Neonatal patterns of breathing after cesarean section with or without epidural fentanyl.

abstract：BACKGROUND:Drugs used for sedation in anesthesia and intensive care may cause pharyngeal dysfunction and increased risk for aspiration. In this study, the authors investigate the impact of sedative doses of morphine and midazolam on pharyngeal function during swallowing and coordination of breathing and swallowing. ME...

journal_title：Anesthesiology

authors： Hårdemark Cedborg AI,Sundman E,Bodén K,Hedström HW,Kuylenstierna R,Ekberg O,Eriksson LI

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Volatile anesthetics such as isoflurane are widely used in clinical and research contexts. Concerns have been raised that the effects of these drugs on the central nervous system may result in long-term impairment after surgery or general anesthesia. Hence, this study aimed to detect how different isoflurane...

journal_title：Anesthesiology

authors： Valentim AM,Di Giminiani P,Ribeiro PO,Rodrigues P,Olsson IA,Antunes LM

更新日期：2010-11-01 00:00:00

abstract：:The effects of gamma-aminobutyric acid (GABA) on the induction of convulsions by local anesthetics were investigated in mice and rats. Intraventricular administration of 0.8-1.6 mg GABA protected rats against convulsions induced by procaine, lidocaine, cocaine, and tetracaine in a dose-related manner. Intraperitoneal ...

journal_title：Anesthesiology

authors： Ikeda M,Dohi T,Tsujimoto A

更新日期：1982-05-01 00:00:00

abstract：BACKGROUND:Pulsus alternans is a classic type of abnormal pulse. It can be defined as a regular alternation of pulse amplitude in which runs of weak and strong beats follow each other alternatively without any change in cycle length. It may be a sign of severe decompensated congestive heart failure. The authors infrequ...

journal_title：Anesthesiology

authors： Saghaei M,Mortazavian M

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Voltage-gated Na channels modulate membrane excitability in excitable tissues. Inhibition of Na channels has been implicated in the effects of volatile anesthetics on both nervous and peripheral excitable tissues. The authors investigated isoform-selective effects of isoflurane on the major Na channel isofor...

journal_title：Anesthesiology

authors： OuYang W,Hemmings HC Jr

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Although respiratory depression is the most well-known and dangerous side effect of opioids, no pharmacokinetic-pharmacodynamic model exists for its quantitative analysis. The development of such a model was the aim of this study. METHODS:After institutional approval approval and informed consent were obtai...

journal_title：Anesthesiology

authors： Bouillon T,Schmidt C,Garstka G,Heimbach D,Stafforst D,Schwilden H,Hoeft A

更新日期：1999-07-01 00:00:00

abstract：:Myocardial ischemia results when halothane is administered to animals with severe coronary stenosis. This study was done to separate the effect of halothane, per se, on myocardial ischemia from indirect cardiovascular effects, primarily hypotension, that might cause ischemia by altering the oxygen supply-demand balanc...

journal_title：Anesthesiology

authors： Buffington CW

更新日期：1986-05-01 00:00:00

abstract：BACKGROUND:Several beneficial effects of local anesthetics (LAs) were shown to be due to inhibition of G protein-coupled receptor signaling. Differences in exposure time might explain discrepancies in concentrations of LAs required to achieve these protective effects in vivo and in vitro (approximately 100-fold higher)...

journal_title：Anesthesiology

authors： Hollmann MW,Herroeder S,Kurz KS,Hoenemann CW,Struemper D,Hahnenkamp K,Durieux ME

更新日期：2004-04-01 00:00:00

abstract：:Using magnetic resonance spectroscopy, the authors tested whether cerebral concentrations of inhaled anesthetics do not increase proportionately at inspired concentrations exceeding 3% 1) because anesthetics bind to and saturate specific sites in the brain or 2) because anesthetic-induced depression of ventilation lim...

journal_title：Anesthesiology

authors： Lockhart SH,Cohen Y,Yasuda N,Kim F,Litt L,Eger EI 2nd,Chang LH,James T

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND:Optimal risk adjustment is a requisite precondition for monitoring quality of care and interpreting public reports of hospital outcomes. Current risk-adjustment measures have been criticized for including baseline variables that are difficult to obtain and inadequately adjusting for high-risk patients. The a...

