Metformin and ovarian cancer survival: is there a rational warrant for belief?

Abstract:

:Metformin (MF) represents the first-line drug used to treat type 2 diabetes. Recently, MF has also been reported to be a potential and promising anti-cancer agent for some gynecological cancers' prevention. MF, as an anti-tumorigenic factor, may reduce the chance of developing ovarian cancer by targeting IL-6. By acting on IL-6 expression, metformin might have a positive impact on the main molecular pathways strictly connected with pathogenesis and biological features of ovarian cancer. Further investigation is warranted to better define the use of MF as a possible treatment option in the fight against ovarian cancer.

journal_name

Arch Gynecol Obstet

authors

Mormile R

doi

10.1007/s00404-019-05252-3

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

797-798

issue

4

eissn

0932-0067

issn

1432-0711

pii

10.1007/s00404-019-05252-3

journal_volume

300

pub_type

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