The immunodeficiency virus coreceptor, Bonzo/STRL33/TYMSTR, is expressed by macaque and human skin- and blood-derived dendritic cells.

abstract：:Despite repeated exposures to HIV-1, some individuals remain seronegative. This study reports that sera from a fraction of exposed seronegative (ESN) subjects showed HIV-neutralizing activity; 5 of 17 ESN sera and none of 17 controls neutralized two different HIV-1 primary isolates (range of neutralizing titers: 1/20 ...

journal_title：AIDS research and human retroviruses

authors： Lopalco L,Pastori C,Cosma A,Burastero SE,Capiluppi B,Boeri E,Beretta A,Lazzarin A,Siccardi AG

更新日期：2000-01-20 00:00:00

abstract：:The Northeastern Brazilian region has experienced a constant increase in the number of newly reported AIDS cases over the last decade, but the genetic diversity of HIV-1 strains currently disseminated in this region remains poorly explored. HIV-1 pol sequences were obtained from 140 patients followed at outpatient cli...

journal_title：AIDS research and human retroviruses

authors： Delatorre E,Couto-Fernandez JC,Bello G

更新日期：2017-07-01 00:00:00

abstract：:Up to now, all known env subtype E viruses (CRF01-AE) have had the same mosaic structure with subtype A, and no other env subtype E HIV-1 viruses with non-A subtypes in their genomes have been described. In this report we describe the full-length genome sequence of an env subtype E isolate with a recombinant genome di...

journal_title：AIDS research and human retroviruses

authors： Vidal N,Mulanga-Kabeya C,Nzilambi N,Delaporte E,Peeters M

更新日期：2000-12-10 00:00:00

abstract：:Pathogenic microorganisms encode proteins that antagonize specific aspects of innate or adaptive immunity. Just as the study of the HIV-1 accessory protein Vif led to the identification of cellular cytidine deaminases as host defense proteins, the study of HIV-1 Vpu recently led to the discovery of the interferon-indu...

journal_title：AIDS research and human retroviruses

authors： Tokarev A,Skasko M,Fitzpatrick K,Guatelli J

更新日期：2009-12-01 00:00:00

abstract：:Mycophenolate mofetil (MMF), the bioavailable form of mycophenolic acid (MPA), has been proposed as adjuvant therapy for human immunodeficiency virus type 1 (HIV-1) infection. MPA can inhibit viral replication and might blunt virus-induced immunopathology. However, other effects of this inhibitor might be detrimental ...

journal_title：AIDS research and human retroviruses

authors： Kaur R,Klichko V,Margolis D

更新日期：2005-02-01 00:00:00

abstract：:We investigated whether V3-binding assays might be useful to analyze human immunodeficiency virus type 1 (HIV-1) variants in different geographic regions. We showed that strong cross-reactivity between subtype-specific V3 peptides is almost inevitable in standard indirect enzyme-linked immunosorbent assays (EIA), impa...

journal_title：AIDS research and human retroviruses

authors： Barin F,Lahbabi Y,Buzelay L,Lejeune B,Baillou-Beaufils A,Denis F,Mathiot C,M'Boup S,Vithayasai V,Dietrich U,Goudeau A

更新日期：1996-09-01 00:00:00

abstract：:We recently reported a novel adhesion pathway in lymphocytes that is mediated by cyclin-dependent kinase (Cdk) 4 activity and mediates lymphocyte interactions with endothelial matrix. We now demonstrate that HIV-infected lymphocytes also use Cdk4 to mediate spontaneous adhesion to fibronectin and endothelial matrix. W...

journal_title：AIDS research and human retroviruses

authors： Chow YH,Liu L,Schwartz B,Harlan JM,Schnapp LM

更新日期：2012-12-01 00:00:00

abstract：:Osteopenia is a common and debilitating side-effect of HAART, yet little is known concerning the effects of HAART on bone metabolism. We reported previously that zidovudine (AZT) stimulates osteoclastogenesis in vitro and causes osteopenia in mice. Here, we confirmed that the AZT-induced osteoclastogenesis is dependen...

