Resveratrol regulates N-methyl-D-aspartate receptor expression and suppresses neuroinflammation in morphine-tolerant rats.


BACKGROUND:In the present study, we examined the effects and mechanisms of the Chinese herb resveratrol on attenuation of morphine tolerance in rats. METHODS:Male Wistar rats were implanted with 2 intrathecal catheters; one catheter was connected to a mini-osmotic pump, used for either morphine (15 μg/h) or saline (1 μL/h) infusion for 5 days. On day 5, resveratrol (7.5, 15, 30, or 60 μg), dimethyl sulfoxide (5 μL), or saline (5 μL) was injected via the other catheter immediately after the discontinued morphine infusion. Three hours later, intrathecal morphine (15 μg in 5 μL saline) was given. All rats received the nociceptive tail-flick test every 30 minutes for 120 minutes after the morphine challenge. RESULTS:Long-term morphine infusion induced antinociceptive tolerance and up-regulated N-methyl-D-aspartate receptor (NMDAR) subunit NR1 and NR2B expression in the synaptosome fraction of the tolerant spinal cord dorsal horn. Resveratrol pretreatment provided a significant antinociceptive effect of morphine in morphine-tolerant rats, and it was associated with reversal of the up-regulated NR1 and NR2B subunits in the synaptosome fraction of morphine-tolerant rat spinal cords. NR1/NR2B-specific antagonist ifenprodil treatment produced a similar effect as that of resveratrol. Furthermore, an increase of postsynaptic density-95/NR1/NR2B complex immunoprecipitation in morphine-tolerant rat spinal cord was also inhibited by resveratrol pretreatment. Moreover, chronic morphine infusion activated glial cells with an increase of proinflammatory cytokine tumor necrosis factor-α, interleukin-1β, and interleukin-6 mRNA expression in morphine-tolerant rat spinal cords and these effects were suppressed by resveratrol pretreatment before the morphine challenge. CONCLUSIONS:Resveratrol attenuates morphine tolerance by inhibiting neuroinflammation and down-regulating NMDAR NR1 and NR2B subunit expression. Resveratrol regulates the NMDAR expression, which might be involved in a loss of scaffolding postsynaptic density-95 protein.


Anesth Analg


Anesthesia and analgesia


Tsai RY,Chou KY,Shen CH,Chien CC,Tsai WY,Huang YN,Tao PL,Lin YS,Wong CS




Has Abstract


2012-10-01 00:00:00














  • The effects of paracetamol and parecoxib on kidney function in elderly patients undergoing orthopedic surgery.

    abstract::The common adverse effects of traditional nonsteroidal antiinflammatory drugs on renal function include reductions in renal blood flow, glomerular filtration rate, and sodium and potassium excretion, mainly via inhibition of renal cyclooxygenase. We designed the present study to determine the effects of IV paracetamol...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Koppert W,Frötsch K,Huzurudin N,Böswald W,Griessinger N,Weisbach V,Schmieder RE,Schüttler J

    更新日期:2006-11-01 00:00:00

  • Cerebral metabolism assessed with microdialysis in uncontrolled hemorrhagic shock after penetrating liver trauma.

    abstract::In a porcine model of uncontrolled hemorrhagic shock, we evaluated the effects of fluid resuscitation versus arginine vasopressin (AVP) combined with hypertonic-hyperoncotic hydroxyethyl starch solution (HHS) on cerebral perfusion pressure (CPP) and on cerebral metabolism using intracerebral microdialysis. Sixteen ane...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Meybohm P,Cavus E,Bein B,Steinfath M,Brand PA,Scholz J,Dörges V

    更新日期:2006-10-01 00:00:00

  • Minimum alveolar anesthetic concentration of fluorinated alkanols in rats: relevance to theories of narcosis.

    abstract:UNLABELLED:The Meyer-Overton hypothesis predicts that the potency of conventional inhaled anesthetics correlates inversely with lipophilicity: minimum alveolar anesthetic concentration (MAC) x the olive oil/gas partition coefficient equals a constant of approximately 1.82 +/- 0.56 atm (mean +/- SD), whereas MAC x the o...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Eger EI 2nd,Ionescu P,Laster MJ,Gong D,Hudlicky T,Kendig JJ,Harris RA,Trudell JR,Pohorille A

    更新日期:1999-04-01 00:00:00

  • Age and the spread of local anesthetic solutions in the epidural space.

    abstract::Sensory level of anesthesia following the injection of 20 ml of 1.5% lidocaine with epinephrine (1:200,000) in 238 adult males averaged T7.7, T5.6, and T5.1 at 10, 20, and 30 minutes, respectively. Patient age had no significant effect on local anesthetic requirements per spinal segment per unit height until age 40 ye...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Park WY,Massengale M,Kim SI,Poon KC,Macnamara TE