journal_title：Anesthesiology

authors： Dalton JE,Kurz A,Turan A,Mascha EJ,Sessler DI,Saager L

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Neuronal voltage-dependent potassium (K) currents are crucial for various cellular functions, such as the integration of temporal information in the central nervous system. Data for the effects of intravenous anesthetics on human neuronal K currents are limited. It was the authors' aim to evaluate the concen...

journal_title：Anesthesiology

authors： Friederich P,Urban BW

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:Resiniferatoxin is a potent capsaicin analog. Intrathecal administration leads to selective, prolonged opening of the transient receptor potential V1 ion channel, which is localized mainly to C-fiber primary afferent nociceptive sensory neurons. Following work in laboratory animals, the authors explored the ...

journal_title：Anesthesiology

authors： Brown DC,Iadarola MJ,Perkowski SZ,Erin H,Shofer F,Laszlo KJ,Olah Z,Mannes AJ

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Evidence concerning the concentrations of volatile anesthetics that prevent learning and recall is limited. Epinephrine is believed to enable learning during anesthesia. We investigated the effects of isoflurane and its interaction with epinephrine on learning and subsequent retention of the rabbit's classic...

journal_title：Anesthesiology

authors： el-Zahaby HM,Ghoneim MM,Johnson GM,Gormezano I

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:Although neuromuscular blocking agents do not cross the blood-brain barrier, they may penetrate the central nervous system under particular circumstances and eventually cause neurotoxic consequences. METHODS:The effects of neuromuscular blocking agents on excitatory and inhibitory transmission in area CA1 o...

journal_title：Anesthesiology

authors： Chiodini FC,Tassonyi E,Fuchs-Buder T,Fathi M,Bertrand D,Muller D

更新日期：1998-04-01 00:00:00

abstract：:The effects of epinephrine 1/200,000 as an adjuvant to epidural morphine were investigated in three healthy male volunteers, during 26-h observation sessions. Peak blood concentrations of morphine were 44 +/- 12.9 ng/ml after plain morphine and 13.7 +/- 6.7 ng/ml after epinephrine-morphine. Cutaneous hypalgesia was mo...

journal_title：Anesthesiology

authors： Bromage PR,Camporesi EM,Durant PA,Nielsen CH

更新日期：1983-03-01 00:00:00

abstract：:Statin therapy is well established for prevention of cardiovascular disease. Statins may also reduce postoperative mortality and morbidity via a pleiotropic (non-lipid-lowering) effect. The authors conducted a meta-analysis to determine the influence of statin treatment on adverse postoperative outcomes in patients un...

journal_title：Anesthesiology

authors： Hindler K,Shaw AD,Samuels J,Fulton S,Collard CD,Riedel B

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Although intravenous patient-controlled analgesia opioids and epidural analgesia offer improved analgesia for postoperative patients treated on an acute pain service, these modalities also expose patients to some risk of serious morbidity and even mortality. Root cause analysis, a process for identifying the...

journal_title：Anesthesiology

authors： Paul JE,Buckley N,McLean RF,Antoni K,Musson D,Kampf M,Buckley D,Marcoux M,Frketich R,Thabane L,Cheng J

更新日期：2014-01-01 00:00:00

abstract：:The effects of vasopressor therapy on intracranial pressure (ICP) during hypotension were evaluated in 45 adult cats anesthetized with pentobarbital and hyperventilated via an endotracheal tube with nitrous oxide, 70 per cent, and oxygen, 30 per cent, to maintain Paco2 25 plus or minus 5 torr. Hypotension was induced ...

journal_title：Anesthesiology

authors： Stullken EH Jr,Sokoll MD

更新日期：1975-04-01 00:00:00

abstract：BACKGROUND:The mechanisms that underlie the supraspinal central nervous system effects of systemic lidocaine are poorly understood and not solely explained by Na(+) channel blockade. Among other potential targets is the hyperpolarization-activated cation current, I(h), which is blocked by lidocaine in peripheral neuron...

journal_title：Anesthesiology

authors： Putrenko I,Schwarz SK

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Halothane anesthesia causes spindles in the electroencephalogram (EEG), but the cellular and molecular mechanisms generating these spindles remain incompletely understood. The current study tested the hypothesis that halothane-induced EEG spindles are regulated, in part, by pontine cholinergic mechanisms. M...

