Thyroid-stimulating hormone, 5-HTTLPR genotype, and antidepressant response in depressed women.

Abstract:

:Basal serum thyroid-stimulating hormone (TSH) levels may predict antidepressant efficacy in patients with major depressive episodes (MDE), but data are inconsistent. As the SS genotype of the 5-HTTLPR polymorphism has been associated with a lower antidepressant efficacy in women with MDE, we aimed at assessing the relationship between normal basal TSH, 5-HTTLPR, and antidepressant efficacy in women. A total of 71 women and 28 men, with normal baseline TSH serum levels, hospitalized for a MDE, were assessed for 5-HTTLPR genotypes and prospectively followed for short-term antidepressant efficacy. Women with SS genotype had higher TSH levels (P=0.002) and a worse antidepressant response (P=0.046) than the women with LL/LS genotype, whereas no significant difference was shown in men. In multivariate analyses, antidepressant response in women was explained by TSH and 5-HTTLPR, but not by other variables. Further research is needed to understand the underlying mechanism explaining interactions between sex, TSH, and serotonergic function.

journal_name

Psychiatr Genet

journal_title

Psychiatric genetics

authors

Gressier F,Trabado S,Verstuyft C,Bouaziz E,Hardy P,Fève B,Becquemont L,Corruble E

doi

10.1097/YPG.0b013e3283457be5

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

253-6

issue

5

eissn

0955-8829

issn

1473-5873

journal_volume

21

pub_type

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