Evaluation of genetic substructure in the Irish Study of High-Density Schizophrenia Families.

abstract：BACKGROUND:The dopamine transporter gene (DAT1) is an established genetic risk factor for attention deficit hyperactivity disorder (ADHD). Therefore, we hypothesized that DAT1 may also influence the manifestation of ADHD-related traits in the normal population. METHODS:A quantitative association study was carried out ...

journal_title：Psychiatric genetics

authors： Jeong SH,Choi KS,Lee KY,Kim EJ,Kim YS,Joo EJ

更新日期：2015-06-01 00:00:00

abstract：:3q29 deletion syndrome is caused by a heterozygous 1.6 Mb deletion on chromosome 3, which occurs in about 1 in 30 000 births. Phenotypic features of this syndrome include mild-to-moderate intellectual disability, autism spectrum disorder, slightly dysmorphic facial features, ataxic gait, and chest-wall deformity. Gast...

journal_title：Psychiatric genetics

authors： Kaur H,Thom RP,Neumeyer AM,Bilancia CG,Wray SH,McDougle CJ

更新日期：2020-08-01 00:00:00

abstract：:Since Lesch and colleagues reported an association between anxiety-related traits (Neuroticism) and a functional polymorphism in the serotonin transporter gene regulatory region (5-HTTLPR), there have been several reports on 5-HTTLPR and personality traits with both positive and negative results. The present study was...

journal_title：Psychiatric genetics

authors： Du L,Bakish D,Hrdina PD

更新日期：2000-12-01 00:00:00

abstract：:A polymorphic 44-nucleotide insertion/deletion in the promoter region of the serotonin transporter gene (5-HTTLPR) has been shown to affect the level of expression of the serotonin transporter protein. An association between anxiety-related behavioural traits and the short form of the 5-HTTLPR has been reported. We de...

journal_title：Psychiatric genetics

authors： Ricketts MH,Hamer RM,Sage JI,Manowitz P,Feng F,Menza MA

更新日期：1998-07-01 00:00:00

abstract：:Although current psychiatric nosology separates bipolar disorder and schizophrenia into non-overlapping categories, there is growing evidence of a partial aetiological overlap between them from linkage, genetic epidemiology and molecular genetics studies. Thus, it is important to determine whether genes implicated in ...

journal_title：Psychiatric genetics

authors： Prata DP,Breen G,Munro J,Sinclair M,Osborne S,Li T,Kerwin R,St Clair D,Collier DA

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVE:Disturbances in catecholamine transmission have been implicated in schizophrenia. Dopamine beta-hydroxylase catalyses the conversion of dopamine to norepinephrine in noradrenergic cells. We attempted to investigate a putative functional promoter polymorphism in the dopamine beta-hydroxylase gene (DBH) for ass...

journal_title：Psychiatric genetics

authors： Jönsson EG,Abou Jamra R,Schumacher J,Flyckt L,Edman G,Forslund K,Mattila-Evenden M,Rylander G,Asberg M,Bjerkenstedt L,Wiesel FA,Propping P,Cichon S,Nöthen MM,Sedvall GC

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:Tryptophan hydroxylase is the rate-limiting enzyme in the serotonin biosynthetic pathway and plays an important role in the regulation of serotonin levels. Recently, a brain-specific isoform, tryptophan hydroxylase 2 or n-tryptophan hydroxylase, has been discovered. Some studies reported genetic and functiona...

journal_title：Psychiatric genetics

authors： Harvey M,Gagné B,Labbé M,Barden N

更新日期：2007-02-01 00:00:00

abstract：:For a period in the mid-1990s, soon after the discovery of the involvement of trinucleotide repeat expansions in fragile-X syndrome (both A and E), Huntington's disease, myotonic dystrophy, and a number of hereditary ataxias, there was a clear sense that this new disease mechanism might provide answers for psychiatric...

journal_title：Psychiatric genetics

authors： Vincent JB

更新日期：2016-08-01 00:00:00

abstract：:Chromosome 12q is a region of interest for the genetics of bipolar affective disorder because of reports of apparent cosegregation between this disorder and Darier's disease in a small number of families. Findings from a recent linkage study suggest that this chromosomal region may contain a susceptibility gene for bi...

journal_title：Psychiatric genetics

authors： Dawson E,Gill M,Curtis D,Castle D,Hunt N,Murray R,Powell J

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVES:The genetic basis of schizophrenia is obscure. In an XX male patient with schizophrenia we previously showed that one X;Y translocation breakpoint was in pseudoautosomal region 1 (PAR1) with the effect that the proximal segment of PAR1 from the PAR1 boundary to acetylserotonin N-methyl transferase (ASMT) dis...