journal_title：Anesthesiology

authors： Keifer JC,Baghdoyan HA,Lydic R

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Anesthetic preconditioning (APC) with sevoflurane reduces myocardial ischemia-reperfusion injury. The authors tested whether two brief exposures to sevoflurane would lead to a better preconditioning state than would a single longer exposure and whether dual exposure to a lower (L) concentration of sevofluran...

journal_title：Anesthesiology

authors： Riess ML,Kevin LG,Camara AK,Heisner JS,Stowe DF

更新日期：2004-03-01 00:00:00

abstract：:The authors studied anesthetic mutagenesis following exposure in vivo by use of an adaptation of the mouse spermatozoa morphology assay of Wyrobek and Bruce. The epididymal spermatozoa of (C57B1/C3H)F1 mice were examined for morphologic abnormalities following exposure to near-0.1 MAC and greater concentrations of gen...

journal_title：Anesthesiology

authors： Land PC,Owen EL,Linde HW

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:Norepinephrine has been investigated as a potential alterative to phenylephrine for maintaining blood pressure during spinal anesthesia for cesarean delivery with the advantage of less depression of maternal heart rate and cardiac output. However, the relative potencies of these two vasopressors have not bee...

journal_title：Anesthesiology

authors： Ngan Kee WD

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Although evidence of its effects is tentative, acupuncture has long been used in the treatment of multiple maladies. So far, it has not been possible to discriminate the effects of the venue from specific results of needling itself, thus physicians merely depend on patients' statements. The authors investiga...

journal_title：Anesthesiology

authors： Agarwal-Kozlowski K,Lange AC,Beck H

更新日期：2009-09-01 00:00:00

abstract：:The neonatal neurobehavioral effects of bupivacaine, mepivacaine, and 2-chloroprocaine used in random sequence for pudendal block anesthesia were studied. The neurobehavioral status of 54 infants was studied 4 and 24 hours after delivery. Except for a significant difference in the responses to pinprick, there was no s...

journal_title：Anesthesiology

authors： Merkow AJ,McGuinness GA,Erenberg A,Kennedy RL

更新日期：1980-04-01 00:00:00

abstract：BACKGROUND:The authors used the American Society of Anesthesiologists Closed Claims Project database to determine changes in the proportion of claims for death or permanent brain damage over a 26-yr period and to identify factors associated with the observed changes. METHODS:The Closed Claims Project is a structured e...

journal_title：Anesthesiology

authors： Cheney FW,Posner KL,Lee LA,Caplan RA,Domino KB

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Mechanical ventilation (MV) is a life-saving intervention in patients with acute respiratory failure. However, prolonged MV results in ventilator-induced diaphragm dysfunction (VIDD), a condition characterized by both diaphragm fiber atrophy and contractile dysfunction. Previous work has shown that calpain, ...

journal_title：Anesthesiology

authors： Smuder AJ,Nelson WB,Hudson MB,Kavazis AN,Powers SK

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Perfluorocarbon (PFC) liquids are known to improve gas exchange and pulmonary function in various models of acute respiratory failure. Vaporization has been recently reported as a new method of delivering PFC to the lung. Our aim was to study the effect of PFC vapor on the ventilation/perfusion (VA/Q) matchi...

journal_title：Anesthesiology

authors： Hübler M,Souders JE,Shade ED,Polissar NL,Schimmel C,Hlastala MP

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:The cardiovascular side effects of volatile anesthetics are one of the chief causes of postoperative complications in children, and infants seem to be at the greatest risk for this. This study compared cardiovascular changes at equipotent concentrations of sevoflurane and halothane in infants. METHODS:Thirt...

journal_title：Anesthesiology

authors： Wodey E,Pladys P,Copin C,Lucas MM,Chaumont A,Carre P,Lelong B,Azzis O,Ecoffey C

更新日期：1997-10-01 00:00:00

abstract：:The effect of chronic renal failure (RF) on the pharmacokinetics of morphine was studied in nine patients with end-stage RF, aged 58 +/- 8 yr (SD), and in seven control patients, aged 58 +/- 15 yr, undergoing peripheral surgery under general anesthesia. All patients received 0.2 mg X kg-1 as an intravenous bolus injec...

journal_title：Anesthesiology

authors： Chauvin M,Sandouk P,Scherrmann JM,Farinotti R,Strumza P,Duvaldestin P

更新日期：1987-03-01 00:00:00