    abstract::Severity scores are used to predict the outcome of acute pancreatitis (AP). Several scores are used in adult patients, but none has been thoroughly validated for specific use in paediatric patients. We retrospectively collected data from 48 children with AP (13 severe and 35 mild). The main causes were trauma (23%), i...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e318254c1c7

    authors: Fabre A,Petit P,Gaudart J,Mas E,Vial J,Olives JP,Sarles J

    更新日期:2012-09-01 00:00:00

  • Are bilirubin and plasma lipid profiles of premature infants dependent on the lipid emulsion infused?

    abstract::The effect of a lipid emulsion containing long-chain triglycerides (LCT) and supplemented with L-carnitine on plasma lipids and bilirubin in premature neonates on total parenteral nutrition was compared to that of lipid emulsions containing either LCT or a mixture of LCT and medium-chain triglycerides (MCT). In a doub...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00005176-199507000-00004

    authors: Rubin M,Naor N,Sirota L,Moser A,Pakula R,Harell D,Sulkes J,Davidson S,Lichtenberg D

    更新日期:1995-07-01 00:00:00

  • Development of a Prognostic Score to Predict Mortality in Patients With Pediatric Acute Liver Failure.

    abstract:OBJECTIVES:This study aims to develop a new prognostic score based on changes in serial laboratory data from patients with pediatric acute liver failure (PALF). METHODS:We retrospectively reviewed data on 146 patients with PALF at the Seoul National University Children Hospital (SNUCH) and the Asan Medical Center (AMC...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002625

    authors: Lee EJ,Kim JW,Moon JS,Kim YB,Oh SH,Kim KM,Ko JS

    更新日期:2020-06-01 00:00:00

  • Ineffectiveness of breath methane excretion as a diagnostic test for lactose malabsorption.

    abstract:BACKGROUND:In clinical and field conditions, breath gas analysis has been widely used in evaluating carbohydrate digestion. A field study was performed to determine the prevalence of lactose malabsorption in Myanmar children and to evaluate the possibility of using breath methane excretion to indicate lactose malabsorp...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199905000-00006

    authors: Myo-Khin,Bolin TD,Khin-Mar-Oo,Tin-Oo,Kyaw-Hla S,Thein-Myint T

    更新日期:1999-05-01 00:00:00

  • Quality of health care in the United States: implications for pediatric inflammatory bowel disease.

    abstract::The Institute of Medicine's publications To Error is Human and Crossing the Quality Chasm publicized the widespread deficits in US health care quality. Emerging studies continue to reveal deficits in the quality of adult and pediatric care, including subspecialty care. In recent years, key stakeholders in the health c...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 历史文章,杂志文章,评审

    doi:10.1097/MPG.0b013e3181a491e7

    authors: Boyle BM,Palmer L,Kappelman MD

    更新日期:2009-09-01 00:00:00

  • Vitamin D Intervention and Bone: A Randomized Clinical Trial in Fair- and Dark-skinned Children at Northern Latitudes.

    abstract:OBJECTIVES:The aim of the study was to evaluate vitamin D status and effects of vitamin D intervention on bone mineral density (BMD) and content (BMC) in children with fair and dark skin in Sweden during winter. METHODS:In a 2-center prospective double-blinded randomized intervention study 5- to 7-year-old children (n...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MPG.0000000000002031

    authors: Karlsland Åkeson P,Åkesson KE,Lind T,Hernell O,Silfverdal SA,Öhlund I

    更新日期:2018-09-01 00:00:00

  • Granulomatous Upper Gastrointestinal Inflammation in Pediatric Ulcerative Colitis.

    abstract:OBJECTIVES:Differentiating ulcerative colitis (UC) and Crohn disease (CD) can be clinically challenging, especially in children. Granulomatous inflammation has traditionally been attributed to CD. Crypt-associated giant cells and granulomas, however, have been observed in colonic biopsies of patients with UC. This phen...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001771

    authors: Queliza K,Ihekweazu FD,Schady D,Jensen C,Kellermayer R

    更新日期:2018-04-01 00:00:00

  • Prospective analysis of nonadherence in autoimmune hepatitis: a common problem.

    abstract:OBJECTIVES:To prospectively assess nonadherence to medications, the relationship between nonadherence and medical outcome and the relationship between a psychiatric risk factor (posttraumatic stress) and nonadherence in patients with a diagnosis of autoimmune hepatitis. PATIENTS AND METHODS:Data were obtained in child...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/01.mpg.0000239735.87111.ba

    authors: Kerkar N,Annunziato RA,Foley L,Schmeidler J,Rumbo C,Emre S,Shneider B,Shemesh E

    更新日期:2006-11-01 00:00:00

  • Dependability of esophageal pH-monitoring data in infants on cutoff limits: the oscillatory index.