journal_title：Psychiatric genetics

authors： Ross NL,Mavrogiannis LA,Sargent CA,Knight SJ,Wadekar R,DeLisi LE,Crow TJ

更新日期：2003-06-01 00:00:00

abstract：INTRODUCTION:Recent biopsychological research on stress-related psychopathology shows promising evidence for the 5-hydroxytryptamine (5-HT) transporter linked polymorphic region (5-HTTLPR) genotype by life event interaction on depression. Yet, there appears to be variability in replicating such findings. From leading c...

journal_title：Psychiatric genetics

authors： Markus CR

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:Recent research implicates the catechol-O-methyltransferase (COMT) ValMet polymorphism in stress sensitivity, through modulation of hypothalamic-pituitary-adrenal (HPA) function. In healthy samples, Met homozygosity has been associated with greater HPA activity (i.e., cortisol) and stress sensitivity, though ...

journal_title：Psychiatric genetics

authors： Walder DJ,Trotman HD,Cubells JF,Brasfield J,Tang YL,Walker EF

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVE:The National Institute of Mental Health's effort to rectify the underrepresentation of American Blacks in the genetic studies of psychiatric disorders has met with mixed success. This study was designed to understand some of the barriers to recruitment. METHODS:Men and women, who were of Black, White or Hisp...

journal_title：Psychiatric genetics

authors： Murphy EJ,Wickramaratne P,Weissman MM

更新日期：2009-08-01 00:00:00

abstract：:Several studies suggest increased activity of phospholipase A2 in schizophrenic patients. In the present study, variants of four genes coding for phospholipase A2 enzyme groups (sPLA2, cPLA2, iPLA2 and PAFAH) were analysed in a case-control sample using 240 schizophrenic patients and 312 healthy controls. No differenc...

journal_title：Psychiatric genetics

authors： Junqueira R,Cordeiro Q,Meira-Lima I,Gattaz WF,Vallada H

更新日期：2004-09-01 00:00:00

abstract：:As an initial step for genome-wide association studies, we sought an association between schizophrenia and 34 microsatellite markers on chromosomes 19, 20, 21 and 22 by a case-control design. The samples examined for an association were 168 schizophrenic patients and 146 control subjects in the Japanese population. Th...

journal_title：Psychiatric genetics

authors： Kitao Y,Inada T,Arinami T,Hirotsu C,Aoki S,Iijima Y,Yamauchi T,Yagi G

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Genetic, environmental, and cognitive factors play a role in the development and recurrence of depression. More specifically, cognitive biases have been associated with depression risk genes and life events. Recently, the mineralocorticoid receptor NR3C2 gene, and in particular the rs5534 polymorphism, has b...

journal_title：Psychiatric genetics

authors： Vrijsen JN,Vogel S,Arias-Vásquez A,Franke B,Fernández G,Becker ES,Speckens A,van Oostrom I

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Ethanol-induced dopamine (DA) release in the mesolimbic system may reinforce excessive alcohol intake and the progression of alcohol dependence. Within this reward system, the DA transporter (DAT1) plays a key role in the regulation of dopaminergic neurotransmission through presynaptic DA reuptake. OBJECTIV...

journal_title：Psychiatric genetics

authors： Lind PA,Eriksson CJ,Wilhelmsen KC

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVES:The OPRL1 gene encodes the nociceptin/orphanin FQ receptor, which plays a role in regulating tolerance and behavioral responses to morphine. However, there is limited information on whether variants of OPRL1 are associated with vulnerability to develop opiate addiction. In this study, we examined five varian...

journal_title：Psychiatric genetics

authors： Briant JA,Nielsen DA,Proudnikov D,Londono D,Ho A,Ott J,Kreek MJ

更新日期：2010-04-01 00:00:00

abstract：:Since 1969, several classical linkage studies suggested an X-chromosome locus for bipolar affective disorder. However, methods using highly polymorphic DNA markers have provided conflicting evidence for linkage, and an X-chromosomal locus for bipolar disorder remains controversial. More recently, Pekkarinen et al. (19...

journal_title：Psychiatric genetics

authors： Vallada HP,Vasques L,Curtis D,Zatz M,Kirov G,Lauriano V,Gentil V,Murray RM,McGuffin P,Owen M,Gill M,Craddock N,Collier DA

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVE:The role of the human serotonin transporter protein (5-HTT) gene in psychiatric disorders suggests that its variation may influence the comorbidity pattern and the heterogeneity of alcoholism. The aim of the present study is to verify possible associations between the 5-HTTLPR control region polymorphism with...

journal_title：Psychiatric genetics

authors： Marques FZ,Hutz MH,Bau CH

更新日期：2006-06-01 00:00:00

abstract：:A new structural polymorphism (Ser311/Cys311) in the dopamine D2 receptor (DRD2) gene has recently been reported to be associated with schizophrenia, particularly in patients with a positive family history of schizophrenia (Arinimi et al., 1994). However these findings remain controversial (Asherson et al., 1994; Nank...

