Characterization of tyramine β-hydroxylase, an enzyme upregulated by stress in Periplaneta americana.

abstract：:There is evidence that insulin-like growth factor-binding protein (IGFBP-2), a modulator of the actions of IGFs, also has IGF-independent effects in human tumor cell lines. These involve specific binding of IGFBP-2 to alpha5beta1-integrin, followed by alterations in the phosphorylation status of downstream signaling m...

journal_title：Journal of molecular endocrinology

authors： Frommer KW,Reichenmiller K,Schutt BS,Hoeflich A,Ranke MB,Dodt G,Elmlinger MW

更新日期：2006-08-01 00:00:00

abstract：:Two forms of prolactin (tiPRLI and tiPRLII), with only 69% sequence identity, have been previously described in the cichlid fish tilapia (Oreochromis species). In the present study we have attempted to investigate the biological activity of these two prolactin forms during adaptation to a hyperosmotic environment. For...

journal_title：Journal of molecular endocrinology

authors： Auperin B,Rentier-Delrue F,Martial JA,Prunet P

更新日期：1994-02-01 00:00:00

abstract：:Insulin-regulated aminopeptidase (IRAP, EC 3.4.11.3) in adipocytes is well known to traffic between high (HDM) and low (LDM) density microsomal fractions toward the plasma membrane (MF) under stimulation by insulin. However, its catalytic preference for aminoacyl substrates with N-terminal Leu or Cys is controversial....

journal_title：Journal of molecular endocrinology

authors： Alponti RF,Viana LG,Yamanouye N,Silveira PF

更新日期：2015-08-01 00:00:00

abstract：:The mechanism behind Ca(2)(+) entry into the parathyroid cells has been widely debated, and the molecular identities of the responsible ion channels have not been established yet. In this study, we show that the parathyroid cells lack voltage-operated Ca(2)(+) channels. Passive store depletion by thapsigargin, on the ...

journal_title：Journal of molecular endocrinology

authors： Lu M,Bränström R,Berglund E,Höög A,Björklund P,Westin G,Larsson C,Farnebo LO,Forsberg L

更新日期：2010-05-01 00:00:00

abstract：:Activation of the hypothalamo-pituitary-adrenal (HPA) axis during stress is associated with increased expression of genes that code for regulatory hormones such as corticotrophin-releasing factor (CRF) and ACTH. The identity of the transcription factors that mediate these changes in gene expression is not known. In th...

journal_title：Journal of molecular endocrinology

authors： Whitehead D,Carter DA

更新日期：1997-12-01 00:00:00

abstract：:We studied the effect of adenosine on prolactin secretion by the anterior pituitary, and the transduction mechanisms whereby the purine exerts its action. Adenosine inhibited prolactin release in basal and in vasoactive intestinal peptide (VIP)- or TRH-stimulated conditions. Pertussis toxin pretreatment reduced the in...

journal_title：Journal of molecular endocrinology

authors： Scorziello A,Landolfi E,Grimaldi M,Meucci O,Ventra C,Avallone A,Postiglione A,Schettini G

更新日期：1993-12-01 00:00:00

abstract：:The mannose 6-phosphate/IGF 2 receptor (IGF2R) is comprised of 15 extra-cellular domains that bind IGF2 and mannose 6-phosphate ligands. IGF2R transports ligands from the Golgi to the pre-lysosomal compartment and thereafter to and from the cell surface. IGF2R regulates growth, placental development, tumour suppressio...

journal_title：Journal of molecular endocrinology

authors： Rezgui D,Williams C,Savage SA,Prince SN,Zaccheo OJ,Jones EY,Crump MP,Hassan AB

更新日期：2009-04-01 00:00:00

abstract：:Leptin (Lep), an adipose-derived hormone, exerts very important functions in the body mainly on energy storage and availability. The physiological effects of Lep controlling the body weight and suppressing appetite are mediated by the long form of Lep receptor in the hypothalamus. Lep receptor activates several downst...

journal_title：Journal of molecular endocrinology

authors： Folch J,Pedrós I,Patraca I,Sureda F,Junyent F,Beas-Zarate C,Verdaguer E,Pallàs M,Auladell C,Camins A

更新日期：2012-10-10 00:00:00

abstract：:The genomic structure and transcriptional regulation of the rat apelin receptor (APJR) were analysed by rapid amplification of 5' cDNA ends (5'-RACE), transient expression assays and DNA-protein interaction. Analysis of the 5'-flanking region of a rat genomic clone shows no TATA box, but a putative CAAT box and severa...

journal_title：Journal of molecular endocrinology

authors： O'Carroll AM,Lolait SJ,Howell GM

更新日期：2006-02-01 00:00:00

abstract：:Urocortin (Ucn), a corticotropin-releasing factor (CRF)-related neuropeptide binding both CRF type 1 receptor (CRFR1) and CRFR2, has recently been found in prostate cancer. However, no report has yet been known to elucidate the roles of Ucn in prostate cancer via the two receptors. In this study, the expression of bot...