    abstract::The cutoff limit for pathologic gastroesophageal reflux (GER) has been arbitrary, although generally accepted determined at pH 4.00. The influence of a small pH error (0.25 pH units above or below pH 4.00) was analyzed in 173 consecutive pH monitorings. This appeared to cause a misinterpretation of the data in 51 of 1...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199010000-00004

    authors: Vandenplas Y,Lepoudre R,Helven R

    更新日期:1990-10-01 00:00:00

  • Zinc supplementation for the treatment of diarrhea in infants in Pakistan, India and Ethiopia.

    abstract:OBJECTIVE:This randomized, placebo controlled trial was designed to assess the safety and efficacy of 10-mg zinc supplementation for the treatment of acute diarrhea in infants. METHODS:A total of 1110 infants aged 28 days to 5 months with acute diarrhea were enrolled and randomized to receive either zinc (n = 554) or ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/01.mpg.0000232018.40907.00

    authors: Fischer Walker CL,Bhutta ZA,Bhandari N,Teka T,Shahid F,Taneja S,Black RE,Zinc Study Group.

    更新日期:2006-09-01 00:00:00

  • Childhood Bladder and Bowel Dysfunction Questionnaire: Development, Feasibility, and Aspects of Validity and Reliability.

    abstract:OBJECTIVES:The aim of the study was to develop a questionnaire evaluating the frequency of symptoms over time of concomitant childhood bladder and bowel dysfunctions (CBBDs) in 5- to 12-year-old children and to assess its feasibility and aspects of validity and reliability. METHODS:The Childhood Bladder and Bowel Dysf...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001461

    authors: van Engelenburg-van Lonkhuyzen ML,Bols EMJ,Bastiaenen CHG,Benninga MA,de Bie RA

    更新日期:2017-06-01 00:00:00

  • Re-treatment of children with chronic hepatitis C who did not respond to interferon-alpha treatment.

    abstract:BACKGROUND:Many patients with chronic hepatitis C do not respond to antiviral treatment. In adult patients the re-treatment of these patients has been extensively investigated. Because the response to re-treatment in children is not well defined we evaluated the efficacy and safety of interferon (IFN)-alpha plus ribavi...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章

    doi:10.1097/MPG.0b013e3181d9c7f6

    authors: Gerner P,Hilbich J,Wenzl TG,Behrens R,Walther F,Kliemann G,Enninger A,Wirth S

    更新日期:2010-08-01 00:00:00

  • Lymphangioendothelioma of the liver in a neonate.

    abstract::The case report describes the clinical features, imaging findings, and pathology of a lymphangioendothelioma that almost entirely replaced the liver parenchyma in a neonate. No other organs were involved. ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:

    authors: Peters ME,Gilbert-Barness EF,Rao B,Odell GB

    更新日期:1989-07-01 00:00:00

  • Immunogenecity of hepatitis A and B vaccination in pediatric patients with inflammatory bowel disease.

    abstract:OBJECTIVES:Aim of the study was to evaluate the response to hepatitis A and B vaccination in pediatric patients with inflammatory bowel disease (IBD). METHODS:A total of 47 patients with IBD (25 ulcerative colitis, 14 Crohn's disease, and 8 indeterminate colitis) ages 3 to 17 years were compared with 50 healthy age- a...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e31827dd87d

    authors: Urganci N,Kalyoncu D

    更新日期:2013-04-01 00:00:00

  • Erythromycin fails to improve feeding outcome in feeding-intolerant preterm infants.

    abstract:OBJECTIVE:Approximately half of extremely low birth weight infants have feeding intolerance, which delays their achievement of full enteral feedings. Erythromycin, a motilin receptor agonist, triggers migrating motor complexes and accelerates gastric emptying in adults with feeding intolerance. Few studies have assesse...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00005176-200309000-00015

    authors: ElHennawy AA,Sparks JW,Armentrout D,Huseby V,Berseth CL

    更新日期:2003-09-01 00:00:00

  • Normal serum indices of bone collagen biosynthesis and degradation in small for gestational age infants.

    abstract::Serum carboxyterminal propeptide of type I procollagen (PICP) and cross-linked carboxyterminal telopeptide of type I collagen (ICTP), new markers of bone collagen type I biosynthesis and degradation, have not been studied in small for gestational age (SGA) infants. In an earlier study, we found a lower bone mineral co...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199610000-00004

    authors: Namgung R,Tsang RC,Sierra RI,Ho ML

    更新日期:1996-10-01 00:00:00

  • Prolonged postprandial abdominal pain following Kawasaki syndrome with acute gallbladder hydrops: association with impaired gallbladder emptying.

    abstract::Acute hydrops of the gallbladder is a well-recognized complication of Kawasaki syndrome. We report a case of a child with this syndrome whose gallbladder hydrops slowly resolved after intravenous gamma-globulin therapy. However, he continued to experience postprandial right upper quadrant abdominal pain. Hepatobiliary...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199110000-00013

    authors: Bishop WP,Kao SC

    更新日期:1991-10-01 00:00:00

  • γ-Glutamyl transpeptidase level as a screening marker among diverse etiologies of infantile intrahepatic cholestasis.

