Hamilton acute pain service safety study: using root cause analysis to reduce the incidence of adverse events.

abstract：BACKGROUND:Optimal risk adjustment is a requisite precondition for monitoring quality of care and interpreting public reports of hospital outcomes. Current risk-adjustment measures have been criticized for including baseline variables that are difficult to obtain and inadequately adjusting for high-risk patients. The a...

journal_title：Anesthesiology

authors： Dalton JE,Kurz A,Turan A,Mascha EJ,Sessler DI,Saager L

更新日期：2011-06-01 00:00:00

abstract：:The authors have previously attributed the mechanism for the 50-67% decrease in the required dose of thiopental for induction of anesthesia in aged human patients to a decrease in the initial distribution volume for thiopental. Using a larger group of patients and volunteers studied in the laboratory, the authors have...

journal_title：Anesthesiology

authors： Stanski DR,Maitre PO

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND:Cortical networks generate diverse patterns of rhythmic activity. Theta oscillations (4-12 Hz) are commonly observed during spatial learning and working memory tasks. The authors ask how etomidate, acting predominantly via gamma-aminobutyric acid type A (GABAA) receptors containing beta2 or beta3 subunits, a...

journal_title：Anesthesiology

authors： Drexler B,Roether CL,Jurd R,Rudolph U,Antkowiak B

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:Exogenous pyruvate and ethyl pyruvate (EP), the key ingredient in a new Ringer's solution in clinical trials, are antioxidants as well as metabolic substrates. In vivo studies show both to be protective in oxidative stress, with EP being better. The authors used an acute rat brain slice preparation to compar...

journal_title：Anesthesiology

authors： Zeng J,Liu J,Yang GY,Kelly MJ,James TL,Litt L

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:There is substantial and growing literature on the actions of general anesthetics on a variety of neurotransmitter-gated ion channels, with the greatest attention being focused on inhibitory gamma-amino butyric acid type A receptors. In contrast, glutamate receptors, the most important class of fast excitato...

journal_title：Anesthesiology

authors： Plested AJ,Wildman SS,Lieb WR,Franks NP

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:General anesthetics reduce neuron loss following focal cerebral ischemia in rodents. The relative efficacy of this action among different anesthetics clinically used for neuroprotection is uncertain. In addition, it remains unclear how anesthetics compare to neuroprotection afforded by mild hypothermia. This...

journal_title：Anesthesiology

authors： Popovic R,Liniger R,Bickler PE

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:In acute lung injury positive end-expiratory pressure (PEEP) and recruitment maneuver are proposed to optimize arterial oxygenation. The aim of the study was to evaluate the impact of such a strategy on lung histological inflammation and hyperinflation in pigs with acid aspiration-induced lung injury. METHO...

journal_title：Anesthesiology

authors： Ambrosio AM,Luo R,Fantoni DT,Gutierres C,Lu Q,Gu WJ,Otsuki DA,Malbouisson LM,Auler JO Jr,Rouby JJ,Experimental ARDS Study Group.

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:The combining of epidural anesthesia with general anesthesia impairs central and peripheral thermoregulatory control and therefore is often accompanied by unintended intraoperative hypothermia. However, little is known about the cardiovascular response to hypothermia during combined epidural and general anes...

journal_title：Anesthesiology

authors： Yoshida M,Shibata K,Itoh H,Yamamoto K

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND:Deep hypothermia has been associated with an increased incidence of postoperative neurologic dysfunction after cardiac surgery in children. Recent studies suggest an excitotoxic mechanism involving overstimulation of glutamate receptors. Extracellular glutamate uptake occurs primarily by astrocytes. Astrocyt...

journal_title：Anesthesiology

authors： Bissonnette B,Pellerin L,Ravussin P,Daven VB,Magistretti PJ

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:Conflicting opinions are present in the literature regarding the origin of the negative inotropic effect of propofol on the myocardium. This study aims to resolve these discrepancies by investigating the inotropic effects of propofol the L-type calcium channels and the sodium-calcium exchanger (NCX). METHOD...

journal_title：Anesthesiology

authors： de Ruijter W,Stienen GJ,van Klarenbosch J,de Lange JJ

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Dexmedetomidine is an alpha 2 agonist with potential utility in clinical anesthesia for both its sedative and sympatholytic properties. METHODS:The pharmacokinetics and hemodynamic changes that occurred in ten healthy male volunteers were determined after administration of dexmedetomidine 2 micrograms/kg by...

