Abstract：
OBJECTIVE:Effective cytotoxic treatment options for advanced cervical cancer are exceedingly limited. Therefore, interest has increased in targeted therapeutics for the treatment of cervical cancer. Cetuximab, a monoclonal antibody, binds specifically to the epidermal growth factor receptor (EGFR) and competitively inhibits the binding of epidermal growth factor and other ligands. In cervical cancer the expression of EGFR is reported in up to 85% of the tumour cells. Therefore, Cetuximab monotherapy could be a new option in the treatment of patients with advanced cervical cancer. STUDY DESIGN:Five patients with advanced cervical cancer were treated with Cetuximab monotherapy as third- to fifth-line therapy between 2005 and 2008 in our institution. The tumour stage at the time of diagnosis ranged between IIB and IVB. Cetuximab was applied with an initial loading dose of 400 mg/m(2) followed by a dose of 250 mg/m(2) weekly. RESULTS:Only one patient (20%) had a stable disease, and the other four a progressive disease during Cetuximab monotherapy, after the RECIST criteria. Four out of five patients (80%) developed an acneiform rash as a common observed side effect of Cetuximab therapy. The median survival time from the beginning of the Cetuximab therapy was 8.6 months. CONCLUSION:No advantage could be found in the treatment with Cetuximab monotherapy in patients with advanced cervical cancer in this study. Further studies are necessary to evaluate the significance of Cetuximab in the treatment of advanced cervical cancer.
journal_name
Arch Gynecol Obstetjournal_title
Archives of gynecology and obstetricsauthors
Hertlein L,Lenhard M,Kirschenhofer A,Kahlert S,Mayr D,Burges A,Friese Kdoi
10.1007/s00404-010-1389-1subject
Has Abstractpub_date
2011-01-01 00:00:00pages
109-13issue
1eissn
0932-0067issn
1432-0711journal_volume
283pub_type
杂志文章abstract：BACKGROUND:Giant myomas of the uterus are uncommon, particularly in developed countries. CASE:This report illustrates a case of a woman with a bilobated giant myoma of the uterus weighed in total 27.7 kg. The patient had an abdominal distension first noted 18 months before and the personal history evidenced difficulti...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-007-0523-1
更新日期：2008-07-01 00:00:00
abstract：:We studied the prognostic value of anaemia in the evolution of patients with early stages of uterine cervix cancer and treated with radical surgery. An observational study of 114 patients treated for cervical cancer at the "La Fe" Maternity Hospital in Valencia (Spain) during the period 1971 to 1989. Survival analyses...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-002-0296-5
更新日期：2003-01-01 00:00:00
abstract：PURPOSE:To calculate the measurement error of the hourly fetal urine production rate (HFUPR) and evaluate the implication of different methods for measuring the HFUPR, i.e. ellipsoid versus sum-of-cylinders method. METHODS:The calculation was based on sonographic documentation of the increased bladder volumes during t...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-009-1242-6
更新日期：2010-11-01 00:00:00
abstract：OBJECTIVE:To assess the impact of pre-hCG elevated progesterone on live birth outcomes during GnRH agonist long down regulated protocol assisted reproduction cycles. DESIGN:Retrospective cohort study. SETTING:Single Centre Private IVF Clinic. PATIENTS:A total of 582 consecutive cycles of IVF/ICSI in 2003. INTERVENT...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-011-2045-0
更新日期：2012-02-01 00:00:00
abstract：:In the original article publication, the authors given name and family name were interchanged. ...
