Abstract:
PURPOSE:To evaluate the clinical efficacy of letrozole on ovulation induction and hormone replacement therapy (HRT) during endometrial preparation for frozen-thawed embryo transfer (FET). METHODS:We analyzed totally 1,230 cycles of patients that underwent FET from October 2010 to September 2012. Seven hundred and thirteen cycles of patients with ovulation disorders that underwent FET were randomly assigned to two groups by case control study. 359 cycles received letrozole ovulation induction and 354 cycles received HRT during endometrial preparation for FET, respectively. In the corresponding period, 517 cycles of patients with normal ovulation in the natural cycle group for FET endometrial preparation served as controls. Reproduction-related clinical outcomes of patients in the three groups were compared. RESULTS:The embryo implantation rate of patients in letrozole group (30.4 %) was significantly higher than the HRT group (22.8 %, P < 0.05). The clinical pregnancy rate of patients in the letrozole group (53.2 %) was significantly higher than the HRT group (44.4 %, P < 0.05), while no significant difference was observed between the letrozole and natural cycle groups (51.3 %, P > 0.05). Estradiol levels on the day of human chorionic gonadotropin administration in the letrozole group were significantly lower than those in the natural cycle group (280.32 ± 125.39 pg/ml and 351.06 ± 123.03 pg/ml, respectively; P < 0.05). The live birth rate of patients in letrozole group (44.6 %) was significantly higher than the HRT group (32.5 %, P < 0.05), while abortion rate (12.0 %) was significantly lower than the HRT group (21.0 %, P < 0.05). There were no significant differences in number of mature follicles, endometrial thickness, duration of follicle growth between the letrozole and the natural cycle groups, and there were no significant differences in twin birth rate and ectopic pregnancy rate among the three groups (all P values >0.05). CONCLUSIONS:Ovulation induction with letrozole during endometrial preparation for FET has a higher rate of pregnancy success and a lower abortion rate than HRT. Letrozole treatment exhibits clinical progression and outcomes similar to those patients undergoing a natural cycle or normal ovulation cycle. Therefore, letrozole treatment may be an effective option in endometrial preparation for FET in patients with ovulation disorders or irregular menstruation.
journal_name
Arch Gynecol Obstetjournal_title
Archives of gynecology and obstetricsauthors
Li SJ,Zhang YJ,Chai XS,Nie MF,Zhou YY,Chen JL,Tao GSdoi
10.1007/s00404-013-3044-0subject
Has Abstractpub_date
2014-03-01 00:00:00pages
687-93issue
3eissn
0932-0067issn
1432-0711journal_volume
289pub_type
杂志文章,随机对照试验abstract::The effect of stress during labour on the plasma concentration of prolactin and cortisol was studied in 30 healthy multiparous women. The plasma concentrations of prolactin and cortisol were measured by radioimmunoassay during oxytocin induced labour, spontaneous labour, delivery and postpartum 24 h. The parturients w...
journal_title:Archives of gynecology and obstetrics
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abstract::Association of pregnancy with esophageal cancer is an extremely rare event. The symptoms are frequently masked by factors related to normal pregnancy and diagnostic approaches are restricted by physical and psychological clinical events. Hence, the cancer stage is usually advanced at the time of diagnosis. The approac...
journal_title:Archives of gynecology and obstetrics
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abstract:OBJECTIVE:To explore the etiologic factors and treatments of iatrogenic ureteral and bladder injury during obstetric and gynecologic operations. METHODS:Forty-one patients who underwent traditional obstetric and gynecologic operations were found with iatrogenic ureteral and bladder injury, and recruited into our study...
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abstract:PURPOSE:To investigate the efficacy of bupivacaine-soaked spongostan in cesarean section wound for postoperative anxiety level, satisfaction and early postpartum depression rate. METHODS:A total of 121 women, American Society of Anesthesiologists physical status I-II, scheduled to undergo general anesthesia and electi...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,随机对照试验
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abstract::Three new progestins with a high gestagenic potency have been developed as derivatives of the levonorgestrel (in brackets: biological active substance in the human): desogestrel (3-keto-desogestrel), norgestimate (norgestimate), gestodene (gestodene). In combination with low dosages of ethinylestradiol (30-35 microgra...
journal_title:Archives of gynecology and obstetrics
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abstract:PURPOSE:This systematic review and meta-analysis aimed to compare the effectiveness of unilateral vs. bilateral laparoscopic ovarian drilling (ULOD vs. BLOD) for improving fertility outcomes in infertile women with clomiphene-resistant polycystic ovary syndrome (PCOS) as well as its effect on ovarian reserve. METHODS:...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,meta分析,评审
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journal_title:Archives of gynecology and obstetrics
pub_type: 临床试验,杂志文章
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abstract::Intrauterine retention of foetal bones is an uncommon but recognised complication of late termination of pregnancy. Secondary subfertility, abnormal uterine bleeding and vaginal discharge are the usual presenting complaints. We report a case of prolonged retention of foetal bones for 14 years in a woman who presented ...
journal_title:Archives of gynecology and obstetrics
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journal_title:Archives of gynecology and obstetrics
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journal_title:Archives of gynecology and obstetrics
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journal_title:Archives of gynecology and obstetrics
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journal_title:Archives of gynecology and obstetrics
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journal_title:Archives of gynecology and obstetrics
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journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,随机对照试验
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journal_title:Archives of gynecology and obstetrics
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journal_title:Archives of gynecology and obstetrics
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journal_title:Archives of gynecology and obstetrics
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journal_title:Archives of gynecology and obstetrics
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journal_title:Archives of gynecology and obstetrics
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,随机对照试验
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journal_title:Archives of gynecology and obstetrics
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journal_title:Archives of gynecology and obstetrics
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journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,评审
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abstract:PURPOSE:To assess the main neonatal morbidity results in relation to induced labour indications. METHODS:Historical groups from a total of 3,817 deliveries over a three year period (2009, 2010 and 2011) in "Mancha-Centro" Hospital (Alcázar de San Juan) formed the study group. All programmed and non-avoidable caesarean...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
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journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
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更新日期:2005-09-01 00:00:00
abstract:PURPOSE:To investigate copeptin levels in women with GDM and women with uncomplicated pregnancies. METHODS:This case-control study was conducted on 45 women with GDM and 40 women with uncomplicated pregnancies. The maternal serum levels of copeptin were measured with enzyme-linked immunosorbent assay. RESULTS:Copepti...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
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更新日期:2013-11-01 00:00:00
abstract:INTRODUCTION:Bilateral mucinous cystadenoma of the ovary are extremely rare. These tumors are benign and might lead to abdominal distension, if no secondary symptoms occur and patient delay the consultation of physicians. CASE:A 60-year-old patient was admitted to the internal medicine department for constipation and ...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-008-0634-3
更新日期:2009-01-01 00:00:00