journal_title：AIDS research and human retroviruses

authors： Pan G,Kilby M,McDonald JM

更新日期：2006-11-01 00:00:00

abstract：:The prevalence of human immunodeficiency virus type 1 (HIV-1) is highest among men who have sex with men (MSM) in Jamaica but no genotypic data are available on the virus strains that are responsible for the epidemic among this key population. HIV-1 polymerase (pol) genes from 65 MSM were sequenced and used to predict...

journal_title：AIDS research and human retroviruses

authors： Collins-Fairclough AM,Dennis AM,Nelson JA,Weir SS,Figueroa JP

更新日期：2015-08-01 00:00:00

abstract：:We report here a novel HIV-1 second-generation recombinant form (CRF01_AE/CRF07_BC) composed of CRF01_AE and CRF07_BC, identified among men who have sex with men (MSM) in Jilin, with four breakpoints observed in the pol, vif, and vpr genes. The CRF01_AE regions of the recombinant were clustered with the CRF01_AE linea...

journal_title：AIDS research and human retroviruses

authors： Li X,Ning C,He X,Yang Y,Xing H,Hong K,Shao Y,Yang R

更新日期：2013-12-01 00:00:00

abstract：:We have studied a woman with transfusion-acquired HIV who appears to have contained infectious virus to consistently undetectable levels over a 13-year period without antiviral treatment. She received the infected transfusion for intra- and postpartum blood loss immediately after delivery of her second child in 1981. ...

journal_title：AIDS research and human retroviruses

authors： Schwartz D,Sharma U,Busch M,Weinhold K,Matthews T,Lieberman J,Birx D,Farzedagen H,Margolick J,Quinn T

更新日期：1994-12-01 00:00:00

abstract：:Antibodies to the carboxy-terminal constant (C5) region 5 of the HIV-1 envelope glycoprotein gp120 have previously been associated with slow disease progression. This is one of the regions on gp120 that interact with the transmembrane glycoprotein, gp41, anchoring it to the viral and infected cell membrane. This study...

journal_title：AIDS research and human retroviruses

authors： Sørensen B,Sommerfelt MA,Stjernholm G,Smith PL,Ökvist M,Hovden AO,Hoddevik G,Redfield R,Ustina V,Jelmert Ø,Zeldis J,Dalgleish A

更新日期：2017-06-01 00:00:00

abstract：:Little is known about the consequences of short cycles of structured treatment interruption or definitive interruption of HAART for both T cell subset dynamics and T lymphoproliferative responses (LPR). Immunological follow-up was performed in 45 early chronical HIV-1-infected patients during short STI cycles during t...

journal_title：AIDS research and human retroviruses

authors： Libois A,López A,Garcia F,Castro P,Maleno MJ,García A,Climent N,Arnedo M,Gallart T,Gatell JM,Plana M

更新日期：2006-07-01 00:00:00

abstract：:The derivation of ethyl-methanesulfonate (EMS) mutagenized subclones from the CEM T-cell line has been described. These clones expressed CD4 and bound soluble gp120, however, two of the generated clones were markedly reduced in their ability to form syncytia after infection with either gp160-vaccinia vector or cell-fr...

journal_title：AIDS research and human retroviruses

authors： Gruber MF,Hewlett IK,Simms T,Vujcic L,Manischewitz J,Golding H

更新日期：1992-06-01 00:00:00

abstract：:Genetic polymorphisms within the MHC encoding region have the strongest impact on HIV disease progression of any in the human genome and provide important clues to the mechanisms of HIV immune control. Few analyses have been undertaken of HLA alleles associated with rapid disease progression. HLA-B*07:02 is an HLA cla...

