Allelic variation of the 5-HT2C receptor (HTR2C) in bulimia nervosa and binge eating disorder.

abstract：OBJECTIVES:PDLIM5 (ENH, LIM protein) [Postsynaptic Density-95/discs large/Zone occludens-1 (PDZ) and Lin-11, Isl-1, Mec-3 (LIM) domain 5;] is an adaptor protein that selectively binds protein kinase C-epsilon (PKC epsilon) to N-type Ca channels in brain neurons. As it has been suggested that alterations in protein kina...

journal_title：Psychiatric genetics

authors： Squassina A,Manchia M,Manconi F,Piccardi M,Ardau R,Chillotti C,Severino G,Del Zompo M

更新日期：2008-06-01 00:00:00

abstract：:Catechol-O-methyltransferase (COMT) catalyses the methylation, and hence the inactivation, of catecholamines including the neurotransmitters dopamine and noradrenaline. There is evidence implicating COMT as a candidate gene for a number of neuropsychiatric conditions including bipolar disorder. A long recognized popul...

journal_title：Psychiatric genetics

authors： Mynett-Johnson LA,Murphy VE,Claffey E,Shields DC,McKeon P

更新日期：1998-01-01 00:00:00

abstract：:Anorexia nervosa (AN) is a serious and heritable psychiatric disorder. To date, studies of copy number variants (CNVs) have been limited and inconclusive because of small sample sizes. We conducted a case-only genome-wide CNV survey in 1983 female AN cases included in the Genetic Consortium for Anorexia Nervosa. Follo...

journal_title：Psychiatric genetics

authors： Yilmaz Z,Szatkiewicz JP,Crowley JJ,Ancalade N,Brandys MK,van Elburg A,de Kovel CGF,Adan RAH,Hinney A,Hebebrand J,Gratacos M,Fernandez-Aranda F,Escaramis G,Gonzalez JR,Estivill X,Genetic Consortium for Anorexia Nervosa, Well

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVES:Monozygotic twins with near-identical genotypes and discordance for complex diseases represent an exceptional resource to ascertain disease etiology. This strategy has been particularly effective with the availability of high-resolution complete individual genome sequencing. The challenge is using effective ...

journal_title：Psychiatric genetics

authors： Reble E,Castellani CA,Melka MG,O'Reilly R,Singh SM

更新日期：2017-04-01 00:00:00

abstract：:Genetic research of cocaine abuse has been relatively limited among the African-American population. Since the serotonin transporter (5HTT) may be involved in modulating effects of cocaine, we investigated whether allelic variants of the 5HTT gene may confer susceptibility to cocaine dependence among African-American ...

journal_title：Psychiatric genetics

authors： Patkar AA,Berrettini WH,Hoehe M,Hill KP,Gottheil E,Thornton CC,Weinstein SP

更新日期：2002-09-01 00:00:00

abstract：OBJECTIVE:Biological evidence in both human and animal studies suggests α7 neuronal nicotinic acetylcholine receptor subunit gene (CHRNA7) as a suitable functional candidate for genetic studies in psychiatric populations. This gene maps to chromosome 15q13-14, a major linkage hotspot for schizophrenia (SCH) and bipolar...

journal_title：Psychiatric genetics

authors： Ancín I,Barabash A,Vázquez-Álvarez B,Santos JL,Sánchez-Morla E,Martínez JL,Aparicio A,Peláez JC,Díaz JA

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVE:To examine the heritabilities of symptoms of posttraumatic stress disorder (PTSD), anxiety, depression, and the shared genetic component of these symptoms among family members exposed to the 1988 Spitak earthquake in Armenia. METHODS:Two hundred members of 12 multigenerational families exposed to the Spitak ...

journal_title：Psychiatric genetics

authors： Goenjian AK,Noble EP,Walling DP,Goenjian HA,Karayan IS,Ritchie T,Bailey JN

更新日期：2008-12-01 00:00:00

abstract：:Evidence for a dysfunction of the N-methyl-D-aspartate (NMDA) type of ionotropic glutamate receptors in schizophrenic patients, comes from neurochemical and clinical pharmacologic data. Therefore, the NMDAR1 gene can be regarded as an interesting candidate gene for schizophrenia. Several groups have tried to identify ...

journal_title：Psychiatric genetics

authors： Paus S,Rietschel M,Schulze TG,Ohlraun S,Diaconu CC,Van Den Bogaert A,Maier W,Propping P,Cichon S,Nöthen MM

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:The main aim of the current study was to investigate epigenetic alterations in serotonin 2A receptor (HTR2A) exon I CpG sites as possible risk factors for suicidal behavior. We also aimed to analyze the epigenetic alterations in two different tissues as epigenetic mechanisms are tissue specific. These epigene...

