Type-II endometrial cancer: role of adipokines.

Abstract:

BACKGROUND:Type-II endometrial cancer is an estrogen independent and one of the most lethal types of cancer having poor prognosis. Adipokines play a crucial role in the triggering Type-II EMC. In addition, adipokines modulators, therefore, may have beneficial effects in the treatment of Type-II endometrial cancer, which was clinically evidenced. AREAS COVERED:This review presents the role of various adipokines involved and also the suitable modulators to treat Type-II endometrial cancer. CONCLUSION:In the present review, we try to discuss the role of individual adipokines in the pathogenesis of Type-II endometrial cancer, and also the possible beneficial effects of adipokines modulator in the treatment of Type-II endometrial cancer.

journal_name

Arch Gynecol Obstet

authors

Garikapati KK,Ammu VVVRK,Krishnamurthy PT,Chintamaneni PK,Pindiprolu SKSS

doi

10.1007/s00404-019-05181-1

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

239-249

issue

2

eissn

0932-0067

issn

1432-0711

pii

10.1007/s00404-019-05181-1

journal_volume

300

pub_type

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