    更新日期:1980-10-01 00:00:00

  • A response algorithm for the low-pressure alarm condition.

    abstract::A response algorithm consists of a logical sequence of maneuvers to be performed in response to a specific condition. With the advent of alarm-equipped monitors that alert anesthesiologists to the presence of potentially hazardous clinical conditions, a need has arisen to develop the corresponding alarm-oriented respo...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Raphael DT,Weller RS,Doran DJ

    更新日期:1988-09-01 00:00:00

  • Blood Substitutes and Oxygen Therapeutics: A Review.

    abstract::Despite the exhaustive search for an acceptable substitute to erythrocyte transfusion, neither chemical-based products such as perfluorocarbons nor hemoglobin-based oxygen carriers have succeeded in providing a reasonable alternative to allogeneic blood transfusion. However, there remain scenarios in which blood trans...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Jahr JS,Guinn NR,Lowery DR,Shore-Lesserson L,Shander A

    更新日期:2021-01-01 00:00:00

  • Protocolized intensive care unit management of analgesia, sedation, and delirium improves analgesia and subsyndromal delirium rates.

    abstract:BACKGROUND:Sedatives and analgesics, in doses that alter consciousness in the intensive care unit (ICU), contribute to delirium and mortality. Pain, agitation, and delirium can be monitored in ICU patients. These symptoms were noted before (PRE) and after (POST) a protocol to alleviate undesirable symptoms. Analgesia a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Skrobik Y,Ahern S,Leblanc M,Marquis F,Awissi DK,Kavanagh BP

    更新日期:2010-08-01 00:00:00

  • The effects of serotonin biosynthesis inhibition on nicotine and nifedipine-induced analgesia in rats.

    abstract:UNLABELLED:The calcium channel blocker nifedipine has analgesic properties that are enhanced by nicotine. Although it is not known how this analgesic state might affect the awareness of anginal pain and impending myocardial infraction, recent studies have shown an increased mortality associated with the use of large do...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Hunt TE,Wu WH,Zbuzek VK

    更新日期:1998-11-01 00:00:00

  • Increasing halothane concentrations reduce nitroprusside dose requirement.

    abstract::There has been no description of the hemodynamic dose-response relationship between halothane and sodium nitroprusside (SNP), although these drugs are used together frequently for induction of deliberate hypotension. Utilizing aortic root cannulation and thermister-tipped pulmonary artery catheterization, this relatio...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Bedford RF

    更新日期:1978-07-01 00:00:00

  • Inhaled anesthetic potency in aged Alzheimer mice.

    abstract:BACKGROUND:The number of elderly patients with frank or incipient Alzheimer's disease (AD) requiring surgery is growing as the population ages. General anesthesia may exacerbate symptoms of and the pathology underlying AD, so minimizing anesthetic exposure may be important. This requires knowledge of whether the contin...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Bianchi SL,Caltagarone BM,Laferla FM,Eckenhoff RG,Kelz MB

    更新日期:2010-02-01 00:00:00

  • Postoperative intensive care unit drug fever caused by dexmedetomidine.

    abstract::Dexmedetomidine hydrochloride is a potent, highly selective alpha-2 adrenergic receptor agonist, broadly used as a sedative drug in intensive care units. We describe the case of a 59-yr-old patient who experienced drug fever caused by dexmedetomidine hydrochloride. The patient was transferred to the intensive care uni...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Okabe T,Takeda S,Akada S,Hongo T,Sakamoto A

    更新日期:2009-05-01 00:00:00

  • Transient atrioventricular block after release of aortic cross-clamp.

    abstract::To determine the incidence of atrioventricular (A-V) block, 86 patients, aged 58.9 +/- 10.4 yr, undergoing elective coronary artery bypass grafting (CABG) during aortic cross-clamping (ACC) and cold potassium cardioplegia were investigated. The incidence and duration of complete A-V block after release of the aortic c...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Baraka AS,Taha SK,Yazbeck VK,Rizkallah PA,Zughbi JP,Aouad MJ,Rouhana CS,Nader AM

    更新日期:1995-01-01 00:00:00

  • Incorporating simulation-based objective structured clinical examination into the Israeli National Board Examination in Anesthesiology.

    abstract::We describe the unique process whereby simulation-based, objective structured clinical evaluation (OSCE) has been incorporated into the Israeli board examination in anesthesiology. Development of the examination included three steps: a) definition of clinical conditions that residents are required to handle competentl...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Berkenstadt H,Ziv A,Gafni N,Sidi A

