Cell death and neuronal differentiation of glioblastoma stem-like cells induced by neurogenic transcription factors.

abstract：:Alzheimer's disease (AD) and prion disease are characterized neuropathologically by extracellular deposits of Abeta and PrP amyloid fibrils, respectively. In both disorders, these cerebral amyloid deposits are co-localized with a broad variety of inflammation-related proteins (complement factors, acute-phase protein, ...

journal_title：Glia

authors： Eikelenboom P,Bate C,Van Gool WA,Hoozemans JJ,Rozemuller JM,Veerhuis R,Williams A

更新日期：2002-11-01 00:00:00

abstract：:The phenotype of a fully differentiated, mature Schwann cell is apparently largely determined by Schwann cell-axon interactions. In vitro, elevation of intracellular cAMP levels in Schwann cells induces a phenotype which resembles that of a mature, i.e., axon-related, Schwann cell. Therefore, an important role for cAM...

journal_title：Glia

authors： Mews M,Meyer M

更新日期：1993-07-01 00:00:00

abstract：:The possibility of a modular organization of non-neuronal elements was analyzed in the opercular region of the striate neocortex in adult New World monkeys. For this purpose, and in order to follow possible correlations in the general organization of neuronal and astroglial elements, immunocytochemical procedures for ...

journal_title：Glia

authors： Colombo JA,Schleicher A,Zilles K

更新日期：1999-01-01 00:00:00

abstract：:We have previously shown that cultured astrocytes from neonatal rat cerebral cortex are depolarized by GABA. The underlying ionic mechanism, activation of a Cl- conductance and responses to an agonist and antagonists were found to be similar to those of the neuronal GABAA receptor (Kettenmann et al.: Brain Research 40...

journal_title：Glia

authors： Backus KH,Kettenmann H,Schachner M

更新日期：1988-01-01 00:00:00

abstract：:Inflammatory changes have been found in Parkinson's disease, in humans intoxicated with the parkinsonian toxin MPTP, and in animal models of the disease. However, it is still not known whether inflammatory changes are responsible for active nerve cell death or if they have a protective role against neurodegeneration. ...

journal_title：Glia

authors： Barcia C,Sánchez Bahillo A,Fernández-Villalba E,Bautista V,Poza Y Poza M,Fernández-Barreiro A,Hirsch EC,Herrero MT

更新日期：2004-05-01 00:00:00

abstract：:Astrocytes, together with microglia and macrophages, participate in innate inflammatory responses in the CNS. Although inflammatory mediators such as interferons generated by astrocytes may be critical in the defense of the CNS, sustained unopposed cytokine signaling could result in harmful consequences. Interferon re...

journal_title：Glia

authors： Tarassishin L,Loudig O,Bauman A,Shafit-Zagardo B,Suh HS,Lee SC

更新日期：2011-12-01 00:00:00

abstract：:Glial cell-mediated potassium and glutamate homeostases play important roles in the regulation of neuronal excitability. Diminished potassium and glutamate buffering capabilities of astrocytes result in hyperexcitability of neurons and abnormal synaptic transmission. The role of the different K+ channels in maintainin...

journal_title：Glia

authors： Kucheryavykh YV,Kucheryavykh LY,Nichols CG,Maldonado HM,Baksi K,Reichenbach A,Skatchkov SN,Eaton MJ

更新日期：2007-02-01 00:00:00

abstract：:The interface between the blood and the cerebrospinal fluid (CSF) is formed by the choroid plexuses (CPs), which are specialized structures located within the brain ventricles. They are composed of a vascularized stroma surrounded by a tight epithelium that controls molecular and cellular traffic between the blood and...

journal_title：Glia

authors： Nataf S,Strazielle N,Hatterer E,Mouchiroud G,Belin MF,Ghersi-Egea JF

更新日期：2006-08-15 00:00:00

abstract：:Kainate (KA), quisqualate (QA), and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) stimulated gamma-aminobutyric acid [3H]gamma-aminobutyric acid (GABA) release from cultured cerebellar type 2 astrocytes and from their bipotential precursors. The evoked release was prevented by the antagonist 6-cyano-...

journal_title：Glia

authors： Gallo V,Patrizio M,Levi G

更新日期：1991-01-01 00:00:00

abstract：:In mammalian brain peripheral benzodiazepine (PBZD) receptors are predominantly localized on astroglial cells. Previous studies utilizing whole membrane preparations from brain and peripheral organs of various species have indicated several distinctions between the drug-receptor interactions of the two prototypic PBZD...

journal_title：Glia

authors： Itzhak Y,Baker L,Norenberg MD

更新日期：1993-11-01 00:00:00

abstract：:Oligodendrocytes were studied in the anterior medullary velum (AMV) of the rat using the monoclonal antibody Rip, an oligodendrocyte marker of unknown function. Confocal microscopic imaging of double immunofluorescent labelling with antibodies to Rip and carbonic anhydrase II (CAII) revealed two biochemically and morp...