journal_title：Archives of gynecology and obstetrics
pub_type： 已发布勘误
doi：10.1007/s00404-019-05279-6
更新日期：2019-10-01 00:00:00
abstract：PURPOSE:Hydrotubation has been considered to be a complimentary procedure to reproductive surgery, usually being conducted after surgery. The objective of this work was to assess the potential value of intra-operative hydrotubation in improving fertility of tubal infertile women. METHODS:180 tubal infertile women were...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00404-012-2525-x
更新日期：2013-01-01 00:00:00
abstract：AIM:Breast cancer 2, early onset (BRCA2) has been reported to be associated with familial breast and ovarian cancer. Several proteins interact with conserved regions of BRCA2, which play significant roles in DNA damage repair and centrosomal localization. This study was aimed to identify a novel protein, Wilms tumor 1 ...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-016-4176-9
更新日期：2016-11-01 00:00:00
abstract：PURPOSE:To compare the effectiveness of intravenous carbetocin to that of intravenous oxytocin for prevention of atonic postpartum hemorrhage (PPH) after vaginal delivery in high-risk singleton pregnancies. METHODS:This triple-blind randomized controlled trial included singleton pregnant women who delivered at Siriraj...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00404-018-4806-5
更新日期：2018-08-01 00:00:00
abstract：PURPOSE:The purpose of our study was to evaluate obstetrical and fetal outcomes in pregnancies complicated by acute appendicitis, and to specifically evaluate the impact of peritonitis. METHODS:We conducted a population-based cohort study using the Healthcare Cost and Utilization Project-Nationwide Inpatient Sample fr...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-014-3276-7
更新日期：2014-10-01 00:00:00
abstract：INTRODUCTION:Morbid obesity is perhaps the most common nutritional disorder seen in pregnancy, and morbidly obese parturients have more pregnancy complication than normal body mass index (BMI) pregnant patients. Combined spinal epidural anesthesia (CSEA) has become a well-established alternative to epidural analgesia f...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-004-0634-x
更新日期：2005-04-01 00:00:00
abstract：PURPOSE:Recent evidence suggests that ADP-ribosylation factor-like tumor suppressor gene 1(ARLTS1) may act as a tumor suppressor gene. However, its role in tumor chemotherapy remains unclear. The aim of this study is to investigate the effects of ARLTS1 gene in regulation of chemosensitivity in ovarian cystadenocarcino...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-010-1782-9
更新日期：2011-11-01 00:00:00
abstract：:We assessed the value of preoperative chest x-rays in gynecological patients. Abnormalities were noted in the chest x-rays of 10% of 1175 patients with genital or breast disorders. When the chest x-ray was abnormal, 48% of patients had no clinical features of intrathoracic disease. Abnormal chest x-ray results did not...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/BF00932085
更新日期：1988-01-01 00:00:00
abstract：PURPOSE:Epithelial-mesenchymal transition (EMT) endows cells with migratory and invasive properties, a prerequisite for the establishment of endometriotic lesions. However, the role EMT might play in the pathophysiology of endometriosis is still unknown. Therefore, we examined five recognized markers for EMT in endomet...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-013-3040-4
更新日期：2014-04-01 00:00:00
abstract：PRESENTATION:We detected an unusual placental lake under the membranes between the two lobes of a placenta bilobate with a turbulent blood flow in it. This was an extraordinary maternal lake: simply the accumulation of maternal blood inside the intervillous space in an area where villous structures were absent between ...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-004-0649-3
更新日期：2005-01-01 00:00:00
abstract：PURPOSE:Hypoxia inducible factor-1α (HIF-1α), regulated in development and DNA damage response-1 (REDD1), and mammalian target of rapamycin (mTOR) play distinct roles in response to hypoxia. The aim of this study was to evaluate whether the HIF-1α-REDD1-mTOR-mediated hypoxic stress response also operates normally in es...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-016-4186-7
更新日期：2016-11-01 00:00:00
abstract：OBJECTIVE:We compared the safety and effectiveness of oxytocin, dinoprostone and misoprostol for cervical priming. STUDY DESIGN:A total of 218 patients were enrolled to receive between one and three treatments according to physicians' options. The end points were: (1) vaginal delivery or Bishop score ≥ 8 at the end of...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-011-1844-7
更新日期：2011-12-01 00:00:00
abstract：INTRODUCTION:Although breast cancer is a major health problem worldwide, metastatic disease to the lower genital tract remains to be a rare event. CASE REPORT:A 64-year old woman was admitted to our hospital due to newly diagnosed ascites and peripheral edema. A computer tomography had shown peritoneal carcinosis but ...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-011-1843-8
更新日期：2011-03-01 00:00:00