journal_title：AIDS research and human retroviruses

authors： Kløverpris HN,Adland E,Koyanagi M,Stryhn A,Harndahl M,Matthews PC,Shapiro R,Walker BD,Ndung'u T,Brander C,Takiguchi M,Buus S,Goulder P

更新日期：2014-05-01 00:00:00

abstract：:An atypical HIV-1 strain (CAM001) was identified in a pregnant Cameroonian woman in 1995. HMA subtyping of the env region was unsuccessful, and sequence analyses were performed. Unique sequence motifs were found at the V3 tip (GAGRALHA and GAGRAWIHA), and phylogenetic studies showed that the env C2-V5 sequence branche...

journal_title：AIDS research and human retroviruses

authors： Roques P,Menu E,Narwa R,Scarlatti G,Tresoldi E,Damond F,Mauclère P,Dormont D,Chaouat G,Simon F,Barré-Sinoussi F

更新日期：1999-11-20 00:00:00

abstract：:To help in the vaccine development, WHO-UNAIDS launched a program for the isolation and characterization of subtype C viruses, the most prevalent HIV-1 subtype in the world. Isolates were obtained from Brazil, China, India, Israel, and South Africa, countries in which these strains are circulating. In this study we ge...

journal_title：AIDS research and human retroviruses

authors： Sánchez-Merino V,Herrero CC,Amorin-Nink A,von Briesen H,López-Galíndez C,World Health Organization-UNAIDS Network for Isolation and Characterization.

更新日期：2003-01-01 00:00:00

abstract：:Several regulatory sequences have been characterized in the HTLV-I promoter. We report here identification of a sequence element downstream of the transcriptional start site within the first 52 nucleotides of the 5' R region, which acts negatively on the activity of the HTLV-I promoter. Determination of the half-lives...

journal_title：AIDS research and human retroviruses

authors： Montagne J,Jalinot P

更新日期：1995-09-01 00:00:00

abstract：:Ascorbic acid (ascorbate or vitamin C) has been shown to suppress the induction of HIV in latently infected T lymphocytic cells following stimulation with a tumor promoter (PMA) and inflammatory cytokine (TNF-alpha). To assess whether this inhibition was mediated via modulation of the cellular transcription factor, NF...

journal_title：AIDS research and human retroviruses

authors： Harakeh S,Jariwalla RJ

更新日期：1997-02-10 00:00:00

abstract：:Natural polymorphisms of HIV-1, often associated with drug resistance, are widely described in protease and reverse transcriptase regions but data on their presence in the integrase region, especially in non-B subtypes, are still very limited. We aimed to characterize naturally occurring polymorphisms in the integrase...

journal_title：AIDS research and human retroviruses

authors： Avi R,Huik K,Sadam M,Karki T,Krispin T,Ainsalu K,Paap P,Schmidt J,Nikitina N,Lutsar I

更新日期：2010-10-01 00:00:00

abstract：:The concept that HIV causes AIDS only by directly killing CD4 cells has been questioned by a number of investigators. There has been experimental support for a number of indirect mechanisms such as apoptosis, anergy, superantigen-induced cell proliferation and depletion, defective signaling, molecular mimicry, and aut...

journal_title：AIDS research and human retroviruses

authors： Gougeon ML,Colizzi V,Dalgleish A,Montagnier L

更新日期：1993-03-01 00:00:00

abstract：:Monocytes are known as an alternative target for HIV/SIV infection, but the contribution of monocytes to viral spread in a host is unclear. In this study, CD14 monocytes were monitored in 6 macaques until six weeks postinfection (wpi) with SIVmac239 to evaluate their contribution to viral load. The monocyte count in b...

journal_title：AIDS research and human retroviruses

authors： Kuwata T,Kodama M,Sato A,Suzuki H,Miyazaki Y,Miura T,Hayami M

更新日期：2007-03-01 00:00:00

abstract：:We studied 123 samples from adult chronic HIV patients initiating HAART from various centers around a newly established clinical trial site in Pretoria. Each sample was sequenced in at least one structural gene (pol, gag, and env) or functional gene (vif, vpr, and vpu). A subset of 25 samples was subjected to near ful...

