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Malignant pericardial effusion and cardiac tamponade originating from uterine carcinosarcoma.

Abstract：

BACKGROUND:Cardiac tamponade caused by gynecologic malignancies are extremely rare. CASE:A 56-year-old woman was referred to our hospital with vaginal bleeding and abdominal distension. Computed tomography showed massive peritoneal fluid, peritoneal dissemination, swelling of the paraaortic lymph nodes and liver metastasis. Endometrial biopsy showed an admixture of both carcinomatous and sarcomatous elements. The final pathological diagnosis was uterine carcinosarcoma, homologous type. After four cycles of chemotherapy consisting of ifosfamide, adriamycin, and cisplatin, we performed laparotomy, and then two additional courses of chemotherapy were administered postoperatively. Eight months after chemotherapy, echocardiography demonstrated massive pericardial effusion with features of tamponade such as diastolic compression of the right ventricle. Cytological examination of the pericardial fluid showed two different cellular patterns, epithelial and non-epithelial components. CONCLUSION:Although cardiac tamponade is rare and has a poor prognosis, it is important for physicians to consider this possibility in the course of treating of uterine carcinosarcoma.

journal_name

Arch Gynecol Obstet

journal_title

Archives of gynecology and obstetrics

authors

Shimizu S,Yajima M,Yoshii A,Nishikawa T,Ohta H

doi

10.1007/s00404-008-0701-9

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

373-5

issue

3

eissn

0932-0067

issn

1432-0711

journal_volume

279

pub_type

杂志文章

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