journal_title：Psychiatric genetics

authors： Laurent C,Bodeau-Péan S,Campion D,d'Amato T,Jay M,Dollfus S,Thibault F,Petit M,Samolyk D,Martinez M

更新日期：1994-01-01 00:00:00

abstract：:The purpose of this study was to investigate the effects of the 5-HTTLPR and brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms on self-reported Big Five personality traits and their facets in a population representative sample of adolescents. The sample consisted of both cohorts of the Estonian Children ...

journal_title：Psychiatric genetics

authors： Hiio K,Merenäkk L,Nordquist N,Parik J,Oreland L,Veidebaum T,Harro J

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:Postpartum depression (PPD) is an under diagnosed and under treated mood disorder, with negative impact on both the mother and the infant's health. The aim of this study is to examine whether genetic variations in the monoaminergic neurotransmitter system, together with environmental stressors, contribute to ...

journal_title：Psychiatric genetics

authors： Comasco E,Sylvén SM,Papadopoulos FC,Sundström-Poromaa I,Oreland L,Skalkidou A

更新日期：2011-02-01 00:00:00

abstract：:Genetic research of cocaine abuse has been relatively limited among the African-American population. Since the serotonin transporter (5HTT) may be involved in modulating effects of cocaine, we investigated whether allelic variants of the 5HTT gene may confer susceptibility to cocaine dependence among African-American ...

journal_title：Psychiatric genetics

authors： Patkar AA,Berrettini WH,Hoehe M,Hill KP,Gottheil E,Thornton CC,Weinstein SP

更新日期：2002-09-01 00:00:00

abstract：OBJECTIVES:Autism is a neurodevelopmental disorder, and genetic factors play an important role in its pathogenesis. Earlier findings suggest the CNTNAP2 as a predisposition locus of autism, but no study has been carried out on the possible association of CNTNAP2 with autism in the Chinese Han population. METHODS:In th...

journal_title：Psychiatric genetics

authors： Li X,Hu Z,He Y,Xiong Z,Long Z,Peng Y,Bu F,Ling J,Xun G,Mo X,Pan Q,Zhao J,Xia K

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:Recent studies have implicated the involvement of proteins regulating neurotransmitter release in the etiology of attention deficit hyperactivity disorder. On the basis of the role of synapsin III in the modulation of neurotransmitter release, we tested this gene as a candidate contributing to the genetic sus...

journal_title：Psychiatric genetics

authors： Makkar R,Gomez L,Wigg KG,Ickowicz A,Pathare T,Tannock R,Malone M,Kennedy JL,Schachar R,Barr CL

更新日期：2007-04-01 00:00:00

abstract：:Basal serum thyroid-stimulating hormone (TSH) levels may predict antidepressant efficacy in patients with major depressive episodes (MDE), but data are inconsistent. As the SS genotype of the 5-HTTLPR polymorphism has been associated with a lower antidepressant efficacy in women with MDE, we aimed at assessing the rel...

journal_title：Psychiatric genetics

authors： Gressier F,Trabado S,Verstuyft C,Bouaziz E,Hardy P,Fève B,Becquemont L,Corruble E

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:The main aim of the current study was to investigate epigenetic alterations in serotonin 2A receptor (HTR2A) exon I CpG sites as possible risk factors for suicidal behavior. We also aimed to analyze the epigenetic alterations in two different tissues as epigenetic mechanisms are tissue specific. These epigene...

journal_title：Psychiatric genetics

authors： Bani-Fatemi A,Strauss J,Zai C,Wong AHC,de Luca V

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVES:Research implicates the A1 allele of the dopamine D2 receptor gene (DRD2) Taq1A polymorphism in the development of depression and anxiety. Furthermore, recent papers suggest that children with A1 allele of this gene may receive less positive parenting, and that the effects of this gene on child symptoms may ...

journal_title：Psychiatric genetics

authors： Hayden EP,Klein DN,Dougherty LR,Olino TM,Laptook RS,Dyson MW,Bufferd SJ,Durbin CE,Sheikh HI,Singh SM

更新日期：2010-12-01 00:00:00

abstract：:Family, twin and adoption studies highlight the influence of genes in the aetiology of schizophrenia, though the mode of inheritance is unclear. We have been conducting a systematic search for major genes in schizophrenia using a series of multiply affected families and report preliminary results of linkage under hete...

journal_title：Psychiatric genetics

authors： Lin MW,Curtis D,Williams N,Arranz M,Nanko S,Collier D,McGuffin P,Murray R,Owen M,Gill M

更新日期：1995-10-01 00:00:00