journal_title：AIDS research and human retroviruses

authors： Musyoki A,Mothapo K,Rakgole J,Lukhwareni A,Bessong P,Selabe G,Bredell H,Williamson C,Mphahlele MJ

更新日期：2012-09-01 00:00:00

abstract：:Current methods to detect intraclade HIV dual infection are poorly suited for determining its prevalence in large cohorts. To investigate the potential of ultra-deep sequencing to screen for dual infection, we compared it to bulk sequence-based synonymous mixture index and the current standard of single genome sequenc...

journal_title：AIDS research and human retroviruses

authors： Pacold M,Smith D,Little S,Cheng PM,Jordan P,Ignacio C,Richman D,Pond SK

更新日期：2010-12-01 00:00:00

abstract：:We partially purified the human immunodeficiency virus (HIV) glycoprotein gp41 from infected H9 cells by immunoaffinity chromatography using a column containing the M25 monoclonal antibody (diMarzo-Veronese et al., 1985). A pH 11.5 buffer worked best for eluting the glycoprotein from this column. The eluted gp41 was u...

journal_title：AIDS research and human retroviruses

authors： Zweig M,Showalter SD,Bladen SV,Gilden RV,Arthur LO,Robey WG,Nara PL,Fischinger PJ

更新日期：1988-02-01 00:00:00

abstract：:A strain of mouse transgenic for the env gene of the HIV-1 virus was used to study the immunogenicity of a gp160-derived vaccine (the protein encoded by the HIV env gene) and its effect on disease progression. Untreated transgenic mice frequently developed a rapidly progressive renal disease similar to that affecting ...

journal_title：AIDS research and human retroviruses

authors： Shirai A,Klinman DM

更新日期：1993-10-01 00:00:00

abstract：:Although the breadth of the human immunodeficiency virus type 1 (HIV-1)-specific cellular immune response and its impact on the control of viral replication have already been addressed, reported data have proven controversial. We hypothesize that the nature of targeted epitopes, rather than the simple breadth or magni...

journal_title：AIDS research and human retroviruses

authors： Tarosso LF,Vieira VA,Sauer MM,Tomiyama HI,Kalil J,Kallas EG

更新日期：2017-08-01 00:00:00

abstract：:An EBV-transformed lymphoblastoid B cell clone (A12) derived from peripheral blood lymphocytes of an HIV-1-infected individual is described. The immunoglobulin isotype produced by this clone was IgM, and Southern blot analysis of immunoglobulin gene rearrangement showed a monoclonal pattern. The A12 monoclonal antibod...

journal_title：AIDS research and human retroviruses

authors： Amadori A,Ciminale V,Calabro ML,Tessarollo L,Francavilla E,Chieco-Bianchi L

更新日期：1989-02-01 00:00:00

abstract：:In India Kaposi's sarcoma is rarely seen in AIDS patients. Hence the current belief is that the incidence of human herpesvirus-8 (HHV-8) is very low in this subcontinent, most probably due to the heterosexual route of HIV transmission. However, there is a scarcity of data on the prevalence of HHV-8 in India. In India ...

journal_title：AIDS research and human retroviruses

authors： Munawwar A,Sharma SK,Gupta S,Singh S

更新日期：2014-12-01 00:00:00

abstract：:HIV-1 subtype B isolates have previously been described in India only in the state of Andhra Pradesh, while subtype C isolates have been reported as widespread in the Bombay and Goa regions of India. Gag subtype was determined in HIV-1 isolates from six Indians and one Ethiopian. One Indian was a native of Goa resid...

journal_title：AIDS research and human retroviruses

authors： Voevodin A,Crandall KA,Seth P,al Mufti S

更新日期：1996-05-01 00:00:00