Abstract:
OBJECTIVE:To investigate the application value of the ADC(difference) value in evaluating the pathological grade of uterine cervical cancer and to analyse the correlations among microvascular density (MVD), vascular endothelial growth factor (VEGF) expression and maximum ADC(difference) value. METHODS:Fifty-six patients with uterine cervical cancer were included in this prospective study. All underwent conventional MRI and DWI. MVD and VEGF were evaluated by immunohistochemical staining with anti-CD34 and anti-VEGF, respectively. RESULTS:Maximum ADC(difference) value and MVD count showed statistical differences among different pathological grades (P < 0.001, P < 0.001). There was a significant positive linear correlation between the maximum ADC(difference) value and pathological tumour grade (P < 0.001), and also between MVD count and pathological tumour grade (P < 0.001). No significant differences were found between the level of VEGF expression and pathological tumour grade (P = 0.222). The maximum ADC(difference) value correlated positively with both the MVD count and the level of VEGF expression (P < 0.001, P < 0.001). CONCLUSIONS:Quantitative analysis of maximum ADC(difference) value of uterine cervical cancer may represent the grade of tumour differentiation and provide valuable information on tumour microcirculation and perfusion, thus allowing a promising new method of non-invasively assessing the pathological grade, which could serve as a substitution for assessing tumour angiogenesis.
journal_name
Eur Radioljournal_title
European radiologyauthors
Liu Y,Ye Z,Sun H,Bai Rdoi
10.1007/s00330-012-2657-1subject
Has Abstractpub_date
2013-03-01 00:00:00pages
757-65issue
3eissn
0938-7994issn
1432-1084journal_volume
23pub_type
杂志文章abstract:OBJECTIVES:We invented a drape-like shield against scattered X-rays that can safely come into contact with medical equipment or people during fluoroscopically guided procedures. The shield can be easily removed from a C-arm unit using one hand. We evaluated the use of the novel removable shield during the endoscopic re...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-014-3186-x
更新日期:2014-08-01 00:00:00
abstract::Several studies have shown that the thickness of tongue carcinoma is related to prognosis and to the likelihood of cervical node metastases. We investigated whether preoperative estimates of tumor thickness and volume, as determined from magnetic resonance imaging (MRI), correlated with histologic thickness and might ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-006-0263-9
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abstract::The purpose of this study was to determine the feasibility and features of low-field MR imaging in performing interstitial laser ablation of osteoid osteomas. Between September 2001 and April 2002, five consecutive patients with clinical and imaging findings suggesting osteoid osteoma and referred for removal of osteo...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-003-1897-5
更新日期:2003-10-01 00:00:00
abstract::The purpose was to provide a diffusion-weighted whole-body magnetic resonance (MR) imaging sequence with background body signal suppression (DWIBS) at 3.0 Tesla. A diffusion-weighted spin-echo echo-planar imaging sequence was combined with the following methods of fat suppression: short TI inversion recovery (STIR), s...
journal_title:European radiology
pub_type: 杂志文章
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journal_title:European radiology
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doi:10.1007/s00330-012-2563-6
更新日期:2013-01-01 00:00:00
abstract:UNLABELLED:This paper summarizes information about breast MRI to be provided to women and referring physicians. After listing contraindications, procedure details are described, stressing the need for correct scheduling and not moving during the examination. The structured report including BI-RADS® categories and furth...
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pub_type: 杂志文章,评审
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更新日期:2015-12-01 00:00:00
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journal_title:European radiology
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pub_type: 杂志文章,随机对照试验
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更新日期:2019-06-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:1996-01-01 00:00:00
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更新日期:2013-07-01 00:00:00
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更新日期:2001-01-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章,评审
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更新日期:2005-03-01 00:00:00