Abstract：
:In Parkinson's disease both limb and cranial sensorimotor functions are impaired, leading to a profound diminished quality of life for many patients. Toxin and genetic animal models of Parkinson's disease are likely essential for understanding the pathology associated with these impairments as well as for the development and testing of potential therapeutics. Here we describe useful novel and established behavioral outcome measures for assessing limb and cranial sensorimotor functions in toxin and genetic models of parkinsonism in rats and mice.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Fleming SM,Schallert T,Ciucci MRdoi
10.1016/j.bbr.2012.02.034subject
Has Abstractpub_date
2012-06-01 00:00:00pages
317-22issue
2eissn
0166-4328issn
1872-7549pii
S0166-4328(12)00156-8journal_volume
231pub_type
杂志文章,评审abstract：:Sustained attention is defined as the ability or capacity to remain focused on the occurrence of rare events over long periods of time. We describe here the development of a novel, operant-based attention task that can be learned by mice in 8-10 days. Mice were trained on a 2-choice visual discrimination task in an op...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2009.04.036
更新日期：2009-12-01 00:00:00
abstract：:The endogenous opioid system is involved in ethanol reinforcement. Ethanol-induced changes in opioidergic transmission have been extensively studied in adult organisms. However, the impact of ethanol exposure at low or moderate doses during early ontogeny has been barely explored. We investigated the effect of prenata...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.08.022
更新日期：2014-11-01 00:00:00
abstract：:The effect of intraseptal injections of lidocaine before a first or a second session in the elevated plus-maze, in a test-retest paradigm, was investigated. In addition to gross session analyses, a minute-by-minute analysis of the sessions was used to evaluate both anxiety and memory. Lidocaine injections before the t...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.02.011
更新日期：2010-06-26 00:00:00
abstract：:Early life stress in rodents is associated with increased amygdala volume in adulthood. In humans, the amygdala develops rapidly during the first two years of life. Thus, disturbed care during this period may be particularly important to amygdala development. In the context of a 30-year longitudinal study of impoveris...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2016.03.050
更新日期：2016-07-15 00:00:00
abstract：:Aggression can be modulated by both genetic and environmental factors. Here, we analyse how the serotonin transporter (5-HTT) genotype and the environmental situation in which a contest takes place shape the display of offensive aggression. Therefore, male wildtype, heterozygous, and homozygous 5-HTT knockout mice, wh...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.01.029
更新日期：2011-06-01 00:00:00
abstract：:The context preexposure facilitation effect (CPFE) is a variant of context fear conditioning in which context preexposure facilitates conditioning to immediate foot shock. Learning about context (preexposure), associating the context with shock (training), and expression of context fear (testing) occur in successive p...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2013.03.043
更新日期：2013-07-01 00:00:00
abstract：:In recent years, considerable emphasis has been placed upon the putative role of nucleus accumbens dopamine systems in appetitive motivation and positive reinforcement. However, considerable evidence indicates that brain dopamine in general, and nucleus accumbens dopamine in particular, is involved in aspects of avers...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/0166-4328(94)90153-8
更新日期：1994-04-18 00:00:00
abstract：:Rats with hippocampal aspiration lesions (HIPP), cortical control lesions (CORT) or sham operations (SHAM) were trained on a delayed alternation GO/NO-GO task, in which responding was reinforced on odd-numbered GO trials but was not reinforced on even-numbered NO-GO trials. The number of responses required to obtain r...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(05)80250-5
更新日期：1992-03-15 00:00:00
abstract：:It has been reported that more than one fourth of the world's population suffers from sleep problems. However, there is not a stable and reliable animal model to mimic the persistent and periodic features of sleep disorders, and correspondingly, the feasibility and effectiveness of repeated behavioral tests remains to...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2016.12.034
更新日期：2017-03-15 00:00:00
abstract：:Because of the organization of visual and motor pathways, simple manual responses to a light stimulus in the right or left visual hemifields are performed faster with uncrossed hand-field combinations than with crossed hand-field combinations. Uncrossed responses can be integrated within a single hemisphere, whereas c...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(94)90126-0
更新日期：1994-10-20 00:00:00
abstract：:Neuronal activity was recorded in the hippocampal formation, the parahippocampal gyrus and medial inferotemporal cortex of monkeys performing memory tasks. In a modified delayed matching to sample task in which 2 sequentially presented stimuli were compared on each trial, a match condition required a right panel press...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(90)90038-g
更新日期：1990-10-30 00:00:00
abstract：:The selective CRF₁ (corticotropin releasing factor type 1) receptor antagonist SSR125543 has been previously shown to attenuate the long-term behavioral and electrophysiological effects produced by traumatic stress exposure in mice. Sleep disturbances are one of the most commonly reported symptoms by people with post-...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.11.006
更新日期：2015-02-15 00:00:00
abstract：:The effect of ritanserin (5-HT2 antagonist) on scopolamine (muscarinic cholinergic antagonist)-induced amnesia in Morris water maze (MWM) was investigated. Rats were divided into eight groups and bilaterally cannulated into CA1 region of the hippocampus. One week later, they received repeatedly vehicles (saline, DMSO,...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2005.11.016
更新日期：2006-04-03 00:00:00
abstract：:The present study tested eight boys with attention-deficit/hyperactivity disorder (ADHD) and 12 normal boys (comparison group), aged 7-12 years, to investigate the hypothesis that ADHD is associated with a steeper and shorter delay-of-reinforcement gradient than is normal. A two-component schedule of reinforcement was...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：
更新日期：1998-07-01 00:00:00
