Short communication: T cell activation in HIV-1/herpes simplex virus-2-coinfected Kenyan women receiving valacyclovir.

abstract：:African monkeys can be naturally infected with SIV but do not progress to AIDS. Since mutations in the human CCR5 gene have been shown to influence susceptibility to HIV infection and disease progression, we have now investigated whether mutations in CCR5-coding sequences in African nonhuman primates can explain speci...

journal_title：AIDS research and human retroviruses

authors： Müller-Trutwin MC,Corbet S,Hansen J,Georges-Courbot MC,Diop O,Rigoulet J,Barré-Sinoussi F,Fomsgaard A

更新日期：1999-07-01 00:00:00

abstract：:The immunoreactivity of HTLV-III-infected individuals and virus-inoculated chimpanzees with gp120 synthetic peptides of the HTLV-III gp120 envelope principle neutralizing domain (amino acid 301-324 sequences), derived from the HTLV-III isolates 3B, RF, MN, WMJ2, and SC were determined. Sequential bleeds from an infect...

journal_title：AIDS research and human retroviruses

authors： Devash Y,Matthews TJ,Drummond JE,Javaherian K,Waters DJ,Arthur LO,Blattner WA,Rusche JR

更新日期：1990-03-01 00:00:00

abstract：:Nucleoside analog reverse transcriptase inhibitors (NRTIs) constitute the most commonly used drugs in antiretroviral therapy. NRTIs differ with respect to their host cell toxicity. We compared the in vitro effect of zidovudine (AZT; 2 μg/ml), lamivudine (3TC; 5 μg/ml), stavudine (d4T; 1 μg/ml), and tenofovir (TFV; 1 μ...

journal_title：AIDS research and human retroviruses

authors： Enomoto L,Anderson PL,Li S,Edelstein CL,Weinberg A

更新日期：2011-01-01 00:00:00

abstract：:Natural polymorphisms of HIV-1, often associated with drug resistance, are widely described in protease and reverse transcriptase regions but data on their presence in the integrase region, especially in non-B subtypes, are still very limited. We aimed to characterize naturally occurring polymorphisms in the integrase...

journal_title：AIDS research and human retroviruses

authors： Avi R,Huik K,Sadam M,Karki T,Krispin T,Ainsalu K,Paap P,Schmidt J,Nikitina N,Lutsar I

更新日期：2010-10-01 00:00:00

abstract：:Human T-lymphotrophic virus type II (HTLV-II) has not yet been associated with any disease. Little is known about the proviral loads of HTLV-II in vivo and its relationship, if any, to lack of pathogenicity. We determined the HTLV-II proviral copy number in peripheral blood lymphocyte (PBL) samples from 49 HTLV-II-inf...

journal_title：AIDS research and human retroviruses

authors： Woods TC,Graber JM,Hershow RC,Khabbaz RF,Kaplan JE,Heneine W

更新日期：1995-10-01 00:00:00

abstract：:Monitoring HIV subtype distribution is important for understanding transmission dynamics. Subtype B has historically been dominant in Australia, but in recent years new clades have appeared. Since 2000, clade data have been collected as part of HIV surveillance in South Australia. The aim of this study was to evaluate...

journal_title：AIDS research and human retroviruses

authors： Hawke KG,Waddell RG,Gordon DL,Ratcliff RM,Ward PR,Kaldor JM

更新日期：2013-02-01 00:00:00

abstract：:The antiretroviral (ARV) service at Edendale Hospital in Pietermaritzburg, KwaZulu-Natal, South Africa has initiated more than 9,000 adults on therapy since 2004; however, virological outcomes among this patient cohort have not been systematically assessed. We conducted a retrospective chart review of patients initiat...

journal_title：AIDS research and human retroviruses

authors： Costiniuk CT,Sigal A,Jenabian MA,Nijs P,Wilson D

更新日期：2014-06-01 00:00:00

abstract：:There is an urgent need for a prophylactic vaccine to protect individuals from AIDS and to help abate the growing epidemic. In October 1993, the Conference on Advances in AIDS Vaccine Development reviewed the state-of-the-art in vaccine research and confirmed both the progress that has been made and the challenges tha...

