Abstract:
OBJECTIVE:The objective of this study was to compare NO-donor isosorbide mononitrate to misoprostol, both applied as vaginal tablets for cervical ripening prior to first trimester curettage in patients with missed abortion. MATERIALS AND METHODS:Thirty women with missed abortion were assigned after a random list to be treated either with 200 microg gemeprost (Cytotec, Pfizer, Germany) or with 40 mg isosorbide mononitrate for cervical priming at least 3 h before curettage. Vaginal bleeding or the intracervical presence of products of conception was documented. The largest number of Hegar's dilator, which could be introduced without difficulty and the largest number of Hegar's dilator at which cervical dilation was performed and the ease of mechanical dilation was assessed. RESULTS:There were no significant differences in cervical ripeness before procedure nor in ease of dilation. In the misoprostol group, the cervical canal was more dilated before any procedure (median of Hegar's dilator 6 vs. 5) and after dilation (median of Hegar's dilator 11 vs. 10), although this difference was not significant. Vaginal bleeding occurred in two patients in each group. Products of conception were only found in the cervix of one patient of the misoprostol group. SYNOPSIS:Vaginal application of isosorbidemononitrate in cervical priming prior to curettage abortion is as effective as vaginal application of misoprostol.
journal_name
Arch Gynecol Obstetjournal_title
Archives of gynecology and obstetricsauthors
David M,Chen FCdoi
10.1007/s00404-005-0014-1subject
Has Abstractpub_date
2005-12-01 00:00:00pages
144-5issue
3eissn
0932-0067issn
1432-0711journal_volume
273pub_type
杂志文章,随机对照试验abstract::The use of GnRH antagonists has revolutionized ovarian stimulation for assisted reproduction. Two GnRH antagonists are clinically available, namely, cetrorelix and ganirelix. Several studies have directly compared these new stimulation protocols against the long GnRH agonist protocol. To evaluate whether there is a re...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,meta分析
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journal_title:Archives of gynecology and obstetrics
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journal_title:Archives of gynecology and obstetrics
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pub_type: 杂志文章,随机对照试验
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journal_title:Archives of gynecology and obstetrics
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journal_title:Archives of gynecology and obstetrics
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journal_title:Archives of gynecology and obstetrics
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journal_title:Archives of gynecology and obstetrics
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journal_title:Archives of gynecology and obstetrics
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journal_title:Archives of gynecology and obstetrics
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journal_title:Archives of gynecology and obstetrics
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journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,meta分析
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journal_title:Archives of gynecology and obstetrics
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journal_title:Archives of gynecology and obstetrics
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journal_title:Archives of gynecology and obstetrics
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journal_title:Archives of gynecology and obstetrics
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journal_title:Archives of gynecology and obstetrics
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journal_title:Archives of gynecology and obstetrics
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journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,meta分析,评审
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journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
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journal_title:Archives of gynecology and obstetrics
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journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,评审
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更新日期:2016-10-01 00:00:00