Abstract：
INTRODUCTION:Diabetes and pregnancy can be associated in two ways: pregnancy that occurs in women who are already diabetic (diabetes of pre-gestational origin); and diabetes that occur in women who are already pregnant [gestational diabetes mellitus (GDM) (O'sullivan 1961)]. Patients with previous GDM history have higher risk of developing diabetes outside of pregnancy. Accumulating literature had suggested that adiponectin plays a role in the pathophysiology of this metabolic syndrome, and several of the common single nucleotide polymorphisms (SNP) in adiponectin gene have been identified in type 2 diabetes. Thus, one of the commonly found SNP was studied to determine its association with GDM. OBJECTIVE:To identify the association of SNP45TG with GDM. METHODS:This is a cross-sectional study involving pregnant mothers of <18 gestational weeks, who were recruited from three local antenatal clinics in Selangor, Malaysia. Their genomic DNA was extracted from EDTA treated whole blood using commercialized kit. Adiponectin gene was amplified through conventional PCR and SNP was detected using restriction enzyme SmaI. Plasma adiponectin level, fructosamine level and HbA(1c) percentage were also examined. RESULTS:Among the 79 antenatal patients recruited, 53 patients were normal and 26 were diagnosed with GDM. Among the 53 normal patients, 18 carry TG/GG genotype. Meanwhile, among the 26 patients that were diagnosed with GDM 15 carry TG/GG genotype. Significant association was found between SNP45TG with GDM ( χ(2) = 4.038; P < 0.05). In addition, normal patients with TT genotype have significantly higher plasma adiponectin level compared to other groups. CONCLUSION:We concluded that SNP45TG in adiponectin gene is associated with the occurrence of GDM.
journal_name
Arch Gynecol Obstetjournal_title
Archives of gynecology and obstetricsauthors
Low CF,Mohd Tohit ER,Chong PP,Idris Fdoi
10.1007/s00404-010-1548-4subject
Has Abstractpub_date
2011-06-01 00:00:00pages
1255-60issue
6eissn
0932-0067issn
1432-0711journal_volume
283pub_type
杂志文章abstract：PURPOSE:To compare pregnancy outcomes in grand-multiparous (GMP) women with and without one previous cesarean delivery (CD), and to evaluate the number of previous successful vaginal deliveries after a CD needed to reduce the complication rate of trials of labor after a previous CD. METHODS:This is a retrospective coh...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
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pub_type： 杂志文章,随机对照试验
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pub_type： 杂志文章
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,评审
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
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journal_title：Archives of gynecology and obstetrics
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pub_type： 杂志文章
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更新日期：2015-02-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
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更新日期：2002-01-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,评审
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更新日期：1989-01-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,评审
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journal_title：Archives of gynecology and obstetrics
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更新日期：2015-04-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-004-0649-3
更新日期：2005-01-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2004-09-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,随机对照试验
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更新日期：2005-12-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
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更新日期：2019-05-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
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