Genetic and structural characterization of the growth hormone gene and protein from tench, Tinca tinca.

Abstract:

:The analysis of the tench growth hormone gene structure revealed a comparable organization of coding and non-coding regions than other from cyprinid species. Based on the performed mRNA and amino acid sequence alignments, gh tench is related to Asian than to European representatives of Cyprinidae family. Second aim of the work was to characterize and predict protein structure of the tench growth hormone. Tinca tinca GH share many common features with human GH molecule. The Tench GH protein binds to the growth hormone receptor (GHR) using two regions I and II that are situated at opposite sites of molecule. Binding site I is placed in the central part of T. tinca GH and H 189 amino acid in the middle region of the IV helix is crucial for GH-GHR interactions.

journal_name

Fish Physiol Biochem

authors

Panicz R,Sadowski J,Drozd R

doi

10.1007/s10695-012-9661-x

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

1645-1653

issue

6

eissn

0920-1742

issn

1573-5168

pii

10.1007/s10695-012-9661-x

journal_volume

38

pub_type

杂志文章