journal_title：AIDS research and human retroviruses

authors： Johnston MI,Noe JS,Killen JY

更新日期：1994-01-01 00:00:00

abstract：:A comparative study at the genomic and protein level was performed between two immunologically related spumaretroviruses, the human HSRV and the simian SFV6. Cross immunoprecipitation analysis with specific polyclonal and monoclonal antisera indicates shared antigenic determinants. However, restriction analysis of the...

journal_title：AIDS research and human retroviruses

authors： Tobaly-Tapiero J,Santillana-Hayat M,Giron ML,Guillemin MC,Rozain F,Périès J,Emanoil-Ravier R

更新日期：1990-07-01 00:00:00

abstract：:Dendritic cells (DCs) have been shown to be important in the replication of human and simian immunodeficiency viruses (HIV and SIV, respectively) in vivo and in vitro. DCs express CD4 and several chemokine receptors, such as CCR5 and CXCR4, which are important for viral entry. In vivo, DCs are abundant at body surface...

journal_title：AIDS research and human retroviruses

authors： Ignatius R,Wei Y,Beaulieu S,Gettie A,Steinman RM,Pope M,Mojsov S

更新日期：2000-07-20 00:00:00

abstract：:We recently reported a novel adhesion pathway in lymphocytes that is mediated by cyclin-dependent kinase (Cdk) 4 activity and mediates lymphocyte interactions with endothelial matrix. We now demonstrate that HIV-infected lymphocytes also use Cdk4 to mediate spontaneous adhesion to fibronectin and endothelial matrix. W...

journal_title：AIDS research and human retroviruses

authors： Chow YH,Liu L,Schwartz B,Harlan JM,Schnapp LM

更新日期：2012-12-01 00:00:00

abstract：:Bacterial vaginosis (BV) has been linked to an increased risk of human immunodeficiency virus (HIV) acquisition and transmission in observational studies, but the underlying biological mechanisms are unknown. We measured biomarkers of subclinical vaginal inflammation, endogenous antimicrobial activity, and vaginal flo...

journal_title：AIDS research and human retroviruses

authors： Thurman AR,Kimble T,Herold B,Mesquita PM,Fichorova RN,Dawood HY,Fashemi T,Chandra N,Rabe L,Cunningham TD,Anderson S,Schwartz J,Doncel G

更新日期：2015-11-01 00:00:00

abstract：:Vaginal anti-HIV antibody responses may be beneficial, and possibly required, for vaccine-induced protection against HIV infection acquired through receptive vaginal intercourse. We have previously determined that intranasal immunization with a hybrid HIV peptide and cholera toxin induced vaginal anti-HIV IgA response...

journal_title：AIDS research and human retroviruses

authors： Staats HF,Montgomery SP,Palker TJ

更新日期：1997-07-20 00:00:00

abstract：:This randomized, open-labeled, multicenter study was designed to assess safety and pharmacokinetics of dronabinol (Marinol) tablets and megestrol acetate (Megace) micronized tablets, alone and in combination, for treatment of HIV wasting syndrome. Weight and quality of life data were also collected. Fifty-two patients...

journal_title：AIDS research and human retroviruses

authors： Timpone JG,Wright DJ,Li N,Egorin MJ,Enama ME,Mayers J,Galetto G

更新日期：1997-03-01 00:00:00

abstract：:HIV-1 viremia has been shown to induce several phenotypic and functional abnormalities in natural killer (NK) cells. To assess immune defects associated with HIV viremia, we examined NK cell function, differentiation status, and phenotypic alterations based on expression of inhibitory and activating receptors on NK ce...

journal_title：AIDS research and human retroviruses

authors： Zulu MZ,Naidoo KK,Mncube Z,Jaggernath M,Goulder PJR,Ndung'u T,Altfeld M,Thobakgale CF

