[New progestins in oral hormonal contraceptives].

Abstract:

:Three new progestins with a high gestagenic potency have been developed as derivatives of the levonorgestrel (in brackets: biological active substance in the human): desogestrel (3-keto-desogestrel), norgestimate (norgestimate), gestodene (gestodene). In combination with low dosages of ethinylestradiol (30-35 micrograms) an excessive steroid overload can be avoided, which is not necessary for contraceptive efficacy and control of the menstrual cycle. As an effect of dose reducing during long-time studies only a mild impact on the lipids and carbohydrates, and blood coagulation could be observed. The clinical side effects are moderate and for most patients acceptable.

journal_name

Arch Gynecol Obstet

authors

Runnebaum B,Rabe T

doi

10.1007/BF02417654

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

1000-5

issue

1-4

eissn

0932-0067

issn

1432-0711

journal_volume

245

pub_type

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