Secondary malignant fibrous histiocytoma of thigh with surface ulceration following radiotherapy for carcinoma cervix.

Abstract:

INTRODUCTION:Radiotherapy is known to cause rarely various malignancies including leukemia, sarcoma, and thyroid and lung carcinoma. Post-radiation sarcomas account for 0.5-5.5% of all sarcomas; and include extra skeletal osteosarcoma, fibrosarcoma leiomyosarcoma, and malignant fibrous histiocytoma. Reports on post radiotherapy malignant fibrous histiocytoma in cervical cancer patients are rare. CASE REPORT:We present a case of 45-years-old female diagnosed with squamous cell carcinoma of the uterine cervix stage IIB; she underwent a radical hysterectomy with pelvic lymphadenectomy and postoperative radiotherapy and chemotherapy. Five years later, she presented with ulcerated nodular masses in right and left medial aspect of thigh. Cytological and histological diagnosis of the masses was malignant fibrous histiocytoma which was further confirmed by immunohistochemistry. CONCLUSION:Post-irradiation sarcoma must be considered in patients of carcinoma cervix treated with radiotherapy, when soft tissue mass is seen in the previously irradiated area. It should be differentiated from metastasis from primary tumor with the help of appropriate markers as it has a grave prognosis.

journal_name

Arch Gynecol Obstet

authors

Arora P,Wadhwa R,Khurana N,Jain S,Hadke NS

doi

10.1007/s00404-010-1699-3

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

79-82

eissn

0932-0067

issn

1432-0711

journal_volume

283 Suppl 1

pub_type

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