journal_title：Anesthesiology

authors： Dyck JB,Maze M,Haack C,Vuorilehto L,Shafer SL

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:Recent interest in shortening the fasting interval after ingestion of milk products demonstrated large volumes of breast milk in the stomach 2 h after breastfeeding. Although aspiration is a rare event, if it were to occur with human breast milk, it is important to understand the extent of the lung injury th...

journal_title：Anesthesiology

authors： O'Hare B,Lerman J,Endo J,Cutz E

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:Use of high-dose inhalational anesthesia during open fetal surgery may induce maternal-fetal hemodynamic instability and fetal myocardial depression. The authors' preliminary human retrospective study demonstrated less fetal bradycardia and left ventricular systolic dysfunction with lower dose desflurane sup...

journal_title：Anesthesiology

authors： Ngamprasertwong P,Michelfelder EC,Arbabi S,Choi YS,Statile C,Ding L,Boat A,Eghtesady P,Holland K,Sadhasivam S

更新日期：2013-04-01 00:00:00

abstract：:Ten patients with parenchymal acute respiratory failure (ARF) underwent computed tomography (CT) scans while in the supine and prone positions. At equal levels of positive end-expiratory pressure, the authors measured the changes of CT density in dorsal and ventral basilar lung regions induced by the change of positio...

journal_title：Anesthesiology

authors： Gattinoni L,Pelosi P,Vitale G,Pesenti A,D'Andrea L,Mascheroni D

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Inhalational anesthetics inhibit the nitric oxide-guanylyl cyclase signaling pathway, but the site of this inhibition is not yet clear. This study was designed to test the hypothesis that receptor activation or downstream signaling events leading to nitric oxide synthase activation are important sites for th...

journal_title：Anesthesiology

authors： Zuo Z,Tichotsky A,Johns RA

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND:When performing experiments at room temperature with volatile general anesthetics and in vitro mammalian preparations (such as isolated neurons), the question arises as to which concentrations of anesthetics are "clinically relevant." Different choices can lead to different interpretations of the anesthetic ...

journal_title：Anesthesiology

authors： Franks NP,Lieb WR

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:Results from previous studies on the effect of nitrous oxide (N2O) on the cerebral circulation are conflicting. Early reports claim N2O to have no effect whereas recent findings demonstrate a cerebral cortical vasodilatation during N2O inhalation, but the regional cerebral blood flow (CBF) in the subcortical...

journal_title：Anesthesiology

authors： Reinstrup P,Ryding E,Algotsson L,Berntman L,Uski T

更新日期：1994-08-01 00:00:00

abstract：:The relationship between the extent of preoperative beta-adrenoceptor blockade and the hemodynamic properties of dobutamine was investigated in patients scheduled for elective myocardial revascularization during isoflurane-nitrous oxide anesthesia. Twenty patients had been treated with beta-adrenoceptor blocking drugs...

journal_title：Anesthesiology

authors： Tarnow J,Komar K

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND:Acute kidney injury is a common complication after cardiac surgery, leading to increased morbidity and mortality. One suggested cause for acute kidney injury is extracorporeal circulation-induced ischemia-reperfusion injury. In animal studies, cyclosporine has been shown to reduce ischemia-reperfusion injury...

journal_title：Anesthesiology

authors： Ederoth P,Dardashti A,Grins E,Brondén B,Metzsch C,Erdling A,Nozohoor S,Mokhtari A,Hansson MJ,Elmér E,Algotsson L,Jovinge S,Bjursten H

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Hypotension is a common side effect of general anesthesia induction, and when severe, it is related to adverse outcomes. Ultrasonography of inferior vena cava (IVC) is a reliable indicator of intravascular volume status. This study investigated whether preoperative ultrasound IVC measurements could predict h...

journal_title：Anesthesiology

authors： Zhang J,Critchley LA

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Long-term neuroprotection by isoflurane has been questioned. The authors examined factors in experimental models potentially critical to definition of enduring isoflurane neuroprotection. METHODS:Rats were prepared for temporary middle cerebral artery occlusion (MCAO). Pericranial normothermia was maintaine...

