当前位置： SCI文献检索 > ARCHIVES OF GYNECOLOGY AND OBSTETRICS期刊下所有文献 > IVF/ICSI outcomes of the OCP plus GnRH agonist protocol versus the OCP plus GnRH antagonist fixed protocol in women with PCOS: a randomized trial.

IVF/ICSI outcomes of the OCP plus GnRH agonist protocol versus the OCP plus GnRH antagonist fixed protocol in women with PCOS: a randomized trial.

Abstract：

OBJECTIVE:To compare the IVF/ICSI outcomes of the long GnRH agonist and the fixed GnRH antagonist protocol in women with PCOS. DESIGN:Randomized controlled trial. SETTING:Baskent University Department of Obstetrics and Gynecology. PATIENTS:Three hundred women with PCOS. INTERVENTIONS:IVF/ICSI following the long GnRH agonist down-regulation or the fixed GnRH antagonist protocols. MAIN OUTCOME MEASURES:Ongoing pregnancy rates. RESULTS:Ongoing pregnancy rates were 36.4 % in the OCP + GnRH agonist group and 35.9 % in the OCP + GnRH antagonist group (p > 0.05). Progesterone levels on the day of hCG (0.76 ± 0.71 vs. 0.58 ± 0.50), endometrial thickness on the day of hCG (11.57 ± 2.50 vs. 10.50 ± 2.01), total gonadotropin used (1388.71 ± 482.39 vs. 1253.25 ± 415.81), and duration of COH (9.07 ± 1.96 vs. 8.39 ± 1.75) were significantly lower in the OCP + GnRH antagonist group. CONCLUSION:The OCP + long GnRH agonist and the OCP + fixed GnRH antagonist protocols yield similar ongoing pregnancy rates in women with PCOS. Although this study consisting three hundred patients, seems to be large enough in a single center, we were not able to reach to the actual size of power analysis which was approximately 3,000.

journal_name

Arch Gynecol Obstet

journal_title

Archives of gynecology and obstetrics

authors

Haydardedeoglu B,Kilicdag EB,Parlakgumus AH,Zeyneloglu HB

doi

10.1007/s00404-012-2348-9

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

763-9

issue

3

eissn

0932-0067

issn

1432-0711

journal_volume

286

pub_type

杂志文章,随机对照试验

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