journal_title：Journal of molecular endocrinology

authors： Jin L,Zhang Q,Guo R,Wang L,Wang J,Wan R,Zhang R,Xu Y,Li S

更新日期：2011-09-07 00:00:00

abstract：:DNA encoding the N-terminal 415 residues of the human thyrotrophin receptor (predicted to code for the large extracellular region) was introduced into Chinese hamster ovary (CHO) cells using the glutamine synthetase/cytomegalovirus amplifiable expression system, and into E. coli using the pGEX-3X expression vector. Su...

journal_title：Journal of molecular endocrinology

authors： Harfst E,Johnstone AP,Nussey SS

更新日期：1992-12-01 00:00:00

abstract：:In the last 15 years, single-cell technologies have become robust and indispensable tools to investigate cell heterogeneity. Beyond transcriptomic, genomic and epigenome analyses, technologies are constantly evolving, in particular toward multi-omics, where analyses of different source materials from a single cell are...

journal_title：Journal of molecular endocrinology

authors： Cheung LYM,Rizzoti K

更新日期：2020-08-01 00:00:00

abstract：:Metformin improves obesity-associated metabolic dysregulation, but has controversial effects on adipose tissue inflammation. The objective of the study is to examine the direct effect of metformin on adipocyte inflammatory responses and elucidate the underlying mechanisms. Adipocytes were differentiated from 3T3-L1 ce...

journal_title：Journal of molecular endocrinology

authors： Qi T,Chen Y,Li H,Pei Y,Woo SL,Guo X,Zhao J,Qian X,Awika J,Huo Y,Wu C

更新日期：2017-07-01 00:00:00

abstract：:The mechanisms underlying sex determination and differentiation in fishes are labile in response to environmental parameters. Sex-specific phenotypes are largely regulated by sex steroids, and the inhibition or the stimulation of aromatase can reverse sex as well as alter secondary sexual characteristics in fishes. Am...

journal_title：Journal of molecular endocrinology

authors： Orlando EF,Katsu Y,Miyagawa S,Iguchi T

更新日期：2006-10-01 00:00:00

abstract：:The expression of genes encoding corticotropin-releasing factor (CRF) and its receptor type-1 (CRF1R) and type-2alpha (CRF2R) has been studied in the brain of rats with streptozotocin (STZ)-induced diabetes and adrenalectomy (ADX). Diabetic rats had a lower body weight compared to control rats. Food and water intake w...

journal_title：Journal of molecular endocrinology

authors： Huang Q,Timofeeva E,Richard D

更新日期：2006-10-01 00:00:00

abstract：:A subset of over-expressed microRNAs (miRNAs) identified in parathyroid carcinomas (Ca) compared to normal glands belongs to C19MC, a cluster on chromosome 19q13.4 involved in stem cell biology and tumourigenesis. In this study, the expression of C19MC-MIR371-3 clusters and the molecular mechanisms presiding their mod...

journal_title：Journal of molecular endocrinology

authors： Vaira V,Elli F,Forno I,Guarnieri V,Verdelli C,Ferrero S,Scillitani A,Vicentini L,Cetani F,Mantovani G,Spada A,Bosari S,Corbetta S

更新日期：2012-07-26 00:00:00

abstract：:The neurohypophysial nonapeptides vasotocin (VT) and mesotocin (MT) are the amphibian counterparts of arginine vasopressin (AVP) and oxytocin (OT). We have here reported the cloning and functional characterization of the receptors for vasotocin (VTR) and mesotocin (MTR) in two species of frog, Rana catesbeiana and Ran...

journal_title：Journal of molecular endocrinology

authors： Acharjee S,Do-Rego JL,Oh DY,Moon JS,Ahn RS,Lee K,Bai DG,Vaudry H,Kwon HB,Seong JY

更新日期：2004-08-01 00:00:00

abstract：:Seven bovine follistatin (FS) cDNA clones were isolated from a bovine ovarian follicle cDNA library. The predicted amino acid sequences revealed that six of the cDNA clones represented an FS precursor of 344 amino acids which corresponded to a mature FS of 315 amino acids (FS 315), with one cDNA clone containing the e...

journal_title：Journal of molecular endocrinology

authors： Saleh M,Garcia S,Mercer JE,Findlay JK

更新日期：1994-12-01 00:00:00

abstract：:The biologically active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (VD3), exerts its tissue-specific actions through binding to its intracellular vitamin D receptor (VDR) which functions as a heterodimer with retinoid X receptor (RXR) to recognize vitamin D response elements (VDRE) and activate target genes. Up...

journal_title：Journal of molecular endocrinology

authors： Tsoumpra MK,Sawatsubashi S,Imamura M,Fukumoto S,Takeda S,Matsumoto T,Aoki Y

更新日期：2020-04-01 00:00:00

abstract：:Association between the (AC)(n) dinucleotide repeat polymorphism at the 5'-end of the aldose reductase gene and the occurrence of diabetic nephropathy was conducted. We examined eight studies consisting of ten Caucasian type 1 diabetes mellitus case-control comparisons and eight studies consisting of nine type 2 diabe...

