Abstract:
OBJECTIVE:Epidemiological and clinical studies suggest that the rates of antisocial behavior, depression, and impulsive substance use are increased among individuals diagnosed with alcohol dependence relative to those who are not. Thus, the present study conducted genome-wide linkage scans of antisocial behavior, depression, and impulsive substance use in the University of California at San Francisco Family Alcoholism Study. METHODS:Antisocial behavior, depressive symptoms, and impulsive substance use were assessed using three scales from the Minnesota Multiphasic Personality Inventory - 2nd ed.: the Antisocial Practices content scale, the Depression content scale, and the revised MacAndrew Alcoholism scale. Linkage analyses were carried out using a variance components approach. RESULTS:Suggestive evidence of linkage to three genomic regions independent of alcohol and cannabis dependence diagnostic status was observed: the Antisocial Practices content scale showed evidence of linkage to chromosome 13 at 11 cM, the MacAndrew Alcoholism scale showed evidence of linkage to chromosome 15 at 47 cM, and all three scales showed evidence of linkage to chromosome 17 at 57-58 cM. CONCLUSION:Each of these regions has shown previous evidence of linkage and association to substance dependence as well as other psychiatric disorders such as mood and anxiety disorders, attention-deficit hyperactivity disorder, and schizophrenia, thus suggesting potentially broad relations between these regions and psychopathology.
journal_name
Psychiatr Genetjournal_title
Psychiatric geneticsauthors
Gizer IR,Ehlers CL,Vieten C,Feiler HS,Gilder DA,Wilhelmsen KCdoi
10.1097/YPG.0b013e328353fb77subject
Has Abstractpub_date
2012-10-01 00:00:00pages
235-44issue
5eissn
0955-8829issn
1473-5873journal_volume
22pub_type
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/YPG.0b013e32834c0cb2
更新日期:2012-04-01 00:00:00
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journal_title:Psychiatric genetics
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doi:10.1097/00041444-200409000-00007
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journal_title:Psychiatric genetics
pub_type: 杂志文章
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journal_title:Psychiatric genetics
pub_type: 杂志文章,meta分析
doi:10.1097/YPG.0b013e32801da2e2
更新日期:2007-06-01 00:00:00
abstract::It is well established that approximately 50% of the variance in personality traits is genetic. The goal of this study was to investigate a relationship between personality traits and the T-182C polymorphism in the norepinephrine transporter gene. The participants included 115 healthy adults with no history of psychia...
journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/00041444-200506000-00012
更新日期:2005-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/YPG.0000000000000266
更新日期:2020-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/00041444-200509000-00006
更新日期:2005-09-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/00041444-199808040-00004
更新日期:1998-01-01 00:00:00
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更新日期:2002-03-01 00:00:00
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journal_title:Psychiatric genetics
pub_type:
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pub_type: 杂志文章,多中心研究
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doi:10.1097/00041444-200106000-00003
更新日期:2001-06-01 00:00:00
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doi:
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journal_title:Psychiatric genetics
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doi:10.1097/00041444-200209000-00007
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/00041444-200109000-00010
更新日期:2001-09-01 00:00:00
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journal_title:Psychiatric genetics
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doi:10.1097/YPG.0000000000000259
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pub_type: 杂志文章
doi:10.1097/YPG.0000000000000081
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/00041444-200309000-00007
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/YPG.0b013e328133f342
更新日期:2007-10-01 00:00:00
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pub_type: 杂志文章
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/YPG.0b013e32833a212f
更新日期:2010-12-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/YPG.0b013e328012a0c6
更新日期:2007-04-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 临床试验,杂志文章
doi:10.1097/YPG.0b013e3282df0939
更新日期:2008-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/00041444-199505030-00004
更新日期:1995-10-01 00:00:00