journal_title：Glia

authors： Butt AM,Ibrahim M,Ruge FM,Berry M

更新日期：1995-07-01 00:00:00

abstract：:The synthesis, transport, and insertion of jimpy proteolipid protein and DM20 were studied in normal (158N) and jimpy (158JP) immortalized oligodendrocyte lines. Four different expression vectors encoding fusion proteins composed of native PLP and DM20 or jimpy PLP or DM20 were linked to enhanced green fluorescent pro...

journal_title：Glia

authors： Ghandour MS,Feutz AC,Jalabi W,Taleb O,Bessert D,Cypher M,Carlock L,Skoff RP

更新日期：2002-12-01 00:00:00

abstract：:Gliogenesis in the mammalian CNS continues after birth, with astrocytes being generated well into the first two postnatal weeks. In this study, we have isolated an A2B5(+) astrocyte precursor (APC) from the postnatal rat forebrain, which is capable of differentiating into mature astrocytes in serum-free medium without...

journal_title：Glia

authors： Lin G,Goldman JE

更新日期：2009-04-15 00:00:00

abstract：:Synaptic zinc ions released during synaptic transmission interact with pre- and postsynaptic neuroreceptors, thus modulating neurotransmission. It is likely that they have to be efficiently cleared from the extracellular milieu to assure subsequent synaptic events. Both neurons and glia are assumed to participate in t...

journal_title：Glia

authors： Varea E,Alonso-Llosà G,Molowny A,Lopez-Garcia C,Ponsoda X

更新日期：2006-09-01 00:00:00

abstract：:Retinoic acid (RA), a metabolite of vitamin A, is required for the regulation of growth and development. Aberrant expression of molecules involved in RA signaling has been reported in various cancer types including glioblastoma multiforme (GBM). Cellular retinoic acid-binding protein 2 (CRABP2) has previously been sho...

journal_title：Glia

authors： Liu RZ,Li S,Garcia E,Glubrecht DD,Poon HY,Easaw JC,Godbout R

更新日期：2016-06-01 00:00:00

abstract：:The idea of a metabolic coupling between neurons and astrocytes in the brain has been entertained for about 100 years. The use recently of simple and well-compartmentalized nervous systems, such as the honeybee retina or purified preparations of neurons and glia, provided strong support for a nutritive function of gli...

journal_title：Glia

authors： Tsacopoulos M,Poitry-Yamate CL,Poitry S,Perrottet P,Veuthey AL

更新日期：1997-09-01 00:00:00

abstract：:Accumulating evidence has revealed that astrocytes are potential targets for various neurotransmitters. Here we investigated the effects of prostaglandins (PGs) on signal transduction in purified primary cultures of rat type-1 and type-2 astrocytes. PGF2 alpha, PGD2, and 9 alpha,11 beta-PGF2, a metabolite of PGD2 and ...

journal_title：Glia

authors： Ito S,Sugama K,Inagaki N,Fukui H,Giles H,Wada H,Hayaishi O

更新日期：1992-01-01 00:00:00

abstract：:Simvastatin, a lipophilic statin that crosses the blood-brain barrier, is being evaluated as a potential therapy for multiple sclerosis (MS) due to its anti-inflammatory properties. We assessed the effects of simvastatin on cultures of rat newborn and human fetal oligodendrocyte progenitor cells (OPCs) and human adult...

journal_title：Glia

authors： Miron VE,Rajasekharan S,Jarjour AA,Zamvil SS,Kennedy TE,Antel JP

更新日期：2007-01-15 00:00:00

abstract：:Extracellular matrix molecules are involved in the cellular functions of proliferation, migration, morphological differentiation, and synaptic plasticity. One candidate molecule of the extracellular matrix is the chondroitin sulfate proteoglycan neurocan. To determine whether neurocan expression is regulated by neuron...

journal_title：Glia

authors： Schwarzacher SW,Vuksic M,Haas CA,Burbach GJ,Sloviter RS,Deller T

更新日期：2006-05-01 00:00:00

abstract：:alpha-Synuclein, a gene whose mutations, duplication, and triplication has been linked to autosomal dominant familial Parkinson's disease (fPD), appears to play a central role in the pathogenesis of sporadic PD (sPD) as well. Enhancement of neurodegeneration induced by mutant alpha-synuclein has been attributed to dat...

journal_title：Glia

authors： Zhang W,Dallas S,Zhang D,Guo JP,Pang H,Wilson B,Miller DS,Chen B,Zhang W,McGeer PL,Hong JS,Zhang J

