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Role of hysteroscopy and endometrial biopsy in women with unexplained infertility.

Abstract：

OBJECTIVES:This study was designed to evaluate the role of hysteroscopy and endometrial biopsy in women with unexplained infertility. PATIENTS AND METHODS:Women with unexplained infertility were included in this prospective study, evaluated with transvaginal sonography and diagnostic hysteroscopy. Diagnostic hysteroscopy was performed between the 7th and 11th day of the cycle. The criteria for hysteroscopic findings were based on the cervical canal, uterine cavity, endometrium, visualization of the ostium tubae and lesions of the utero-tubal junction. After the hysteroscopic examination, endometrial biopsy was performed using a Pipelle endometrial suction curette. Patients were classified according to the hysteroscopy results into four groups: patients with no abnormality detected (14), patients with cervical abnormalities (six), patients with endometrial abnormalities (73) and patients with uterine abnormalities (seven). RESULTS:One hundred women with unexplained infertility were included. All patients underwent diagnostic hysteroscopy, except for seven patients: six patients had stenotic external or internal cervical ostium and one had inadequate visualization as the uterine cavity was filled with blood. Based on hysteroscopic findings, 31 patients were finally diagnosed with endometrial polyps; 14 endometritis; 15 endometrial hyperplasia; six submucous myomas; seven intrauterine synechiae (73 cases = endometrial abnormalities group); seven congenital uterine anomalies (uterine abnormalities group), six cervical stenosis (cervical abnormalities group) and 14 women without any uterine abnormalities (no abnormalities group). Analysis of samples obtained using the Pipelle endometrial suction curette was non-diagnostic in 16 cases; the most common endometrial pathological feature detected by this analysis was endometritis (15%). CONCLUSIONS:Routine hysteroscopy and endometrial biopsy should be used as a basic part of the work-up for women with unexplained infertility.

journal_name

Arch Gynecol Obstet

journal_title

Archives of gynecology and obstetrics

authors

Makled AK,Farghali MM,Shenouda DS

doi

10.1007/s00404-013-2931-8

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

187-92

issue

1

eissn

0932-0067

issn

1432-0711

journal_volume

289

pub_type

杂志文章

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