    更新日期:2006-03-01 00:00:00

  • Novel small molecule α9α10 nicotinic receptor antagonist prevents and reverses chemotherapy-evoked neuropathic pain in rats.

    abstract:BACKGROUND:Peripheral neuropathy is a common dose-limiting side effect of chemotherapy. There are no clinically proven analgesics for the treatment of this condition. Drugs from different classes have been tested with mixed results. Identification of novel molecular targets for analgesic(s) is important. Antagonism of ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Wala EP,Crooks PA,McIntosh JM,Holtman JR Jr

    更新日期:2012-09-01 00:00:00

  • The role of the anesthesiologist in fast-track surgery: from multimodal analgesia to perioperative medical care.

    abstract:BACKGROUND:Improving perioperative efficiency and throughput has become increasingly important in the modern practice of anesthesiology. Fast-track surgery represents a multidisciplinary approach to improving perioperative efficiency by facilitating recovery after both minor (i.e., outpatient) and major (inpatient) sur...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: White PF,Kehlet H,Neal JM,Schricker T,Carr DB,Carli F,Fast-Track Surgery Study Group.

    更新日期:2007-06-01 00:00:00

  • Verifying correct endotracheal intubation by measurement of end-tidal carbon dioxide during an ex utero intrapartum treatment procedure.

    abstract::The ex utero intrapartum treatment (EXIT) procedure provides time to secure the airway of the fetus while utero-placental circulation supplies the fetus with oxygen. We report the anesthetic management of a fetus with a large neck mass during an EXIT procedure in which the confirmation of correct endotracheal intubati...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Eschertzhuber S,Keller C,Mitterschiffthaler G,Jochberger S,Kühbacher G

    更新日期:2005-09-01 00:00:00

  • Decreased incidence and mortality of anaphylaxis to chymopapain.

    abstract::A recognized side effect of chemonucleolysis is life-threatening anaphylaxis to chymopapain. In the clinical trials of chymopapain, 13 cases of anaphylaxis were reported in 1585 administrations (0.82%). Two patients died. Data from a postmarketing survey (48,239 questionnaires) were reviewed to identify factors influe...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Moss J,Roizen MF,Nordby EJ,Thisted R,Apfelbaum JL,Schreider BD,McDermott DJ

    更新日期:1985-12-01 00:00:00

  • Continuous Transversus Abdominis Plane Nerve Blocks: Does Varying Local Anesthetic Delivery Method-Automatic Repeated Bolus Versus Continuous Basal Infusion-Influence the Extent of Sensation to Cold?: A Randomized, Triple-Masked, Crossover Study in Volunt

    abstract:BACKGROUND:It remains unknown whether continuous or scheduled intermittent bolus local anesthetic administration is preferable for transversus abdominis plane (TAP) catheters. We therefore tested the hypothesis that when using TAP catheters, providing local anesthetic in repeated bolus doses increases the cephalad-caud...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Khatibi B,Said ET,Sztain JF,Monahan AM,Gabriel RA,Furnish TJ,Tran JT,Donohue MC,Ilfeld BM

    更新日期:2017-04-01 00:00:00

  • Residual halothane: Patient and personnel exposure.

    abstract::In addition to offering further data on the exposure of surgical and recovery-room personnel to low levels of halothane in room air, the authors demonstrate the presence of halothane levels in the blood of some surgical patients managed by other inhalation agents from machines previously used for halothane. The author...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Nicholson JA,Sada T,Aldrete JA

    更新日期:1975-07-01 00:00:00

  • Comparison of tropisetron, droperidol, and saline in the prevention of postoperative nausea and vomiting after gynecologic surgery.

    abstract::This study was performed to compare the efficacy of tropisetron, droperidol, and saline in the prevention of postoperative nausea and vomiting (PONV) and to compare the possible adverse effects of these drugs in gynecologic incontinence surgery. Using a randomized, double-blind study design, we studied 150 women under...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Purhonen S,Kauko M,Koski EM,Nuutinen L

    更新日期:1997-03-01 00:00:00

  • The effects of tramadol and morphine on immune responses and pain after surgery in cancer patients.

    abstract:UNLABELLED:There has been growing interest in determining the possible immune consequences of opioid administration for the management of postoperative pain. We studied the effects of morphine and tramadol on pain and immune function during the postoperative period in 30 patients undergoing abdominal surgery for uterin...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Sacerdote P,Bianchi M,Gaspani L,Manfredi B,Maucione A,Terno G,Ammatuna M,Panerai AE

    更新日期:2000-06-01 00:00:00

  • A Methyltransferase Inhibitor (Decitabine) Alleviates Intergenerational Effects of Paternal Neonatal Exposure to Anesthesia With Sevoflurane.

