The prognosis of stage IA synchronous endometrial endometrioid and ovarian carcinomas.

Abstract:

INTRODUCTION:Little is known about the prevalence and prognosis of synchronous endometrial and ovarian carcinomas. This report explores the survival outcomes of synchronous stage IA endometrioid endometrial and stage IA ovarian carcinomas in a retrospective cohort study. METHODS:All cases of pathological confirmed synchronous stage IA endometrial endometrioid and ovarian carcinomas from June 1, 2010, to June 1, 2017, in a teaching hospital were reviewed. Patients were followed up to February 1, 2019. Survival outcomes were compared between patients with and without synchronous carcinomas. RESULTS:In total, 841 cases with confirmed FIGO stage IA endometrioid endometrial carcinomas were included in the study; 33 patients (3.9%) had synchronous stage IA ovarian carcinomas, including 27 (81.8%) and 6 (18.2%) cases of endometrioid and mixed endometrioid/clear cell subtypes, respectively. After a median follow-up time of 56.8 months, 829 patients (97.9%) had definitive survival outcomes. Synchronous ovarian carcinomas had no impact on disease-free, overall or cancer-specific overall survival in univariate and multivariate analyses. CONCLUSION:In these patients with stage IA endometrioid endometrial carcinoma, the genuine incidence of synchronous stage IA ovarian carcinoma was very low, and synchronous carcinoma had no significant effects on survival outcomes.

journal_name

Arch Gynecol Obstet

authors

Zhan X,Li L,Wu M,Lang J

doi

10.1007/s00404-019-05288-5

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

1045-1052

issue

4

eissn

0932-0067

issn

1432-0711

pii

10.1007/s00404-019-05288-5

journal_volume

300

pub_type

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