abstract：INTRODUCTION:Craniosynostosis is a condition characterized by a premature closure of one or more skull sutures and refers to a wide spectrum of cranial malformation with an estimated birth of 1:2,000-1:4,000 live births. Four receptors (FGFR 1, FGFR 2, FGFR 3, FGFR 4) involving mutation in the fibroblast growth factor ...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,评审
doi：10.1007/s00404-010-1643-6
更新日期：2011-04-01 00:00:00
abstract：PURPOSE:To test the reliability of the admission test to identify the compromised fetus and thus reduce the neonatal morbidity and mortality by early intervention. METHODS:A prospective analysis over a period of 1 year from December 2007 to December 2008 included 100 antepartum patients and were evaluated for perinata...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-010-1406-4
更新日期：2010-10-01 00:00:00
abstract：INTRODUCTION:Conization of the uterine cervix is a common gynecological procedure that sometimes causes cervical stenosis which creates difficulties for future gynecological procedures. MATERIAL:We present a very unusual case where strenuous effort was needed to obtain safe access to the endocervical canal and endomet...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-010-1832-3
更新日期：2011-03-01 00:00:00
abstract：PURPOSE:The systemic inflammatory response markers have been reported to be associated with the prognosis of various cancers. We conducted this meta-analysis of retrospective studies to evaluate and identify the prognostic impact of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) on ovarian ...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00404-018-4678-8
更新日期：2018-04-01 00:00:00
abstract：PURPOSE:To investigate the role of epigenetic inactivation of hMLH1 during the malignant transformation of ovarian endometriosis (EMs), and to explore the relationship between the epigenetic inactivation of hMLH1 in eutopic endometria and the malignant transformation of ovarian EMs. METHODS:The target tissue from 29 c...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-011-1922-x
更新日期：2012-01-01 00:00:00
abstract：INTRODUCTION:Controlled ovarian stimulation (COS) with intrauterine insemination (IUI) is an effective treatment in cases of cervical factor, unexplained infertility and mild male factor. The optimal timing of IUI after human chorionic gonadotrophin (hCG) after COS with clomiphene citrate is debatable and may be a fact...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00404-011-1950-6
更新日期：2011-10-01 00:00:00
abstract：PURPOSE:Since the first description about oxygen toxicity made by Joseph Priestley, the oxidative stress has been enrolled as a key factor in the pathogenesis of endometriosis. Our aim was to review oxidative stress biomarkers measured in patients with endometriosis. METHODS:Relevant studies were identified by searche...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,评审
doi：10.1007/s00404-012-2439-7
更新日期：2012-10-01 00:00:00
abstract：PURPOSE:This study aimed to develop a valid and reliable tool for evaluation of sexual health assessment in infertile women. METHODS:This was a mixed exploratory study consisting of two phases. At phase one, we reviewed the existing instruments and interviewed 20 infertile women to generate an item pool. Then, the res...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-020-05832-8
更新日期：2020-10-19 00:00:00
abstract：PURPOSE:To investigate the efficacy of bupivacaine-soaked spongostan in cesarean section wound for postoperative anxiety level, satisfaction and early postpartum depression rate. METHODS:A total of 121 women, American Society of Anesthesiologists physical status I-II, scheduled to undergo general anesthesia and electi...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00404-014-3201-0
更新日期：2014-08-01 00:00:00
abstract：AIM:In order to assess the responsiveness of short forms of the Incontinence Impact Questionnaire (IIQ-7) and Urogenital Distress Inventory (UDI-6) in a subset of women undergoing radical operations for gynecologic cancer. MATERIALS AND METHODS:Women with cervical cancer without any abnormal urodynamic abnormalities w...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-010-1823-4
更新日期：2011-11-01 00:00:00
abstract：INTRODUCTION:Bacterial vaginosis (BV) is the most common vaginal disorder in reproductive-age women. The condition is characterised by the replacement of a healthy, lactobacilli-dominated vaginal microbiota by anaerobic and facultative anaerobic bacteria. BV increases the risk of acquisition of STIs and is associated w...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,评审
doi：10.1007/s00404-019-05142-8
更新日期：2019-07-01 00:00:00
abstract：OBJECTIVE:To investigate whether episiotomy prevents 3rd or 4th degree perineal tears in critical conditions such as shoulder dystocia, instrumental deliveries (vacuum or forceps), persistent occiput-posterior position, fetal macrosomia (>4,000 g), and non-reassuring fetal heart rate (NRFHR) patterns. METHODS:A retros...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-012-2460-x
更新日期：2012-12-01 00:00:00
abstract：OBJECTIVE:We aimed to evaluate perinatal outcome of seven pregnancies with twin reserve arterial perfusion sequence. MATERIALS AND METHODS:The study group included seven cases of acardiac twins. Out of seven acardiac twins, two cases were in follow-up without any interventions. We performed four alcohol ablation and o...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-008-0640-5
更新日期：2008-12-01 00:00:00