    abstract:BACKGROUND:Neonatal exposure to sevoflurane induces neurobehavioral and neuroendocrine abnormalities in exposed male rats (generation F0) and neurobehavioral, but not neuroendocrine, abnormalities in their male, but not female, offspring (generation F1). These effects of sevoflurane are accompanied by a hypermethylated...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Xu N,Lei L,Lin Y,Ju LS,Morey TE,Gravenstein N,Yang J,Martynyuk AE

    更新日期:2020-10-01 00:00:00

  • Ipsilateral shoulder pain after thoracotomy with epidural analgesia: the influence of phrenic nerve infiltration with lidocaine.

    abstract:UNLABELLED:Patients receiving effective thoracic epidural analgesia for postthoracotomy pain may still complain of severe ipsilateral shoulder pain. The etiology of this pain is unclear. In this randomized, double-blinded, placebo-controlled study, we investigated the effect of phrenic nerve infiltration with lidocaine...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Scawn ND,Pennefather SH,Soorae A,Wang JY,Russell GN

    更新日期:2001-08-01 00:00:00

  • Cyclooxygenase inhibition in ventilator-induced lung injury.

    abstract:BACKGROUND:We tested the hypothesis that inhibition of cyclooxygenase (COX) attenuates in vivo ventilator-induced lung injury (VILI) in a prospective, randomized laboratory investigation in a university-affiliated laboratory. Adult male rats were anesthetized and randomized with or without nonselective COX inhibition (...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Niitsu T,Tsuchida S,Peltekova V,Engelberts D,Copland I,Otulakowski G,Post M,Kavanagh BP

    更新日期:2011-01-01 00:00:00

  • Potentiation and antagonism of vecuronium by decamethonium.

    abstract::Enhancement of a vecuronium neuromuscular blockade by prior administration of succinylcholine has been attributed to both pharmacokinetic and pharmacodynamic mechanisms. This study was performed to elucidate the mechanism of this interaction using decamethonium as the agonist drug. In five healthy patients undergoing ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Feldman S,Fauvel N

    更新日期:1993-03-01 00:00:00

  • A Comparison of Photoplethysmography Versus Esophageal Doppler for the Assessment of Cardiac Index During Major Noncardiac Surgery.

    abstract:BACKGROUND:In this prospective observational study, we compared changes in cardiac index (CI) during fluid challenge using photoplethysmography (PPG; Nexfin™) (CIPPG) versus esophageal Doppler (ED) (CIED) in major noncardiac surgery patients. METHODS:Measurements were obtained when the attending anesthesiologist decid...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Blanié A,Soued M,Benhamou D,Mazoit JX,Duranteau J

    更新日期:2016-02-01 00:00:00

  • Clinical pharmacokinetics of carbonated local anesthetics. II: Interscalene brachial block model.

    abstract::A double-blind comparison of 1.1% lidocaine carbonate and 1.0% lidocaine hydrochloride was carried out in 30 healthy adult patients undergoing upper-extremity surgery under interscalene brachial plexus block. Epinephrine (1:200,000) was added to both solutions just before injection. As compared to lidocaine hydrochlor...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Sukhani R,Winnie AP

    更新日期:1987-12-01 00:00:00

  • Continuous positive airway pressure versus noninvasive pressure support ventilation to treat atelectasis after cardiac surgery.

    abstract::Atelectasis is common after cardiac surgery and may result in impaired gas exchange. Continuous positive airway pressure (CPAP) is often used to prevent or treat postoperative atelectasis. We hypothesized that noninvasive pressure support ventilation (NIPSV) by increasing tidal volume could improve the evolution of at...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Pasquina P,Merlani P,Granier JM,Ricou B

    更新日期:2004-10-01 00:00:00

  • Perioperative Diabetes Insipidus Caused by Anesthetic Medications: A Review of the Literature.

    abstract::Diabetes insipidus (DI) is an uncommon perioperative complication that can occur secondary to medications or surgical manipulation and can cause significant hypovolemia and electrolyte abnormalities. We reviewed and evaluated the current literature and identified 24 cases of DI related to medications commonly used in ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Van Decar LM,Reynolds EG,Sharpe EE,Harbell MW,Kosiorek HE,Kraus MB

    更新日期:2021-01-06 00:00:00

  • Epidural labor analgesia is associated with a decreased risk of postpartum depression: a prospective cohort study.

    abstract:BACKGROUND:Postpartum depression is a common psychiatric disorder in parturients after delivery. The etiology remains unclear, and multiple factors may be involved. In this study, we investigated whether epidural labor analgesia was associated with a decreased risk of postpartum depression development. METHODS:Two hun...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Ding T,Wang DX,Qu Y,Chen Q,Zhu SN

    更新日期:2014-08-01 00:00:00