更新日期：2017-12-01 00:00:00

abstract：:An atypical HIV-1 strain (CAM001) was identified in a pregnant Cameroonian woman in 1995. HMA subtyping of the env region was unsuccessful, and sequence analyses were performed. Unique sequence motifs were found at the V3 tip (GAGRALHA and GAGRAWIHA), and phylogenetic studies showed that the env C2-V5 sequence branche...

journal_title：AIDS research and human retroviruses

authors： Roques P,Menu E,Narwa R,Scarlatti G,Tresoldi E,Damond F,Mauclère P,Dormont D,Chaouat G,Simon F,Barré-Sinoussi F

更新日期：1999-11-20 00:00:00

abstract：:Data reporting sexually transmitted infection (STI) incidence rates among HIV-negative U.S. men who have sex with men (MSM) are lacking. In addition, it is difficult to analyze the effect of STI on HIV acquisition given that sexual risk behaviors confound the relationship between bacterial STIs and incident HIV. The I...

journal_title：AIDS research and human retroviruses

authors： Kelley CF,Vaughan AS,Luisi N,Sanchez TH,Salazar LF,Frew PM,Cooper HL,Diclemente R,del Rio C,Sullivan PS,Rosenberg ES

更新日期：2015-06-01 00:00:00

abstract：:To provide a better understanding of the role of placenta in vertical human immunodeficiency virus (HIV) transmission, we have studied the infection of placental trophoblast in a group of 15 mother-neonate pairs. By nested PCR amplification of the C2V3 env gene region, HIV-1 has been found to infect the placenta in fi...

journal_title：AIDS research and human retroviruses

authors： Zachar V,Zacharova V,Fink T,Thomas RA,King BR,Ebbesen P,Jones TB,Goustin AS

更新日期：1999-12-10 00:00:00

abstract：:A previously described self-complementary oligodeoxynucleotide termed triplex-forming oligodeoxynucleotide (TFO A), 54 bases in length, designed against the polypurine tract of HIV-1 RNA, inhibited viral replication at a 1 to 3 microM concentration in acutely infected cells, whereas antisense and scrambled sequence ol...

journal_title：AIDS research and human retroviruses

authors： Jendis J,Strack B,Volkmann S,Böni J,Mölling K

更新日期：1996-08-10 00:00:00

abstract：:The humoral immune response is a mechanism that potently suppresses or prevents viral infections. However, genetic diversity and resistance to antibody-mediated neutralization are serious obstacles in controlling HIV-1 infection. In this study, we isolated monoclonal antibodies from an SIV-infected macaque by using th...

journal_title：AIDS research and human retroviruses

authors： Kuwata T,Katsumata Y,Takaki K,Miura T,Igarashi T

更新日期：2011-05-01 00:00:00

abstract：:Population genotyping (PG) can underestimate resistance if resistance-containing low abundance variants go undetected. PG and clonal analysis (CA) results were compared in virologic failures (VFs) from a 48-week clinical trial that evaluated once-daily fosamprenavir/ritonavir (FPV/r) 1400 mg/100 mg or atazanavir/riton...

journal_title：AIDS research and human retroviruses

authors： Ross LL,Weinberg WG,DeJesus E,Fischl MA,Horton JH,Pappa KA,Lancaster CT,Pakes GE,Smith KY

更新日期：2010-04-01 00:00:00

abstract：:Subunit vaccines based on recombinant proteins have proved useful for inducing antibody responses and they are safe for widespread use because they do not contain any live components. Unfortunately, they do not typically induce the types of cell-mediated immune responses required to control viral pathogens; specifical...

journal_title：AIDS research and human retroviruses

authors： Newman MJ,Munroe KJ,Anderson CA,Murphy CI,Panicali DL,Seals JR,Wu JY,Wyand MS,Kensil CR

更新日期：1994-07-01 00:00:00

abstract：:Using blood samples from primary HIV-1 infection (PHI) patients obtained in Lyon, France, we characterized the newly transmitted HIV-1 variants in this area during the 1992-1996 period. As PHI samples allowed the precise timing of the transmission event, we were able to date the introduction of non-B subtypes or recom...

