Abstract:
:The FKBP5 protein is of importance for the function of the glucocorticoid receptor. The purpose of the present study was to examine the possible association between the different genotypes of rs1360780 in the FKBP5 gene, and clinical symptoms in patients with unipolar depression. Seven hundred eighteen patients and 673 controls from the Danish Psychiatric Biobank were participated. No association was found between any genotype and diagnosis of unipolar depression. It was found that the group of depressed patients with the CC genotype showed significantly earlier start of treatment with medicine, had a significantly greater tendency to be treated with electroconvulsive therapy and showed a significantly higher frequency of family history of depression compared with the combined group of patients with the CT and TT genotypes. The only informations about controls were their sex and that they were recruited from the blood bank. The clinical data were not complete for all patients.
journal_name
Psychiatr Genetjournal_title
Psychiatric geneticsauthors
Dam H,Buch JOD,Nielsen AB,Weikop P,Werge T,Jørgensen MBdoi
10.1097/YPG.0000000000000228subject
Has Abstractpub_date
2019-12-01 00:00:00pages
220-225issue
6eissn
0955-8829issn
1473-5873journal_volume
29pub_type
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doi:10.1097/YPG.0b013e32833511ce
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/00041444-199421000-00004
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更新日期:1997-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Psychiatric genetics
pub_type: 杂志文章
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