Abstract:
:Although current psychiatric nosology separates bipolar disorder and schizophrenia into non-overlapping categories, there is growing evidence of a partial aetiological overlap between them from linkage, genetic epidemiology and molecular genetics studies. Thus, it is important to determine whether genes implicated in the aetiology of schizophrenia play a role in bipolar disorder, and vice versa. In this study we investigated a total of 15 single nucleotide polymorphisms (SNPs), and all possible haplotypes, of genes that have been previously implicated in schizophrenia or bipolar disorder - RGS4, PRODH, COMT and GRK3 - in a sample of 213 cases with bipolar affective disorder type 1 and 197 controls from Scotland. We analysed the polymorphisms allele-wise, genotype-wise and, for each gene, haplotype-wise but obtained no result that reached nominal significance (p<0.05) for an association with the disease status. In conclusion, we could not find evidence of association between RGS4, PRODH, COMT and GRK3 genes and bipolar affective disorder 1 in the Scottish population.
journal_name
Psychiatr Genetjournal_title
Psychiatric geneticsauthors
Prata DP,Breen G,Munro J,Sinclair M,Osborne S,Li T,Kerwin R,St Clair D,Collier DAdoi
10.1097/01.ypg.0000242190.43773.cesubject
Has Abstractpub_date
2006-12-01 00:00:00pages
229-30issue
6eissn
0955-8829issn
1473-5873pii
00041444-200612000-00003journal_volume
16pub_type
信件abstract:OBJECTIVE:To examine the heritabilities of symptoms of posttraumatic stress disorder (PTSD), anxiety, depression, and the shared genetic component of these symptoms among family members exposed to the 1988 Spitak earthquake in Armenia. METHODS:Two hundred members of 12 multigenerational families exposed to the Spitak ...
journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/YPG.0b013e3283060f48
更新日期:2008-12-01 00:00:00
abstract::Since Lesch and colleagues reported an association between anxiety-related traits (Neuroticism) and a functional polymorphism in the serotonin transporter gene regulatory region (5-HTTLPR), there have been several reports on 5-HTTLPR and personality traits with both positive and negative results. The present study was...
journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/00041444-200010040-00002
更新日期:2000-12-01 00:00:00
abstract::In an epidemiologic sample of female-female twin pairs, we previously reported analyses of lifetime major depression. Because lifetime mania was not assessed, we could not differentiate unipolar from bipolar illness. Having completed such an evaluation in this sample, we now examine three questions: (i) does removing ...
journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::P300 has been demonstrated abnormal for a variety of neuropsychiatric disorders, and heritability has been proposed. We analyzed the event-related potentials for three DRD2 genotype groups in 134 normal young females. The results demonstrate that there is no association for DRD2 genotype and P300 components. Our negat...
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pub_type: 杂志文章
doi:10.1097/00041444-200109000-00010
更新日期:2001-09-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/00041444-199808040-00004
更新日期:1998-01-01 00:00:00
abstract::Numerous family, twin and adoption studies have reported a strong genetic component for attention deficit hyperactivity disorder (ADHD). In addition, an extensive amount of literature has implicated abnormalities of the dopaminergic system. In view of this evidence, genes that influence dopaminergic transmission have ...
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doi:10.1097/01.ypg.0000107932.32051.1c
更新日期:2004-06-01 00:00:00
abstract::The 12th Annual Pharmacogenetics in Psychiatry meeting was held in Hollywood, Florida, from 31 May to 1 June 2013, in conjunction with the NCDEU meeting. It included a series of oral presentations as well as a poster session. This report summarizes the presentations at the conference. ...
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更新日期:2010-02-01 00:00:00
abstract::The FKBP5 protein is of importance for the function of the glucocorticoid receptor. The purpose of the present study was to examine the possible association between the different genotypes of rs1360780 in the FKBP5 gene, and clinical symptoms in patients with unipolar depression. Seven hundred eighteen patients and 67...
journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/YPG.0000000000000228
更新日期:2019-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/YPG.0b013e32835fe3e1
更新日期:2013-06-01 00:00:00
abstract::Since 1969, several classical linkage studies suggested an X-chromosome locus for bipolar affective disorder. However, methods using highly polymorphic DNA markers have provided conflicting evidence for linkage, and an X-chromosomal locus for bipolar disorder remains controversial. More recently, Pekkarinen et al. (19...
journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/00041444-199800830-00008
更新日期:1998-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/YPG.0b013e3280111877
更新日期:2007-02-01 00:00:00
abstract::There is evidence for a genetic contribution to attention-deficit hyperactivity disorder (ADHD), although no candidate genes have attained genome-wide significance to date. Given that the noradrenergic system has been implicated in ADHD, the gene for the α2-adrenergic receptor (ADRA2A) has been hypothesized to contrib...
journal_title:Psychiatric genetics
pub_type: 杂志文章,meta分析
doi:10.1097/YPG.0b013e3283631509
更新日期:2013-08-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/YPG.0b013e32835d700d
更新日期:2013-04-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/YPG.0000000000000266
更新日期:2020-12-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/00041444-199622000-00004
更新日期:1996-07-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1097/YPG.0000000000000141
更新日期:2016-08-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/YPG.0b013e32834c0cb2
更新日期:2012-04-01 00:00:00
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journal_title:Psychiatric genetics
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doi:10.1097/YPG.0000000000000081
更新日期:2015-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/00041444-200503000-00001
更新日期:2005-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/01.ypg.0000056681.82896.6b
更新日期:2003-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/YPG.0b013e3283050aca
更新日期:2008-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/YPG.0b013e3283643671
更新日期:2013-12-01 00:00:00
abstract::Genetic factors play a role in the vulnerability to cocaine dependence. The reinforcing properties of cocaine are related to the dopaminergic system, and, in particular, the dopamine receptors have been linked to the reward mechanisms. The present study examines the role of the variants TaqI A of the dopamine D2 recep...
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pub_type: 杂志文章
doi:10.1097/00041444-200509000-00006
更新日期:2005-09-01 00:00:00
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doi:10.1097/YPG.0b013e328133f342
更新日期:2007-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/00041444-200106000-00003
更新日期:2001-06-01 00:00:00
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更新日期:2010-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/00041444-200112000-00004
更新日期:2001-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/00041444-199400440-00007
更新日期:1994-01-01 00:00:00