journal_title：Journal of molecular endocrinology

authors： Xu M,Chen X,Yan L,Cheng H,Chen W

更新日期：2008-05-01 00:00:00

abstract：:The somatostatin (SRIF) system, which includes the SRIF ligand and receptors, regulates anterior pituitary gland function, mainly inhibiting hormone secretion and to some extent pituitary tumor cell growth. SRIF-14 via its cognate G-protein-coupled receptors (subtypes 1-5) activates multiple cellular signaling pathway...

journal_title：Journal of molecular endocrinology

authors： Eigler T,Ben-Shlomo A

更新日期：2014-08-01 00:00:00

abstract：:The development of an efficient expression system for insulin-like growth factor-I (IGF-I) in Escherichia coli as a fusion protein is described. The fusion protein consists of an N-terminal extension made up of the first 46 amino acids of methionyl porcine GH ([Met1]-pGH) followed by the dipeptide Val-Asn. The latter ...

journal_title：Journal of molecular endocrinology

authors： King R,Wells JR,Krieg P,Snoswell M,Brazier J,Bagley CJ,Wallace JC,Ballard FJ,Ross M,Francis GL

更新日期：1992-02-01 00:00:00

abstract：:The main regulators of aldosterone secretion in adrenal gland zona glomerulosa (ZG) cells are the hormones angiotensin II (Ang II) and adrenocorticotrophin (ACTH) and small increases in the extracellular potassium (K(+)) concentration. The action of these agonists is mediated by different signalling systems - ACTH is ...

journal_title：Journal of molecular endocrinology

authors： Foster RH

更新日期：2004-06-01 00:00:00

abstract：:Binding of 125I-labelled arginine vasotocin (AVT) was studied in isolated intact gill cells obtained from eels (Anguilla anguilla) adapted to fresh water (FW) or to sea water (SW). Experiments carried out at 20 degrees C showed maximum and stable binding beyond 10 min of incubation. Specific binding, determined by usi...

journal_title：Journal of molecular endocrinology

authors： Guibbolini ME,Henderson IW,Mosley W,Lahlou B

更新日期：1988-09-01 00:00:00

abstract：:Activins are cytokines of the transforming growth factor beta family, which plays a central role in the determination of cell fate and the regulation of tissue balance. Family members are composed of two subunits and this dimerization is critical for liganding their cognate receptors and execution of proper functions....

journal_title：Journal of molecular endocrinology

authors： Vejda S,Cranfield M,Peter B,Mellor SL,Groome N,Schulte-Hermann R,Rossmanith W

更新日期：2002-04-01 00:00:00

abstract：:Fibroblast growth factor 23 (FGF23) is a phosphotropic hormone that belongs to a subfamily of endocrine FGFs with evolutionarily conserved functions in C. elegans and fruit flies. FAM20C phosphorylates FGF23 post-translationally, targeting to proteolysis through subtilisin-like proprotein convertase FURIN, resulting i...

journal_title：Journal of molecular endocrinology

authors： Ho BB,Bergwitz C

更新日期：2020-12-01 00:00:00

abstract：:Testicular Leydig cells (LC) are modulated by several pathways, one of them being the histaminergic system. Heme oxygenase-1 (HO-1), whose upregulation comprises the primary response to oxidative noxae, has a central homeostatic role and might dysregulate LC functions when induced. In this report, we aimed to determin...

journal_title：Journal of molecular endocrinology

authors： Raices T,Varela ML,Monzón CM,Correa Torrado MF,Pagotto RM,Besio Moreno M,Mondillo C,Pignataro OP,Pereyra EN

更新日期：2019-10-01 00:00:00

abstract：:It has been suggested that the thyroid itself may contribute to the inflammatory process observed in autoimmune thyroiditis by releasing the cytokines interleukin-1 alpha (IL-1 alpha), interleukin-6 (IL-6) and interleukin-8 (IL-8), but studies of cytokine gene expression in thyrocytes have been limited and conflicting...

journal_title：Journal of molecular endocrinology

authors： Watson PF,Pickerill AP,Davies R,Weetman AP

更新日期：1995-08-01 00:00:00

abstract：:Previous studies have demonstrated that TRH is a potent stimulator of alpha-MSH secretion from frog pituitary melanotrophs. In order to determine the intracellular events responsible for TRH-evoked alpha-MSH release, we have investigated the effect of TRH on polyphosphoinositide breakdown in frog pars intermedia. Neur...

journal_title：Journal of molecular endocrinology

authors： Desrues L,Tonon MC,Vaudry H

更新日期：1990-10-01 00:00:00

abstract：:Nuclear receptors (NRs) have been targets of intensive drug development for decades due to their roles as key regulators of multiple developmental, physiological and disease processes. In breast cancer, expression of the estrogen and progesterone receptor remains clinically important in predicting prognosis and determ...

journal_title：Journal of molecular endocrinology

authors： Doan TB,Graham JD,Clarke CL

更新日期：2017-04-01 00:00:00