journal_title：Psychiatric genetics

authors： Bani-Fatemi A,Strauss J,Zai C,Wong AHC,de Luca V

更新日期：2017-12-01 00:00:00

abstract：:Although current psychiatric nosology separates bipolar disorder and schizophrenia into non-overlapping categories, there is growing evidence of a partial aetiological overlap between them from linkage, genetic epidemiology and molecular genetics studies. Thus, it is important to determine whether genes implicated in ...

journal_title：Psychiatric genetics

authors： Prata DP,Breen G,Munro J,Sinclair M,Osborne S,Li T,Kerwin R,St Clair D,Collier DA

更新日期：2006-12-01 00:00:00

abstract：:The trichorhinophalangeal syndrome is a rare genetic disorder with a classical clinical triad of sparse hair, bulbous nose, and short digits. There are three known phenotypes, and the type II with exostoses in long bones is known as Langer-Giedion syndrome. Here, we describe a 28-year-old Sri Lankan male with Langer-G...

journal_title：Psychiatric genetics

authors： Chandradasa M,Williams S

更新日期：2018-06-01 00:00:00

abstract：:Since Lesch and colleagues reported an association between anxiety-related traits (Neuroticism) and a functional polymorphism in the serotonin transporter gene regulatory region (5-HTTLPR), there have been several reports on 5-HTTLPR and personality traits with both positive and negative results. The present study was...

journal_title：Psychiatric genetics

authors： Du L,Bakish D,Hrdina PD

更新日期：2000-12-01 00:00:00

abstract：:Recent reports on susceptibility loci for manic depression have sparked lively debate. The pros and cons of these findings are discussed from a methodological vantage point, with implications for linkage studies generally. ...

journal_title：Psychiatric genetics

authors： Baron M

更新日期：1997-04-01 00:00:00

abstract：:A new structural polymorphism (Ser311/Cys311) in the dopamine D2 receptor (DRD2) gene has recently been reported to be associated with schizophrenia, particularly in patients with a positive family history of schizophrenia (Arinimi et al., 1994). However these findings remain controversial (Asherson et al., 1994; Nank...

journal_title：Psychiatric genetics

authors： Laurent C,Bodeau-Péan S,Campion D,d'Amato T,Jay M,Dollfus S,Thibault F,Petit M,Samolyk D,Martinez M

更新日期：1994-01-01 00:00:00

abstract：:Dysregulation of the immune system has been suggested to play a role in the complex etiology of obsessive-compulsive disorder. In this context, tumor necrosis factor-alpha is considered an interesting candidate for genetic studies as overproduction of tumor necrosis factor-alpha, which may be genetically modulated, ca...

journal_title：Psychiatric genetics

authors： Zai G,Arnold PD,Burroughs E,Richter MA,Kennedy JL

更新日期：2006-02-01 00:00:00

abstract：:We report here linkage data on two families with multiple cases of schizophrenia originating from the genetically isolated population of Finland. We analyzed chromosomal DNA regions containing relevant candidate genes for schizophrenia and chromosomal regions which have been among the most widely studied in schizophre...

journal_title：Psychiatric genetics

authors： Hovatta I,Seppälä J,Pekkarinen P,Tanskanen A,Lönnqvist J,Peltonen L

更新日期：1994-10-01 00:00:00

abstract：:Family, twin and adoption studies highlight the influence of genes in the aetiology of schizophrenia, though the mode of inheritance is unclear. We have been conducting a systematic search for major genes in schizophrenia using a series of multiply affected families and report preliminary results of linkage under hete...

journal_title：Psychiatric genetics

authors： Lin MW,Curtis D,Williams N,Arranz M,Nanko S,Collier D,McGuffin P,Murray R,Owen M,Gill M

更新日期：1995-10-01 00:00:00

abstract：:Catechol-O-methyltransferase (COMT) metabolizes catecholamines such as dopamines, noradrenaline and adrenaline. It exists as common high and low activity alleles in the population (determined by a valine 158 methionine polymorphisms), and high red blood cell activity of COMT has previously been associated with schizop...

journal_title：Psychiatric genetics

authors： Kunugi H,Vallada HP,Sham PC,Hoda F,Arranz MJ,Li T,Nanko S,Murray RM,McGuffin P,Owen M,Gill M,Collier DA

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND:Serotonin transporter gene (SLC6A4) variations have been proposed as an explanation for interindividual differences in selective serotonin reuptake inhibitors (SSRIs) effects. Quantitative assessment of genetic influences is necessary to evaluate whether genetic testing before antidepressant prescription wou...

journal_title：Psychiatric genetics

authors： Smits KM,Smits LJ,Peeters FP,Schouten JS,Janssen RG,Smeets HJ,van Os J,Prins MH

更新日期：2008-08-01 00:00:00

abstract：:Altered intracellular calcium homeostasis and oxidative stress are involved in the pathophysiology of bipolar disorder (BD)-I. To explore the genes contributing to these abnormalities, we examined the association with BD of the iPLA2β (PLA2G6), a signaling enzyme that mobilizes the arachidonic acid signaling cascade a...