    abstract:OBJECTIVES:Low γ-glutamyl transpeptidase (GGT) level is an important marker for progressive familial intrahepatic cholestasis, yet the cutoff level and clinical application is not well defined. This study aimed to evaluate the role of GGT as a screening marker among diverse etiologies of infantile cholestasis. METHODS...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000000538

    authors: Lu FT,Wu JF,Hsu HY,Ni YH,Chang MH,Chao CI,Chen HL

    更新日期:2014-12-01 00:00:00

  • Decreased interleukin-10 secretion by peripheral blood mononuclear cells in children with irritable bowel syndrome.

    abstract:BACKGROUND AND AIMS:The aim of the present study was to evaluate proinflammatory and anti-inflammatory cytokine levels in children with irritable bowel syndrome (IBS). PATIENTS AND METHODS:Thirty-five children with IBS (17 diarrhea-predominant, 7 constipation-predominant, and 11 mixed type) and 25 healthy children as ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3181fd9816

    authors: Hua MC,Lai MW,Kuo ML,Yao TC,Huang JL,Chen SM

    更新日期:2011-04-01 00:00:00

  • Bowel preparation for pediatric colonoscopy procedures.

    abstract::Colonoscopy is a routinely performed procedure in children and adolescents. Proper visualization of the intestinal mucosa, completion of the procedure, including examination of the terminal ileum, detection of pathological lesions, and therapeutic maneuvers, all are highly dependent on the quality of the bowel prepara...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:10.1097/MPG.0b013e3181eb6a1c

    authors: Hunter A,Mamula P

    更新日期:2010-09-01 00:00:00

  • Changes in Proteases, Antiproteases, and Bioactive Proteins From Mother's Breast Milk to the Premature Infant Stomach.

    abstract:OBJECTIVE:Our previous studies suggested that human milk proteases begin to hydrolyze proteins in the mammary gland and continue within the term infant' stomach. No research has measured milk protease and pepsin activity in the gastric aspirates of preterm infants after human milk feeding. This study investigated how t...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001719

    authors: Demers-Mathieu V,Nielsen SD,Underwood MA,Borghese R,Dallas DC

    更新日期:2018-02-01 00:00:00

  • ESPGHAN 2012 Guidelines for Coeliac Disease Diagnosis: Validation Through a Retrospective Spanish Multicentric Study.

    abstract:OBJECTIVES:A large retrospective multicentre study was conducted in Spain to evaluate the efficiency of the new European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) criteria for the diagnosis of coeliac disease (CD). METHODS:The study protocol was approved by the ethics committee of Hos...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MPG.0000000000000870

    authors: Donat E,Ramos JM,Sánchez-Valverde F,Moreno A,Martinez MJ,Leis R,Peña-Quintana L,Castillejo G,Fernández S,Garcia Z,Ortigosa L,Balmaseda E,Marugán JM,Eizaguirre FJ,Lorenzo H,Barrio J,Ribes-Koninckx C,SEGHNP Working Group

    更新日期:2016-02-01 00:00:00

  • Adaptation of New Colombian Food-based Complementary Feeding Recommendations Using Linear Programming.

    abstract:OBJECTIVE:The aim of the study was to use linear programming (LP) analyses to adapt New Complementary Feeding Guidelines (NCFg) designed for infants aged 6 to 12 months living in poor socioeconomic circumstances in Bogota to ensure dietary adequacy for young children aged 12 to 23 months. DESIGN:A secondary data analy...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MPG.0000000000001662

    authors: Tharrey M,Olaya GA,Fewtrell M,Ferguson E

    更新日期:2017-12-01 00:00:00

  • Cow's-milk allergy is a risk factor for the development of FGIDs in children.

    abstract:OBJECTIVES:Functional gastrointestinal disorders (FGIDs) are common in children. Their pathogenesis remains unknown and is most likely multifactorial. We hypothesized that noninfectious causes of inflammation affecting the gastrointestinal (GI) tract early in life, such as cow's-milk allergy (CMA), can predispose to th...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3181e85b55

    authors: Saps M,Lu P,Bonilla S

    更新日期:2011-02-01 00:00:00

  • Celiac Diasease-associated lncRNA Named HCG14 Regulates NOD1 Expression in Intestinal Cells.

    abstract:OBJECTIVE:The aim of the study is to identify additional celiac disease associated loci in the major histocompatibility complex (MHC) independent from classical HLA risk alleles (HLA-DR3-DQ2) and to characterize their potential functional impact in celiac disease pathogenesis at the intestinal level. METHODS:We perfor...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001970

    authors: Santin I,Jauregi-Miguel A,Velayos T,Castellanos-Rubio A,Garcia-Etxebarria K,Romero-Garmendia I,Fernandez-Jimenez N,Irastorza I,Castaño L,Bilbao JR

    更新日期:2018-08-01 00:00:00