A comparison of misoprostol, controlled-release dinoprostone vaginal insert and oxytocin for cervical ripening.

Abstract:

OBJECTIVE:We compared the safety and effectiveness of oxytocin, dinoprostone and misoprostol for cervical priming. STUDY DESIGN:A total of 218 patients were enrolled to receive between one and three treatments according to physicians' options. The end points were: (1) vaginal delivery or Bishop score ≥ 8 at the end of 12 h, (2) vaginal delivery by 12 h or difference ≥ 4 between the initial and 12th hour Bishop scores. Statistical analyses were performed with ANOVA, Krustal Wallis, Scheffe, χ², Fisher, Advanced χ², and Kolmogorov-Smirnov tests. Tukey's HSD was used as a post hoc test. RESULTS:Misoprostol showed statistical significance for the rate of vaginal delivery <12 h, ≥ 8 Bishop score at the end of 12 h, and cervical change of ≥ 4 Bishop scores within 12 h (p = 0.013). CONCLUSIONS:Comparison between cases Bishop score <4 showed that misoprostol is more effective than dinoprostone and oxytocin. Considering Bishop score = 0 cases we calculated no statistical significance.

journal_name

Arch Gynecol Obstet

authors

Silfeler DB,Tandogan B,Ayvaci H,Silfeler I,Yenidede I,Dayicioglu V

doi

10.1007/s00404-011-1844-7

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

1331-7

issue

6

eissn

0932-0067

issn

1432-0711

journal_volume

284

pub_type

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