Placental histopathological findings in obese and nonobese women with complicated and uncomplicated pregnancies.

Abstract:

PURPOSE:To investigate the role of placental abnormalities in complicated and uncomplicated pregnancies in obese women. METHODS:Placentas from patients with complicated or uncomplicated pregnancies and a pregravid body mass index (BMI) of ≥30 kg/m2 were analyzed histopathologically for lesions consistent with maternal and fetal circulation abnormalities and inflammatory lesions related to the maternal or fetal response. Findings were compared with a normal-weight control group matched by mode of delivery and presence/type of pregnancy complications. RESULTS:The obese group consisted of 28 women of whom 46% had a complicated pregnancy. The obese group had a higher rate of maternal inflammatory lesions than the normal-weight control group (43 vs. 3.6%, p<0.001). There was no difference between the obese women with complicated and uncomplicated pregnancies in mean placental weight or lesions associated with fetal or maternal vascular supply. CONCLUSION:Placental inflammatory lesions may underlie the worse pregnancy course of obese women relative to normal-weight women.

journal_name

Arch Gynecol Obstet

authors

Bar J,Schreiber L,Saruhanov E,Ben-Haroush A,Golan A,Kovo M

doi

10.1007/s00404-012-2450-z

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

1343-7

issue

6

eissn

0932-0067

issn

1432-0711

journal_volume

286

pub_type

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