Abstract:
OBJECTIVE:Disturbances in catecholamine transmission have been implicated in schizophrenia. Dopamine beta-hydroxylase catalyses the conversion of dopamine to norepinephrine in noradrenergic cells. We attempted to investigate a putative functional promoter polymorphism in the dopamine beta-hydroxylase gene (DBH) for association with schizophrenia. METHODS:Unrelated schizophrenic patients (n=155) and control subjects (n=436) were analysed with regard to the DBH -1021 C/T variant. RESULTS:No significant allele or genotype differences were found. CONCLUSIONS:The present results do not support a major involvement of the DBH gene in schizophrenia in the Swedish population investigated.
journal_name
Psychiatr Genetjournal_title
Psychiatric geneticsauthors
Jönsson EG,Abou Jamra R,Schumacher J,Flyckt L,Edman G,Forslund K,Mattila-Evenden M,Rylander G,Asberg M,Bjerkenstedt L,Wiesel FA,Propping P,Cichon S,Nöthen MM,Sedvall GCdoi
10.1097/00041444-200309000-00007subject
Has Abstractpub_date
2003-09-01 00:00:00pages
175-8issue
3eissn
0955-8829issn
1473-5873journal_volume
13pub_type
杂志文章abstract::We report here linkage data on two families with multiple cases of schizophrenia originating from the genetically isolated population of Finland. We analyzed chromosomal DNA regions containing relevant candidate genes for schizophrenia and chromosomal regions which have been among the most widely studied in schizophre...
journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/00041444-199400430-00004
更新日期:1994-10-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/YPG.0000000000000042
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/YPG.0b013e32832a4f7b
更新日期:2009-06-01 00:00:00
abstract::Animal and human studies have implicated oxytocin in affiliative and prosocial behaviors. We tested whether genetic variation in the oxytocin receptor (OXTR) gene is associated with conduct disorder (CD). Utilizing a family-based sample of adolescent probands recruited from an adolescent substance abuse treatment prog...
journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/YPG.0b013e32834c0cb2
更新日期:2012-04-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 杂志文章
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journal_title:Psychiatric genetics
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更新日期:2010-04-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 杂志文章,评审
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更新日期:2019-10-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 杂志文章
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/00041444-199906000-00009
更新日期:1999-06-01 00:00:00
abstract::Disturbed glutamatergic neurotransmission has been implicated in the pathogenesis of schizophrenia and bipolar disorder, with the N-methy-D-aspartate receptors being in the focus of research. The NR1 subunit, which is encoded by the gene GRIN1, plays a key role in the functionality of N-methy-D-aspartate receptors. We...
journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/01.ypg.0000242194.36150.2b
更新日期:2006-10-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/YPG.0b013e32835d700d
更新日期:2013-04-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/YPG.0b013e32833a212f
更新日期:2010-12-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/01.ypg.0000056681.82896.6b
更新日期:2003-06-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/00041444-199909000-00011
更新日期:1999-09-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/00041444-200203000-00007
更新日期:2002-03-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/YPG.0b013e32835863f0
更新日期:2012-12-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/00041444-199422000-00002
更新日期:1994-07-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/YPG.0b013e3283060f48
更新日期:2008-12-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/YPG.0b013e328133f342
更新日期:2007-10-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/YPG.0b013e32835fe3e1
更新日期:2013-06-01 00:00:00
abstract::The trichorhinophalangeal syndrome is a rare genetic disorder with a classical clinical triad of sparse hair, bulbous nose, and short digits. There are three known phenotypes, and the type II with exostoses in long bones is known as Langer-Giedion syndrome. Here, we describe a 28-year-old Sri Lankan male with Langer-G...
journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/YPG.0000000000000195
更新日期:2018-06-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/YPG.0b013e328353fb77
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:The National Institute of Mental Health's effort to rectify the underrepresentation of American Blacks in the genetic studies of psychiatric disorders has met with mixed success. This study was designed to understand some of the barriers to recruitment. METHODS:Men and women, who were of Black, White or Hisp...
journal_title:Psychiatric genetics
pub_type: 杂志文章
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更新日期:2009-08-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/YPG.0000000000000086
更新日期:2015-06-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/YPG.0b013e3283457be5
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Copy number variants (CNVs) are genetic rearrangements, such as deletions and duplications, which result in a deviation from the normal number of copies of a given gene segment. CNVs are implicated in many neuropsychiatric disorders. Deletions of the human chromosomal region 16p11.2 are one of the most commo...
journal_title:Psychiatric genetics
pub_type: 杂志文章
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更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Serotonin transporter gene (SLC6A4) variations have been proposed as an explanation for interindividual differences in selective serotonin reuptake inhibitors (SSRIs) effects. Quantitative assessment of genetic influences is necessary to evaluate whether genetic testing before antidepressant prescription wou...
journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/YPG.0b013e3283050aca
更新日期:2008-08-01 00:00:00
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journal_title:Psychiatric genetics
pub_type: 杂志文章
doi:10.1097/YPG.0b013e328012a0c6
更新日期:2007-04-01 00:00:00