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A prospective, double-blind, randomized, placebo-controlled clinical trial of bromocriptin in clomiphene-resistant patients with polycystic ovary syndrome and normal prolactin level.

Abstract：

OBJECTIVE:The purpose of this study was to examine the effects of of bromocriptin combined with clomiphene citrate in clomiphene-resistant patients with polycystic ovary syndrome and normal prolactin level. DESIGN:Prospective, double-blind, controlled study. SETTING:University teaching hospital. PATIENTS:One hundred polycystic ovary patients and normal prolactin (PRL) who were clomiphene citrate resistant. INTERVENTIONS:Treatment group received 150 mg clomiphene citrate on days 5-9 and 7.5 mg bromocriptin continuously. Control group received the same protocol of clomiphene citrate combined with placebo. MAIN OUTCOME MEASURES:Hormonal status, follicular monitoring, ovulation rate. RESULTS:Follicular development (follicular size greater than 15 mm) was observed in 12 (25.5%) and eight (15.1%) women in treatment and placebo group respectively ( P=0.29). The serum prolactin level was within normal limits in all patients before treatment. After 3 and 6 months of treatment with bromocriptin, there was a significant decrease in serum level of prolactin ( P=0.000001). No any significant differences was seen in ovulation, and serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEAS), progesterone (P) between treatment and placebo group after treatment. CONCLUSIONS:The only significant effect of long-term bromocriptin therapy in clomiphene citrate resistant polycystic ovary women was to lower the serum prolactin concentration. It was also concluded that 10-15% of patients with polycystic ovaries experienced occasional ovulatory cycles and pregnancy whether or not they were on treatment.

journal_name

Arch Gynecol Obstet

journal_title

Archives of gynecology and obstetrics

authors

Parsanezhad ME,Alborzi S,Namavar Jahromi B

doi

10.1007/s00404-002-0437-x

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

125-9

issue

eissn

0932-0067

issn

1432-0711

journal_volume

269

pub_type

临床试验,杂志文章,随机对照试验

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A prospective, double-blind, randomized, placebo-controlled clinical trial of bromocriptin in clomiphene-resistant patients with polycystic ovary syndrome and normal prolactin level.