abstract：:Regulation of CNS arousal is important for a wide variety of functions, including the initiation of all motivated behaviors. Usually studied with pharmacological or hormonal tools, CNS arousal can also be elevated by deep brain stimulation (DBS), in the human brain and in animals. The effectiveness of DBS is conventio...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.06.009
更新日期：2010-12-25 00:00:00
abstract：:The area postrema (AP), a chemosensitive organ located in the fourth ventricle, has been shown to mediate the formation of a lithium-induced conditioned taste avoidance (CTA) in rats. The present experiments examined the role of the AP in the discrimination between two equimolar solutions of sodium chloride (NaCl) and...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(97)02279-1
更新日期：1997-08-01 00:00:00
abstract：:The spontaneously hypertensive rat (SHR) has been studied extensively as a purported rodent model of attention-deficit/hyperactivity disorder (ADHD). Because ADHD in humans is partially defined by marked impulsivity, SHRs, if a valid model of ADHD, ought to behave more impulsively than their normotensive parent strain...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2007.09.008
更新日期：2008-02-11 00:00:00
abstract：:We present the case for a model-based approach to the statistical analysis of rodent locomotion data for which previous research has established that the time course of behavioral change follows a specified parametric form. Inadequacies of statistical methods commonly applied to such data are described. Regression mod...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(01)00311-4
更新日期：2002-01-07 00:00:00
abstract：:The effects of the selective opiate kappa-receptor agonist tifluadom on memory were investigated in a passive avoidance task in 3 sets of experiments carried out with DBA/2 (DBA) mice both familiarized and unfamiliarized with the apparatus. In a first set of experiments, tifluadom (1.0 or 2.5, but not 0.5 mg/kg) admin...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(85)90172-x
更新日期：1985-05-01 00:00:00
abstract：:Prepulse inhibition (PPI) of the startle reflex is an operational measure of sensorimotor gating. The dopamine receptor agonist-mediated disruption of PPI in rats is widely used as a model of the sensorimotor gating deficiencies demonstrated in schizophrenia patients. As a possible tool for validation of a pig model o...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2004.04.014
更新日期：2004-12-06 00:00:00
abstract：:Bilateral lesions were made, confined to the orbitofrontal part of the prefrontal cortex (OF) of male WEZOB rats at 3 different ages (30, 45 and 60 days) and behavioural changes were studied in adulthood. In a test situation for intermale aggression OF-lesioned animals showed a higher level of aggression than their co...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(83)90032-3
更新日期：1983-12-01 00:00:00
abstract：:Binge eating is a dysregulated form of feeding behavior that occurs in multiple eating disorders including binge-eating disorder, the most common eating disorder. Feeding is a complex behavioral program supported through the function of multiple brain regions and influenced by a diverse array of receptor signaling pat...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2016.03.046
更新日期：2016-07-01 00:00:00
abstract：:Hedonic intake of strongly rewarding foods is independent from biological needs and, thus, a common cause of obesity. The effect of potato chips on energy intake in a snacking model could be explained by their fat/carbohydrate content (FCHc). The present study investigated if the FCHc shapes energy intake patterns and...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2019.02.041
更新日期：2019-05-17 00:00:00
abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder associated with cognitive deterioration and neuropsychiatric symptoms. Sensorimotor gating deficit has been identified in neuropsychiatric diseases. The aim of the present study was to evaluate the possible sensorimotor gating deficit and its correlation to memo...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2012.05.007
更新日期：2012-07-15 00:00:00
abstract：:Xenin is a gut hormone that reduces food intake by partly acting through the hypothalamus via neurotensin receptor 1 (Ntsr1). However, specific signaling pathways that mediate xenin-induced feeding suppression are not fully understood. Activation of Ntsr1 leads to the activation of the extracellular signal-regulated k...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2016.06.026
更新日期：2016-10-01 00:00:00
abstract：:In order to find out the possible earliest biomarkers of Parkinson's disease (PD) cholinopathy, we followed the impact of bilateral pedunculopontine tegmental nucleus (PPT) lesion in rat on: the cortical and hippocampal sleep/wake states architectures, all sleep states related EEG microstructures, sleep spindles, the ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.11.021
更新日期：2018-02-26 00:00:00
abstract：:Fetal Alcohol Syndrome (FAS) is associated with high rates of drug addiction in adulthood. One possible basis for increased drug use in this population is altered sensitivity to drug-associated contexts. This experiment utilized a rat model of FASD to examine behavioral and neural changes in the processing of drug cue...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.06.003
更新日期：2017-08-14 00:00:00
abstract：:Astrocyte dysfunction is implicated in clinical depression. There is a paucity of animal models to assess the role of astrocytes in depression pathogenesis. Refinement of an existing model is described here. Administration of the astrocytic toxin L-alpha aminoadipic acid (L-AAA) to the pre-limbic cortex (PLC) was asse...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2019.01.015
更新日期：2019-04-19 00:00:00
abstract：:The developmental trajectories of theta band (4-7 Hz) event-related oscillations (EROs), a key neurophysiological constituent of the P3 response, were assessed in 2170 adolescents and young adults ages 12 to 25. The theta EROs occurring in the P3 response, important indicators of neurocognitive function, were elicited...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2015.06.020
更新日期：2015-10-01 00:00:00
abstract：RATIONALE:Addiction is characterized by inflexible drug consumption: unpleasant consequences are accepted. Rat studies with several drugs proved that long-term voluntary intake induced abstinence-outlasting excessive and inflexible consumption. OBJECTIVE:Establishing a long-term model of oral self-administration of ni...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.10.011
更新日期：2011-03-01 00:00:00