journal_title：AIDS research and human retroviruses

authors： Vachot L,Ataman-Onal Y,Terrat C,Durand PY,Ponceau B,Biron F,Verrier B

更新日期：2004-07-01 00:00:00

abstract：:The nucleotide sequence of the gp41 transmembrane protein coding region of human immunodeficiency virus type 1 (HIV-1) proviral DNA obtained from blood and cerebrospinal fluid (CSF) from 6 individuals was determined by direct sequencing of polymerase chain reaction (PCR)-amplified DNA. The direct sequencing approach w...

journal_title：AIDS research and human retroviruses

authors： Steuler H,Storch-Hagenlocher B,Wildemann B

更新日期：1992-01-01 00:00:00

abstract：:The HIV-1 subtype A epidemic affecting injecting drug users (IDU) in former Soviet Union (FSU) countries started dramatically in Odessa, southern Ukraine, in 1995, and is caused by a variant of monophyletic origin, often designated IDU-A. We phylogenetically analyzed one near full-length genome and two partial sequenc...

journal_title：AIDS research and human retroviruses

authors： Thomson MM,de Parga EV,Vinogradova A,Sierra M,Yakovlev A,Rakhmanova A,Delgado E,Casado G,Muñoz M,Carmona R,Vega Y,Pérez-Alvarez L,Contreras G,Medrano L,Osmanov S,Nájera R

更新日期：2007-12-01 00:00:00

abstract：:HIV infection is a risk factor for the tumorigenesis including non-AIDS-defining cancers such as those of the gastrointestinal tract. However, the mechanisms underlying such cancer outgrowth are still unknown. Furthermore, combined HIV/cancer studies are difficult to evaluate using primate models or in the clinical pa...

journal_title：AIDS research and human retroviruses

authors： Lu R,Wu S,Zhang Y,Xia Y,Huelsmann EJ,Lacek AT,Nabatiyan A,Richards MH,Narasipura SD,Lutgen V,Chen H,Kaufman HL,Chen D,Al-Harthi L,Zloza A,Sun J

更新日期：2014-07-01 00:00:00

abstract：:Several broadly neutralizing antibodies (bNAbs) that can target HIV strains with large degrees of variability have recently been identified. However, efforts to induce synthesis of such bNAbs that can protect against HIV infection have not met with much success. Identification of specific epitopes encoded in the HIV-1...

journal_title：AIDS research and human retroviruses

authors： Cheedarla N,Sundaramurthi JC,Hemalatha B,Anangi B,Nesakumar M,Ashokkumar M,Vidya Vijayan KK,Tripathy SP,Swaminathan S,Vaniambadi SK,Ramanathan DV,Hanna LE

更新日期：2019-02-01 00:00:00

abstract：:More than 200 sera from macaques immunized with several different vaccine preparations were tested in various assays with cells of human and macaque origin. Only in instances where whole inactivated SIV preparations were used for immunization, were reactivities found with normal human cells, and this was the case in e...

journal_title：AIDS research and human retroviruses

authors： Langlois AJ,Weinhold KJ,Matthews TJ,Greenberg ML,Bolognesi DP

更新日期：1992-09-01 00:00:00

abstract：:Cytotoxic T lymphocytes that specifically lyse HIV-1-infected cells occur at uncommonly high frequency in the blood of infected individuals. The CTL response is dominated by the recognition of a small number of peptides encoded by HIV-1 structural and regulatory genes. These two facts have enabled us to develop potent...

journal_title：AIDS research and human retroviruses

authors： Lieberman J,Fabry JA,Shankar P,Beckett L,Skolnik PR

更新日期：1995-02-01 00:00:00

abstract：:It became evident that tenofovir DF (TDF) causes a modest and gradual decline in GFR, however, the impact of long-term use of TDF on tubular function has not been fully evaluated. In 40 patients treated with TDF and 23 patients treated with other NRTIs, urine beta(2)-microglobulin (U-BMG), percentage tubular reabsorpt...

journal_title：AIDS research and human retroviruses

authors： Kinai E,Hanabusa H

更新日期：2009-04-01 00:00:00