journal_title：Anesthesiology

authors： Sakai H,Sheng H,Yates RB,Ishida K,Pearlstein RD,Warner DS

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Because oral erythromycin administration has been associated with reduced elimination of alfentanil, suspicion has been raised about related opioids with similar metabolic pathways. A controlled crossover study of sufentanil pharmacokinetics was undertaken to resolve this issue. METHODS:Six subjects had mea...

journal_title：Anesthesiology

authors： Bartkowski RR,Goldberg ME,Huffnagle S,Epstein RH

更新日期：1993-02-01 00:00:00

abstract：:Five healthy, nonpregnant volunteers were studied before and after induction of lumbar epidural anesthesia to determine the cause of central hypothermia during epidural anesthesia. Cutaneous heat loss was measured from 10 area-weighted sites using thermal flux transducers. Oxygen consumption was measured and converted...

journal_title：Anesthesiology

authors： Hynson JM,Sessler DI,Glosten B,McGuire J

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:Ketamine is a commonly used anesthetic, but the mechanistic basis for its clinically relevant actions remains to be determined. The authors previously showed that HCN1 channels are inhibited by ketamine and demonstrated that global HCN1 knockout mice are twofold less sensitive to hypnotic actions of ketamine...

journal_title：Anesthesiology

authors： Zhou C,Douglas JE,Kumar NN,Shu S,Bayliss DA,Chen X

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Cardiac preconditioning, including that induced by halogenated anesthetics, is an innate protective mechanism against ischemia-reperfusion injury. The adenosine triphosphate-sensitive potassium (K(ATP)) channels are considered essential in preconditioning mechanism. However, it is unclear whether K(ATP) chan...

journal_title：Anesthesiology

authors： Marinovic J,Bosnjak ZJ,Stadnicka A

更新日期：2006-07-01 00:00:00

abstract：:Low concentrations of ethanol (17 mM) inhibited development of spontaneous mechanical activity (vasomotion) in isolated rat portal veins. Low concentrations of ethanol potentiated, however, contractions induced by epinephrine, but not those induced by angiotensin or potassium. Higher concentrations of ethanol, such as...

journal_title：Anesthesiology

authors： Edgarian H,Altura BM

更新日期：1976-04-01 00:00:00

abstract：:Medical records of 38 patients undergoing anesthesia and surgery for removal of an insulinoma were reviewed to determine 1) the safety of avoiding intraoperative glucose, 2) the appropriate frequency of plasma glucose analysis, and 3) the accuracy of using rebound hyperglycemia as an indication of tumor removal. Plasm...

journal_title：Anesthesiology

authors： Muir JJ,Endres SM,Offord K,van Heerden JA,Tinker JH

更新日期：1983-11-01 00:00:00

abstract：INTRODUCTION:The current investigation aimed to study the efficacy of hemostatic therapy guided either by conventional coagulation analyses or point-of-care (POC) testing in coagulopathic cardiac surgery patients. METHODS:Patients undergoing complex cardiac surgery were assessed for eligibility. Those patients in whom...

journal_title：Anesthesiology

authors： Weber CF,Görlinger K,Meininger D,Herrmann E,Bingold T,Moritz A,Cohn LH,Zacharowski K

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:The Pediatric Craniofacial Collaborative Group established the Pediatric Craniofacial Surgery Perioperative Registry to elucidate practices and outcomes in children with craniosynostosis undergoing complex cranial vault reconstruction and inform quality improvement efforts. The aim of this study is to determ...

journal_title：Anesthesiology

authors： Stricker PA,Goobie SM,Cladis FP,Haberkern CM,Meier PM,Reddy SK,Nguyen TT,Cai L,Polansky M,Szmuk P,Fiadjoe J,Soneru C,Falcon R,Petersen T,Kowalczyk-Derderian C,Dalesio N,Budac S,Groenewald N,Rubens D,Thompson D,Wat

更新日期：2017-02-01 00:00:00

abstract：:Addition of glucose (16.7 mM) to isolated pieces of rat pancreas increased insulin secretion 5.4-fold over basal secretion rates. Ether at 1, 1.5 and 2 MAC inhibited this insulinogenic effect of glucose in a dose-related manner by 5, 18 (P less than 0.01) and 29 (P less than 0.01) per cent, respectively. ...

journal_title：Anesthesiology

authors： Gingerich RL,Paradise RR,Wright PH

更新日期：1979-07-01 00:00:00