更新日期：2007-08-15 00:00:00

abstract：:Annexin II (AX II) is a member of the family of calcium-dependent actin- and phospholipid-binding proteins implicated in numerous intracellular functions such as signal transduction, membrane trafficking, and mRNA transport, as well as in the regulation of membrane/cytoskeleton contacts and extracellular functions. AX...

journal_title：Glia

authors： Hayashi A,Nakashima K,Yamagishi K,Hoshi T,Suzuki A,Baba H

更新日期：2007-08-01 00:00:00

abstract：:Neurons in organotypic hippocampal slice cultures (OHSCs) are known to preserve morphological and physiological features of the in vivo situation; however, little is known about the properties of microglial cells under these in vitro conditions. In this study, we addressed the question whether microglial cells in OHSC...

journal_title：Glia

authors： Hailer NP,Jarhult JD,Nitsch R

更新日期：1996-12-01 00:00:00

abstract：:Heterosynaptic long-term depression (hLTD) at untetanized synapses accompanying the induction of long-term potentiation (LTP) spatially sharpens the activity-induced synaptic potentiation; however, the underlying mechanism remains unclear. We found that hLTD in the hippocampal CA1 region is caused by stimulation-induc...

journal_title：Glia

authors： Chen J,Tan Z,Zeng L,Zhang X,He Y,Gao W,Wu X,Li Y,Bu B,Wang W,Duan S

更新日期：2013-02-01 00:00:00

abstract：:We first classified 12 malignant glioma cell lines into three different groups (types 1-3) with respect to major histocompatibility complex (MHC) class II expression and analyzed each group based on the different expression status of the class II transactivator (CIITA) gene. Glioma type 1 (2 of 12) showed constitutive...

journal_title：Glia

authors： Takamura Y,Ikeda H,Kanaseki T,Toyota M,Tokino T,Imai K,Houkin K,Sato N

更新日期：2004-03-01 00:00:00

abstract：:Mechanisms that regulate the amount of releasable Ca2+ in intracellular stores of cultured mouse astrocytes were investigated using digital imaging of fura-2 loaded cells. At rest, the cytoplasmic Ca2+ concentration, [Ca2+]cyt, was about 110 nM. In the absence of extracellular Ca2+, cyclopiazonic acid (CPA), an inhibi...

journal_title：Glia

authors： Golovina VA,Bambrick LL,Yarowsky PJ,Krueger BK,Blaustein MP

更新日期：1996-04-01 00:00:00

abstract：:The substantia nigra pars reticulata (SNr) is a major output nucleus of the basal ganglia circuitry particularly sensitive to pathological dopamine depletion. Indeed, hyperactivity of SNr neurons is known to be responsible for some motor disorders characteristic of Parkinson's disease. The neuronal processing of basal...

journal_title：Glia

authors： Bosson A,Boisseau S,Buisson A,Savasta M,Albrieux M

更新日期：2015-04-01 00:00:00

abstract：:Microglia have diverse actions, ranging from synapse pruning in development to cytotoxic effects in disease. Brain energy metabolism and substrate availability vary under normal and disease states, but how these variations influence microglial function is relatively unknown. Microglia, like most other cell types, expr...

journal_title：Glia

authors： Ghosh S,Castillo E,Frias ES,Swanson RA

更新日期：2018-06-01 00:00:00

abstract：:Astrocytes are the gatekeepers of neuronal energy supply. In neurodegenerative diseases, bioenergetics demand increases and becomes reliant upon fatty acid oxidation as a source of energy. Defective fatty acid oxidation and mitochondrial dysfunctions correlate with hippocampal neurodegeneration and memory deficits in ...

journal_title：Glia

authors： Konttinen H,Gureviciene I,Oksanen M,Grubman A,Loppi S,Huuskonen MT,Korhonen P,Lampinen R,Keuters M,Belaya I,Tanila H,Kanninen KM,Goldsteins G,Landreth G,Koistinaho J,Malm T

更新日期：2019-01-01 00:00:00

abstract：:Minocycline, a derivative of the antibiotic tetracycline, displays neuroprotective properties in various models of neurodegenerative diseases and is now used in clinical trials, because of its relative safety and tolerability. Minocycline passes the blood-brain barrier and is presumed to inhibit microglial activation....

journal_title：Glia

authors： Familian A,Boshuizen RS,Eikelenboom P,Veerhuis R

更新日期：2006-02-01 00:00:00

abstract：:Astrocytes support neurons not only physically but also chemically by secreting neurotrophic factors and energy substrates. Moreover, astrocytes establish a glial network and communicate through gap junctions in the brain. Connexin 43 (Cx43) is one of major component proteins in astrocytic gap junctions. Heterozygote ...

journal_title：Glia

authors： Nakase T,Yoshida Y,Nagata K

更新日期：2006-10-01 00:00:00