Abstract:
OBJECTIVE:Novelty seeking is a trait that has been consistently associated with problem behaviours. There is evidence for heritability of novelty seeking, but the molecular genetic basis of the trait is still widely unclear. METHODS:The interaction between polymorphisms of catechol-O-methyltransferase (COMT) and serotonin receptor 2A genes was examined in relation to novelty seeking and its different subscales in healthy Finnish adults. A subsample of 1214 participants derived from a population-based sample was genotyped for the COMT Val158Met (rs4680) and HTR2A T102C (rs6313) genes. Novelty seeking was measured twice, with a 4-year interval, using Cloninger's Temperament and Character Inventory. RESULTS:The interaction between COMT Val158Met and HTR2A T102C polymorphisms was found to be associated with subscale impulsiveness. T/T carriers of HTR2A T102C polymorphism, that also had Met/Met genotype of COMT Val158Met single nucleotide polymorphism, scored significantly higher on impulsiveness than Val allele carriers (P=0.005). CONCLUSION:Our results suggest that the interaction between dopaminergic and serotonergic genes might underlie impulsiveness. Together with earlier research our results also stress the importance of considering novelty seeking as a heterogeneous trait with its subscales having different genetic backgrounds.
journal_name
Psychiatr Genetjournal_title
Psychiatric geneticsauthors
Salo J,Pulkki-Råback L,Hintsanen M,Lehtimäki T,Keltikangas-Järvinen Ldoi
10.1097/YPG.0b013e32833a212fsubject
Has Abstractpub_date
2010-12-01 00:00:00pages
273-81issue
6eissn
0955-8829issn
1473-5873journal_volume
20pub_type
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
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更新日期:2016-06-01 00:00:00