Abstract:
:Catechol-O-methyltransferase (COMT) catalyses the methylation, and hence the inactivation, of catecholamines including the neurotransmitters dopamine and noradrenaline. There is evidence implicating COMT as a candidate gene for a number of neuropsychiatric conditions including bipolar disorder. A long recognized population variation in COMT activity exists and it has recently been established that variation in enzyme activity results from a polymorphic genetic variation within the COMT gene which can be readily assayed as a polymerase chain reaction (PCR)-based restriction fragment length polymorphism (RFLP). A collection of 60 Irish bipolar I probands have been genotyped together with their parents. Tests comparing transmitted and non-transmitted alleles provide no evidence that the polymorphism contributes to a susceptibility to bipolar disorder within the sample as a whole. However, amongst female bipolar I probands (n = 30) there was a tendency for the low-activity allele of COMT to be preferentially transmitted. Furthermore, a re-examination of an Irish case-control sample resulted in a similar observation amongst female bipolar I sufferers and pooling the data sets strengthened the findings.
journal_name
Psychiatr Genetjournal_title
Psychiatric geneticsauthors
Mynett-Johnson LA,Murphy VE,Claffey E,Shields DC,McKeon Pdoi
10.1097/00041444-199808040-00004subject
Has Abstractpub_date
1998-01-01 00:00:00pages
221-5issue
4eissn
0955-8829issn
1473-5873journal_volume
8pub_type
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journal_title:Psychiatric genetics
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doi:10.1097/YPG.0b013e328133f342
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更新日期:2018-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/YPG.0b013e32832a4f7b
更新日期:2009-06-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/YPG.0b013e32834371e8
更新日期:2011-10-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Psychiatric genetics
pub_type: 信件
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更新日期:2006-12-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 杂志文章
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更新日期:2017-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/YPG.0b013e32833a212f
更新日期:2010-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/00041444-200512000-00012
更新日期:2005-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/00041444-199524000-00005
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pub_type:
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更新日期:2014-10-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 杂志文章,meta分析
doi:10.1097/YPG.0b013e3283631509
更新日期:2013-08-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/00041444-200209000-00007
更新日期:2002-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2008-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-02-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/00041444-200503000-00001
更新日期:2005-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/YPG.0b013e3283060f48
更新日期:2008-12-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 临床试验,杂志文章
doi:10.1097/YPG.0b013e3282df0939
更新日期:2008-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/YPG.0b013e32833a1ff3
更新日期:2010-08-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/00041444-199909000-00011
更新日期:1999-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/00041444-200203000-00007
更新日期:2002-03-01 00:00:00