journal_title：Psychiatric genetics

authors： Xu C,Warsh JJ,Wang KS,Mao CX,Kennedy JL

更新日期：2013-04-01 00:00:00

abstract：:Chromosome 12q is a region of interest for the genetics of bipolar affective disorder because of reports of apparent cosegregation between this disorder and Darier's disease in a small number of families. Findings from a recent linkage study suggest that this chromosomal region may contain a susceptibility gene for bi...

journal_title：Psychiatric genetics

authors： Dawson E,Gill M,Curtis D,Castle D,Hunt N,Murray R,Powell J

更新日期：1995-01-01 00:00:00

abstract：:The purpose of the present study was to investigate the association between the monocyte chemoattractant protein-1 (MCP-1) promoter -2518 polymorphism and schizophrenia. One hundred and twenty-three schizophrenic inpatients and 114 healthy controls participated in this study. Genotyping was performed by polymerase cha...

journal_title：Psychiatric genetics

authors： Pae CU,Chung KI,Kim JJ,Yu HS,Lee CU,Lee SJ,Lee C,Jun TY,Serretti A,Paik IH

更新日期：2004-06-01 00:00:00

abstract：:There is evidence for a genetic contribution to attention-deficit hyperactivity disorder (ADHD), although no candidate genes have attained genome-wide significance to date. Given that the noradrenergic system has been implicated in ADHD, the gene for the α2-adrenergic receptor (ADRA2A) has been hypothesized to contrib...

journal_title：Psychiatric genetics

authors： Shiffrin ND,Gruber J,Glatt SJ,Faraone SV

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVE:The role of the human serotonin transporter protein (5-HTT) gene in psychiatric disorders suggests that its variation may influence the comorbidity pattern and the heterogeneity of alcoholism. The aim of the present study is to verify possible associations between the 5-HTTLPR control region polymorphism with...

journal_title：Psychiatric genetics

authors： Marques FZ,Hutz MH,Bau CH

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:The dopamine transporter gene (DAT1) is an established genetic risk factor for attention deficit hyperactivity disorder (ADHD). Therefore, we hypothesized that DAT1 may also influence the manifestation of ADHD-related traits in the normal population. METHODS:A quantitative association study was carried out ...

journal_title：Psychiatric genetics

authors： Jeong SH,Choi KS,Lee KY,Kim EJ,Kim YS,Joo EJ

更新日期：2015-06-01 00:00:00

abstract：:Corticotropin-releasing factor-binding protein regulates the availability of free corticotropin-releasing factor and is a functional candidate gene for affective disorders. The aim of this study was to examine the association between polymorphisms in CRF-BP gene and bipolar disorder in an isolated Swedish population. ...

journal_title：Psychiatric genetics

authors： Van Den Eede F,Venken T,Van Den Bogaert A,Del-Favero J,Norrback KF,Nilsson LG,Adolfsson R,Van Broeckhoven C,Claes SJ

更新日期：2007-10-01 00:00:00

abstract：:This study investigates the genetic association between methyl-CpG-binding domain (MBD) gene polymorphisms and schizophrenia. A total of 200 family trios consisting of fathers, mothers, and affected offspring with schizophrenia were recruited as our participants. Four tag SNPs on MBD1 (rs125555, rs140689, rs140687, an...

journal_title：Psychiatric genetics

authors： Xie B,Yu Y,Meng X,Yu Q,Shi J,Sang H,Kou C

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:Epidemiological and clinical studies suggest that the rates of antisocial behavior, depression, and impulsive substance use are increased among individuals diagnosed with alcohol dependence relative to those who are not. Thus, the present study conducted genome-wide linkage scans of antisocial behavior, depre...

journal_title：Psychiatric genetics

authors： Gizer IR,Ehlers CL,Vieten C,Feiler HS,Gilder DA,Wilhelmsen KC

更新日期：2012-10-01 00:00:00

abstract：INTRODUCTION:The importance of dopamine D2 receptors (DRD2) for central nervous dopaminergic signalling makes variants in the DRD2 gene potential modulators of the risk or course of various behavioural, psychiatric or neurologic diseases (e.g. addiction, schizophrenia, Parkinson's disease). We developed Pyrosequencing ...

journal_title：Psychiatric genetics

authors： Doehring A,Kirchhof A,Lötsch J

更新日期：2009-10-01 00:00:00

abstract：:Using 23 multiplex pedigrees we tested for linkage between schizophrenia and a microsatellite polymorphism for the D5 dopamine receptor gene (DRD5). Assuming autosomal dominant inheritance and a maximum penetrance of 0.6, an overall lod score of -4.54 was derived at 0% recombination. For recessive transmission the sum...

journal_title：Psychiatric genetics

authors： Ravindranathan A,Coon H,DeLisi L,Holik J,Hoff M,Brown A,Shields G,Crow T,Byerley W

更新日期：1994-07-01 00:00:00